Navegando por Palavras-chave "follow-up studies"
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- ItemSomente MetadadadosAbnormal eating behaviors in adolescent and young adult women from southern Brazil: Reassessment after four years(Dr Dietrich Steinkopff Verlag, 2006-12-01) Nunes, Maria Angelica; Olinto, Maria Teresa A.; Camey, Suzi; Morgan, Christina; Mari, Jair de Jesus; Univ Fed Rio Grande Sul; Univ Vale do Rio dos Sinos; Univ Fed RS; Universidade Federal de São Paulo (UNIFESP)Objective To investigate whether abnormal eating behaviors in young women could predict eating disorders after 4 years. Method 56 women were identified as presenting abnormal eating behaviors in a cross-sectional study (Eating Attitudes Test-26 and Edinburgh Bulimic Investigation Test). They were matched for age and neighborhood to two controls (n = 112). Four years later, they were re-assessed with the two screening questionnaires plus the Composite International Diagnostic Interview (CIDI 2.1). Results Women with abnormal eating behaviors at baseline showed a high probability of presenting abnormal eating behaviors but it was not associated with eating disorders 4 years later. They were also at higher risk for obsessive-compulsive disorder, post-traumatic stress disorder, and specific phobia. Discussion Abnormal eating behaviors were related to the maintenance of the disturbed behavior over the years, and were associated with increased probability for psychiatric diagnoses.
- ItemSomente MetadadadosCalcineurin Inhibitor Minimization in the Symphony Study: Observational Results 3 Years after Transplantation(Wiley-Blackwell, 2009-08-01) Ekberg, H.; Bernasconi, C.; Tedesco-Silva Junior, Hélio [UNIFESP]; Vitko, S.; Hugo, C.; Demirbas, A.; Reyes Acevedo, R.; Grinyo, J.; Frei, U.; Vanrenterghem, Y.; Daloze, P.; Halloran, P. F.; Lund Univ; F Hoffmann La Roche Ltd; Universidade Federal de São Paulo (UNIFESP); IKEM; FAU Erlangen Nurnberg; Akdeniz Univ; Hosp Miguel Hidalgo; Ciutat Univ Bellvitge; Charite Virchow Klinikum; Katholieke Univ Leuven; CHUM Montreal; Univ AlbertaThe Symphony study showed that at 1 year posttransplant, a regimen based on daclizumab induction, 2 g mycophenolate mofetil (MMF), low-dose tacrolimus and steroids resulted in better renal function and lower acute rejection and graft loss rates compared with three other regimens: two with low-doses of cyclosporine or sirolimus instead of tacrolimus and one with no induction and standard cyclosporine dosage. This is an observational follow-up for 2 additional years with the same endpoints as the core study. Overall, 958 patients participated in the follow-up. During the study, many patients changed their immunosuppressive regimen (e.g. switched from sirolimus to tacrolimus), but the vast majority (95%) remained on MMF. During the follow-up, renal function remained stable (mean change: -0.6 ml/min), and rates of death, graft loss and acute rejection were low (all about 1% per year). the MMF and low-dose tacrolimus arm continued to have the highest GFR (68.6 +/- 23.8 ml/min vs. 65.9 +/- 26.2 ml/min in the standard-dose cyclosporine, 64.0 +/- 23.1 ml/min in the low-dose cyclosporine and 65.3 +/- 26.2 ml/min in the low-dose sirolimus arm), but the difference with the other arms was not significant (p = 0.17 in an overall test and 0.077, 0.039 and 0.11, respectively, in pair-wise tests). the MMF and low-dose tacrolimus arm also had the highest graft survival rate, but with reduced differences between groups over time, and the least acute rejection rate. in the Symphony study, the largest ever prospective study in de novo kidney transplantation, over 3 years, daclizumab induction, MMF, steroids and low-dose tacrolimus proved highly efficacious, without the negative effects on renal function commonly reported for standard CNI regimens.
- ItemAcesso aberto (Open Access)O comportamento de beber entre dependentes de álcool: estudo de seguimento(Faculdade de Medicina da Universidade de São Paulo, 2006-01-01) Fontes, Andrezza [UNIFESP]; Figlie, Neliana Buzi [UNIFESP]; Laranjeira, Ronaldo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)BACKGROUND: Alcohol dependents seeking specialized alcohol treatment present modest rates of success in treatment programs. Alcohol dependents with gastrointestinal diseases present a worse prognostic and increased mortality rate compared with other non-alcoholic gastroenterology outpatients and the general population. OBJECTIVE: To present the results of a study verifying outcomes of alcohol dependents following their treatment in one of two different clinic types. METHODS: Follow-up study on 228 alcohol dependents: 114 from a specialist alcohol treatment service and 144 from a gastroenterology clinic, both located within the Hospital São Paulo (UNIFESP). RESULTS: A high rate of mortality was found for the overall sample (15%; n = 34), with 70.5% (n = 24) of these deaths occurring in the gastroenterology clinic. The outpatients from the specialist alcohol treatment service were younger and more severely dependent on alcohol, having suffered from more alcohol-related problems in both emotional and mental health aspects. Patients in the gastroenterology group reported less pain but greater social compromise. CONCLUSION: Constant adaptation of interventions to meet alcohol dependents' needs was evidenced, along with a need to implement more effective treatment approaches, coupled with psychosocial interventions to tackle drink use within the gastroenterology clinic itself.
- ItemSomente MetadadadosCrack cocaine: A five-year follow-up study of treated patients(Karger, 2007-01-01) Ribeiro, M.; Dunn, J.; Sesso, R.; Lima, M. S.; Laranjeira, R.; Universidade Federal de São Paulo (UNIFESP); Camden & Islington Mental Hlth & Social Care Trus; Fed Univ PelotasObjectives: To follow-up a group of 131 crack cocaine users and examine drug use, treatment experience, employment status, involvement in crime and mortality at 2 and 5 years. Methods: Consecutive crack-dependent patients who were admitted to a detoxification unit in São Paulo between 1992 and 1994 were re-interviewed on two occasions: 1995-1996 and 1998-1999. Results: 5 years after treatment information was obtained on 124 (95%) of the original cohort. 39.7% (n = 52) of the patients reported having been abstinent from cocaine for at least the last year, and 21.4% (n = 28) had used the drug. of those subjects not using cocaine at 2 years, 19 (62%) were still abstinent at 5 years. Twenty-three (17.6%) patients had died by the 5-year follow-up with homicide, due to firearms or other weapons, being the commonest cause ( n = 13). the annual adjusted mortality rate for the sample was 24.92 deaths/1,000 individuals, the excess mortality rate was of 21.64 deaths/1,000 individuals, and the standardized mortality ratio was 7.60. A history of injecting drug use, unemployment at the time of the index admission and administrative discharge at the index admission were factors that contributed to the risk of dying over the next 5 years. Conclusions: There was a progressive movement towards abstinence over the follow-up period, and there was evidence that once abstinence had been achieved it was maintained. On the other hand, the mortality rate was extremely high and was higher among those who were still using crack at 2 years. Copyright (c) 2007 S. Karger AG, Basel.