Navegando por Palavras-chave "eosinophils"
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- ItemSomente MetadadadosThe chemokines secretion and the oxidative stress are targets of low-level laser therapy in allergic lung inflammation(Wiley-V C H Verlag Gmbh, 2016) Carvalho, Jorge Luis Costa [UNIFESP]; Aparecida de Brito, Aurileia; Ligeiro de Oliveira, Ana Paula; de Castro Faria Neto, Hugo Caire; Pereira, Thiago Martini; Carvalho, Regiane Albertini de [UNIFESP]; Anatriello, Elen [UNIFESP]; Aimbire, Flavio [UNIFESP]Recent studies show that low-level laser therapy (LLLT) has an important anti-inflammatory action in acute lung inflammation. The present work explored if laser therapy is able to antagonize eosinophils and allergic inflammation induced by oxidative stress in Balb/c mice. Forty-eight hours after challenge, the leukocyte counting, ROS and nitrite/nitrate level, RANTES, CCL3, CCL8 as well as eotaxins were measured in the bronchoalveolar lavage fluid (BALF) of laser-treated mice or not. Into the lung, some chemokines receptors, the iNOS activity and mRNA expression, and the activities of superoxide dismutase (SOD), catalase, gluthatione, NADPH oxidase activities and thiobarbituric acid reactive species (T-Bars) were measured. Laser-treated allergic mice presented reduction of both the ICAM-1 and eosinophil in the lungs. RANTES, CCL8, CCL3 and eotaxins were reduced in BALF of laser-treated allergic mice. In allergic mice lung LLLT decreased the CCR1 and CCR3 and restored the oxidative stress balance as well. Laser decreased the lipidic peroxidation in allergic mice lung as much as increased SOD, GPx and GR. It shows that LLLT on allergic lung inflammation involves leukocyte-attractant chemokines and endogenous antioxidant. Based on results, LLLT may ultimately become a non-invasive option in allergic lung disease treatment. [GRAPHICS] The top figure illustrates the laser decreasing the eosinophils migration into BALF and the bottom figure shows the laser upregulating the expression of heme-oxygenase (anti-oxidant enzyme) in lung tissue anti-oxidant.
- ItemAcesso aberto (Open Access)Eosinophilic inflammation in allergic asthma(Frontiers Research Foundation, 2013-01-01) Possa, Samantha S.; Leick, Edna A.; Prado, Carla Maximo [UNIFESP]; Martins, Milton A.; Tiberio, Iolanda F. L. C.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)Eosinophils are circulating granulocytes involved in pathogenesis of asthma. A cascade of processes directed by Th2 cytokine producing T-cells influence the recruitment of eosinophils into the lungs. Furthermore, multiple elements including interleukin (IL)-5, IL-13, chemoattractants such as eotaxin, Clara cells, and CC chemokine receptor (CCR)3 are already directly involved in recruiting eosinophils to the lung during allergic inflammation. Once recruited, eosinophils participate in the modulation of immune response, induction of airway hyperresponsiveness and remodeling, characteristic features of asthma. Various types of promising treatments for reducing asthmatic response are related to reduction in eosinophil counts both in human and experimental models of pulmonary allergic inflammation, showing that the recruitment of these cells really plays an important role in the pathophysiology of allergic diseases such asthma.
- ItemSomente MetadadadosNasal lavage is better than blood count in predicting sputum eosinophilia(Wiley-Blackwell, 2015-05-01) Amorim, M. M. [UNIFESP]; Fernandes, P. B. L. [UNIFESP]; Caetano, L. B. [UNIFESP]; Dracoulakis, S. [UNIFESP]; Santoro, I. L. [UNIFESP]; Fernandes, A. L. G. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)