Navegando por Palavras-chave "dicyclomine"

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    Effects of the M1 Muscarinic Antagonist Dicyclomine on Emotional Memory Retrieval
    (Amer Psychological Assoc, 2016) Soares, Juliana Carlota Kramer [UNIFESP]; Perfetto, Juliano Genaro [UNIFESP]; Antonio, Bruno Brito [UNIFESP]; Oliveira, Maria Gabriela Menezes [UNIFESP]
    Extensive research has shown the involvement of the central cholinergic system in the acquisition and consolidation of tasks involving conditioned fear responses, such as those observed in contextual fear conditioning (CFC), tone fear conditioning (TFC) and inhibitory avoidance (IA). However, there are few data concerning the role of this system in the memory retrieval process. Therefore, the present study aimed to compare the effects of the administration of an M1 antagonist on retrieval during these tasks. For each behavioral procedure, groups of male Wistar rats were trained. Twenty-four hr later, they were treated with different doses of dicyclomine (16, 32, or 64 mg/kg, i.p.) or with saline 30 min before the test session. The results showed that dicyclomine at doses of 16 and 32 mg/kg impaired CFC without interfering with IA performance. Moreover, only 64 mg/kg impaired TFC. These data suggest that M1 muscarinic receptors contribute to memory retrieval in CFC and TFC but are not essential for retrieval in IA.
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    Effects of the M1 Muscarinic Antagonist Dicyclomine on Emotional Memory Retrieval
    (Amer Psychological Assoc, 2016) Soares, Juliana Carlota Kramer [UNIFESP]; Perfetto, Juliano Genaro [UNIFESP]; Antonio, Bruno Brito [UNIFESP]; Oliveira, Maria Gabriela Menezes [UNIFESP]
    Extensive research has shown the involvement of the central cholinergic system in the acquisition and consolidation of tasks involving conditioned fear responses, such as those observed in contextual fear conditioning (CFC), tone fear conditioning (TFC) and inhibitory avoidance (IA). However, there are few data concerning the role of this system in the memory retrieval process. Therefore, the present study aimed to compare the effects of the administration of an M1 antagonist on retrieval during these tasks. For each behavioral procedure, groups of male Wistar rats were trained. Twenty-four hr later, they were treated with different doses of dicyclomine (16, 32, or 64 mg/kg, i.p.) or with saline 30 min before the test session. The results showed that dicyclomine at doses of 16 and 32 mg/kg impaired CFC without interfering with IA performance. Moreover, only 64 mg/kg impaired TFC. These data suggest that M1 muscarinic receptors contribute to memory retrieval in CFC and TFC but are not essential for retrieval in IA.
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    Interaction between glutamatergic-NMDA and cholinergic-muscarinic systems in classical fear conditioning
    (Elsevier B.V., 2008-09-30) Perez Figueredo, Larissa Zeggio [UNIFESP]; Moreira, Karin Monteiro [UNIFESP]; Ferreira, Tatiana Lima [UNIFESP]; Fornari, Raquel Vecchio [UNIFESP]; Menezes Oliveira, Maria Gabriela [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    A number of studies have suggested that the glutamatergic and cholinergic systems are both involved in learning and memory processes and that they interact in order to facilitate these processes. However, the role of M1-muscarinic receptors in mediating this interaction has not been elucidated.The aim of this study was to determine whether the concomitant administration of MK-801 (noncompetitive NMDA antagonist) and dicyclomine (M1-muscarinic antagonist - DIC) in sub-effective doses impairs contextual fear conditioning (hippocampal-dependent task) and tone fear conditioning tasks (hippocampal-independent task).The results showed that concomitant pre-training administration of DIC (8.0 mg/kg) and MK-801 (0.07 mg/kg) - two sub-effectives doses for the contextual fear conditioning task - does impair the performance of animals on this task (as measured by freezing behavior time). Tone fear conditioning tasks were not affected by the drugs either administered separately or concurrently.The pre-training administration of sub-effective doses of MK-801 and DIC in combination impairs performance on contextual fear conditioning task (hippocampal-dependent), but not on tone fear conditioning task (hippocampal-independent). These data support the hypothesis that the interaction between glutamatergic and cholinergic systems in hippocampus-dependent learning and memory processes probably occurs through M1 receptor. (C) 2008 Elsevier Inc. All rights reserved.
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    Interaction between M1-muscarinic and glutamatergic NMDA receptors on an inhibitory avoidance task
    (Elsevier B.V., 2005-11-30) Moreira, K. M.; Ferreira, T. L.; Fornari, R. V.; Figueredo, LZP; Oliveira, MGM; Universidade Federal de São Paulo (UNIFESP)
    It has been demonstrated that MK-801 potentiates the effects of the non-selective muscarinic antagonist scopolamine on memory in rats. in this study, we investigated the role of the M1-muscarinic receptor in this interaction, by administering different doses of dicyclomine (DIC) and MK-801 in combination to male Wistar rats before training on the inhibitory avoidance task. MK-801 and DIC in sub-effective doses were administered in combination. It was observed that MK-801 at a dose of 0.1125 mg/kg with a sub-effective dose of 8 mg/kg of DIC significantly impaired the retention test when compared with saline-treated animals, i.e. MK-801 potentiated the effects of dicyclomine on memory impairment. Our results suggest an important role for the M1-muscarinic receptor in the synergistic interaction between cholinergic muscarinic and glutamatergic NMDA receptors, which is in line with the findings that the interactive modulation between these two neurotransmitters systems constitutes an important mechanism in cognitive functions. (c) 2005 Elsevier Inc. All rights reserved.
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    Role of muscarinic M1 receptors in inhibitory avoidance and contextual fear conditioning
    (Elsevier B.V., 2006-09-01) Kramer Soares, Juliana Carlota; Fornari, Raquel Vecchio; Menezes Oliveira, Maria Gabriela; Universidade Federal de São Paulo (UNIFESP)
    The objective of the present study was to observe the effects of pre-training or post-training administration of dicyclomine, a M1 muscarinic antagonist, on inhibitory avoidance (IA) and contextual fear conditioning (CFC) and to investigate if the effects observed with the pre-training administration of dicyclomine are state-dependent. for each behavioral procedure (IA and CFC) groups of Wistar male rats were treated with saline or dicyclomine either 30 min before training (pre-training), immediately after training or 30 min before training/30 min before test (pre-training/pre-test). the animals were tested 24 h after training. the acquisition of IA and CFC was impaired by pre-training administration of dicyclomine. the consolidation of both tasks was not affected by dicyclomine given immediately after training. Pre-training/pre-test administration of dicyclomine impaired both tasks, an effect similar to that observed in the group which only received pre-training administration. Pre-test treatment induced dissociation between both tasks, impairing CFC retrieval, without interfering with the animals avoidance response. These results show that the dicyclomine did not affect IA and CFC consolidation, suggesting specific involvement of M1 muscarinic receptor only in acquisition these tasks, and these effects was not state-dependent. However, it is possible that the retrieval of these tasks may be mediated, at least in part, by different neurochemical mechanisms and may be dissociated by dicyclomine. (c) 2006 Elsevier Inc. All rights reserved.