Navegando por Palavras-chave "orofacial movements"

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    Antidyskinetic effects of risperidone on animal models of tardive dyskinesia in mice
    (Elsevier B.V., 2003-04-15) Carvalho, R. C.; Silva, R. H.; Abilio, V. C.; Barbosa, P. N.; Frussa, R.; Universidade Federal de São Paulo (UNIFESP)
    The effects of risperidone, an atypical neuroleptic, were investigated on two animal models of tardive dyskinesia (TD). the repeated administration of reserpine (1.0 mg/kg) or haloperidol (2.0 mg/kg) induces orofacial movements in mice, which are very similar to those observed in humans presenting TD. the effects of acute or repeated treatment with several doses of risperidone (0.1; 0.5; 2.0 or 4.0) on the expression and development of orofacial movements in reserpine- and haloperidol-treated male mice were investigated. the results showed that risperidone per se did not induce the development of orofacial movements. in addition, this drug was able to attenuate the expression and the development of reserpine-as well as haloperidol-induced orofacial movements. These results are in line with several clinical studies that suggest not only a lower incidence of TD in schizophrenic patients treated with risperidone, but also an antidyskinetic effect of this drug in patients previously treated with classical neuroleptics. (C) 2003 Elsevier Science Inc. All rights reserved.
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    Effects of buspirone on an animal model of tardive dyskinesia
    (Elsevier B.V., 1999-11-01) Queiroz, Claudio MT [UNIFESP]; Frussa-Filho, Roberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    1. the effects of buspirone were studied on an animal model of tardive dyskinesia, i.e., the quantification of orofacial dyskinesia in rats repeatedly treated with reserpine.2. Rats were co-treated with saline [SAL] or buspirone [BUS] (3.0 mg/kg, i.p., twice daily) and vehicle [VEH] or reserpine [RES] (0.1 mg/kg, s.c., once every other day) for 19 days. On the day 20, the animals were observed for quantification of the behavioral parameters of orofacial dyskinesia: tongue protrusion and vacuous chewing movements frequencies and duration of twitching of the facial musculature.3. Rats of the SAL+RES group exhibited a significant increase in the three behavioral parameters of orofacial dyskinesia relative to the rats of the SAL+VEH group. However, animals of the BUS+RES group showed only an increased frequency of vacuous chewing movements when compared to animals of the SAL+VEH group. in addition, the duration of the facial twitching was significantly decreased in the BUS+RES group in relation to rats of the SAL+RES group. There were no significant differences in the orofacial parameters between the BUS+VEH and the SAL+VEH groups.4. Because it was also verified that chronic buspirone treatment was able to increase apomorphine-induced yawning behavior, the possibility is raised that buspirone attenuates reserpine-induced orofacial dyskinesia through the development of dopamine autoreceptor supersensitivity.
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    Effects of social isolation on aging-induced orofacial movements in rats
    (Elsevier B.V., 2005-09-15) Ricardo, V. P.; Frussa, R.; Silva, R. H.; Lopez, G. B.; Patti, C. L.; Zanier-Gomes, P. H.; Araujo, N. P.; Lima, AJO; Carvalho, R. C.; Kameda, SR; Abilio, V. C.; Universidade Federal de São Paulo (UNIFESP)
    World population is becoming older, and aging is a common risk factor for a number of pathologies. in this respect, it is important to study possible factors that could modify alterations implicated in the process of aging. the aim of the present study is to verify the effects of social isolation on the expression of orofacial movements in adult and old rats. Adult and old rats were housed isolated for 5 days or kept in their home cages in groups of six. Before and after this period, orofacial movements and open-field general activity were evaluated. Aging-induced orofacial movements were abolished by isolation. On the other hand, isolated adult rats presented an increase in orofacial movements. General activity was decreased by aging but was not modified by isolation. Our results indicate that social isolation produces different effects in adult and old rats, and these effects are specific for orofacial movements and not related to a decrease in general motor activity. (c) 2005 Elsevier Inc. All rights reserved.