Navegando por Palavras-chave "osteodistrofia renal"

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    Association between indoxyl sulfate and bone histomorphometry in pre-dialysis chronic kidney disease patients
    (Sociedade Brasileira de Nefrologia, 2014-09-01) Barreto, Fellype Carvalho; Barreto, Daniela Veit; Canziani, Maria Eugênia Fernandes [UNIFESP]; Tomiyama, Cristianne; Higa, Andrea; Mozar, Anaïs; Glorieux, Griet; Vanholder, Raymond; Massy, Ziad; Carvalho, Aluizio Barbosa de [UNIFESP]; Jules Verne University of Picardy; Universidade Federal de São Paulo (UNIFESP); University Hospital Gent; Pontifical Catholic University of Paraná
    Introduction: Experimental studies have suggested that indoxyl sulfate (IS), a protein-bound uremic toxin, may be involved in the development of renal osteodystrophy. Objective: evaluate the association between IS levels and biochemical parameters related to mineral metabolism and bone histomorphometry in a cohort of pre-dialysis chronic kidney disease (CKD) patients. Methods: This is a post-hoc analysis of an observational study evaluating the association between coronary calcification and bone biopsy findings in 49 patients (age: 52 ± 10 years; 67% male; estimated glomerular filtration rate: 36 ± 17 ml/min). Serum levels of IS were measured. Results:Patients at CKD stages 2 and 3 presented remarkably low bone formation rate. Patients at CKD stages 4 and 5 presented significantly higher osteoid volume, osteoblast and osteoclast surface, bone fibrosis volume and bone formation rate and a lower mineralization lag time than CKD stage 2 and 3 patients. We observed a positive association between IS levels on one hand and the bone formation rate, osteoid volume, osteoblast surface and bone fibrosis volume on the other. Multivariate regression models confirmed that the associations between IS levels and osteoblast surface and bone fibrosis volume were both independent of demographic and biochemical characteristics of the study population. A similar trend was observed for the bone formation rate. Conclusion: Our findings demonstrated that IS is positively associated with bone formation rate in pre-dialysis CKD patients.
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    Fórum nacional de discussão das diretrizes do KDIGO para o distúrbio mineral e ósseo da doença renal crônica (DMO-DRC): uma análise crítica frente à relidade Brasileira
    (Sociedade Brasileira de Nefrologia, 2010-09-01) Moysés, Rosa Maria Affonso; Cancela, Ana Ludimila Espada; Gueiros, José Edvanilson Barros; Barreto, Fellype Carvalho; Neves, Carolina Lara; Canziani, Maria Eugênia Fernandes [UNIFESP]; Oliveira, Rodrigo Bueno de; Jorgetti, Vanda; Carvalho, Aluizio Barbosa de [UNIFESP]; Universidade de São Paulo (USP); Universidade Federal de Pernambuco Hospital das Clínicas; Universidade de Picardie; Universidade Federal da Bahia; Universidade Federal de São Paulo (UNIFESP)
    On November 14th, 2009, the Brazilian Society of Nephrology coordinated the Brazilian Discussion Meeting on the new KDIGO (Kidney Disease: Improving Global Outcomes) guidelines. The purpose of this meeting, which was attended by 64 nephrologists, was to discuss these new guidelines from the Brazilian perspective. This meeting was supported by an unrestricted grant of the biotechnology company Genzyme, which did not have access to the meeting room or to the discussion sections. This article brings a summary of the KDIGO guidelines and of the discussions by the attendees.