Navegando por Palavras-chave "postmenopause"
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- ItemSomente MetadadadosAnalysis of collagen in parametrium and vaginal apex of women with and without uterine prolapse(Springer, 2002-11-01) Takano, C. C.; Girao, MJBC; Sartori, MGF; Castro, R. A.; Arruda, R. M.; Simoes, M. J.; Baracat, E. C.; Lima, G. R. de; Universidade Federal de São Paulo (UNIFESP)Our objective was to compare the amount of collagen in parametrium and vaginal apex between women with uterine prolapse at pre- and postmenopause, and in women without prolapse. the study included 22 premenopausal women without prolapse (group A), 10 premenopausal women with prolapse (group 13), and 23 postmenopausal women with prolapse (group Q (total 55). Patients in group A underwent abdominal hysterectomy for uterine leiomyoma, and patients in groups B and C underwent vaginal hysterectomy. During the surgical procedure we obtained biopsies from the lateral parametrium and vaginal apex. the tissue was stained for histological analysis with picrosirius. We observed a lower amount of collagen in the parametrium of women with uterine prolapse, both in menacme and in postmenopause, than in the parametrium of women without prolapse. We observed no statistically significant difference in vaginal apex between the groups.
- ItemSomente MetadadadosComparative bioavailability study of an once-a-week matrix versus a twice-a-week reservoir transdermal estradiol delivery systems in postmenopausal women(Elsevier B.V., 1996-04-01) Baracat, Edmundo [UNIFESP]; |Haidar, Mauro [UNIFESP]; Castelo, Adauto [UNIFESP]; Tufik, Sergio [UNIFESP]; Lima, Geraldo Rodrigues de [UNIFESP]; Vieira, Jose Gilberto Henrique [UNIFESP]; Peloso, U.; Casoy, J.; Universidade Federal de São Paulo (UNIFESP); WYETH BRAZIL; WYETH AYERST INTAn open-label, randomised, crossover study was conducted with in healthy postmenopausal women to compare the relative bioavailability of a matrix transdermal estradiol delivery system worn for 7 consecutive days, versus a reservoir transdermal patch worn for 4 days followed by its immediate replacement by another patch worn for further 3 consecutive days. There was a minimum 7-day washout period between the two study periods. Both systems were labelled to release approximately 50 mu g/day of estradiol. Twenty-six subjects were evaluated with regard to estradiol serum levels. Blood samples were taken immediately before and at regular intervals until 192 h after the initiation of each study treatment (patch application) and assayed for estradiol. There was no difference between the patches with regard to C-max. Based on the relative bioavailability, one matrix patch proved to be bioequivalent to two reservoir patches worn consecutively for 7 days. These results demonstrate the ability of one matrix patch to deliver consistent therapeutic levels of estradiol over a 7-day period.
- ItemSomente MetadadadosCYP17 polymorphism and hot flushes in postmenopausal women(Informa Healthcare, 2008-01-01) Massad-Costa, A. M. [UNIFESP]; Nogueira-de-Souza, N. C. [UNIFESP]; Carvalho, Cristina Valletta de [UNIFESP]; Silva, I. D. da [UNIFESP]; Guindalini, C. [UNIFESP]; Nogueira, R. C. [UNIFESP]; Soares, J. M. [UNIFESP]; Haidar, Mauro Abi [UNIFESP]; Baracat, E. C.; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)Objective To investigate the association between the CYP17 alpha gene polymorphism and hot flushes in postmenopausal women.Methods Ninety-three non-hysterectomized, postmenopausal women were enrolled in this study. Vasomotor symptoms were assessed at the baseline visit and based on information provided by each participant. the genotypic polymorphism of CYP17 alpha gene was analyzed by PCR-RFLP assay using genomic DNA isolated from peripheral blood lymphocytes.Results Thirty-six women reported hot flushes of mild intensity, 25 reported hot flushes of moderate intensity and 32 of severe intensity. There was no significant difference between the severity of hot flushes and the CYP17 genotype or allele frequencies, 0.58 and 0.67 respectively. No association was found between hot flush severity and the CYP17 allele (odds ratio = 1.17, p = 0.61).Conclusion the results of this study suggest that the CYP17 MspAI polymorphism was not significantly associated with an increased risk of reporting hot flushes.At the World Congress on Menopause in Madrid, May 2008, Dr Massad-Costa was awarded the Robert Greenblatt Prize for Basic Science for the study reported in this paper.
- ItemAcesso aberto (Open Access)Efeitos das isoflavonas na função sexual na pós-menopausa(Universidade Federal de São Paulo (UNIFESP), 2013-08-28) Araujo, Teresa Raquel Embirucu de [UNIFESP]; Haidar, Mauro Abi [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: The purpose of this study was to analyze the effects of soybean extract with high concentration of isoflavones in postmenopausal sexual function by the sexual questionnaire Female Sexual Function (FSFI) and vaginal cytology. Materials and methods: This is a randomized, double-bind, placebocontrolled clinical trial with 84 postmenopausal patients. The patients were allocated in two groups: Group A, with 43 patients receiving 60mg daily of oral isoflavones, and Group B, with 41 receiving placebo. The power calculation of 80% was 90 patients. Results: There was not difference between both groups in relation to FSFI domains: sexual desire, arousal, lubrication, satisfaction and pain (p>0.05). The maturation value of vaginal epithelium of group A was similar to group B. Conclusion: Our data suggests the isoflavones may not have benefits on the postmenopausal sexual function.
- ItemSomente MetadadadosEffects of topical estradiol on the facial skin collagen of postmenopausal women under oral hormone therapy: A pilot study(Elsevier B.V., 2007-02-01) Patriarca, Marisa T.; Goldman, Katy Z.; Santos, Jose M. dos; Petri, Valeria; Simoes, Ricardo Santos; Soares, Jose M.; Simoes, Manuel J.; Baracat, Edmund C.; Universidade Federal de São Paulo (UNIFESP)Objective: To analyze the dermal collagen of 15 postmenopausal women who had being treated with systemic estrogen replacement before and after using topical a 0.01% estrogen treatment.Methods: Fifteen patients were included in this clinical trial using the systemic estrogen therapy for at least I year (minimum and maximum lengths of therapy were 13 and 40 months, respectively). A facial punch was performed in the preauricular area for collecting samples before and after the 16 weeks of treatment. Blood samples were also collected for estradiol level determination. the morphometric determination of epithelial and dermal thickness as well as dermal collagen were measured using a suitable software. the paired Student's t-test was used for statistical analysis.Results: the epithelial and dermal thickness enhanced after the topic estrogen therapy (P < 0.01). the amount of collagen significantly increased after 16 weeks of treatment (P < 0.001). the estrogen levels did not significant increase after the topical therapy (P > 0.05).Conclusion: Our data suggested that topical estrogen associated to systemic estrogen therapy seems to increase the expression of skin collagen amount, which may prove to be beneficial for the postmenopausal facial skin. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
- ItemAcesso aberto (Open Access)Effects of vitamin D supplementation on pulmonary function in postmenopausal women following an aquatic exercise program(Sbem-Soc Brasil Endocrinologia & Metabologia, 2017) Nolasco, Rodrigo [UNIFESP]; Moreira, Linda D. F. [UNIFESP]; Bocalini, Danilo S.; Fronza, Fernanda C. A. O.; Marin, Rosangela Villa [UNIFESP]; Lazaretti-Castro, Marise [UNIFESP]Objective: This study sought to investigate the effects of vitamin D supplementation and aquatic exercise on pulmonary function in postmenopausal women. Materials and methods: This prospective and controlled study included 104 women (62 +/- 6.5 years) divided into three groups: a control group lacking vitamin D and calcium supplementation which remained sedentary (CG
- ItemSomente MetadadadosImpact of insomnia on pain in postmenopausal women(Taylor & Francis Ltd, 2017) Frange, Cristina [UNIFESP]; Naufel, Maria Fernanda Soares [UNIFESP]; Andersen, Monica Levy [UNIFESP]; Ribeiro, Eliane Beraldi [UNIFESP]; Girão, Manoel João Batista Castello [UNIFESP]; Tufik, Sergio [UNIFESP]; Hachul, Helena [UNIFESP]Background: Sleep disturbances and pain are assumed to be reciprocally linked. Insomnia and pain are central symptoms of the postmenopausal period and are closely related. Insomnia affects quality of life, increases pain sensitivity, the risk of pain-related disability, and other health problems.Objective: To investigate whether insomnia influences aspects of pain (pain intensity and the effect of pain on daily function) in postmenopausal women, and to evaluate the objective sleep pattern of insomniacs with pain.Methods: Fifty-seven women completed questionnaires about insomnia, climacteric symptoms, and pain. Polysomnography data were collected as well as their medical history. Patients were allocated into three groups: control, subthreshold insomnia, and insomnia. Pain intensity, climacteric symptoms and objective sleep pattern were compared between groups.Results: Postmenopausal women with insomnia had statistically significant higher pain interference in their activities (e.g. relationships with other people, enjoyment of life and sleep) than controls, and had more severe climacteric symptoms. There were no statistically significant differences in pain intensity and objective sleep pattern between groups.Conclusions: Insomnia status affected climacteric symptoms and pain interference, but not pain intensity in postmenopausal women. Women with insomnia had higher rates of climacteric symptoms than those without insomnia or those with subthreshold insomnia. No changes in objective sleep pattern were found.
- ItemSomente MetadadadosPower Doppler of the urethra in continent or incontinent, pre- and postmenopausal women(Springer, 2000-06-01) Jarmy-Di Bella, ZIK; Girao, MJBC; Sartori, MFG; Di Bella, V; Lederman, H. M.; Baracat, E. C.; Lima, G. R.; Universidade Federal de São Paulo (UNIFESP)Urethral pressure should exceed bladder pressure, both at rest and on stress, for urinary continence to occur. A decrease in urethral pressure is a major factor explaining the pathogenesis of urinary incontinence. A number of elements, such as smooth and striated periurethral muscles, and connective, vascular and elastic tissues, contribute to urethral pressure. the periurethral vessels are influenced by hormonal changes during the menstrual cycle, during pregnancy and postmenopause. We studied the periurethral vessels in 97 women, 57 of whom were incontinent and 40 continent, using power color Doppler velocimetry. the number of periurethral vessels, systolic peak, minimum diastolic values, pulsatility and resistance indexes, as well as systolic-diastolic ratio, were assessed. Statistically significant differences were found between incontinent women in the premenopausal period and those in the postmenopausal period, regarding the number of periurethral vessels, systolic peak, minimum diastolic values, pulsatility and resistance indexes.
- ItemSomente MetadadadosSleep disturbances, oxidative stress and cardiovascular risk parameters in postmenopausal women complaining of insomnia(Taylor & Francis Ltd, 2006-08-01) Campos, H. Hachul de; Brandao, L. C.; D'Almeida, V.; Grego, B. H. C.; Bittencourt, L. R.; Tufik, S.; Baracat, E. C.; Universidade Federal de São Paulo (UNIFESP)Objective the aim of this work was to investigate cardiovascular risk factors and oxidative stress parameters as well as sleep disturbances in polysomnography recordings of 38 postmenopausal women with insomnia.Methods Polysomnography recordings were performed on subjects for sleep analysis. Oxidative stress parameters were analyzed by measuring blood concentration of catalase, superoxide dismutase (SOD), thiobarbituric acid reactive substances (TBARS) and glutathione. for cardiovascular risk factors, we measured plasma levels of homocysteine, folic acid and vitamin B6.Results Findings of polysomnography recordings revealed: 68% experienced decreased sleep efficiency, 50% had apnea, 7.8% had periodic leg movements and 2.6% had bruxism (involuntary gnashing and grinding of the teeth during sleep). Our results showed that the majority of our subjects presented normal concentrations of the parameters studied according to standards reached in our laboratory. the only notable exception was TBARS. in this case, only 21% displayed normal values. We also found inverse correlations between SOD activity and both age and time of menopause.Conclusions Although all women complained of insomnia, 50% of them demonstrated apnea during polysomnography recordings. of the parameters measuring oxidative stress, only TBARS levels were increased in our sample. Some clinical data, such as time of onset of menopause, may be associated with the oxidative stress status of these women, probably due to the lack of estrogen and to sleep disturbances, such as apnea.
- ItemSomente MetadadadosSulfated glycosaminoglycans of periurethral tissue in pre- and postmenopausal women(Elsevier B.V., 2008-08-01) Feldner, Paulo Cezar [UNIFESP]; Ferreira Sartori, Marair Gracio [UNIFESP]; Nader, Helena B. [UNIFESP]; Dietrich, Carl P. [UNIFESP]; Lima, Geraldo Rodrigues de [UNIFESP]; Baracat, Edmund Chada [UNIFESP]; Batista Castello Girao, Manoel Joao [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: the objective was to determine the sulfated glycosaminoglycans (GAGs) of the extracellular matrix (ECM) in pre- and postmenopausal women.Study design: Periurethral tissue was obtained from 44 consecutive women who underwent surgery for urinary incontinence, for pelvic organ prolapse, or for other gynecologic benign conditions. Biopsy specimens were assessed by biochemical methods to characterize and quantify,sulfated GAG. Measurements were made of total GAG, chondroitin sulfate, dermatan sulfate and of heparan sulfate. Data were compared using the t-test.Results: Patients were divided into two groups (pre- and postmenopausal groups) and dermatan sulfate was the most predominant glycosaminoglycan. Postmenopausal women had significantly less total sulfated glycosaminoglycans (p < 0.01), dermatan sulfate (p < 0.01) and chondroitin sulfate (p < 0.05) than premenopausal women. We did not observe any differences in heparan sulfate.Conclusions: Postmenopausal women showed quantitative differences in the biochemical characteristics of the ECM in periurethral tissue by analysis of sulfated GAG. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
- ItemSomente MetadadadosSulfated glycosaminoglycans of the vagina and perineal skin in pre- and postmenopausal women, according to genital prolapse stage(Springer, 2004-08-01) Bezerra, LRPS; Feldner, P. C.; Kati, L. M.; Girao, MJBC; Sartori, M. G.; Baracat, E. C.; Lima, G. R. de; Nader, H. B.; Dietrich, C. P.; Universidade Federal de São Paulo (UNIFESP)The aim of this study was to analyze the amount and types of sulfated glycosaminoglycans (GAGs) of the extracellular matrix (ECM) in the posterior vaginal wall and perineal skin in menacme and postmenopausal women, according to genital prolapse stage. Samples of vaginal tissue and perineal skin were obtained from 40 women who underwent vaginal surgery. Sulfated glycosaminoglycans were extracted by extensive tissue maxatase digestion, submitted to electrophoresis on agarose gel, and their concentrations were determined by densitometry. Dermatan sulphate (DS) was the predominant GAG, followed by chondroitin sulfate (CS) and heparan sulfate (HS). in the vagina there was a significant decrease in total GAGs, CS, DS and HS in postmenopausal women with prolapse stage 2 and 3 compared to the premenopausal group, independent of the stage. in stage 2 and 3 postmenopausal patients there was a significant decrease of DS and HS compared to the stage 1 postmenopausal group. in perineal skin there was no significant difference between total GAG amount, DS and HS. However, the amount of CS in premenopausal stage 1 patients was significantly than that in postmenopausal patients stage 1 and stages 2 and 3. in conclusions, there are quantitative and qualitative differences in GAGs of the ECM in vaginal wall and perineal skin between women in menacme and the postmenopause, according to genital prolapse stage.