Repositório Institucional - Unifesp :: Navegando por Palavras-chave "infertility"

Navegando por Palavras-chave "infertility"

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Clinical Outcome of Intracytoplasmic Sperm Injection in Infertile Men With Treated and Untreated Clinical Varicocele
(Elsevier B.V., 2010-10-01) Esteves, Sandro C. [UNIFESP]; Oliveira, Fernanda V.; Bertolla, Ricardo P.; Universidade Federal de São Paulo (UNIFESP)
Purpose: We evaluated the impact of varicocelectomy on intracytoplasmic sperm injection outcomes in infertile men with clinical varicocele.Materials and Methods: We studied 242 infertile men with a history of clinical varicocele who underwent intracytoplasmic sperm injection. of the men 80 underwent prior subinguinal microsurgical varicocelectomy (treated group 1) and 162 had any grade of clinical varicocele (untreated group 2) at sperm injection. We compared semen analysis results before and after varicocelectomy, and the sperm injection procedure outcomes. Mean time from surgery to sperm injection was 6.2 months. Logistic regression was done to verify whether varicocelectomy influenced the odds of clinical pregnancy, live birth and miscarriage.Results: We noted an improved total number of motile sperm (6.7 x 10(6) vs 15.4 x 10(6), p < 0.01) and a decreased sperm defect score (2.2 vs 1.9, p = 0.01) after vs before varicocele repair. the clinical pregnancy (60.0% vs 45.0%, p = 0.04) and live birth (46.2% vs 31.4%, p = 0.03) rates after the sperm injection procedure were higher in the treated than in the untreated group. the chance of achieving clinical pregnancy (OR 1.82; 95% CI 1.06-3.15) and live birth (OR 1.87, 95% CI 1.08-3.25) by the sperm injection procedure were significantly increased while the chance of miscarriage was decreased (OR 0.433, 95% CI 0.22-0.84) after varicocele was treated.Conclusions: Results suggest that varicocelectomy improves clinical pregnancy and live birth rates by intracytoplasmic sperm injection in infertile couples in which the male partner has clinical varicocele. the chance of miscarriage may be decreased if varicocele is treated before assisted reproduction.
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Concomitant use of FSH and low-dose recombinant hCG during the late follicular phase versus conventional controlled ovarian stimulation for intracytoplasmic sperm injection cycles
(Taylor & Francis Ltd, 2017) Rebello Iaconelli, Carla Andrade; Setti, Amanda Souza; Almeida Ferreira Braga, Daniela Paes [UNIFESP]; Louzada Maldonado, Luiz Guilherme; Iaconelli, Assumpto, Jr.; Borges, Edson, Jr.; Aoki, Tsutomu
The objective of this study was to investigate the effects of low-dose hCG supplementation on ICSI outcomes and controlled ovarian stimulation (COS) cost. Three hundred and thirty patients undergoing ICSI were split into groups according to the COS protocol: (i) control group (n=178), including patients undergoing conventional COS treatment
Acesso aberto (Open Access)
Discinesia ciliar primária: quando o pediatra deve suspeitar e como diagnosticar?
(Sociedade de Pediatria de São Paulo, 2007-12-01) Olm, Mary Anne K. [UNIFESP]; Adde, Fabíola Villac; Silva Filho, Luiz Vicente F. Da; Rodrigues, Joaquim Carlos; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
OBJECTIVE: To review primary ciliary dyskinesia (PCD) and its ultrastructural aspects, to differentiate primary from secondary ciliary defects and to describe the clinical features, screening and diagnostic laboratorial tests, and the clinical management of this disorder. DATA SOURCES: A bibliographical search was obtained from Medline, Lilacs and SciELO databases, from 1980 to 2007. DATA SYNTHESIS: PCD is an autossomic recessive disorder with abnormal structure and/or function of the cilia, leading to reduced mucociliary clearance. The clinical manifestations include upper and lower respiratory tracts, with recurrent ear, sinus and lung infections that may progress to bronchiectasis. Situs inversus and male infertility are other clinical features of this disorder. PCD should be suspected by pediatricians in the following clinical situations: full term neonates with respiratory distress without apparent causes, presence of dextrocardia, infants with chronic cough and/or recurrent upper airways infections in the absence of immunodeficiency and cystic fibrosis, children with atypical asthma and bronchiectasis without a definitive cause. The diagnostic screening tests are the saccharine and nasal nitric oxide tests. Functional and ultrastructural evaluations demand an electronic microscopic analysis and the observation of the frequency and the pattern of the ciliary movement. CONCLUSIONS: Although the prevalence of PCD is low, the difficulties in establishing the diagnosis due to the complex investigations demanded and the unfamiliarity of the disease by physicians lead to underdiagnosis. Early diagnosis and treatment of PCD are essential to reduce the morbidity and to avoid complications.
Acesso aberto (Open Access)
Effects of acupuncture and moxa treatment in patients with semen abnormalities
(Science China Press, 2003-12-01) Gurfinkel, Edson [UNIFESP]; Cedenho, Agnaldo Pereira [UNIFESP]; Yamamura, Ysao [UNIFESP]; Srougi, Miguel [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Aim: To evaluate the effect of Chinese Traditional Medicine, acupuncture and moxa treatment, on the semen quality in patients with semen abnormalities. Methods: In a prospective, controlled and blind study, nineteen patients, aged 24 years similar to 42 years and married for 3 years similar to 11 years without children with semen abnormalities in concentration, morphology and/or progressive motility without apparent cause, were randomized into two groups and submitted to acupuncture and moxa treatment at the therapeutic (Study Group) and the indifferent points (Control Group), respectively, for 10 weeks. Semen analyses were performed before and after the treatment course. Results: The patients of the Study Group presented a significant increase in the percentage of normal-form sperm compared to the Control Group (calculated U = 16.0, critical U = 17.0). Conclusion: The Chinese Traditional Medicine acupuncture and moxa techniques significantly increase the percentage of normal-form sperm in infertile patients with oligoastenoteratozoospermia without apparent cause. (Asian J Androl 2003 Dec; 5: 345-348).
Acesso aberto (Open Access)
Effects of the technique of cryopreservation and dilution/centrifugation after thawing on the motility and vitality of spermatozoa of oligoasthenozoospermic men
(Sociedade Brasileira de Urologia, 2003-04-01) Esteves, Sandro C. [UNIFESP]; Spaine, Deborah M. [UNIFESP]; Cedenho, Agnaldo Pereira [UNIFESP]; Srougi, Miguel [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
OBJECTIVE: Comparing in human semen samples with low initial quality, the effects of 2 techniques of cryopreservation and dilution/centrifugation after thawing on the spermatic motility and vitality. MATERIALS AND METHODS: Semen samples from 15 oligo and/or asthenozoospermic individuals assisted in the infertility sector of a tertiary hospital were obtained through masturbation. The samples were divided into 2 portions of equal volume, and diluted (1:1; v/v) with the cryoprotector containing glycerol (Test yolk buffer). One portion was frozen through the technique of liquid nitrogen vapor with static phases (group I - GI), while the other was frozen through a programmable biological freezer with linear speed (Planer, Kryo 10, series III) (group II - GII). The following parameters were assessed before freezing and after thawing: percentage of spermatozoa with progressive motility (Prog%) and percentage of live spermatozoa (Vit%). After defrosting, Prog% was assessed before and after removal of cryoprotector diluent, in different time intervals (zero, 3 h, and 24 h). The statistical analysis has been accomplished by using the non-parametric tests of Wilcoxon and Friedman. RESULTS: There was significant reduction of Prog% and Vit% from before freezing to after defrosting in both groups, I and II (p < 0.001). Values of Prog% and Vit% were not statistically different between groups, after thawing. It has been observed a significant reduction in Prog% among portions frozen with the automated technique after dilution and centrifugation for removal of cryoprotector (p = 0.006). After cryoprotector removal, Prog% has been kept unaltered, in both groups, during the first 3 hours of incubation, although being superior in group I (p = 0,04). There was a significant decrease in Prog% after 24 hours of incubation, in both groups (p < 0,01). CONCLUSION: For human semen samples with low initial quality, freezing through vapor technique or through the automated technique showed to be equivalent in regarding recovery of live spermatozoa with progressive motility. The effects of dilution and centrifugation to remove the cryoprotector had a negative impact only in samples frozen through the automated technique. In both techniques, progressive motility is kept constant during the first 3 hours after thawing and removal of the cryoprotector, but is drastically diminished by the end of an incubation period of 24 hours.
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Expression of the HSPA2 gene in ejaculated spermatozoa from adolescents with and without varicocele
(Elsevier B.V., 2006-12-01) Lima, Samira Barbosa [UNIFESP]; Cenedeze, Marcos Antonio [UNIFESP]; Bertolla, Ricardo Pimenta [UNIFESP]; Hassun Filho, Pericles Assad [UNIFESP]; Oehninger, Sergio [UNIFESP]; Cedenho, Agnaldo Pereira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Eastern Virginia Med Sch
Objective: To evaluate mRNA expression of the HSPA2 gene in ejaculated spermatozoa in adolescents with and without varicocele.Design: Controlled prospective study.Setting: Patients in an academic research environment.Patients: Adolescent patients with clinical diagnosed bilateral varicocele grades II and III, and adolescent patients without varicocele.Intervention: Reverse-transcription-polymerase chain reaction (RT-PCR) analysis of HSPA2 gene expression in adolescents with and without varicocele.Main Outcome Measure: Comparative RT-PCR expression analysis of HSPA2 gene mRNA pared to the housekeeping beta-actin gene.Results: Sperm from adolescents with varicocele and oligozoospermia had significantly lower levels of HSPA2 Gene expression than both adolescents without varicocele (controls) and adolescents with varicocele and normal sperm concentration (P < .05). the latter group had a nonsignificant increase in gene expression compared to the control group.Conclusions: This is the first report on HSPA2 gene expression in ejaculated spermatozoa from adolescents and its relationship with varicocele pathology. Results demonstrated that, HSPA2. expression was down-regulated in adolescents with varicocele and oligozoospermia compared to controls. There was a higher, albeit nonsignificant, an in controls gene expression in adolescents with varicocele and normal sperm concentration than in controls. We speculate that expression levels of this gene might be used as a molecular marker for the acquisition of thermal tolerance in ejaculated spermatozoa.
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Individual and seminal characteristics of patients with testicular germ cell tumors
(Elsevier B.V., 2010-11-01) Fraietta, Renato [UNIFESP]; Spaine, Deborah Montagnini [UNIFESP]; Bertolla, Ricardo Pimenta [UNIFESP]; Ortiz, Valdemar [UNIFESP]; Cedenho, Agnaldo Pereira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Objective: To analyze the characteristics of patients with testicular germ cell cancer and compare patients' sperm quality according to histologic type (seminomatous and nonseminomatous tumors).Design: Prospective study.Setting: Sperm bank at a university.Patient(s): One hundred consecutive patients with testicular tumor who had been referred to our infertility center for cryopreservation, between 2004 and 2006.Intervention(s): A questionnaire, through personal interview, was given to all patients and collection of seminal data before cryopreservation was performed.Main Outcome Measure(s): Patient characteristics, including age, time between diagnosis and orchiectomy, history of cryptorchidism, histologic type, and seminal analysis were taken into consideration.Result(s): the mean age of the patients at the time of diagnosis was 26.9 years. the mean time between cancer suspicion and the diagnosis of neoplasm was 58.9 days, and 19.4 more days were necessary until orchiectomy was performed. Eleven patients had a history of cryptorchidism. Thirty-seven patients had seminomatous tumors. Men with a seminoma present a higher number of motile and morphologically normal sperm in the ejaculate than men with a nonseminoma, although individual semen variables are not different.Conclusion(s): the majority of the patients with testicular cancer, referred to our infertility center, are very young, single, do not have children, and are unaware of their fertility potential status by the time diagnosis is made. Men with a nonseminoma present semen of lower quality. (Fertil Steril (R) 2010; 94: 2107-12. (C) 2010 by American Society for Reproductive Medicine.)
Acesso aberto (Open Access)
Male infertility in spinal cord trauma
(Sociedade Brasileira de Urologia, 2005-08-01) Utida, Cristiano [UNIFESP]; Truzzi, Jose C. [UNIFESP]; Bruschini, Homero [UNIFESP]; Simonetti, Rogerio [UNIFESP]; Cedenho, Agnaldo Pereira [UNIFESP]; Srougi, Miguel [UNIFESP]; Ortiz, Valdemar [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); San Francisco Home School Section of Urology
Every year there are 10 thousand new cases of patients victimized by spinal cord trauma (SCT) in the United States and it is estimated that there are 7 thousand new cases in Brazil. Eighty percent of patients are fertile males. Infertility in this patient group is due to 3 main factors resulting from spinal cord lesions: erectile dysfunction, ejaculatory disorder and low sperm counts. Erectile dysfunction has been successfully treated with oral and injectable medications, use of vacuum devices and penile prosthesis implants. The technological improvement in penile vibratory stimulation devices (PVS) and rectal probe electro-ejaculation (RPE) has made such procedures safer and accessible to patients with ejaculatory dysfunction. Despite the normal number of spermatozoa found in semen of spinal cord-injured patients, their motility is abnormal. This change does not seem to be related to changes in scrotal thermal regulation, frequency of ejaculation or duration of spinal cord damage but to factors related to the seminal plasma. Despite the poor seminal quality, increasingly more men with SCT have become fathers through techniques ranging from simple homologous insemination to sophisticated assisted reproduction techniques such as intracytoplasmic sperm injection (ICSI).
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Pesquisa de biomarcadores proteicos para o sucesso da fertilização in vitro clássica através da análise proteômica do meio de cultura
(Universidade Federal de São Paulo (UNIFESP), 2016-06-12) Moreira, Debora Carvalho [UNIFESP]; Spaine, Deborah Montagnini Spaine [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Introduction: Infertility is an important issue that affects many couples around the world and assisted reproduction technique more used in the treatment of these couples is the In Vitro Fertilization (IVF). The main challenge of IVF is to select an embryo with high potential implantation successful without generating unwanted multiple pregnancy. However, this selection is made subjectively by morphological analysis. New non-invasive methods are necessary for selection of embryos with higher implantation potential. Objectives: Evaluate the profile of secreted proteins during sperm-oocyte interaction in the conventional IVF process. Methods: We conducted a prospective cohort study including a total of 20 cases of couples that came to the Human Reproduction Division of UNIFESP and were suitable for conventional IVF. The patients underwent controlled ovarian stimulation as medical guidelines, followed by collection of ovarian follicles by transvaginal puncturing. Oocytes were placed in contact with spermatozoa previously selected in culture media for 18 hours.The remaining culture medium were pooledin the following groups according to the results of fertilization of oocytes and embryo development: normal fertilization (FN): presence of two pronuclei; fertilization failure (FF): absence of pronuclei; abnormal fertilization (FA): absence of pronuclei at the time of check fertilization, but there were embryonic development. The FN group was split into homogeneous development (F1) and heterogeneous (F3 and F4). The excess of albumin was removed from the sample, followed by fractionation and concentration using filter. The proteins were quantified, digested and analyzed by tandem mass spectrometry. Results: 73 proteins were identified. It was possible to identify proteins associated with successful fertilization and development. The main proteins marker were Perlecan (HSPG2) Anti-Thrombin-III (ANT 3), Apolipoprotein A-IV (APO4), Fibrinogenalpha Chain and Protein 4 Retinol-Binding (RET4) that were increased in the culture media and associated with success of IVF and homogeneous development. Conclusion: The embryos with fertilization success secreted a different protein profile from the cases of failure, and it was possible, from these proteins, to infer about embryo developmental outcome. These proteins may be potentially used in IVF success biomarkers in non-invasive testing of embryonic viability.
Acesso aberto (Open Access)
Single nucleotide polymorphisms of the heat shock protein 90 gene in varicocele-associated infertility
(Sociedade Brasileira de Urologia, 2005-06-01) Hassun Filho, Pericles A. [UNIFESP]; Cedenho, Agnaldo Pereira [UNIFESP]; Lima, Samira B. [UNIFESP]; Ortiz, Valdemar [UNIFESP]; Srougi, Miguel [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
PURPOSE: Varicoceles are associated with impaired testicular function and male infertility, but the molecular mechanisms by which fertility is affected have not been satisfactorily explained. Spermatogenesis might be affected by increased scrotal temperature, such as that caused by varicocele. HSP90 is a molecular chaperone expressed in germ cells and is related to spermatogenesis, motility, and both heat and oxidative stress. Possible correlations between coding single region nucleotide polymorphisms (cSNPs) in the HSP90 gene in patients with varicocele associated with infertility were analyzed, and polymorphisms in these exons were characterized through DNA sequencing. MATERIALS AND METHODS: PCR-SSCP and DNA sequencing were used to search for mutations in 18 infertile patients with varicocele, 11 patients with idiopathic infertility and 12 fertile men. DNA was extracted from leucocytes for PCR amplification and SSCP analysis. DNA from samples with an altered band pattern in the SSCP was then sequenced to search for polymorphisms. RESULTS: Three silent polymorphisms that do not lead to amino acid substitutions were identified. CONCLUSION: Mutations in the HSP90 gene do not appear to be a common cause of male factor infertility. The low incidence of gene variation, or SNPs, in infertile men demonstrates that this gene is highly conserved and thus confirms its key role in spermatogenesis and response to heat stress.
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Sperm nuclear apoptotic DNA fragmentation in men with testicular cancer
(Elsevier B.V., 2008-11-01) Ribeiro, Taisa Michelucci [UNIFESP]; Bertolla, Ricardo Pimenta [UNIFESP]; Spaine, Deborah Montagnini [UNIFESP]; Fraietta, Renato [UNIFESP]; Ortiz, Valdemar [UNIFESP]; Cedenho, Agnaldo Pereira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Objective: To verify whether sperm from patients with a semi noma and patients with a non-semi noma present with an increased rate of apoptotic DNA fragmentation, when compared with men without testicular cancer and who had fathered a child in the 2 years preceding the study.Design: Controlled prospective study.Setting: Patients referred to a sperm bank in an academic research environment.Patient(s): Men with a diagnosed seminoma, men with a diagnosed non-seminoma, both after orchiectomy and before adjuvant therapy, and men with proven paternity in the 2 previous years.Main Outcome Measure(s): Rate of nuclear apoptotic sperm DNA fragmentation as assessed by TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling) assay, classified as positive (with DNA fragmentation) or negative (without DNA fragmentation).Result(s): of the 48 men with testicular cancer included in the study, 29 (60.4%) presented a non-seminoma and 19 (39.6%) a seminoma. Patients with non-seminoma presented with lower progressive sperm motility than the control group (57.4% and 66.3%, respectively), but both were still within normal ranges. Sperm concentration was lower in seminoma (31.2 x 10(6)/mL) and in non-seminoma (20.6 x 10(6)/mL) when compared with the control group (78.1 x 10(6)/mL), but values did not differ between the two testicular cancer groups. Sperm morphology was lower in patients with non-seminoma than in the control group (10% and 13.1%, respectively). Results for sperm nuclear apoptotic DNA fragmentation (mean; standard deviation) were 12.6%; 4.5% for the control group, 12.2%; 5.5% for the non-seminoma group, and 12.5%; 6.4% for the seminoma group. No differences were found between the three groups.Conclusion(s): Our results demonstrate that the presence of a seminoma or a non-seminoma is not associated with an increase in sperm apoptotic DNA fragmentation. (Fertil Steril((R)) 2008;90:1782-6. (c) 2008 by American Society for Reproductive Medicine.)
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Sperm nuclear DNA fragmentation and mitochondrial activity in men with varicocele
(Elsevier B.V., 2008-11-01) Blumer, Camile Garcia [UNIFESP]; Fariello, Roberta Maria [UNIFESP]; Restelli, Adriana Ester [UNIFESP]; Spaine, Deborah Montagnini [UNIFESP]; Bertolla, Ricardo Pimenta [UNIFESP]; Cedenho, Agnaldo Pereira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Objective: To verify the impact of varicocele on semen quality and sperm function (DNA integrity and mitochondrial activity).Design: Prospective study. Setting: Patients in an academic research environment.Patient(s): Seventeen patients with a clinical diagnosed varicocele of grade II or III and 20 men without a varicocele.Main Outcome Measure(s): Rate of sperm DNA fragmentation as assessed by the Comet assay and categorized as classes I (no DNA fragmentation), II (little DNA fragmentation), III (meaningful DNA fragmentation), and IV (high DNA fragmentation). Rate of mitochondrial activity as assessed by the diaminobenzidine (DAB) assay and categorized as grades I (all mitochondria active), II (most mitochondria active), III (most mitochondria inactive), and IV (all mitochondria inactive).Result(s): No statistically significant differences were found between the study and control groups with respect to age, ejaculatory abstinence, and round cell count. Men with varicocele had significantly higher ejaculate volume, concentration of immotile sperm, and neutrophil count and lower mean percentage of sperm concentration, progressive motility, and morphology than men in the control group. the study group presented a lower percentage of sperm with little DNA fragmentation (class II) and a higher percentage of sperm with DNA fragmentation (class IV). in addition, the study group presented a greater percentage of sperm with inactive mitochondria (class III).Conclusion(s): Compared with men without varicocele, men with varicocele had a higher percentage of cells with DNA fragmentation and sperm with inactive mitochondria. Indeed, varicocele causes a decrease in motility, concentration, and morphology and an increase in volume and concentration of immotile sperm and neutrophils. the sperm functional evaluation (DNA fragmentation and mitochondrial activity) could be important factors in deciding treatment options for men with varicocele. (Fertil Steril(R) 2008;90:1716-22. (C)2008 by American Society for Reproductive Medicine.)
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Sperm nuclear DNA fragmentation in adolescents with varicocele
(Elsevier B.V., 2006-03-01) Bertolla, Ricardo Pimenta [UNIFESP]; Cedenho, Agnaldo Pereira [UNIFESP]; Hassun, Pericles Assad [UNIFESP]; Lima, Samira Barbosa [UNIFESP]; Ortiz, Valdemar [UNIFESP]; Srougi, Miguel [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Objective: To verify if sperm from adolescents with varicocele have an increased rate of DNA fragmentation when compared with adolescents without varicocele.Design: Controlled prospective study.Setting: Patients in an academic research environment.Patient(s): Adolescent patients with a clinical diagnosed bilateral varicocele, grades II and III, and adolescent patients without a varicocele.Intervention(S): None.Main Outcome Measure(s): Rate of sperm DNA fragmentation as assessed by the Comet assay, graded as class I (no DNA fragmentation), II (little DNA fragmentation), III (meaningful DNA fragmentation), or IV (high DNA fragmentation).Result(s): A higher percentage of cells with no DNA fragmentation (class I) was found in the nonvaricocele group (47.62 +/- 7.69) when compared with the varicocele group (27.52 +/- 10.73). A higher percentage of sperm with class III and class IV DNA fragmentation was found in the varicocele group (20.43 +/- 8.97, and 19.57 +/- 10.68) when compared with the nonvaricocele group (11.38 +/- 5.55, and 5.71 +/- 2.35).Conclusion(s): Although standard semen analysis showed no difference between the groups, adolescents with varicocele have an increase in sperm nuclear DNA fragmentation. Thus DNA fragmentation evaluation, could be important in deciding treatment options for adolescent patients.
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Transurethral resection of the ejaculatory duct in a fertile man
(Elsevier B.V., 2008-05-01) Lacerda, Jose Iran Medeiros [UNIFESP]; Hasegawa, Endric [UNIFESP]; Fraietta, Renato [UNIFESP]; Bertolla, Ricardo Pimenta [UNIFESP]; Cedenho, Agnaldo Pereira [UNIFESP]; Ortiz, Valdemar [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Objective: To report a case of transurethral resection of the ejaculatory duct in a fertile man with normozoospermia.Design: Case report.Setting: Large federal hospital in São Paulo, Brazil.Patient(s): A 29-year-old man with normal semen analysis values who had recently fathered a healthy child, seen with complaint of scrotal pain and reduced ejaculate volume.Intervention(s): Transurethral resection of the ejaculatory duct.Main Outcome Measure(s): Relief of the symptoms.Result(s): Successful relief of the scrotal pain and increase in ejaculate volume after correction of the partial ejaculatory duct obstruction.Conclusion(s): Fertile men with scrotal pain and reduced ejaculate volume may be seen with partial ejaculatory duct obstruction, and surgical transurethral resection of the ejaculatory duct may provide resolution of symptoms. (Fertil Steril (R) 2008; 89: 1260.e13-5. (C) 2008 by American Society for Reproductive Medicine.)
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Tuberculosis of seminal vesicles as a cause of aspermia
(Lippincott Williams & Wilkins, 2003-04-01) Fraietta, Renato [UNIFESP]; Mori, Marcos M. [UNIFESP]; Oliveira, José Marcelo A de [UNIFESP]; Cedenho, Agnaldo P. [UNIFESP]; Srougi, Miguel [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Acesso aberto (Open Access)
Vitamin D Receptor Taql Polymorphism Is Associated With Reduced Follicle Number in Women Utilizing Assisted Reproductive Technologies
(Frontiers Media Sa, 2018) Reginatto, Mila W.; Pizarro, Bartira M.; Antunes, Roberto A.; Mancebo, Ana C. A.; Hoffmann, Luisa; Fernandes, Pamela; Areas, Patricia; Chiamolera, Maria Izabel [UNIFESP]; Silva, Rosane; Souza, Maria do Carmo Borges de; Bloise, Enrrico; Ortiga-Carvalho, Tania M.
Purpose: Calcitriol, or 1,25-hydroxycholecalciferol, is the active form of vitamin D. It binds and activates vitamin D receptor (VDR). Infertility and defective folliculogenesis have been observed in female vdr-knockout mice

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