Navegando por Palavras-chave "choroid"
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- ItemSomente MetadadadosCHOROIDAL IMAGING USING SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY(Lippincott Williams & Wilkins, 2012-05-01) Regatieri, Caio V. [UNIFESP]; Branchini, Lauren; Fujimoto, James G.; Duker, Jay S.; Tufts Univ New England Med Ctr; Universidade Federal de São Paulo (UNIFESP); Boston Univ; MITBackground: A structurally and functionally normal choroidal vasculature is essential for retinal function. Therefore, a precise clinical understanding of choroidal morphology should be important for understanding many retinal and choroidal diseases.Methods: PUBMED (http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed) was used for most of the literature search for this article. the criterion for inclusion of an article in the references for this review was that it included materials about both the clinical and the basic properties of choroidal imaging using spectral-domain optical coherence tomography.Results: Recent reports show successful examination and accurate measurement of choroidal thickness in normal and pathologic states using spectral-domain optical coherence tomography systems. This review focuses on the principles of the new technology that make choroidal imaging using optical coherence tomography possible and on the changes that subsequently have been documented to occur in the choroid in various diseases. Additionally, it outlines future directions in choroidal imaging.Conclusion: Optical coherence tomography is now proven to be an effective non-invasive tool to evaluate the choroid and to detect choroidal changes in pathologic states. Additionally, choroidal evaluation using optical coherence tomography can be used as a parameter for diagnosis and follow-up. RETINA 32: 865-876, 2012
- ItemSomente MetadadadosCHOROIDAL THICKNESS in PATIENTS WITH DIABETIC RETINOPATHY ANALYZED BY SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY(Lippincott Williams & Wilkins, 2012-03-01) Regatieri, Caio V. [UNIFESP]; Branchini, Lauren; Carmody, Jill; Fujimoto, James G.; Duker, Jay S.; Tufts Med Ctr; Universidade Federal de São Paulo (UNIFESP); Boston Univ; MITPurpose: This study was designed to examine choroidal thickness in patients with diabetes using spectral-domain optical coherence tomography.Methods: Forty-nine patients (49 eyes) with diabetes and 24 age-matched normal subjects underwent high-definition raster scanning using spectral-domain optical coherence tomography with frame enhancement software. Patients with diabetes were classified into 3 groups: 11 patients with mild or moderate nonproliferative diabetic retinopathy and no macular edema, 18 patients with nonproliferative diabetic retinopathy and diabetic macular edema, and 20 patients with treated proliferative diabetic retinopathy and no diabetic macular edema (treated proliferative diabetic retinopathy). Choroidal thickness was measured from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction at 500-mu m intervals up to 2,500 mu m temporal and nasal to the fovea.Results: Reliable measurements of choroidal thickness were obtainable in 75.3% of eyes examined. Mean choroidal thickness showed a pattern of thinnest choroid nasally, thickening in the subfoveal region, and thinning again temporally in normal subjects and patients with diabetes. Mean subfoveal choroidal thickness was thinner in patients with diabetic macular edema (63.3 mu m, 27.2%, P < 0.05) or treated proliferative diabetic retinopathy (69.6 mu m, 30.0%, P < 0.01), compared with normal subjects. There was no difference between nonproliferative diabetic retinopathy and normal subjects.Conclusion: Choroidal thickness is altered in diabetes and may be related to the severity of retinopathy. Presence of diabetic macular edema is associated with a significant decrease in the choroidal thickness. RETINA 32: 563-568, 2012
- ItemSomente MetadadadosDissection of Human Retina and RPE-Choroid for Proteomic Analysis(Journal Of Visualized Experiments, 2017) Cabral, Thiago [UNIFESP]; Toral, Marcus A.; Velez, Gabriel; DiCarlo, James E.; Gore, Anuradha M.; Mahajan, MaryAnn; Tsang, Stephen H.; Bassuk, Alexander G.; Mahajan, Vinit B.The human retina is composed of the sensory neuroretina and the underlying retinal pigmented epithelium (RPE), which is firmly complexed to the vascular choroid layer. Different regions of the retina are anatomically and molecularly distinct, facilitating unique functions and demonstrating differential susceptibility to disease. Proteomic analysis of each of these regions and layers can provide vital insights into the molecular process of many diseases, including Age-Related Macular Degeneration (AMD), diabetes mellitus, and glaucoma. However, separation of retinal regions and layers is essential before quantitative proteomic analysis can be accomplished. Here, we describe a method for dissection and collection of the foveal, macular, and peripheral retinal regions and underlying RPE-choroid complex, involving regional punch biopsies and manual removal of tissue layers from a human eye. One-dimensional SDS-PAGE as well as downstream proteomic analysis, such as liquid chromatography-tandem mass spectrometry (LC-MS/MS), can be used to identify proteins in each dissected retinal layer, revealing molecular biomarkers for retinal disease.
- ItemSomente MetadadadosEXERCISE-INDUCED ACUTE CHANGES in SYSTOLIC BLOOD PRESSURE DO NOT ALTER CHOROIDAL THICKNESS AS MEASURED BY A PORTABLE SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY DEVICE(Lippincott Williams & Wilkins, 2013-01-01) Alwassia, Ahmad A.; Adhi, Mehreen; Zhang, Jason Y.; Regatieri, Caio V. [UNIFESP]; Al-Quthami, Adeeb; Salem, Deeb; Fujimoto, James G.; Duker, Jay S.; Tufts Med Ctr; Universidade Federal de São Paulo (UNIFESP); MITPurpose: To measure choroidal thickness in patients manifesting an acute change in systemic arterial blood pressure using a portable spectral-domain optical coherence tomography device (iVue).Methods: Fifteen patients (15 eyes) undergoing cardiac exercise stress testing were scanned using a portable spectral-domain optical coherence tomography system (iVue). Two scan protocols were used: cross line scan for measuring choroidal thickness and the retina map scan to measure retinal thickness. Each patient was scanned before and within 3 minutes after the stress test. Blood pressure was measured at the same time as the acquisition of the scans. Choroidal thickness was measured from the posterior edge of the retinal pigment epithelium to the choroid-sclera junction at 500-mu m intervals up to 1,000 mu m temporal and nasal to the fovea. Retinal thickness was measured by an automated software. All choroidal thickness measurements were performed by two independent observers.Results: Fifteen patients (15 eyes) with a mean age of 60.6 (+/- 10.4 years) were scanned. There was a significant increase in systolic but not diastolic pressure after stress testing (P < 0.05). the mean choroidal thickness measurements showed no significant difference before and after exercise stress testing (P > 0.05). in addition, there was no significant difference in retinal thickness before and after stress testing measurements (P > 0.05).Conclusion: There was no change in choroidal thickness or retinal thickness, despite an acute change in the systemic systolic blood pressure induced by exercise. RETINA 33:160-165, 2013
- ItemSomente MetadadadosGiant annular posttraumatic choroidal rupture(Canadian Ophthal Soc, 2004-08-01) Unonius, Nichard [UNIFESP]; Araujo, J.; Farah, Michel Eid [UNIFESP]; Sallum, Juliana Maria Ferraz [UNIFESP]; Calucci, Daniela [UNIFESP].; Universidade Federal de São Paulo (UNIFESP)
- ItemSomente MetadadadosPresumed eccrine carcinoma metastatic to the choroid(Blackwell Publishing, 2006-09-01) Moura, Leticia R.; Ayres, Bernadete; Feijoo, Luciana; Romano, Sergio; Odashiro, Alexandre N.; Burnier, Miguel N.; IBOL; Oncoclin; Inst Nacl Canc; Universidade Federal de São Paulo (UNIFESP); McGill UnivThe purpose of this article is to describe a patient with presumed choroidal metastasis from an eccrine adenocarcinoma of the scalp. A 45-year-old Caucasian woman presented with decreased visual acuity. Ophthalmologic examination was unremarkable. Her past medical history was significant for eccrine carcinoma of the scalp. the patient developed bilateral cervical lymph node metastases, and received chemotherapy and radiotherapy. She had recurrence of the scalp lesion and developed bone metastasis. the patient was again referred to an ophthalmologist owing to reduced visual acuity. Multiple choroidal metastases were detected in right eye, and one metastatic lesion in left eye. the patient passed away 2 months after choroidal metastases. This is the first report of choroidal metastases from an eccrine carcinoma. This is a rare aggressive neoplasm with poor outcome in most cases of metastatic disease, and in this case report, uveal metastasis was indicative of poor prognosis.