Navegando por Palavras-chave "cytology"

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    Accuracy, sensitivity and specificity of fine needle aspiration biopsy in salivary gland tumours: A retrospective study
    (Medicina Oral S L, 2010-01-01) Stramandinoli, Roberta Targa; Sassi, Laurindo Moacir [UNIFESP]; Pedruzzi, Paola Andrea Galbiatti; Ramos, Gyl Henrique Albrecht; Oliveira, Benedito Valdecir de; Ogata, Daniel Cury; Ioshii, Sergio Ossamu; Erasto Gaertner Hosp; Universidade Federal de São Paulo (UNIFESP); Univ Fed Parana
    Objective: the aim of this study was to evaluate the diagnostic accuracy, sensitivity and specificity of fine needle aspiration biopsies (FNAB) of salivary gland tumours performed at the Erasto Gaertner Hospital over the course of a four year period. Study design: A retrospective study was carried out between 2001-2005 to review the cases of patients with salivary gland tumours who had undergone pre-operative FNAB and had been diagnosed during post-operative histopathology examination. Results: A total of 106 cases of salivary gland tumours were considered for this study, but 27 cases (25.5%) of the samples were considered unsatisfactory for analysis. the sensitivity, specificity and accuracy were calculated considering only the 79 benign and malignant cases in which FNAB provided sufficient samples for analysis. Based on these data, the value of sensitivity was 68.2% (15/22), specificity was 87.7% (50/57), accuracy was 82.3% (65/79), positive predictive value was 68.2% (15/22) and negative predictive value was 87.7% (50/57). Conclusions: Despite the high rate of inadequate samples obtained in the FNAB in this study, the technique offers high specificity, accuracy and acceptable sensitivity.
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    Clinic-cytologic study of conjunctivochalasis and its relation to thyroid autoimmune diseases - Prospective cohort study
    (Lippincott Williams & Wilkins, 2006-08-01) Fiorentini de Almeida, Sandra Flavia; Sousa, Luciene B. de; Vieira, Luis A.; Chiamollera, Maria I.; Barros, Jeison de N.; Universidade Federal de São Paulo (UNIFESP)
    Purpose: To determine the prevalence of conjunctivochalasis in patients with immune thyroid diseases, to determine whether there is any association between the 2 diseases, and to determine cytologic study of conjunctivochalasis through the cytology impression test.Methods: A clinical prospective cohort study carried out by the External Diseases Department in the Ophthalmology Sector and the Thyroid Department in the Endocrinology Sector at Federal University of São Paulo (UNIFESP). the patients included were divided into 2 groups following these inclusion criteria: a control group of 25 patients without thyroid diseases, confirmed after clinical and laboratory examinations (thyroid hormones), or any other ocular diseases. the study group consisted of 31 patients with thyroid diseases, the diagnosis of which was confirmed by the Endocrinology Sector. the thyroidopathies included were autoimmune diseases but excluded nonautoimmune diseases. A protocol endorsed by the UNIFESP was followed, using clinical and ophthalmological history, biomicroscopy, and impression cytology.Results: Fifty-two percent of patients without thyroid diseases and 88% of patients with thyroid diseases presented with conjunctivochalasis. the risk ratio was 1.705 (Pr>chi(2)=0.0038), indicating that there is an association between them. for the impression cytology in inferior bulbar conjunctiva, there was an association between the result of the impression cytology and conjunctivochalasis (Pearson chi(2)=10.1190 Pr=0.006).Conclusion: the prevalence of conjunctivochalasis in patients with autoimmune thyroid diseases was 88%. Patients with autoimmune thyroidopathy presented higher percentages of conjunctivochalasis than the control group, confirming the association between them. the cytologic study showed the highest prevalence of abnormal surface features in eyes with conjunctivochalasis.
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    Conjunctival Impression Cytology Changes Induced by Oral Isotretinoin
    (Lippincott Williams & Wilkins, 2009-10-01) Queiroga, Isabella Bezerra Wanderley de; Vieira, Luiz Antônio [UNIFESP]; Barros, Jeison de Nadai [UNIFESP]; Diniz, Margareth de Fatima Formiga Melo; Morais, Liana Clebia Soares Lima de; Univ Fed Paraiba; Universidade Federal de São Paulo (UNIFESP)
    Purpose: To evaluate the bulbar conjunctiva using impression cytology in patients submitted to oral isotretinoin treatment.Methods: A prospective, cohort study was carried out in a referral ophthalmology practice at the Federal University of Paraiba and in the External Eye Disease Laboratory of the Federal University of Sao Paulo. Twenty-eight patients with acne vulgaris were selected. Impression cytology specimens collected from the temporal bulbar conjunctiva and the superior bulbar conjunctiva of both eyes before and after 3 months of oral isotretinoin treatment were assessed. The doses of isotretinoin varied from 0.35 to 0.88 mg . kg(-1) . d(-1).Results: The percentage of patients in whom impression cytology results were normal was significantly lower during oral isotretinoin treatment compared to the pretreatment phase, decreasing from 75% to 43% in the temporal bulbar conjunctiva and from 100% to 82% in the superior bulbar conjunctiva. In both regions, the parameters most affected were cell-to-cell contact, nucleus-to-cytoplasm ratio, and goblet cell density.Conclusion: Oral isotretinoin for the treatment of acne induces alterations in the conjunctival epithelium of a significant percentage of patients treated with the drug. These alterations are seen both in the exposed conjunctiva (temporal bulbar region) and in the unexposed conjunctiva (superior bulbar region).
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    Nasal lavage, blood or sputum: Which is best for phenotyping asthma?
    (Wiley, 2017) de Farias, Camyla F. [UNIFESP]; Amorim, Maria M. F. [UNIFESP]; Dracoulakis, Michel [UNIFESP]; Caetano, Lilian B. [UNIFESP]; Santoro, Ilka L. [UNIFESP]; Fernandes, Ana L. G. [UNIFESP]
    Background and objectiveDetermination of asthma phenotypes, particularly inflammatory phenotypes, helps guide treatment and management of this heterogeneous disease. Induced sputum cytology has been the gold standard for determination of inflammatory phenotypes, but sputum induction is fairly invasive and technically challenging. Blood and nasal lavage cytology have been suggested as substitutes, but have not been fully verified. The aim of this study is to determine the accuracy of blood and nasal lavage cytometry as indicators of inflammatory phenotypes in asthma. MethodsClinical evaluation, Asthma Control Questionnaire (ACQ) and spirometry were performed for 121 adult asthma patients, and blood, nasal lavage and induced sputum samples were taken. Eosinophils and neutrophils were counted in three samples from each subject. Inflammatory phenotypes (eosinophilic, neutrophilic, mixed and paucicellular) and cells counts were analysed using Venn diagram and receiver operating characteristic (ROC) curve, respectively. Results ACQ score, spirometry and bronchodilator response did not differ among subjects with different inflammatory phenotypes. Inflammatory phenotypes defined by nasal lavage cytometry were in better concordance than those defined by blood cell counts with phenotypes determined by sputum cytology, and were significantly correlated with sputum phenotypes. For eosinophilia, nasal lavage cytology showed better accuracy than blood cytology (area under the curve (AUC): 0.89 vs 0.65). For all phenotypes, sensitivity and positive and negative predictive power were higher for nasal lavage cytometry than for blood. Blood cell counts gave a high level of false positives for all inflammatory phenotypes. ConclusionWe recommend nasal lavage cytology over blood cell count as a substitute for sputum cytology to identify inflammatory phenotypes in asthma.