Navegando por Palavras-chave "genomics"

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    Assessment of the scientific-technological production in molecular biology in Brazil (1996-2007): the contribution of genomics programs
    (Acad Brasileira De Ciencias, 2011-06-01) Meneghini, Rogerio [UNIFESP]; Gamba, Estevao Andre Cabestre [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Several genome sequencing programs were launched in Brazil by the end of the nineties and the early 2000s. The most important initiatives were supported by the ONSA program (http://watson.fapesp.br/onsa/Genoma3.htm) and aimed at gaining domain in genomic technology and bringing molecular biology to the state of art. Two main sets of data were collected in the 1996-2007 period to evaluate the results of these genome programs: the scientific production (Scopus and Web of Science databases) and the register of patents (US Patent and Trademark Office), both related to the progress of molecular biology along this period. In regard to the former, Brazil took a great leap in comparison to 17 other developed and developing countries, being only surpassed by China. As to the register of patents in the area of molecular biology, Brazil's performance lags far behind most of the countries focused in the present study, confirming the Brazilian long-standing tendency of poor achievements in technological innovations when compared with scientific production. Possible solutions to surpass this inequality are discussed.
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    Cancer stem cell genomics: the quest for early markers of malignant progression
    (Expert Reviews, 2009-09-01) Okamoto, Oswaldo Keith [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Biologically distinct populations of neoplastic stem cells have been identified in a variety of human cancers, in which they are associated with the initial steps of tumorigenesis. the intrinsic properties of self-renewal, clonogenicity and multipotency, along with a longer half-life within the body, may render normal adult stem cells more prone to accumulate genetic mutations leading to neoplastic transformation, as predicted by the cancer stem cell hypothesis. Tumor formation is also associated with the pluripotency of embryonic stem cells and may be induced as a consequence of complete dedifferentiation of mature cells, as recently reported for induced pluripotent stem cells. the tumor-initiating cell phenotype may result from genetic alterations affecting the expression of critical genes regulating typical stem cell processes such as self-renewal and pluripotency, in addition to genes determining stem cell senescence or longevity. Detailed genome-wide analysis of cancer stem cells and respective normal counterparts will help elucidate the cellular and molecular nature of tumors, providing fundamental information about the initial steps toward malignant transformation. Devising ways of detecting such genetic and epigenetic alterations and cell populations displaying them would allow medical interventions at the early phases of cancer development, thereby improving the chances of favorable clinical outcomes.
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    Summaries of plenary and selected symposia sessions at the XXIV World Congress of Psychiatric Genetics
    (Lippincott Williams & Wilkins, 2017) Ciobanu, Liliana G.; Ori, Anil P. S.; Pagliaroli, Luca; Polimanti, Renato; Spindola, Leticia M. [UNIFESP]; Vincent, John B.; Cormack, Freida K.
    The XXII World Congress of Psychiatric Genetics, sponsored by the International Society of Psychiatric Genetics, took place in Jerusalem, Israel, from 30 October 2016 to 3 November 2016. A total of 372 participants gathered to discuss the latest findings in the field. The following report was written by early career investigator travel awardees, and student and postdoctoral attendees. Each was assigned one or more sessions as a rapporteur. This manuscript represents topics covered in most, but not all of the presentations during the conference, and contains some of the major notable new findings reported. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
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    Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014
    (Lippincott Williams & Wilkins, 2016) Aas, Monica; Blokland, Gabriella A. M.; Chawner, Samuel J. R. A.; Choi, Shing-Wan; Estrada, Jose; Forsingdal, Annika; Friedrich, Maximilian; Ganesham, Suhas; Hall, Lynsey; Haslinger, Denise; Huckins, Laura; Loken, Erik; Malan-Muller, Stefanie; Martin, Joanna; Misiewicz, Zuzanna; Pagliaroli, Luca; Pardinas, Antonio F.; Pisanu, Claudia; Quadri, Giorgia; Santoro, Marcos L. [UNIFESP]; Shaw, Alex D.; Ranlund, Siri; Song, Jie; Tesli, Martin; Tropeano, Maria; van der Voet, Monique; Wolfe, Kate; Cormack, Freida K.; DeLisi, Lynn
    The XXII World Congress of Psychiatric Genetics, sponsored by the International Society of Psychiatric Genetics, took place in Copenhagen, Denmark, on 12-16 October 2014. A total of 883 participants gathered to discuss the latest findings in the field. The following report was written by student and postdoctoral attendees. Each was assigned one or more sessions as a rapporteur. This manuscript represents topics covered in most, but not all of the oral presentations during the conference, and contains some of the major notable new findings reported. (c) 2016 Wolters Kluwer Health, Inc. All rights reserved.