Navegando por Palavras-chave "fatigue"

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    Avaliação da fatigabilidade em pacientes com esclerose múltipla através do dinamômetro manual
    (Academia Brasileira de Neurologia - ABNEURO, 2006-06-01) Pavan, Karina; Schmidt, Kizi; Ariça, Tatiana De Ambrosio; Mendes, Maria Fernanda [UNIFESP]; Tilbery, Charles Peter; Lianza, Sergio; ISCMSP; Universidade Federal de São Paulo (UNIFESP); Santa Casa de Misericórdia de São Paulo Faculdade de Ciências Médicas; FCMSCMSP
    Fatigue is one of the most commom disabling symptoms in multiple sclerosis (MS). The aim of this study was to evaluate the fatigability on patients with MS by the aplication of hand grip isotonic and isometric exercises with dynamometer. As results the fatigability, the isometric strenght and time were statistically similar in the control group and in MS. We conclude that although fatigue is a frequent subjective complaint on MS, the fatigability and the recover after exercises seems to be normal.
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    Circadian variation of fatigue in both patients with paralytic poliomyelitis and post-polio syndrome
    (Academia Brasileira de Neurologia - ABNEURO, 2013-07-01) Viana, Celiana Figueiredo [UNIFESP]; Pradella-Hallinan, Márcia Lurdes de Cássia [UNIFESP]; Quadros, Abrahão Augusto Juviniano [UNIFESP]; Marin, Luis Fabiano [UNIFESP]; Oliveira, Acary Souza Bulle [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objective It was to evaluate the degree of fatigue in patients with paralytic poliomyelitis (PP) and with post-polio syndrome (PPS), and correlate it with parameters of sleep and the circadian cycle. Methods Thirty patients, 17 female (56.7%), participated in the study: they answered the Revised Piper Fatigue Scale and performed a nocturnal polysomnographic study. Eleven had PP (mean age±standard deviation of 47.9±6.4 years), and 19 had PPS (mean age±standard deviation of 46.4±5.6 years). Results Our study showed that fatigue was worse in the afternoon in the PP Group and had a progressive increase throughout the day in the PPS Group. We also observed compromised quality of sleep in both groups, but no statically significant difference was found in the sleep parameters measured by polysomnography. Conclusion Fatigue has a well-defined circadian variation, especially in PPS Group. Poor sleep quality is associated with fatigue and, therefore, sleep disturbances should be evaluated and treated in this group of PPS.
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    Correlação entre qualidade de vida e capacidade funcional na insuficiência cardíaca
    (Sociedade Brasileira de Cardiologia - SBC, 2010-08-01) Nogueira, Ivan Daniel Bezerra [UNIFESP]; Servantes, Denise Maria [UNIFESP]; Nogueira, Patrícia Angélica de Miranda Silva; Pelcerman, Amália [UNIFESP]; Salvetti, Xiomara Miranda [UNIFESP]; Salles, Fernando [UNIFESP]; Almeida, Dirceu Rodrigues de [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Campos Filho, Orlando [UNIFESP]; Oliveira Filho, Japy Angelini [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Rio Grande do Norte
    BACKGROUND: Patients with cardiac failure (CF) present progressive incapacity and decreased quality of life, both related to dyspnea and fatigue. Thus, there is the increasing interest in measring the quality of life (QL), by generic instrument, such as the 36-item Short-Form Health Survey (SF-36), by specific instrument, such as Minnesota Living with Heart Failure (MLHFQ). OBJECTIVE: This study has the objective to correlate the QL surveys, SF-36 and MLHFQ, with the functional capacity of patients with CF, expressed by the cardiopulmonary test and the TC6M. METHODS: Using the SF-36 and MLHFQ surveys for QL evaluation, for the evaluation of the functional capacity, it was used the cardiopulmonary test, being executed using a tredmill with Weber protocol, as well sa the distance covered in the walk test of six minutes (TC6M). RESULTS: Forty-six patients were selected with CF diagnosis (22 men, average age of 52 years old), classes II and III of New York Heart Association. It was observed that the mild correlation between the physical and emotional domains of SF-36 and VE/VCO2.peak (r=-0.3; p<0.05) and the distance covered in TC6M (r=0.4; p<0.05), respectively. It was also observed the mild to moderate correlations of MLHFQ total score with VO2.peak (r=-0.5; p<0.05), the aerobic threshold (r=-0.4; p<0.05) and the distance covered in TC6M (r=-0.5; p<0.05). CONCLUSION: The data suggest that the application of both evaluation instruments of QL, generic (SF-36) and specific (MLHFQ) in patients with CF, showed mild and moderate correlation with the variable of the cardiopulmonary test with the variables of the cardiopulmonary test and the distance covered in TC6M.
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    Cross-cultural validation of the Chalder Fatigue Questionnaire in Brazilian primary care
    (Elsevier B.V., 2007-03-01) Cho, Hyong Jin; Costa, Erico; Menezes, Paulo Rossi; Chalder, Trudie; Bhugra, Dinesh; Wessely, Simon; Universidade Federal de São Paulo (UNIFESP); Kings Coll London; Fundacao Oswaldo Cruz; Universidade de São Paulo (USP)
    Objective: the Chalder Fatigue Questionnaire (CFQ) is an instrument used to measure physical and mental fatigue. We translated and adapted the questionnaire and tested its reliability and validity in a Brazilian primary care setting. Method: A pilot study with 204 consecutive primary care attenders in São Paulo, Brazil, verified the internal consistency and factor structure of the questionnaire. After some modifications through a rigorous translation, back-translation, and cross-cultural adaptation procedure, a validation study was conducted with 304 attenders, who also completed the fatigue section of the Revised Clinical Interview Schedule (CIS-R). Results: the internal consistency of the Brazilian CFQ slightly improved from the pilot to the validation study: Cronbach's alpha from .86 to .88. the two-factor structure (physical and mental fatigue) also improved. According to the receiver operating curve analysis with the fatigue section of the CIS-R as the standard criterion, 3/4 was chosen as the cutoff for Brazilian primary care (sensitivity 69.1% and specificity 79.4%). Conclusion: the Brazilian CFQ had good reliability and validity. the cutoff was determined as 3/4 and the factor structure of the English CFQ was closely reproduced. (c) 2007 Elsevier Inc. All rights reserved.
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    Distúrbios de sono causam impacto na qualidade de vida de mulheres com lúpus eritematoso sistêmico (les)
    (Universidade Federal de São Paulo (UNIFESP), 2015-08-31) Reis, Lilian Karla Cunha dos [UNIFESP]; Trevisani, Virginia Fernandes Moca Trevisani [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Despite the small number of studies regarding sleep disorders, they are a frequent complaint of patients with SLE (62 to 80%) and are related to fatigue, pain, and decreased quality of life (Qol). Objective: To assess the impact of sleep disorders in Qol, pain, and fatigue in women with SLE. Methods: We used the following questionnaires, scales and indices: actigraphy to assess sleeping habits of women with SLE, the Pittsburgh Sleep Quality lndex (PSQI) questionnaire, Medical Outcomes short form 36 (SF-36), the Fatigue Severity Scale (FSS), the Visual Analogue Scale (VAS), the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and the Systemic Lupus International Collaboration Clinics (SLICC). The software used for data analysis was Minitab version 16.1, with a significance level of 5%. Results: We studied 46 women with SLE, who had subjective complaints of bad sleep (PSQI). When we related the PSQI data with the questionnaires, we observed associations with (FSS) (p=0.048), pain (VAS) (p=0.028), the role-physical (RP) (p = 0.017), the role emotional (RE) (p=0.006), and mental health (MH) scales (SF-36) (p = 0.034). In terms of correlation of the actigraphy variables with the scores of the questionnaires, we observed statistical significance correlation with the SF-36 data in the RE scale, as follows: with sleep latency (SL) (p=0.005), number of wake ups after sleep onset (p=0.038) and sleep efficiency (p=0.046). In the use of drugs: yes or no, the only association that we observed was the use of antimalarial drugs and greater SL (p=0.032). The association of the use of prednisone (PDN) and less total sleep time (TST) almost reached significant value (p=0.056). Conclusion: Our study indicates that patients with SLE and sleep disorders experience a negative impact in terms of fatigue, pain, and some scales of Qol (in the RP, RE and MH scales), particularly role emotional, with increased latency and wake ups after sleep onset, reducing sleep efficiency; in addition to the influence of corticoids and antimalarial drugs over these alterations. We also observed consistency in both evaluation methods (actigraphy and PSQI) in sleep latency. We have no conflict of interest in this study.
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    The dysfunction of ammonia in heart failure increases with an increase in the intensity of resistance exercise, even with the use of appropriate drug therapy
    (Sage Publications Ltd, 2014-02-01) Medeiros, Wladimir M. [UNIFESP]; Carvalho, Antonio C. [UNIFESP]; Peres, Paulo [UNIFESP]; De Luca, Fabio A.; Gun, Carlos; Universidade Federal de São Paulo (UNIFESP); Santo Amaro Univ UNISA
    Background: Hyperammonemia during rest periods is a dysfunction in heart failure (HF). the low formation of ammonia during exercise reflects an inefficiency of purine metabolism. Hyperkalemia in response to physical exercise is common in HF and may contribute to a contractile inefficiency in type II fibers, leading to early fatigue. We tested the hypothesis that during resistance exercise of high intensity and low volume, this disorder of ammonia metabolism would be more intense, due to the hyperkalemia present in HF.Methods: Alternating resistance exercise (RE) of low intensity and high volume, and high intensity and low volume, were applied to 18 patients with an interval of 7 days between them (functional class II-III New York Heart Association, FE = 33.5 +/- 4%) and compared with 22 healthy controls matched for age and gender. Ammonia, potassium and lactate levels were assessed before and immediately after the RE.Results: Significant differences: Deltas (control vs. HF) in 40% RE: lactate (mg/dl) 26.3 +/- 10 vs. 37.7 +/- 7; p < 0.001, ammonia (ug/dl) 92.5 +/- 18 vs. 48.9 +/- 9; p < 0.001. Deltas (control vs. HF) in 80% RE: lactate(mg/dl) 45.0 +/- 12 vs. 54.1 +/- 11; p < 0.05, ammonia(ug/dl) 133.5 +/- 22 vs. 32.2 +/- 7; p < 0.001, potassium (mEq/L) 1.6 +/- 0.4 vs. 2.0 +/- 0.8; p < 0.05. A negative correlation was found between the deltas of ammonia and potassium (r = -0.74, p < 0.001) in the HF group.Conclusions: We conclude that in HF, there is an inefficiency of purine metabolism that increases with increasing exercise intensity, but not with an increase of total volume. These findings suggest that hyperkalemia may play an important role in the disorders of purine metabolism.
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    Effects of high intensity running to fatigue on isokinetic muscular strength in endurance athletes
    (Ios Press, 2007-01-01) Denadai, Benedito Sergio [UNIFESP]; Greco, Camila Coelho; Tufik, Sergio [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; UNESP; Universidade Federal de São Paulo (UNIFESP)
    The objective of this study was to examine the effects of high intensity exhaustive running exercise on the muscular torque capacity of the knee extensors for two types of contraction (concentric and eccentric) at different angular velocities (60 and 180 degrees/s) in well-trained runners. Eleven male runners specialized in middle and long-distance running volunteered to participate in this study. Initially each subject performed, on different days, two familiarization sessions on an isokinetic dynamometer and an incremental treadmill test to volitional exhaustion to determine the velocity associated with the onset of blood lactate accumulation (OBLA). The subjects then returned to the laboratory on two occasions, separated by at least seven days, to perform maximal isokinetic knee contractions at each of the velocities under eccentric (Ecc) and concentric (Con) conditions. Conducted randomly, one test was performed after a standardized warm-up period of 5 min at 50% VO2 max. The other test was performed 15 min after continuous running at OBLA until volitional exhaustion. Following this high intensity exercise there was a significant reduction of Con at 60 degrees/s and a significant reduction of Ecc at both velocities. Percent strength losses after running exercise were significantly different between contraction types only at 180 degrees/s. We can conclude that the reduction in isokinetic peak torque of the knee extensors after a session of high intensity exhaustive running exercise at OBLA depends on the contraction type and angular velocity.
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    Effects of prolonged running performed at the intensity corresponding to the onset of blood lactate accumulation, on maximum isokinetic strength in active non-athletic individuals
    (Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia, 2007-06-01) Denadai, Benedito Sérgio; Greco, Camila Coelho; Tufik, Sergio [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Universidade Estadual Paulista (UNESP); Universidade Federal de São Paulo (UNIFESP)
    OBJECTIVE: The objective of this study was to analyze the effects of prolonged continuous running performed at the intensity corresponding to the onset of blood lactate accumulation (OBLA), on the peak torque of the knee extensors, analyzed in relation to different types of contraction and movement velocities in active individuals. METHOD: Eight men (23.4 ± 2.1 years; 75.8 ± 8.7 kg; 171.1 ± 4.5 cm) participated in this study. First, the subjects performed an incremental test until volitional exhaustion to determine the velocity corresponding to OBLA. Then, the subjects returned to the laboratory on two occasions, separated by at least seven days, to perform five maximal isokinetic contractions of the knee extensors at two angular velocities (60 and 180º.s-1) under eccentric and concentric conditions. Eccentric peak torque (EPT) and Concentric peak torque (CPT) were measured at each velocity. One session was performed after a standardized warm-up period (5 min at 50% VO2max). The other session was performed after continuous running at OBLA until volitional exhaustion. These sessions were conducted in random order. RESULTS: There was a significant reduction in CPT only at 60º.s-1 (259.0 ± 46.4 and 244.0 ± 41.4 N.m). However, the reduction in EPT was significant at 60º.s-1 (337.3 ± 43.2 and 321.7 ± 60.0 N.m) and 180º.s-1 (346.1 ± 38.0 and 319.7 ± 43.6 N.m). The relative strength losses after the running exercise were significant different between contraction types only at 180º.s-1. CONCLUSION: We can conclude that, in active individuals, the reduction in peak torque after prolonged continuous running at OBLA may be dependent on the type of contraction and angular velocity.
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    Fatigue in amyotrophic lateral sclerosis: Frequency and associated factors
    (Taylor & Francis Ltd, 2008-04-01) Ramirez, Clarissa; Piemonte, Maria Elisa Pimentel; Callegaro, Dagoberto; Da Silva, Helga Cristina Almeida [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    We aimed to quantify fatigue frequency and evolution in amyotrophic lateral sclerosis (ALS), and to correlate fatigue with factors such as age, sex, educational level, disease duration, functionality, quality of life, dyspnoea, depression and sleepiness. Sixty ALS patients (test group: TG) selected by El Escorial criteria and 60 normal individuals (control group: CG) matched according to sex and age, were followed every three months, during 9 months, by means of self-report scales: Fatigue Assessment Instrument (Fatigue Severity Scale plus three qualitative subscales); ALS Functional Rating Scale; McGill Quality of Life Questionnaire; dyspnoea analogical scale; Beck Depression Inventory and Epworth Sleepiness Scale. Fatigue was reported by 83% of TG (median: 3.6, interquartile range 1.5-5.4), compared with 20% of CG (median: 1, 1 - 1), and was significantly greater in the TG (p < 0.001, Mann-Whitney test). Fatigue severity increased by the ninth month of the study (p=0.0008, Friedman, Muller-Dunn post test). There was no correlation between fatigue and other parameters, except for an inverse correlation with age at disease onset (p=0.0395, Spearman rank correlation). in conclusion, fatigue was frequent in ALS, greater in the youngest patients and worsened during follow-up. Possibly, ALS related fatigue is an independent factor, which deserves individualized approach and treatment.
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    Long-Term Oral Appliance Therapy Improves Daytime Function and Mood in Upper Airway Resistance Syndrome Patients
    (Oxford Univ Press Inc, 2017) Godoy, Luciana B. M. [UNIFESP]; Palombini, Luciana [UNIFESP]; Poyares, Dalva [UNIFESP]; Dal-Fabbro, Cibele [UNIFESP]; Guimaraes, Thais Moura [UNIFESP]; Klichouvicz, Priscila Calixto [UNIFESP]; Tufik, Sergio [UNIFESP]; Togeiro, Sonia Maria [UNIFESP]
    Objectives: To evaluate the long-term effects of an oral appliance on clinical symptoms, respiratory sleep parameters, sleep quality, and sustained attention in patients with upper airway resistance syndrome (UARS) were compared with placebo. Methods: This study was a randomized placebo-controlled clinical trial. Thirty UARS patients were randomized in two groups: placebo and mandibular advancement device (MAD) groups. UARS criteria were presence of sleepiness (Epworth Sleepiness Scale >= 10) and/or fatigue (Modified Fatigue Impact Scale >= 38) associated with an apnea/hypopnea index <= 5 and a respiratory disturbance index (RDI) > 5 events/hour of sleep, and/or flow limitation in more than 30% of total sleep time. All patients completed the Pittsburgh Sleep Quality Index (PSQI), the Functional Outcomes of Sleep Questionnaire, the Beck Anxiety and Depression Inventories, underwent full-night polysomnography, multiple sleep latency test, and Psychomotor Vigilance Test (PVT). Evaluations were performed before and after 1.5 years of treatment. Results: RDI, number of respiratory effort-related arousal, percentage of total sleep time with flow limitation, and arousal index significantly decreased after 1.5 years of MAD treatment. PSQI total score improved, severity of depression symptoms decreased, and mean reaction time in the PVT, based on the first measurement taken at 8: 00 am, significantly decreased (p=.03) at the end of the protocol. Conclusions: The MAD was effective in decreasing respiratory events in UARS patients. For UARS, 1.5 years of oral appliance therapy also improved sleep quality and sustained attention, and decreased the severity of depression symptoms.
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    Oral N-acetylcysteine and exercise tolerance in mild chronic obstructive pulmonary disease
    (Amer Physiological Soc, 2017) Hirai, Daniel M. [UNIFESP]; Jones, Joshua H.; Zelt, Joel T.; da Silva, Marianne L.; Bentley, Robert F.; Edgett, Brittany A.; Gurd, Brendon J.; Tschakovsky, Michael E.; O'Donnell, Denis E.; Neder, J. Alberto
    Heightened oxidative stress is implicated in the progressive impairment of skeletal muscle vascular and mitochondrial function in chronic obstructive pulmonary disease (COPD). Whether accumulation of reactive oxygen species contributes to exercise intolerance in the early stages of COPD is unknown. The purpose of the present study was to determine the effects of oral antioxidant treatment with N-acetylcysteine (NAC) on respiratory, cardiovascular, and locomotor muscle function and exercise tolerance in patients with mild COPD. Thirteen patients [ forced expiratory volume in 1 s (FEV1)-to-forced vital capacity ratio < lower limit of normal (LLN) and FEV1 >= LLN) were enrolled in a double-blind, randomized crossover study to receive NAC (1,800 mg/day) or placebo for 4 days. Severe-intensity constant-load exercise tests were performed with noninvasive measurements of central hemodynamics (stroke volume, heart rate, and cardiac output via impedance cardiography), arterial blood pressure, pulmonary ventilation and gas exchange, quadriceps muscle oxygenation (near-infrared spectroscopy), and estimated capillary blood flow. Nine patients completed the study with no major adverse clinical effects. Although NAC elevated plasma glutathione by similar to 27% compared with placebo (P < 0.05), there were no differences in exercise tolerance (placebo: 325 +/- 47 s, NAC: 336 +/- 51 s), central hemodynamics, arterial blood pressure, pulmonary ventilation or gas exchange, locomotor muscle oxygenation, or capillary blood flow from rest to exercise between conditions (P > 0.05 for all). In conclusion, modulation of plasma redox status with oral NAC treatment was not translated into beneficial effects on central or peripheral components of the oxygen transport pathway, thereby failing to improve exercise tolerance in non-hypoxemic patients with mild COPD. NEW & NOTEWORTHY Acute antioxidant treatment with N-acetylcysteine (NAC) elevated plasma glutathione but did not modulate central or peripheral components of the O-2 transport pathway, thereby failing to improve exercise tolerance in patients with mild chronic obstructive pulmonary disease (COPD).
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    Supplementation with Selenium Can Influence Nausea, Fatigue, Physical, Renal, and Liver Function of Children and Adolescents with Cancer
    (Mary Ann Liebert, Inc, 2015-01-01) Santos Vieira, Maria Luiza dos; Affonso Fonseca, Fernando Luiz [UNIFESP]; Costa, Larissa Grossi; Beltrame, Registila Libania; Sousa Chaves, Carolina Machado de; Cartum, Jairo; Alves, Sarah Isabel P. M. do N. [UNIFESP]; Azzalis, Ligia Ajaime [UNIFESP]; Campos Junqueira, Virginia Berlanga [UNIFESP]; Pereira, Edimar Cristiano [UNIFESP]; Rocha, Katya Cristina; Fac Med ABC; Universidade Federal de São Paulo (UNIFESP)
    The drugs used in chemotherapy treatments have little specificity, attack tumor cells, and also injure proliferative tissues. Knowledge of the functions of micronutrients has greatly increased, especially of Selenium (Se) that presents immunomodulatory and antitumor functions. the present study evaluated the health-related quality of life of patients undergoing chemotherapy for the treatment of leukemias and lymphomas (LL) and solid tumors (ST) while receiving Selenium (Se) supplementation. This is a randomized, double-blind, crossover study that evaluated the quality of life (EORTC-QLQ-C30 questionnaire), renal and liver functions of patients supplemented with Se. There was no statistically significant alteration in LL patients. However, the fatigue and nausea scores after 30 days did decrease in this group as well as in the ST group. After 1 year supplementation with Selenium, a more noticeable decrease in the scores concerning fatigue and nausea could be observed in the ST group, when compared with the beginning of the study. the LL patients also presented a decrease in the fatigue scores and physical functions. the kidney function as well as liver function has improved after Selenium supplementation when compared with the placebo intake in LL and ST patients, more remarkably in the LL group. Supplementation with Selenium promotes the reduction of chemotherapy side effects in cancer patients, especially by improving the conditions of patients with fatigue, nausea, and impaired physical function. Renal and liver functions have also improved.