Navegando por Palavras-chave "menstrual cycle"
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- ItemAcesso aberto (Open Access)Assessment of the proliferative, apoptotic and cellular renovation indices of the human mammary epithelium during the follicular and luteal phases of the menstrual cycle(Biomed Central Ltd, 2005-01-01) Navarrete, Maria Alicia H [UNIFESP]; Maier, Carolina M.; Falzoni, Roberto; Quadros, Luiz Gerk de Azevedo [UNIFESP]; Lima, Geraldo R. [UNIFESP]; Baracat, Edmund Chada [UNIFESP]; Nazario, Afonso CP [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Stanford Univ; APC PatholIntroduction During the menstrual cycle, the mammary gland goes through sequential waves of proliferation and apoptosis. in mammary epithelial cells, hormonal and non-hormonal factors regulate apoptosis. To determine the cyclical effects of gonadal steroids on breast homeostasis, we evaluated the apoptotic index ( AI) determined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling ( TUNEL) staining in human mammary epithelial cells during the spontaneous menstrual cycle and correlated it with cellular proliferation as determined by the expression of Ki-67 during the same period.Methods Normal breast tissue samples were obtained from 42 randomly selected patients in the proliferative ( n = 21) and luteal ( n = 21) phases. Menstrual cycle phase characterization was based on the date of the last and subsequent menses, and on progesterone serum levels obtained at the time of biopsy.Results the proliferation index ( PI), defined as the number of Ki-67-positive nuclei per 1,000 epithelial cells, was significantly larger in the luteal phase (30.46) than in the follicular phase (13.45; P = 0.0033). the AI was defined as the number of TUNEL-positive cells per 1,000 epithelial cells. the average AI values in both phases of the menstrual cycle were not statistically significant ( P = 0.21). However, the cell renewal index ( CRI = PI/AI) was significantly higher in the luteal phase ( P = 0.033). A significant cyclical variation of PI, AI and CRI was observed. PI and AI peaks occurred on about the 24th day of the menstrual cycle, whereas the CRI reached higher values on the 28th day.Conclusions We conclude that proliferative activity is dependent mainly on hormonal fluctuations, whereas apoptotic activity is probably regulated by hormonal and non-hormonal factors.
- ItemAcesso aberto (Open Access)Avaliação do perfil inflamatório, estresse oxidativo e dos estados de humor e de ansiedade em jogadoras de futebol de campo com e sem Síndrome Pré-Menstrual (SPM)(Universidade Federal de São Paulo (UNIFESP), 2015-06-30) Paiva, Roberta Foster Leonidas de [UNIFESP]; Jarmy, Zsuzsanna Ilona Katalin de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)To assess the inflammatory status, oxidative stress and states of mood and anxiety disorders in the field of soccer players with and without Premenstrual Syndrome (PMS) in two phases of the menstrual cycle: follicular and luteal and at two different times: before and after a collective football (acute exercise). METHODS: We evaluated 52 competitive level of players aged between 16 and 30 years. For the determination of SPM and monitoring phases of the menstrual cycle was used questionnaire Daily Symptoms Report (DSR) validated in Portuguese for three consecutive months. For the determination of Mood States and the Anxiety BRUMS and BAI questionnaires in the four periods studied were used. Also collected urine to the four times to assess the inflammatory status and oxidative stress. RESULTS: Analysis of DSR revealed prevalence of PMS in 59.6% of athletes and prevalence of symptoms such as anxiety and water retention. The BRUMS revealed that the group with PMS had higher changes of moods in the two phases of the menstrual cycle, with greater evidence after acute exercise while the group without the SPM showed minor variation of mood and only in the luteal phase of the cycle more also evidence after acute exercise. The BAI has shown an increased state of anxiety only in the group with SPM in the two phases of the cycle, more evident prior to acute exercise. Evaluation of cytokines showed that the group with the SPM has a flash frame associated with PMS and not the exercise acute present in both phases of the menstrual cycle. The athletes with PMS also showed a likely mechanism for maintaining the concentration of oxidative and antioxidative markers in the two phases of the menstrual cycle, not altered by exercise, while no SPM group showed balance between radical production and consumption in the follicular phase and increase oxidant in the luteal phase after the collective, demonstrating the influence of exercise on oxidative mechanism / antioxidative
- ItemSomente MetadadadosEffect of combined oral contraceptives on breast epithelial proliferation in young women(Blackwell Publishing, 2008-09-01) Garcia y Narvaiza, Debora [UNIFESP]; Navarrete, Maria Alicia H. [UNIFESP]; Falzoni, Roberto; Maier, Carolina M.; Nazario, Afonso C. P. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Stanford Univ; APC PatholThe mammary gland undergoes morphologic changes during the menstrual cycle. Proliferation of normal breast epithelium is most extensive during the natural luteal phase. To determine the impact of one cycle of a combined oral contraceptive (COC) on breast homeostasis, we evaluated the proliferation index (PI), determined by KI-67 expression, in normal human mammary epithelial cells and correlated it with cellular proliferation in spontaneous menstrual cycles during the same period. Normal breast tissue samples were obtained from 82 patients randomized in two groups. Forty-two women in group A received one cycle of a COC (30 mu g ethinyl estradiol and 150 mu g levonorgestrel) administrated daily for 21 days, beginning on the first day of the menstrual cycle. Group B patients (n = 40) experienced a natural menstrual cycle. Menstrual cycle phase characterization was based on the date of the last period and subsequent menses and on progesterone serum levels obtained at the time of biopsy. the PI (number of Ki-67-positive nuclei per 1,000 epithelial cells), was significantly larger in group A (5.47 +/- 3.87), than in group B (3.27 +/- 3.24), p < 0.01. A cyclical variation of PI was observed in COC cycles. the rise in PI in the first week of the COC cycles was significantly higher than in the natural cycle (COC = 7.02 +/- 4.94; non-COC = 1.10 +/- 0.67; p < 0.0011). There was no significant difference between the two groups during the other weeks. Additionally, there was an inverse correlation between proliferation and chronological age, irrespective of the stage of the cycle. the PI of COC (p = 0.175) and natural cycles (p = 0.466) were not statistically different in younger patients. COC users have increased proliferative activity at the beginning of the menstrual cycle. This alteration in the pattern of proliferative activity may relate to the increased risk of breast cancer that has been associated with COCs.
- ItemAcesso aberto (Open Access)Estudo do comportamento vocal no ciclo menstrual: avaliação perceptivo-auditiva, acústica e auto-perceptiva(ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, 2004-06-01) Figueiredo, Luciane C. De; Gonçalves, Maria Inês Rebelo [UNIFESP]; Pontes, Antonio; Pontes, Paulo [UNIFESP]; Centro de Estudos da Voz; Universidade Tuiuti do Paraná; Instituto da Laringe - INLAR; Universidade Federal de São Paulo (UNIFESP)During the premenstruation period dysphonia often can be observed and only few women are aware of this voice variation (Quinteiro, 1989). AIM: To verify if there are vocal quality variations between the ovulation period and the first day of the menstrual cycle, by using perceptual-auditory and acoustic analysis, including spectrography, and the self perception of the vocal changes when it occurs. STUDY DESIGN: Case-control. MATERIAL AND METHOD: We studied thirty speech and language pathology students with age ranging from 18 to 25 years, non smokers, with a regular menstrual cycle and who did not take contraceptive. The voices were recorded on the first day of menstruation and on the thirteenth day postmenstruation (ovulation period), for comparison. RESULTS: In the first day of menstruation it was observed: hoarseness and breathiness from light to moderate, vocal instability, voicing interruption, normal pitch and loudness and adequate resonance; worse quality of the harmonics definition, increased amount of noise between them and lower length of superior harmonics. A higher fundamental frequency, higher values of Jitter and Shimmer and a lower harmonic-to-noise ratio was also observed. CONCLUSION: During the menstrual cycle there are changes in the vocal quality, in the harmonic behavior and in the vocal parameters (f0, Jitter, Shimmer and harmonic-to-noise ratio). However, the majority of the students were unaware of the vocal variation during menstruation.
- ItemSomente MetadadadosHuman endometrium mRNA profile assessed by oligonucleotide three-dimensional microarray(Parthenon Publishing Group, 2007-09-01) Otsuka, Audrey Y. [UNIFESP]; Andrade, Priscila M.; Villanova, Fabiola Elizabeth [UNIFESP]; Borra, Ricardo C.; Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Univ IbirapueraOur purpose, in die present work, was to further comprehend the genetic events underlying the response to steroids of human endometrium from the mRNA as well as protein expression point of view. in order to achieve this goal we undertook 10 000-oligonucleotide, three-dimensional microarray analysis, followed by immunohistochemistry, on human normal endometrium in the proliferative and secretory phases of the menstrual cycle. the results revealed that a myriad of genes involved in immune response, calcium metabolism and thyroid hormone response were frequently overexpressed in the second or luteal phase of the menstrual cycle. During die follicular phase, in contrast, overexpression of genes was mainly restricted to those encoding proteins involved in cell proliferation.
- ItemAcesso aberto (Open Access)Incidência da sindrome pré-menstrual na prática de esportes(Sociedade Brasileira de Medicina do Exercício e do Esporte, 2009-10-01) David, Alexandra Martins [UNIFESP]; Di Bella, Zsuzsana Jármi [UNIFESP]; Berenstein, Eliezer; Lopes, Antonio Carlos [UNIFESP]; Vaisberg, Mauro [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Faculdade de Medicina ABCDespite the increasing number of women who practice physical exercise, there are still few reports concerned with anatomy, psychology and mainly hormones that could affect their performance. Although there is a multitude of articles about the effects of physical exercise in menstruation, only a few of them report how this function interferes in women's performance. The association physical exercise - menstruation has been studied but without considering the changes during the cycle, the perimenstrual symptoms. Therefore, the aim of this article was to investigate the incidence and periodicity of pre-menstrual symptoms in athletes. A daily questionnaire was applied with the aim to follow the pre-menstrual symptoms during a period of 3 consecutive months. The population of the study was composed by 31 female athletes in fertile age. RESULTS: The prevalence of PMS in athletes was of 71% and the mainly reported symptoms were irritability (86.5%), mood swings (77.3%) and cramps (72.7%). Other symptoms were reported by 59% of the athletes during the pre-menstrual period. CONCLUSION: Our data show a high prevalence of PMS among athletes.
- ItemSomente MetadadadosA menstruação na qualidade de vida das mulheres: construção de um instrumento de avaliação(Universidade Federal de São Paulo (UNIFESP), 2015-04-29) Goncales, Marlene Bueno [UNIFESP]; Barbieri, Marcia Barbieri [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The modern woman was gradually discovering the possibility of improving their quality of life with regard to menstruation, against their personal and sexual relationship, professional and social activity and leisure. In the absence of a specific instrument, it was decided to construct a tool to assess the quality of life in women during menstrual period. Method: This is a qualitative and descriptive study using the focus group technique. The study was conducted according to the parameters contained in the 466/12 Resolution of the National Health Council. Were conducted two focus groups with women of different socioeconomic status, totaling six meetings with 19 participants. After the meetings, the recorded speeches were transcribed and interpreted based on the Bardin content analysis. Results: From the statements of the subjects were identified six categories, called Physical, Psychological, Level of Independence, Social Affairs, Environment and Personal Beliefs and Myths domains. From these domains emerged subcategories called facets, which have been classified and adapted as the quality of life instrument WHOQOL 100 of the World Health Organization to the quality of life characteristics related to the menstrual period. Final considerations: from the domains and facets it was possible to draw up a list of the elements that made up the instrument to assess the quality of life for women in the menstrual period.
- ItemSomente MetadadadosMetformin versus lifestyle changes in treating women with polycystic ovary syndrome(Informa Healthcare, 2012-03-01) Curi, Daniella D. G.; Fonseca, Angela Maggio; Marcondes, Jose Antonio M.; Almeida, Jose Alcione M.; Bagnoli, Vicente R.; Soares-, Jose Maria [UNIFESP]; Baracat, Edmund Chada; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)Objective: To compare the efficacy of metformin with that of lifestyle changes in patients with polycystic ovary syndrome (PCOS). Design: Prospective, randomized clinical trial of 40 women with PCOS to analyze the effects of metformin and lifestyle intervention treatments on menstrual pattern and hormone and metabolic profile. the duration of treatment was 6 months. Statistical analysis was done using Student's t-test. Results: Fifteen women in the metformin group and 12 in the lifestyle changes group completed the study. the menstrual pattern improved by similar to 67% in both groups. There was a significant decrease in waist circumference in the lifestyle changes group (101.8 +/- 3.9 and 95.1 +/- 3.6, at baseline and at 6 months of treatment, respectively; p<0.001) and in body mass index (BMI) in both groups. the predictor of menstrual pattern improvement was BMI. Conclusions: Both metformin and lifestyle changes may increase the number of menstrual cycles in PCOS. This effect was related to a decrease in BMI.
- ItemAcesso aberto (Open Access)Morphological and ultrastructural aspects of the cyclical changes of human mammary gland during the menstrual cycle(Associação Paulista de Medicina - APM, 1994-06-01) Nazário, Afonso Celso Pinto [UNIFESP]; Simões, Manuel de Jesus [UNIFESP]; Lima, Geraldo Rodrigues de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Analyzing the morphological and ultrastructural features of the mammary gland during the menstrual cycle, the authors observed that in the proliferative phase, the mammary gland consisted of few developed lobules and presented a relative absence of mitotic figures. In this phase, the great majority of the epithelial cells contained small, dark, irregular, rich heterochromatinic nuclei. The mammary stroma showed similar findings, presenting dense connective tissue with few enhanced fibroblasts. During the secretory phase, the lobules were well developed and mitotic figures were usually observed. In this phase, the great majority of the ephitelial cells presented clear voluminous, rich euchromatinic nuclei; the stroma consisted of fibroblasts with voluminous nuclei full of euchromatin. There are evident modifications of the mammary tissue according to the phase of the menstrual cycle. The morphological and ultrastructural modifications indicate higher metabolical and mitotic activities during the secretory phase.
- ItemAcesso aberto (Open Access)Relationship between Anxiety and Interleukin 10 in Female Soccer Players with and Without Premenstrual Syndrome (PMS)(Federacao Brasileira Soc Ginecologia & Obstetricia-Febrasgo, 2017) Foster, Roberta [UNIFESP]; Vaisberg, Mauro [UNIFESP]; de Araujo, Maita Poli [UNIFESP]; Martins, Marcia Aparecida [UNIFESP]; Capel, Tiago [UNIFESP]; Lacerda Bachi, Andre Luis; Katalin de Jarmy-Di Bella, Zsuzsanna Ilona [UNIFESP]Objective To investigate the level of anxiety and its relationship with interleukin (IL)10 (anti inflammatory cytokine that modulates mood swings) in a group of female soccer players. Methods Fifty-two eumenorrheic soccer players were evaluated (age 19.8 +/- 4.7 years). The presence of premenstrual syndrome (PMS) and phases of the menstrual cycle were determined by a daily symptomreport (DSR) kept for 3 consecutivemonths. The concentration of cytokine IL-10 was determined from urine samples collected at four moments: at the follicular and luteal phases of the menstrual cycle, and before (pre) and after (post) the simulated game, and it was quantified by flow cytometry (Luminex xMAP - EMDMillipore, Billerica, MA, USA). The level of anxietywas determined through the BAI anxiety questionnaire answered by all athletes at the same time of the urine collection. The Student t-test, analysis of variance (ANOVA) and Pearson correlation with significance level at 5% were used for data analysis. Results We showed that the prevalence of PMS among female soccer players is similar to that reported in the literature. In addition, we showed that the group withPMS has a higher level of anxiety compared with group without PMS (p = 0.002). Interleukin-10 analysis in players without PMS revealed that there was a significant decrease in the level of this cytokine before the game during the luteal phase when compared with the follicular phase (p < 0.05). The correlation analysis between IL-10 and anxiety showed a negative correlation post-game in the luteal phase in the group without PMS (p = 0.02; r = -0.50) and a positive correlation post-game in the luteal phase in PMS group (p = 0.04; r = 0.36). Conclusion Our results suggest that IL-10 may contribute to reduce anxiety in the group without PMS. This could be attributed to the fact that no IL-10 variation was observed in the group with PMS, which presented higher anxiety symptoms when compared with the group without PMS.