Navegando por Palavras-chave "parturition"

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    Bcl-2 and Bax expressions in pre-term, term and post-term placentas
    (Wiley-Blackwell, 2008-08-01) Daher, Silvia [UNIFESP]; Guimaraes, Alberto Jorge de Sousa [UNIFESP]; Mattar, Rosiane [UNIFESP]; Ishigai, Marcia Marcelino de Souza [UNIFESP]; Barreiro, Erica Giovana [UNIFESP]; Bevilacqua, Estela Maris Andrade Forell [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    ProblemPlacental apoptosis-associated protein imbalance might contribute to the pathogenesis of pre- and post-term birth. Therefore, we evaluated the expression and distribution of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) molecules in term, pre-term and post-term placentas.Method of StudyPlacental samples were collected from women with term (n = 25), pre-term (n = 7) and post-term (n = 10) deliveries. the expression of Bcl-2 and Bax was assessed by immunochemistry on paraffin-embedded placental specimens.ResultsThe pattern of immunostaining for Bcl-2 and Bax was the same in all samples, but not the intensity. the Bax/Bcl-2 ratio was higher in both pre-term and post-term placental samples compared with term placentas as a result of intense reactivity for the pro-apoptotic factor, Bax in pre-term and post-term placentas and, for Bcl-2 decrease in pre-term placentas.ConclusionThese findings suggest that different unbalance mechanisms in placental apoptotic-associated protein expressions may be involved in the physiopathology of pre-term and post-term births.
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    Soluble Fas antigen in term labour
    (Elsevier B.V., 2006-10-01) Daher, S.; Moreira, J. R.; Dalboni, Maria Aparecida [UNIFESP]; Guimaraes, A. J.; Bevilacqua, E.; Mattar, Rosiane [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)