Navegando por Palavras-chave "brain-derived neurotrophic factor"
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- ItemSomente MetadadadosAcute mood effect of donepezil in young, healthy volunteers(Wiley-Blackwell, 2013-05-01) Pompeia, Sabine [UNIFESP]; Gouveia, Juliana Ramos [UNIFESP]; Fernandes Galduroz, Jose Carlos [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective Chronic use of the acetylcholinesterase inhibitor donepezil has been found to improve mood or to induce mania/hypomania in many neuropsychiatric patients with altered cholinergic and dopaminergic tone. Our aim was to determine whether acutely administered donepezil would alter mood in volunteers with no such alterations. Methods This investigation was a double-blind, crossover design study of 15 young, healthy male participants who were allocated in random order to three oral treatments: placebo and 5-mg and 7.5-mg donepezil (doses which exert clinical and acute cognitive effects without considerable peripheral side effects). At the theoretical peak-plasma concentrations of donepezil, volunteers rated how they felt on validated questionnaires, which included various dimensions of subjective feelings. We also assessed changes in brain-derived neurotrophic factor (BDNF), which is increased by donepezil after chronic regimes and is related to modulation of mood. Results Donepezil significantly increased ratings of vigour and anxiety symptoms (medium effect sizes). No changes in bodily symptoms or BDNF were observed. Conclusions Acute donepezil administration in participants with unaltered cholinergic and dopaminergic tone led to positive and negative changes in affect. These results call for further research on the direct mood effects of donepezil. Copyright (c) 2013 John Wiley & Sons, Ltd.
- ItemSomente MetadadadosIncreased basal plasma brain-derived neurotrophic factor levels in sprint runners(Springer, 2011-10-01) Correia, Paulo Roberto [UNIFESP]; Scorza, Fulvio Alexandre [UNIFESP]; Silva, Sergio Gomes da [UNIFESP]; Pansani, Aline [UNIFESP]; Toscano-Silva, Michelle [UNIFESP]; Almeida, Antonio Carlos de; Arida, Ricardo Mario [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Fed Sao Joao del ReiObjective Exercise is known to enhance circulating brain-derived neurotrophic factor (BDNF) levels in healthy humans. BDNF changes have been measured in endurance but not in strength exercise. the present study aimed to investigate whether anaerobic activity such as sprinting differentially alters basal plasma BDNF concentration. Methods Brazilian sprinters (100 m) at either the international (Olympics and Outdoor World Championships) (n = 14) or the domestic level (n = 8), and sedentary subjects (n = 15), were recruited. Plasma BDNF concentrations were analyzed by enzyme-linked immunosorbent assay. Results the basal plasma BDNF concentrations were significantly higher in the international and the domestic sprinters than in the sedentary subjects. in addition, sprinters at the international level had higher plasma BDNF concentrations than those at the domestic level. Conclusion Our findings suggest that increased basal plasma BDNF level is related to enhanced exercise performance.
- ItemSomente MetadadadosInter-relation between brain-derived neurotrophic factor and antioxidant enzymes in bipolar disorder(Wiley-Blackwell, 2016) Mansur, Rodrigo B. [UNIFESP]; Santos, Camila M. [UNIFESP]; Rizzo, Lucas B. [UNIFESP]; Cunha, Graccielle R. [UNIFESP]; Asevedo, Elson [UNIFESP]; Noto, Mariane N. [UNIFESP]; Pedrini, Mariana [UNIFESP]; Zeni, Maiara [UNIFESP]; Cordeiro, Quirino [UNIFESP]; McIntyre, Roger S. [UNIFESP]; Brietzke, Elisa [UNIFESP]Objectives: Accumulating evidence indicates that oxidative stress and neurotrophins have a bidirectional relationship. In this post hoc, exploratory analysis, we investigated the association between plasma brain-derived neurotrophic factor (BDNF) levels and activities of the antioxidant enzymes glutathione peroxidase (GPx) and superoxide dismutase (SOD) in individuals with bipolar disorder (BD) and healthy controls. Methods: We measured plasma levels of BDNF and activities of GPx and SOD in individuals with BD (n=59) and healthy controls (n=26). Information related to current and past psychiatric/medical history, as well as to metabolic comorbidities, was also reported. Results: There were negative correlations between BDNF, GPx (r=-.449, P=.001) and GPx/SOD ratio (r=-.503, P<.001), and a positive correlation between BDNF and SOD (r=.254, P=.020). There was a moderating effect of body mass index (BMI) on the association between BDNF and GPx/SOD rate ratio [(RR)=1.002, P=.034]
- ItemAcesso aberto (Open Access)Maternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspring(Plos One, 2016-01-15) Silva, Sergio Gomes da [UNIFESP]; Almeida, Alexandre Aparecido de [UNIFESP]; Fernandes, Jansen [UNIFESP]; Lopim, Glauber Menezes [UNIFESP]; Cabral, Francisco Romero; Scerni, Débora Amado [UNIFESP]; Oliveira-Pinto, Ana Virginia de; Lent, Robert; Arida, Ricardo Mario [UNIFESP]Clinical evidence has shown that physical exercise during pregnancy may alter brain devel- opment and improve cognitive function of offspring. However, the mechanisms through which maternal exercise might promote such effects are not well understood. The present study examined levels of brain-derived neurotrophic factor (BDNF) and absolute cell num- bers in the hippocampal formation and cerebral cortex of rat pups born from mothers exer- cised during pregnancy. Additionally, we evaluated the cognitive abilities of adult offspring in different behavioral paradigms (exploratory activity and habituation in open field tests, spatial memory in a water maze test, and aversive memory in a step-down inhibitory avoid- ance task). Results showed that maternal exercise during pregnancy increased BDNF lev- els and absolute numbers of neuronal and non-neuronal cells in the hippocampal formation of offspring. No differences in BDNF levels or cell numbers were detected in the cerebral cortex. It was also observed that offspring from exercised mothers exhibited better cognitive performance in nonassociative (habituation) and associative (spatial learning) mnemonic tasks than did offspring from sedentary mothers. Our findings indicate that maternal exer- cise during pregnancy enhances offspring cognitive function (habituation behavior and spa- tial learning) and increases BDNF levels and cell numbers in the hippocampal formation of offspring.