Navegando por Palavras-chave "hepatic steatosis"
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- ItemAcesso aberto (Open Access)Esteatose hepática em uma população escolar de adolescentes com sobrepeso e obesidade(Sociedade Brasileira de Pediatria, 2010-02-01) Lira, Ana R. F. [UNIFESP]; Oliveira, Fernanda Luisa Ceragioli [UNIFESP]; Schimith Escrivão, Maria Arlete Meil [UNIFESP]; Colugnati, Fernando Antonio Basile [UNIFESP]; Taddei, Jose Augusto de Aguiar Carrazedo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: To assess hepatic steatosis by ultrasound method as a concomitant risk factor among overweight adolescents. METHODS: A case-control study including 83 cases (47 overweight and 36 obese) and 89 controls (normal weight), frequency matched by gender, year of birth, pubertal stage (Tanner 4/5), and income. Cases and controls were selected from 1,420 students enrolled in a Vila Mariana public high school, in São Paulo, Brazil. Must et al. criteria were used for nutritional status classification. Nonalcoholic fatty liver disease was diagnosed through hepatic ultrasonography performed and analyzed by one radiologist. Hepatic enzymatic activities (alanine and aspartate transaminases, alkaline phosphatase, gamma-glutamyl transpeptidase) and direct bilirubin were measured. Eight covariables were fitted into logistic regression models; criterion for inclusion of variables was the association with overweight in the bivariate analyses (p < 0.20). A value of p < 0.05 was set as the criterion for inclusion into the final logistic regression models. RESULTS: Prevalence of hepatic steatosis diagnosed through ultrasonography was 27.7% in overweight/obese students and 3.4% in normal weight students. Adjusted odds ratios (95%CI) for images compatible with nonalcoholic fatty liver disease and gamma-glutamyl transpeptidase > 24 U/L were 10.77 (2.45-47.22) and 4.18 (1.46-11.94), respectively. CONCLUSIONS: This is the first population-based study showing that hepatic steatosis is strongly associated with overweight/obesity among adolescents attending a Brazilian public school. The diagnostic tool used in this investigation is a non-invasive method that might be applied to monitor overweight and obese adolescents and to propose actions for preventing more severe hepatic diseases in adulthood.
- ItemSomente MetadadadosInsulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype(Taylor & Francis Ltd, 2009-01-01) Oliveira, Ana C. [UNIFESP]; Parise, Edison Roberto [UNIFESP]; Catarino, Regina M. [UNIFESP]; Lanzoni, Valeria Pereira [UNIFESP]; Leite-Mór, Marilisa Moraes Barros [UNIFESP]; Simon, Karin Argenti [UNIFESP]; Junqueira, Virginia B. C. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Background: Modifications of oxidative stress are reported in hepatitis C. the relationship between insulin resistance (IR), steatosis and oxidative stress is not established. Materials and methods: One hundred and eighty-seven HCV-RNA patients were assessed by determination of biochemical, metabolic and viral features, HOMA-IR and morphological alterations. in the 52-non-3 genotypes sub-group and 35 healthy individuals, thiobarbituric acid (TBARS), total glutathione (total-GSH), vitamins C and E, lycopene, beta-carotene, glutathione peroxidase (GPx), catalase and superoxide dismutase were determined. Results: in non-3 genotype patients, steatosis was associated with higher values of BMI, HOMA-IR and triglycerides. in the 52-HCV sub-group, values of TBARS, GPx and total-GSH differ from the control group. Despite these, differences could not be observed according to the presence of steatosis, patients with IR presented significant differences regarding total-GSH (p = 0.019), beta-carotene (p = 0.006), lycopene (p = 0.005) and GPx (p = 0.009). Conclusion: in non-3 genotype HCV carries, IR, and not steatosis, is associated with modifications in serum levels of oxidative stress.
- ItemAcesso aberto (Open Access)Síndrome metabólica: comparação de critérios diagnósticos(Sociedade Brasileira de Pediatria, 2010-08-01) Cavali, Monica de Lima Raeder [UNIFESP]; Schimith Escrivão, Maria Arlete Meil [UNIFESP]; Brasileiro, Rosana Sarmento [UNIFESP]; Taddei, Jose Augusto de Aguiar Carrazedo [UNIFESP]; Universidade Estadual de Campinas (UNICAMP); Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: To propose a new criterion for the diagnosis of metabolic syndrome (MS) in adolescents and to check its consistency with those proposed by Jolliffe and Janssen and by the International Diabetes Federation (IDF). METHOD: This is a cross-sectional study of 80 obese adolescents aged 14 to 19 years. Anthropometric (weight, height, and waist circumference) and laboratory (fasting triglycerides, HDLc, glucose, and insulin) parameters, as well as blood pressure were evaluated. The HOMA-IR index was used to characterize insulin resistance, and the presence of steatosis was assessed by hepatic ultrasound. Agreement analyses across the three criteria were made using the kappa coefficient. RESULTS: The prevalence of MS was 13.5, 15, and 25% for IDF and Jolliffe and Janssen's criteria and the proposed method, respectively. A nearly perfect agreement between Jolliffe and Janssen's and IDF (kappa = 0.94) criteria and a moderate agreement between the new criteria and the previous two (kappa = 0.46 and 0.41, respectively) were observed. CONCLUSIONS: The highest prevalence of MS was observed with the criterion proposed in this study, which included steatosis and insulin resistance as parameters, thus being able to diagnose a larger number of adolescents at metabolic risk.