Navegando por Palavras-chave "corpus callosum"
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- ItemAcesso aberto (Open Access)Agenesis and lipoma of corpus callosum: Case report(Academia Brasileira de Neurologia - ABNEURO, 1995-09-01) Silva, Délrio Façanha [UNIFESP]; Lima, Márcia Marques; Oliveira, César O.; Oliveira, William N.; Anghinah, Renato; Lima, José Geraldo Camargo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The agenesis and lipoma of the corpus callosum is a very rare association. We report the case of a 18-years old woman with rare epileptic seizures since the age of 6 years, normal neurological examination, as well as normal electroencephalogram. The brain computed tomography scanning and the magnetic resonance showed the lipoma and the agenesis of the corpus callosum.
- ItemSomente MetadadadosFocal transient lesion in the splenium of the corpus callosum in three non-epileptic patients(Springer, 2006-10-01) Rocha, Antonio Jose da; Reis, Fabiano; Pinto Gama, Hugo Pereira; Silva, Carlos Jorge da; Braga, Flavio Tulio; Martins Maia Junior, Antonio Carlos; Cendes, Fernando; Santa Casa Misericordia São Paulo; Universidade Estadual de Campinas (UNICAMP); Universidade Federal de São Paulo (UNIFESP)Introduction We analyzed the imaging features of transient focal lesions in the splenium of the corpus callosum (SCC) in non-epileptic patients receiving antiepileptic drugs (AEDs).Methods We identified signal abnormalities in the SCC in three non-epileptic patients, all of them receiving AEDs. We examined two of these patients with multiplanar magnetic resonance (MR) imaging using 1.0-T equipment including fluid-attenuated inversion recovery (FLAIR), T2-weighted (TSE) and T1-weighted (SE) sequences before and after injection of contrast agent. the third patient was studied using 1.5-T equipment with the same sequences. Additionally, a T1 SE sequence with a magnetization transfer contrast pulse off resonance (T1 SE/MTC), diffusion-weighted imaging (EPI-DWI) and apparent diffusion coefficient (ADC) maps were obtained.Results We observed an identical pattern of imaging abnormalities in all patients characterized by round lesions, hyperintense on FLAIR and hypointense on T1 SE images, located in the central portion of the SCC. One lesion showed homogeneous gadolinium enhancement and perilesional vasogenic edema. This particular lesion showed restricted diffusion confirmed on the ADC map. This pattern was considered consistent with focal demyelination. Follow-up MR examinations showed complete disappearance or a clear reduction in lesion size. All patients had been treated with AEDs, but they did not show any clinical signs of toxicity, interhemispheric symptoms, or abnormal neurological findings (including seizures).Conclusion We believe that our MR findings might be interpreted as transient lesions related to AED toxicity. They presumably resulted from focal demyelination in the central portion of the SCC.
- ItemSomente MetadadadosNeurostructural imaging findings in children with post-traumatic stress disorder: Brief review(Wiley-Blackwell, 2009-01-01) Jackowski, Andrea Parolin [UNIFESP]; Araujo, Celia Maria de [UNIFESP]; Tavares de Lacerda, Acioly Luiz [UNIFESP]; Mari, Jair de Jesus [UNIFESP]; Kaufman, Joan; Universidade Federal de São Paulo (UNIFESP); Sinapse Inst Clin Neurosci; Ctr Res & Clin Trials Sinapse Bairral; Yale UnivChild maltreatment has been associated with different psychiatric disorders. Studies on both animals and humans have suggested that some brain areas would be directly affected by severe psychological trauma. the pathophsysiology of post-traumatic stress disorder (PTSD) appears to be related to a complex interaction involving genetic and environmental factors. Advanced neuroimaging techniques have been used to investigate neurofunctional and neurostructural abnormalities in children, adolescents, and adults with PTSD. This review examined structural brain imaging studies that were performed in abused and traumatized children, and discusses the possible biological mechanisms involved in the pathophysiology of PTSD, the implications and future directions for magnetic resonance imaging (MRI) studies. Published reports in refereed journals were reviewed by searching Medline and examining references of the articles related to structural neuroimaging of PTSD. Structural MRI studies have been performed in adults and children to evaluate the volumetric brain alterations in the PTSD population. in contrast with studies involving adults, in which hippocampus volumetric reduction was the most consistent finding, studies involving children and adolescents with PTSD have demonstrated smaller medial and posterior portions of the corpus callosum.
- ItemSomente MetadadadosReference Values for the Length and Area of the Fetal Corpus Callosum on 3-Dimensional Sonography Using the Transfrontal View(Amer Inst Ultrasound Medicine, 2012-02-01) Araujo Junior, Edward [UNIFESP]; Visentainer, Milena [UNIFESP]; Simioni, Christiane [UNIFESP]; Ruano, Rodrigo; Nardozza, Luciano Marcondes Machado [UNIFESP]; Moron, Antonio Fernandes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objectives-The purpose of this study was to determine reference values for the length and area of the fetal corpus callosum between 20 and 33 weeks' gestation using 3-dimensional sonography.Methods-A cross-sectional study was performed in 293 healthy pregnant women between 20 and 33 weeks' gestation. The length and area of the corpus callosum were obtained via the transfontal view with the metopic suture as an acoustic window using 3-dimensional sonographic aquisitions. Linear and weighted polynomial regression models were used, which were adjusted by residual analysis and the R-2 determination coefficient. Intraobserver and interobserver reproducibilities were analyzed by an intraclass correlation coefficient.Results-The mean corpus callosum length +/- SD varied from 19.52 +/- 2.24 to 40.36 +/- 2.87 mm, whereas the mean area varied from 0.44 +/- 0.11 to 1.47 +/- 0.21 cm(2) at 20 and 33 weeks, respectively. The length and area were highly correlated with gestational age: corpus callosum length = -52.41 + 4.71 x gestational age - 0.06 x gestational age(2) (R-2 = 0.868); and corpus callosum area = -2.47 + 0.16 x gestational age -0.000037 x gestational age(2) (R-2 = 0.765). The intraobserver and interobserver reproducibties were excellent, with intraclass correlation coefficients of 0.98 and 0.94 for the length and 0.99 and 0.90 for the area, respectively.Conclusions-Reference values for the length and the area of the fetal corpus callosum between 20 and 33 weeks' gestation were determined with high reproducibility.
- ItemSomente MetadadadosTestosterone and free thyroxin blood in congenitally acallosal male BALB/cCF mice(Maghira & Maas Publications, 2003-12-01) Mourão-Júnior, Carlos Alberto [UNIFESP]; Schmidt, Sergio Luis; Manhaes, Alex Christian; Universidade do Estado do Rio de Janeiro (UERJ); Universidade Federal de São Paulo (UNIFESP)OBJECTIVES: Approximately 20% of BALB/cCF mice are born with partial or total absence of the corpus callosum. Here, we analyzed testosterone and free thyroxin blood levels in adult male mice of this strain in order to see if these hormones are related to the incidence of callosal defects.METHODS: Blood collected from the axillary blood vessels of 12 normal and 10 acallosal deeply anesthetized adult male mice was used in order to determine testosterone and free thyroxin levels through chemiluminescence (IMMULITE, Diagnostics Products Corporation, USA).RESULTS: No significant difference (one-way ANOVA: F = 0.11, df = 1, p > 0.10) was found between normal ((X) over bar = 1.95, SD = 0.62) and acallosal ((X) over bar = 1.86, SD = 0.62) mice for free thyroxin level. On the other hand, in those mice that had detectable testosterone levels (above 0.2 ng/ml), a significant difference was found (t = 2.8, df = 6.06, p = 0.03): normal mice (n = 7, (X) over bar = 8.73, SD = 7.64) had a higher level than acallosal mice (n = 4, (X) over bar = 0.62, SD = 0.41).CONCLUSIONS: The present results indicate that the incidence of callosal agenesis is not related to free thyroxin levels in the blood of adult BALB/cCF mice. On the other hand, in spite of the fact that low testosterone levels seems to be frequent in male mice of this strain, acallosal mice tend to have lower levels of this hormone than normal mice.