Repositório Institucional - Unifesp :: Navegando por Palavras-chave "diabetes"

Navegando por Palavras-chave "diabetes"

Agora exibindo 1 - 20 de 46

Somente Metadadados
Ação de cratabl, crataeva tapia bark lectin, em modelos experimentais de trombose arterial e diabetes induzidas em camundongos black 6 c57
(Universidade Federal de São Paulo (UNIFESP), 2013-03-27) Salu, Bruno Ramos [UNIFESP]; Oliva, Maria Luiza Vilela Oliva [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
A hiperglicerina crônica nos quadros de diabetes é maior iniciadora de complicações microvasculares, como trombose arterial e é um importante alvo pra intervenções terapêuticas. Espécies de plantas do genêro.
Acesso aberto (Open Access)
Análise de custo-efetividade dos sistemas digital e não digital para avaliação fundoscópica de pacientes diabéticos à distancia
(Universidade Federal de São Paulo (UNIFESP), 2004) Cardoso, Lorival Manoel [UNIFESP]; Lavinsky, Jacó [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Objetivo: Analisar custo-efetividade, comparando as retinografias realizadas em pacientes diabeticos, utilizando sistema digital para captura e teletransmissao de imagens a distancia e o sistema de retinografia convencional. Metodos: Avaliacao de amostra estatisticamente representativa de 840 diabeticos, divididos em quatro grupos de 210 pacientes, com criterios de inclusao e exclusao bem definidos, assim distribuidos: A1 - retinografia digital de pacientes a distancia, A2 - retinografia convencional de pacientes distantes realizada em Porto Alegre, 131 - retinografia digital de comunidade local e 132 - retinografia convencional de comunidade local. Todos os pacientes serao avaliados com base na historia clinica, medida da acuidade visual e realizarao duas retinografias em cada olho, uma centrada na papila e outra na macula. Os grupos A1 e 131 farao retinografia digital com Camara Canon CR6-45NM ou similar e os grupos A2 e 132 com camara convencional de 50 graus marca Topcon com filme de 35mm. Os pacientes do grupo A1 serao fotografados em seu local de origem, por tecnologo treinado e as imagens transmitidas via Internet ao Centro de Leitura em Porto Alegre. Os pacientes dos grupos 131 (digital), A2 e 132 (convencional) serao fotografados em Porto Alegre. Resultados: A analise de custo da retinografia digital e 27 por cento inferior ao da retinografia convencional. Comparando custo das retinografias convencional (A2 e 132) e digital (A1 e 131) dentro de cada grupo observamos: grupo A1, reducao de custo da ordem de 9 por cento em relacao ao grupo A2; reducao de 6,5 por cento quando comparamos o grupo 131 com o grupo 132; reducao de 6 por cento no custo do grupo A1 comparado ao grupo 132 e constatamos ainda nao haver diferenca de custo entre os grupos da retinografia digital A1 e 131. Conclusao: O custo-efetividade da retinografia digital com camara nao midriatica e inferior ao da retinografia convencional, contudo esta reducao e mais evidente nos pacientes de localidades distantes, fotografados em seu local de origem. O sistema de retinografia digital, apresenta vantagens quando comparado ao sistema convencional: evita os gastos de deslocamento, facilita a aderencia ao projeto, estimula os programas preventivos de triagem e deteccao e a consequente prevencao da cegueira ocasionada pela Retinopatia Diabetica, com o onus economico e social que ela acarreta
Somente Metadadados
Are Major Depressive Disorder and Diabetes Mellitus Amyloidogenic Conditions?
(Bentham Science Publ Ltd, 2014-01-01) Baskaran, Anusha; Carvalho, Andre F.; Mansur, Rodrigo Barbachan [UNIFESP]; McIntyre, Roger S.; Queens Univ; Univ Hlth Network; Univ Fed Ceara; Universidade Federal de São Paulo (UNIFESP); Univ Toronto
Major depressive disorder (MDD) and diabetes mellitus (DM) have reciprocal relationship and share common pathophysiological mechanisms in the central nervous system. Depression and diabetes negatively affect cognitive function and are independent risk factors for mild cognitive impairment and Alzheimers disease (AD). It has been hypothesized that alterations in the production and processing of amyloid beta (A beta) may be the principal pathological process in AD. Furthermore, it has been increasingly demonstrated that a long preclinical course precedes AD. A derivative of this observation is the hypothesis that a convergent pathophysiological substrate subserving MDD and DM may promote beta amyloid (A beta) deposition. The present paper will review evidence linking MDD and DM to A beta accumulation, with a particular emphasis on original reports that report on levels of A beta 40, A beta 42 and the A beta 40/42 ratio in plasma, serum, or cerebrospinal fluid of individuals with MDD and DM. The overarching goal herein is to press the point that MDD and DM are amyloidogenic and consequently represent modifiable risk factors for AD in later life. The prognostic intervention and prevention opportunity suggested by this notion is that: 1) increased rates of mood disorders and DM in an aging population will increase the population attributable risk for AD ascribed to these conditions, 2) improved outcomes in mood disorders and DM by effective treating to target may exert a salutary influence on underlying dementia promoting processes, 3) novel and repurposed medications that are capable of normalizing pathophysiological processes in MDD and DM could decrease the vulnerability towards AD.
Somente Metadadados
Autoimmunity does not contribute to the highly prevalent glucose metabolism disturbances in a Japanese Brazilian population
(Int Soc Hypertension Blacks-ishib, 2007-12-01) Hashimoto, Silvia Mizue [UNIFESP]; Gimeno, Suely Godoy Agostinho [UNIFESP]; Matsumura, Luiza Kimiko [UNIFESP]; Franco, Laercio Joel [UNIFESP]; Miranda, Walkiria Lopes [UNIFESP]; Ferreira, Sandra Roberta Gouvea [UNIFESP; Japanese Brazilian Diabetes; Universidade Federal de São Paulo (UNIFESP)
The Japanese Brazilian population has one of the highest prevalences of diabetes worldwide. Despite being non-obese according to standard definitions, their body fat distribution is typically central. We investigated whether a subset of these subjects had autoantibodies that would suggest a slowly progressive form of type 1 diabetes. A total of 721 Japanese Brazilians (386 men) in the 30- to 60-year age group underwent clinical examination and laboratory procedures, including a 75-g oral glucose tolerance test and determinations of serum autoantibodies. Antibodies to glutamic acid decarboxylase (GADab) were determined by radioimmunoassay and to thyroglobulin (TGab) and thyroperoxidase (TPOab) by flow-cytometry assays. Mean body mass index was 25.2 +/- 3.8 kg/m(2), but waist circumference was elevated according to the Asian standards. Diabetes, impaired glucose tolerance, and impaired fasting glycemia were found in 31%, 22%, and 22%, respectively, and 53% of the subjects had metabolic syndrome. Glutamic acid decarboxylase (GADab) was positive in 4.72%, TGab in 9.6%, and TPOab in 10% of the whole sample. When participants were stratified according to the presence of thyroid antibodies, similar frequencies of GADab were found in positive and negative groups. The prevalence rates of glucose metabolism disturbances did not differ between GADab positive and negative groups. Our data did not support the view that autoimmune injury could contribute to the high prevalence of diabetes seen in Japanese Brazilians, and the presence of co-morbidities included in the spectrum of metabolic syndrome favors the classification as type 2 diabetes.
Somente Metadadados
Autoimmunity does not contribute to the highly prevalent glucose metabolism disturbances in a Japanese Brazilian population
(Int Soc Hypertension Blacks-ishib, 2006-12-01) Hashimoto, Silvia Mizue [UNIFESP]; Gimeno, Suely Godoy Agostinho [UNIFESP]; Matsumura, Luiza Kimiko [UNIFESP]; Franco, Laercio Joel [UNIFESP]; Miranda, Walkiria Lopes [UNIFESP]; Ferreira, Sandra Roberta Gouvea [UNIFESP]; JBD Study Grp; Universidade Federal de São Paulo (UNIFESP)
The Japanese Brazilian population has one of the highest prevalences of diabetes worldwide. Despite being non-obese according to standard definitions, their body fat distribution is typically central. We investigated whether a subset of these subjects had autoantibodies that would suggest a slowly progressive form of type 1 diabetes. A total of 721 Japanese Brazilians (386 men) in the 30- to 60-year age group underwent clinical examination and laboratory procedures, including a 75-g oral glucose tolerance test and determinations of serum autoantibodies. Antibodies to glutamic acid decarboxylase (GADab) were determined by radioirnmunoassay and to thyroglobulin (TGab) and thyroperoxidase (TPOab) by flowcytometry assays. Mean body mass index was 25.2 +/- 3.8 kg/m(2), but waist circumference was elevated according to the Asian standards. Diabetes, impaired glucose tolerance, and impaired fasting glycemia were found in 31%, 22%, and 22%, respectively, and 53% of the subjects had metabolic syndrome. Glutamic acid decarboxylase (GADab) was positive in 4.72%, TGab in 9.6%, and TPOab in 10% of the whole sample. When participants were stratified according to the presence of thyroid antibodies, similar frequencies of GADab were found in positive and negative groups. The prevalence rates of glucose metabolism disturbances did not differ between GADab positive and negative groups. Our data did not support the view that autoimmune injury could contribute to the high prevalence of diabetes seen in Japanese Brazilians, and the presence of co-morbidities included in the spectrum of metabolic syndrome favors the classification as type 2 diabetes.
Somente Metadadados
Combined effects of ovariectomy and streptozotocin-induced diabetes in the articular cartilage of rats
(Taylor & Francis Ltd, 2018) Saeki Fernandes, A. [UNIFESP]; Fonseca, C. C. N. [UNIFESP]; Rodrigues da Silva Sasso, G. [UNIFESP]; Carvalho Cezar, L.; Aparecida dos Santos, M. [UNIFESP]; Simoes, M. J.; Simoes, R. S.; Florencio-Silva, R. [UNIFESP]
Aim: To evaluate the combined effects of streptozotocin-induced diabetes (Di) and ovariectomy in the articular cartilage of rats. Methods: Forty adult female Wistar rats were ovariectomized (OVX) or sham-operated. After recovery from surgery, the animals were assigned randomly into four groups: OVX control (OVX-C)
Somente Metadadados
Consumo alimentar em adolescentes com diabetes tipo i: um estudo comparativo com indivíduos saudáveis
(Universidade Federal de São Paulo (UNIFESP), 2015-11-19) Grigolon, Ruth Bartelli [UNIFESP]; Claudino, Angelica de Medeiros Claudino [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Objetivos: Comparar o consumo alimentar de adolescentes com diabetes mellitus tipo I (DMI) com adolescentes saudáveis. Métodos: Trata-se de um estudo de caso controle com 50 adolescentes com DMI e 100 adolescentes saudáveis, do sexo feminino, com idade entre 11 e 16 anos. Dados de consumo alimentar, frequência dos grupos alimentares e de alimentos tipicamente consumidos foram obtidos pelo questionário de frequência alimentar da pirâmide alimentar. Para comparar as diferenças estatísticas entre os grupos foram utilizados teste-t, regressão linear múltipla e teste-z para proporções. Resultados: As adolescentes com DMI consumiram em média mais lipídios (32,9% vs 29,9%), e menos carboidratos (49,9% vs 54%) do que o GC. O consumo de cálcio, fibras, e do número de porções de frutas, hortaliças, leite e derivados, óleos e gorduras foi significativamente maior no grupo DMI, enquanto o de açúcares e doces foi menor. Foi observada uma baixa frequência diária de alimentos consumidos tipicamente por essa faixa etária, sendo que alguns destes alimentos, como sucos industrializados, balas/chicletes e embutidos estiveram presentes de forma mais significativa no GC (p<0,01). Conclusão: Adolescentes com DMI demandam atenção especial com relação à terapia nutricional visando o controle glicêmico e a prevenção de complicações médicas e comorbidades.
Somente Metadadados
Corneal Viscoelasticity Differences Between Diabetic and Nondiabetic Glaucomatous Patients
(Lippincott Williams & Wilkins, 2010-06-01) Engel Castro, Dinorah Piacentini [UNIFESP]; Prata, Tiago Santos [UNIFESP]; Lima, Veronica Castro [UNIFESP]; Biteli, Luis Gustavo [UNIFESP]; Vasconcelos de Moraes, Carlos Gustavo; Paranhos, Augusto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Tufts Univ; New York Eye & Ear Infirm
Purpose: To investigate corneal viscoelasticity in primary open-angle glaucoma patients with and without diabetes mellitus, and to correlate corneal hysteresis (CH) with central corneal thickness (CCT).Methods: in this cross-sectional study, 44 primary open-angle glaucoma patients [19 with diabetes (34 eyes) and 25 without diabetes (40 eyes)] underwent a complete ophthalmic examination. Data collected by masked investigators included CH and CCT using the Ocular Response Analyzer. the mean of 3 measurements was considered for each test. We analyzed the difference between the mean CH in both groups using a general linear model. Partial correlation coefficient between CH and CCT was also calculated.Results: Mean +/- SD age in diabetic and nondiabetic groups was 67.1 +/- 8.7 and 65.9 +/- 15.1, respectively (P=0.77). There was no significant difference regarding mean CCT between diabetic (531.7 +/- 31.3 mm) and nondiabetic (546.6 +/- 37.3 mm) groups (P=0.21). Patients with diabetes presented significantly higher CH values than patients without diabetes (9.1 +/- 1.9 mm Hg vs. 7.8 +/- 1.7 mm Hg, P=0.04). There was a significant and positive correlation between CH and CCT for all patients (r=0.407, P<0.001).Conclusions: Primary open-angle glaucoma patients with diabetes have significantly higher CH values than those without diabetes. CH and CCT results were positively correlated. These findings merit further investigation to assess the role of different CH values on glaucoma evaluation and susceptibility.
Somente Metadadados
Diabetes induces changes of catecholamines in primary mesangial cells
(Elsevier B.V., 2008-01-01) Di Marco, Giovana Seno; Colucci, Juliana Almada [UNIFESP]; Fernandes, Fernanda Barrinha [UNIFESP]; Vio, Carlos Pablo; Schor, Nestor [UNIFESP]; Casarini, Dulce Elena [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Clin Muenster; Pontificia Univ Catolica Chile
Diabetes mellitus is a frequent cause of kidney function damage with diabetic nephropathy being predominantly related to glomerular dysfunction. Diabetes is capable of interfering with distinct hormonal systems, as well as catecholamine metabolism. Since mesangial cells, the major constituent of renal glomerulus, constitute a potential site for catecholamine production, the present study was carried out to investigate alterations in catecholamine metabolism in cultured mesangial cells from the nonobese diabetic mouse, a well-established model for type I diabetes. We evaluated mesangial cells from normoglycemic and hyperglycemic nonobese diabetic mice, as well as cells from normoglycemic Swiss tnice as control. Mesangial cells from normoglycemic mice presented similar profiles concerning all determinations. However, cells isolated from hyperglycemic animals presented increased dopamine and norepinephrine production/secretion. Among the studied mechanisms, we observed an upregulation of tyrosine hydroxylase expression accompanied by increased tetrahydrobiopterin consumption, the tyrosine hydroxylase enzymatic cofactor. However, this increase in synthetic pathways was followed by decreased monoamine oxidase activity, which corresponds to the major metabolic pathway of catecholamines in mesangial cells. in addition, Whole kidney homogenates from diabetic animals also presented increased dopamine and norepinephrine levels when compared to normoglycemic animals. Thus, our results suggest that diabetes alters catecholamine production by interfering with both synthesizing and degrading enzymes, suggesting a possible role of catecholamine in the pathogenesis of acute and chronic renal complications of diabetes mellitus. (C) 2007 Elsevier B.V. All rights reserved.
Somente Metadadados
Disease knowledge in patients attending a diabetic foot clinic
(Amer Orthopaedic Foot & Ankle Soc, Inc, 2005-01-01) Batista, Fabio [UNIFESP]; Pinzur, Michael S.; Loyola Univ; Universidade Federal de São Paulo (UNIFESP)
Background: Foot-specific patient education is an essential element of a health system diabetic foot program. Foot-specific patient education must be individualized, because of cognitive deficits in individuals with long-standing diabetes. Methods: Two hundred and two consecutive patients attending diabetic foot specialty clinics were asked to provide demographics and complete a 10-question multiple-choice questionnaire. All attended the clinics because of their high-risk status for the development of diabetic foot infection or ulcers. All received ongoing foot-specific patient education. Results: In spite of this ongoing patient education program, only approximately 80% were able to respond appropriately to simple questions related to the care of their at-risk feet. Conclusion: This simple quality initiative reinforces the notion that patients with diabetes who are at risk for the development of diabetic foot ulcers should receive ongoing foot-specific patient education. This information needs to be constantly reinforced, as retention drops with time.
Somente Metadadados
Diversity of pathways for intracellular angiotensin II synthesis
(Lippincott Williams & Wilkins, 2009-01-01) Kumar, Rajesh; Boim, Mirian A. [UNIFESP]; Texas A&M Hlth Sci Ctr; Scott & White Mem Hosp & Clin; Cent Texas Vet Healthcare Syst; Universidade Federal de São Paulo (UNIFESP)
Purpose of reviewThe renin-angiotensin system (RAS) has undergone continuous advancement since the initial identification of renin as a pressor agent. Traditionally considered a circulatory system, the RAS is now known to exist as a tissue system as well. Recently, the tissue RAS has been further categorized as intracellular and extracellular. Owing to the unique location, the intracellular RAS encompasses new components, such as cathepsin D and chymase, which participate in intracellular angiotensin (Ang) II synthesis. in this review, evidence of the intracellular RAS and the mechanism of Ang II synthesis in various cell types will be discussed.Recent findingsA physiological role for intracellular Ang II in vascular and cardiac cells has recently been demonstrated. Evidence of intracellular Ang II generation has been shown in several cell types, particularly cardiac, renal, and vascular. Importantly, intracellular synthesis of Ang II is more prominent in hyperglycemic conditions and generally involves angiotensin-converting enzyme-dependent and angiotensin-converting enzyme-independent mechanisms,SummaryThere is significant diversity in the mechanism of intracellular synthesis of Ang II in various cell types and pathological conditions. These observations suggest that a therapeutic intervention to block the RAS should take into consideration the nature of the disorder and the cell type involved.
Somente Metadadados
Efeito da suplementação com l-arginina em músculo, tecido adiposo e ilhotas pancreáticas da prole de ratas diabéticas
(Universidade Federal de São Paulo (UNIFESP), 2013-08-28) Carvalho, Diego Soares [UNIFESP]; Hirata, Aparecida Emiko Hirata [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
A hiperglicemia durante a gravidez pode resultar em defeitos no metabolismo de glicose e na função das células β pancreáticas na prole. Estudos em humanos demonstraram que os filhos de mães diabéticas têm grande predisposição à intolerância a glicose, obesidade, resistência à insulina e hipertensão arterial na idade adulta. O objetivo deste trabalho foi avaliar o impacto do diabetes mellitus materno experimental e a suplementação com Larginina (ARG) sobre ilhotas pancreáticas da prole. A indução do diabetes foi realizada através da administração de estreptozotocina - 60mg/kg. Os animais foram estudados aos 3 meses de idade e receberam tratamento (sacarose ou ARG) desde o desmame. Observamos que o peso e a glicemia de jejum não foram estatisticamente diferentes entre os grupos. A ARG promoveu um aumento significativo da insulinemia basal e na fosforilação da proteína Akt no tecido muscular e no adiposo epididimal no grupo filho de mãe diabética (FA). A interação da p47PHOX com gp91PHOX no tecido muscular esquelético foi maior no grupo filho de mãe diabética (FS) e a ARG diminui este parâmetro significativamente. Já no tecido adiposo não houve diferença entre os grupos. A expressão proteica da p47PHOX nas ilhotas pancreáticas foi significativamente maior no grupo (FS) e ARG diminuiu significativamente a expressão desta proteína. O conteúdo total das enzimas antioxidantes SOD e Catalase bem como a fosforilação da Akt em ilhotas pancreáticas não mudou entre os grupos (FS vs CS) e (FA vs CA). Entretanto, a expressão do PDX-1 foi significativamente menor no grupo (FS) e a ARG foi capaz de reverter este fenômeno. Já no processo secretório de insulina a prole de mãe diabética apresentou maior secreção em baixas e altas concentrações de glicose quando comparado aos filhos de mãe controle (CS vs FS). O tratamento com ARG diminuiu significativamente a secreção de insulina no grupo FA em baixa concentração de glicose (2,8 mM) enquanto que em alta concentração (16,7 mM) manteve-se elevada, possivelmente, no intuito de melhorar a sensibilidade à insulina anteriormente observada neste modelo.
Acesso aberto (Open Access)
Efeito do tratamento da aloe vera no diabetes: estudo por análise proteômica da expressão de proteínas no rim
(Universidade Federal de São Paulo (UNIFESP), 2016-09-27) Santos, Lilian dos [UNIFESP]; Arita, Danielle Yuri [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Diabetes mellitus (DM) is a metabolic syndrome characterized by chronic hyperglycemia, with diabetic nephropathy (ND) as its complication. Several studies have demonstrated that Aloe vera (A. vera) has beneficial effects on DM and its consequences. Proteomic analysis is a tool that systematically studies the set of proteins expressed in a given situation. Therefore, the aim of this study was to evaluate the effect of DM1 on the kidney through proteomic analysis, comparing with animals without DM, besides evaluating the effect of insulin treatment and the buthanolic fraction of A. vera (FB) in order to elucidate the protective mechanism of this plant in renal injury induced by this pathology. The streptozotocin-induced diabetic model was used in male Wistar rats. We observed a hypoglycemic effect of FB, which was able to reduce glycemia lasting up to 6 hours after treatment. There was a statistically significant increase in serum creatinine in the untreated (D) and insulin treated (INS) groups compared to the control group (C). On the other hand, there was no difference in relation to urinary creatinine and creatinine clearance. All groups presented increased 24h proteinuria in relation to the C group. The D group presented some alterations in the histological analysis, with dilated tubules and hyperfiltrant glomeruli. The diabetic group treated with FB presented a discrete but not significant improvement. Proteomic analysis identified 93 proteins with statistical differences between the C and D groups, being 36 proteins related to diabetes, and were grouped into: proteins related to mitochondrial dysfunction, arginine metabolic process, eicosanoic acid eicosatrienoic acid, lactate production, glycolysis/pentoses pathway, lipid metabolism, stress, inflammation, calcium influx, transport and others. In addition, 5 exclusive proteins of group D were found, being 2 proteins related to this syndrome. FB treatment was shown to have a beneficial effect, altering the expression of 11 of these proteins, besides presenting two exclusive proteins. Thus, A. vera may be a promising ally in the treatment of diabetes and kidney damage prevention.
Somente Metadadados
Effect of end-stage renal disease and diabetes on zinc and copper status
(Humana Press Inc, 2006-07-01) Batista, Maria Nazare; Cuppari, Lilian; Campos Pedrosa, Lucia de Fatima; Almeida, Maria Das Gracas; De Almeida, Jose Bruno; Queiroz de Medeiros, Anna Cecilia; Canziani, Maria Eugienia F.; Universidade Federal de São Paulo (UNIFESP); Univ Fed Rio Grande Norte
The aim of this study was to compare the nutritional status of zinc and copper in patients with and without diabetes submitted to chronic hemodialysis. Thirty-three patients with type 2 diabetes (DM group), 30 nondiabetic patients (NDM group), and 20 healthy individuals (control group) were studied. Plasma, erythrocyte, and urinary zinc and plasma copper were obtained from atomic absorption spectrophotometry and ceruloplasmin by immunonephelometry. the anthropometric parameters were similar among the groups. Plasma zinc was lower and erythrocyte zinc was higher in the DM and NDM groups in relation to the control group. No difference in urinary zinc was observed comparing the groups. Plasma copper was higher in the DM group when compared to the NDM and control groups. Ceruloplasmin was similar in the three groups. Serum urea was a positive independent determinant of plasma zinc concentrations. the determinants of erythrocyte zinc were MAMC midarm muscle circumference and Kt/V dialysis adequacy. the determinants of plasma copper concentration were serum creatinine and serum glucose. the results of this study demonstrate an alteration in the distribution of zinc in patients with chronic kidney disease (CKD) independently of the presence of DM. Also, the status of copper seems not to be influenced by CKD, but only by the metabolic derangements associated with diabetes.
Acesso aberto (Open Access)
Effect of thyroparathyroidectomy on urinary acidification in diabetic rats
(Associação Brasileira de Divulgação Científica, 1999-01-01) Gil, Frida Zaladek [UNIFESP]; Cavanal, Maria de Fátima [UNIFESP]; Nascimento-Gomes, G. [UNIFESP]; Silva-Rocha, M.c. [UNIFESP]; Nutti-de-Almeida, M. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
In previous studies we have shown stimulation of renal acid excretion in the proximal tubules of rats with diabetes of short duration, with no important alterations in glomerular hemodynamics; on the other hand, in thyroparathyroidectomized rats (TPTX model), a significant decrease in renal acid excretion, glomerular filtration rate (GFR) and renal plasma flow (RPF) was detected. Since important changes in the parathyroid hormone-vitamin D-Ca axis are observed in the diabetic state, the present study was undertaken to investigate the renal repercussions of thyroparathyroidectomy in rats previously made diabetic by streptozotocin (45 mg/kg). Four to 6 days after the induction of diabetes (DM), a group of rats were thyroparathyroidectomized (DM + TPTX). Renal functional parameters were evaluated by measuring the inulin and sodium para-aminohippurate clearance on the tenth day. The decrease in the GFR and RPF observed in TPTX was not reversed by diabetes since the same alterations were observed in DM + TPTX. Net acid (NA) excretion was unchanged in DM (6.19 ± 0.54), decreased in TPTX (3.76 ± 0.25) and returned to normal levels in DM + TPTX (5.54 ± 0.72) when compared to the control group (6.34 ± 0.14 µmol min-1 kg-1). The results suggest that PTH plays an important vasodilator role regarding glomerular hemodynamics, since in its absence the impairment in GFR and RPF was not reversed by the diabetic state. However, with respect to acid excretion, the presence of diabetes was able to overcome the negative stimulus represented by TPTX.
Acesso aberto (Open Access)
Effects of repeated extracorporeal shock wave on kidney apoptosis of normal and diabetic rat
(Sociedade Brasileira de Urologia, 2008-02-01) Kira, Vicente Massaji [UNIFESP]; Fagundes, Djalma José [UNIFESP]; Bandeira, César Orlando Peralta [UNIFESP]; Kaufman, Oskar [UNIFESP]; Fagundes, Anna T. N. [UNIFESP]; Ortiz, Valdemar [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
OBJECTIVE: To assess the effect of repeated extracorporeal shock waves (ESW) on the apoptosis of renal parenchyma in normal and diabetic rats by the caspase-3 expression. MATERIALS AND METHODS: 80 rats were assigned for ESW (Direx Tripter X1® - 14 KVA) to one of three groups with 50% rats with diabetes (A) and 50% normal (B) in each: G1 (n = 40): no ESW; G2 (n = 20): one ESW; G3 (n = 20): two ESWin an interval of 14 days. The animals were sacrificed 3 days after the ESW and samples of the renal parenchyma were histologically prepared, stained by the caspase-3 cleavage immunohistochemical method, and the apoptotic index (ApIn) was calculated by computer program Image Pro-Plus V 4,5,1 Media Cybernetics® ( ApIn = number of apoptotic cells in the microscopic section / total cells in the microscopic section). RESULTS: There was no statistical difference in ApIn of normal rats with one ESW (8.4 + 0.2) or two ESW (9.1 + 0.3) and both were similar to the control group with no ESW (7.9 + 0.2). The ApIn of diabetic rats with one ESW (7.4 + 0.3) was similar to the normal rats with one or two ESW. On the other hand, the ApIn was statistically higher in diabetic rats with two ESW (11.9 + 0.4) than in diabetic rats with one ESW (7.4 + 0.3). CONCLUSIONS: The ApIn of normal rats with a single (2,000 SW) or repeated ESW (4,000 SW) was similar to the control animals without any ESW. In diabetic rats, the repeated ESW (4,000 SW) may result in an additional risk of tissue damage expressed by the higher ApIn.
Acesso aberto (Open Access)
Ensaio clínico randomizado multicêntrico para avaliar a eficácia de injeções intravítreas de bevacizumabe, triancinolona ou de sua combinação no tratamento do edema macular diabético
(Universidade Federal de São Paulo (UNIFESP), 2015-07-31) Oliveira Neto, Hermelino Lopes de [UNIFESP]; Mattos Junior, Rubens Belfort [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
In diabetic patients, it is estimated that the risk of blindness is twenty times higher than the normal population and approximately 19% of blindness in the world are caused by diabetes mellitus (DM). In Brazil, diabetic retinopathy (DR), a specific microvascular complication, is among the leading causes of irreversible blindness, affecting 7.6% of the population according to the Ministry of Health, and this disease accounts for 4.6% of severe visual impairments. The diabetic macular edema (EMD) is the primary mechanism for vision lossin patients with non-proliferative DR. It arises due to secondary formation of micro aneurysms, changes in the blood-retinal barrier, increasedinflammation and angigenic factors that promote increase in thevascular permeability abd consequent leakage of fluid and lipids to the retina. The EMD treatment includes laser photocoagulation, intravitreal injection of anti-angiogenic drugs or steroids.The aim of this study was to evaluate and compare the efficacy and adverse effects of intravitreous injections of bevacizumab, triancinolone or their combination in the treatment of clinically significant diabetic macular edema through tests of visual acuity and IOP measurements and central macular thickness. This study included142 patients with diabetic retinopathy and clinically significant macular edema from eight cities. It is a randomized, multicenter and masked study. Patients underwent ophthalmologic examination and optical coherence tomography (OCT). Afterwards they were divided into three treatment groups: (1) Bevacizumab-1.25mg /0.05ml; (2) triamcinolone-4mg /0.1ml; (3) Bevacizumab+triancinolone. The obtained average age was 58.8 years for the BEVACIZUMABE group, 57.1 years for the TRIANCINOLONE group and 61years for BEVACIZUMABE+TRIANCINOLONE group(p =0.716). We observed statistically significant improvement in visual acuity (>4lines) in all groups, comparing the results of week 24 with the baseline visit. At week 24 there was no significant difference in the visual acuity between the 3 groups (p =0.436). It was observed reduction in macular thickness in all thegroups (BEVACIZUMABE=103?m, TRIANCINOLONE=160 micrometres BEVACIZUMABE TRIANCINOLONE+=125um), and the TRIANCINOLONE group showed significantly less thick(247 microns) than the bevacizumab group (287 microns). In all groups, there was an IOP increase, and the TRIANCINOLONE group had higher mean value of IOP throughout the study period (18 mmHg) .The average number of injections was higher in the BEVACIZUMABE group (3.2 injections), followed by BEVACIZUMABE+TRIAMCINOLONE (2.4 injections) and TRIANCINOLONA (2.1injections) group.In this investigation no severe adverse event was observed. At the end of the study, there was no significant difference between the groups regarding the visual acuity, intraocular pressure and central macular thickness.
Somente Metadadados
High glucose levels abolish antiatherosclerotic benefits of ACE inhibition in alloxan-induced diabetes in rabbits
(Lippincott Williams & Wilkins, 2005-04-01) Pomaro, Daniel Roberto [UNIFESP]; Ihara, Silvia Saiuli Miki [UNIFESP]; Pinto, Leonor do Espírito Santo de Almeida [UNIFESP]; Ueda, Ivete [UNIFESP]; Casarini, Dulce E. [UNIFESP]; Ebihara, Fabiana [UNIFESP]; Santos, Andreza Oliveira dos [UNIFESP]; Izar, Maria Cristina de Oliveira [UNIFESP]; Fonseca, Francisco Antonio Helfenstein [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Renin-angiotensin system activation is recognized to play an important role in atherosclerosis. This study aimed to verify the antiatherosclerotic effects of ACE inhibition on an experimental model of diabetes and hypercholesterolemia. Diabetes was induced in New Zealand male rabbits with a single dose of alloxan (100 mg/kg, IV), and, according to plasma glucose levels obtained after 1 week, the animals were divided into 2 groups (>= 250 mg/dL or < 250 mg/dL). Each group was randomly assigned to receive or not quinapril (30 mg/d) added to a 0.5% cholesterol-enriched diet. Animals with high glucose levels at 1 week and that remained high after 12 weeks presented higher triglyceride levels (P < 0.02 versus basal). Those initially hyperglycemic but presenting < 250 mg/dL glucose at the end of study formed an additional group. Plasma ACE activity was lower in quinapril-treated animals (P < 0.01 versus untreated groups). However, aorta intima/media ratio and intima area were lower only in the subgroups of quinapril-treated animals with low glucose levels (P < 0.05). Our results support the hypothesis that high plasma glucose may abolish the anti atheroscl erotic effect of ACE inhibitors.
Somente Metadadados
Hope matters to the glycemic control of adolescents and young adults with type 1 diabetes
(Sage Publications Ltd, 2015-05-01) Santos, Fabio R. M. [UNIFESP]; Sigulem, Daniel [UNIFESP]; Areco, Kelsy C. N. [UNIFESP]; Gabbay, Monica Andrade Lima [UNIFESP]; Dib, Sergio A. [UNIFESP]; Bernardo, Viviane [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
This study investigated the association of hope and its factors with depression and glycemic control in adolescents and young adults with type 1 diabetes. A total of 113 patients were invited to participate. Significant negative correlations were found between hope and HbA1c and also between hope and depression. Hope showed a significant association with HbA1c and depression in the stepwise regression model. Among the hope factors, inner positive expectancy was significantly associated with HbA1c and depression. This study supports that hope matters to glycemic control and depression. Intervention strategies focusing on hope should be further explored.
Somente Metadadados
The hypothalamus-pituitary-ovary axis and type 1 diabetes mellitus: a mini review
(Oxford Univ Press, 2006-02-01) Arrais, R. F.; Dib, Sergio Atala [UNIFESP]; Univ Fed Rio Grande Norte; Universidade Federal de São Paulo (UNIFESP)
A high prevalence of menstrual cycle and fertility disturbances has long been associated with diabetes mellitus. However, rationalization of the intrinsic mechanisms of these alterations is controversial and even contradictory. This review considers (i) the relationship between diabetes mellitus, especially type 1 diabetes mellitus (T1DM), and the hypothalamus-pituitary-ovary (HPO) axis, (ii) the state of our knowledge concerning neuroendocrine control and its relationship with dopaminergic and opioid tonus, and (iii) the influence of the hypothalamus-pituitary-adrenal axis on ovarian function. Functional disturbances that occur as a consequence of diabetes are also discussed, but some T1DM-related diseases of autoimmune origin, such as oophoritis, are not further analysed. Although there are clear indications of a relationship between menstrual and fertility alterations and glycaemic control, in many instances the improvement of the latter is not sufficient to reverse such alterations. It appears that the oligoamenorrhoea and amenorrhoea associated with T1DM is mainly of hypothalamic origin (i.e. failure of the GnRH pulse generator) and may be reversible. the importance of the evaluation of the HPO axis in T1DM women with menstrual irregularities, even in the presence of adequate metabolic control, is emphasized.

Navegando por Palavras-chave "diabetes"

Resultados por página

Opções de Ordenação