Navegando por Palavras-chave "mood disorder"

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    Comparison of carbamazepine and lithium in treatment of birolar disorder: a systematic review of randomized controlled trials
    (Wiley-Blackwell, 2009-01-01) Ceron-Litvoc, Daniela [UNIFESP]; Soares, Bernardo Garcia [UNIFESP]; Geddes, John; Litvoc, Julio; Lima, Mauricio Silva de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Oxford; Universidade de São Paulo (USP)
    Objectives To review data from randomized controlled trials (RCTs) assessing the comparative efficacy of carbamazepine and lithium in treatment of acute manic and maintenance phase of bipolar disorder (BD).Design RCTs were identified through a search strategy that included: electronic databases, reference cross-checking, hand search of non-indexed publications. and book chapters on the treatment of BD comparing carbamazepine with lithium. Outcomes investigated were antimanic effect. trial withdrawal, relapse, hospitalization, need for rescue medication, and presence of adverse effects. Selection of studies and data analysis were performed independently by authors. Whenever possible, data from trials were combined through meta-analyses. Relative risks (RR) were estimated for dichotomous data.Results in acute mania. carbamazepine was similar to lithium oil the following Outcomes: trial withdrawal due to adverse effects, number of participants with at least one adverse effect. improvement in the Clinical Global Impression (CGI). in acute mania, carbamazepine was associated with fewer trial withdrawals. in maintenance treatment. carbamazepine was similar to lithium in relapses and hospitalization. but there were fewer trial withdrawals due to adverse effects on lithium.Conclusion This review suggests that carbamazepine might be comparable to lithium in terms of efficacy and safety. and therefore it valuable option in the treatment of both manic and maintenance phases. Copyright (c) 2008 John Wiley & Sons, Ltd.
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    The Putative Impact of Metabolic Health on Default Mode Network Activity and Functional Connectivity in Neuropsychiatric Disorders
    (Bentham Science Publ Ltd, 2014-01-01) Cha, Danielle S.; De Michele, Francesco; Soczynska, Joanna K.; Woldeyohannes, Hanna O.; Kaidanovich-Beilin, Oksana; Carvalho, Andre F.; Malhi, Gin S.; Patel, Hiren; Sim, Kang; Brietzke, Elisa [UNIFESP]; Mansur, Rodrigo Barbachan [UNIFESP]; Dunlop, Katharine A. M.; Alsuwaidan, Mohammad; Baskaran, Anusha; Fagiolini, Andrea; Reznikov, Roman; Kudlow, Paul A.; McIntyre, Roger S.; Univ Hlth Network; Univ Toronto; Univ Roma La Sapienza; Mt Sinai Hosp; Univ Fed Ceara; Univ Sydney; Ctr Addict & Mental Hlth; Natl Univ Singapore; Universidade Federal de São Paulo (UNIFESP); Queens Univ; Univ Siena; Univ Western Ontario
    The default mode network (DMN) describes a distributed network of brain regions that are predominantly activated and engaged during periods of spontaneous, stimulus independent thought (i.e., at rest) and remain quiescent during attention-demanding, goal-directed tasks. Replicated evidence in functional neuroimaging studies suggests that midline cortical and subcortical brain regions responsible for memory, self-relevant emotional and mental processes, as well as information integration comprise the DMN. The DMN is posited to represent self-referential mental activity via a dynamic interplay of cognitive and emotional processes by integrating information from the external environment with introspective thoughts to generate an autobiographical concept of the self.It has been amply documented that irregularities in the DMN and its functional connectivity are associated with various neuropsychiatric disorders. Moreover, accumulating evidence also suggests that individuals with select medical disorders (i.e., metabolic disorders) demonstrate alterations in DMN activity and functional connectivity. However, there is a paucity of data evaluating whether individuals with metabolically-based medical conditions, exhibiting altered DMN activity and functional connectivity, are at increased risk for developing neuropsychiatric disorders. Likewise, potential mechanisms (e.g., altered brain metabolism, insulin resistance) mediating these changes and their implications for novel treatment approaches have yet to be elucidated. Taken together, the overarching aim of this review is to provide a synthetic overview that suggests that this neural circuit may represent a common (or convergent) substrate affected in individuals with select neuropsychiatric and metabolic disorders.
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    Summaries of plenary and selected symposia sessions at the XXIV World Congress of Psychiatric Genetics
    (Lippincott Williams & Wilkins, 2017) Ciobanu, Liliana G.; Ori, Anil P. S.; Pagliaroli, Luca; Polimanti, Renato; Spindola, Leticia M. [UNIFESP]; Vincent, John B.; Cormack, Freida K.
    The XXII World Congress of Psychiatric Genetics, sponsored by the International Society of Psychiatric Genetics, took place in Jerusalem, Israel, from 30 October 2016 to 3 November 2016. A total of 372 participants gathered to discuss the latest findings in the field. The following report was written by early career investigator travel awardees, and student and postdoctoral attendees. Each was assigned one or more sessions as a rapporteur. This manuscript represents topics covered in most, but not all of the presentations during the conference, and contains some of the major notable new findings reported. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
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    Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014
    (Lippincott Williams & Wilkins, 2016) Aas, Monica; Blokland, Gabriella A. M.; Chawner, Samuel J. R. A.; Choi, Shing-Wan; Estrada, Jose; Forsingdal, Annika; Friedrich, Maximilian; Ganesham, Suhas; Hall, Lynsey; Haslinger, Denise; Huckins, Laura; Loken, Erik; Malan-Muller, Stefanie; Martin, Joanna; Misiewicz, Zuzanna; Pagliaroli, Luca; Pardinas, Antonio F.; Pisanu, Claudia; Quadri, Giorgia; Santoro, Marcos L. [UNIFESP]; Shaw, Alex D.; Ranlund, Siri; Song, Jie; Tesli, Martin; Tropeano, Maria; van der Voet, Monique; Wolfe, Kate; Cormack, Freida K.; DeLisi, Lynn
    The XXII World Congress of Psychiatric Genetics, sponsored by the International Society of Psychiatric Genetics, took place in Copenhagen, Denmark, on 12-16 October 2014. A total of 883 participants gathered to discuss the latest findings in the field. The following report was written by student and postdoctoral attendees. Each was assigned one or more sessions as a rapporteur. This manuscript represents topics covered in most, but not all of the oral presentations during the conference, and contains some of the major notable new findings reported. (c) 2016 Wolters Kluwer Health, Inc. All rights reserved.