Navegando por Palavras-chave "bleomycin"
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- ItemAcesso aberto (Open Access)Acidente vascular cerebral isquêmico após quimioterapia com cisplatina, etoposide e bleomicina: relato de caso(Academia Brasileira de Neurologia - ABNEURO, 2003-03-01) Santos, Adrialdo José [UNIFESP]; Malheiros, Suzana Maria Fleury [UNIFESP]; Borges, Lia Raquel Rodrigues [UNIFESP]; Dzik, Carlos [UNIFESP]; Nalli, Darcio G [UNIFESP]; Gabbai, Alberto Alain [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)A 20-year-old man with a germ cell tumor who experienced an ischemic stroke as a complication of cisplatin/etoposide/bleomycin based chemotherapy is reported. The previously reported cases are reviewed as well as the different physiopathologic mechanisms associated with vascular toxicity of this regimen.
- ItemAcesso aberto (Open Access)Cystic craniopharyngioma: intratumoral chemotherapy with alpha interferon(Academia Brasileira de Neurologia - ABNEURO, 2011-02-01) Dastoli, Patrícia Alessandra [UNIFESP]; Nicácio, Jardel Mendonça [UNIFESP]; Silva, Nasjla Saba [UNIFESP]; Capellano, Andrea Maria [UNIFESP]; Toledo, Silvia Regina Caminada de [UNIFESP]; Ierardi, Daniela [UNIFESP]; Cavalheiro, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: To assess whether the cystic craniopharyngiomas can be controlled with the use of intratumoral applications of interferon alpha. METHOD: Nineteen patients with the diagnosis of cystic craniopharyngioma were treated with intratumoral chemotherapy with interferon alpha from January 2002 to April 2006. All patients underwent placement of an intracystic catheter connected to an Ommaya reservoir. Through this reservoir were made applications during chemotherapy cycles. Each cycle corresponded to application of 3,000,000 units of interferon alpha three times per week on alternate days totalizing 36,000,000 units. Response to treatment was evaluated by calculating the tumor volume on MRI control after one, three and six months after the end of each cycle. Patients who developed worsening of symptoms or who had insignificant reduction in tumor volume during follow-up underwent repeat cycle chemotherapy. RESULTS: Four patients received four cycles of chemotherapy, three patients received three cycles, six patients received two cycles and six patients received one. The lower percentage of reduction in tumor volume was 60% and the bigger reduction was 98.37%. Eleven patients had a reduction greater than 90%. Five patients had a tumor reduction between 75 and 90% and in three patients the tumors were reduced by less than 75%. No deaths occurred during treatment and side effects of interferon alpha were well tolerated. No treatment was discontinued. Follow-up after the last application ranged from one year and five months to three years and nine months. CONCLUSION: The intratumoral chemotherapy with interferon alpha decreases the volume of cystic craniopharyngiomas and so far can be considered a new therapeutic alternative.
- ItemSomente MetadadadosDoes the choice of surgical approach to insert an intratumoral catheter influence the results of intratumoral cystic treatment?(Elsevier B.V., 2008-07-01) Zanon, Nelci; Cavalheiro, Sergio; Silva, Marcia C. da; Universidade Federal de São Paulo (UNIFESP)Background: in the literature, only a few articles are related to the surgical approach for insertion of an intratumoral catheter. No one has evaluated the complications related to the different surgical techniques for the treatment of pediatric cystic craniopharyngiomas.Methods: A cooperative, multicenter (France and Brazil) study was carried out and included 50 patients (aged between 9 months and 21 years) diagnosed as having cystic craniopharyngioma treated between 1990 and 2000. Forty-nine children were available for the final analysis. the patients were divided into 3 groups: group I, 24 children who underwent a craniotomy and catheter placement under direct vision using a surgical microscope; group II, 14 children who were submitted to a stereotactic approach for the placement of the intratumoral catheter; and group III, 11 children whose catheters were placed by a freehand approach through a burr hole.Results: Eight children (16.3%) presented complications related to the placement of the catheter, namely, misplacement or leakage. the rate of the complications did not appear to be related to one specific modality of the catheter insertion.Conclusion: Intracystic antiblastic drug injection is one available option in the treatment of cystic craniopharyngiomas. Because of the toxic effect of these drugs on the brain, determination of the exact placement to avoid leakage is mandatory for correct treatment. However, the results of the present study appear to indicate an excessively high incidence of complications whichever technique is used. (C) 2008 Published by Elsevier Inc.
- ItemSomente MetadadadosProtective effect of aminoguanidine in a murine model of pulmonary fibrosis induced by bleomycin(Elsevier B.V., 2000-11-01) Rezende, Mario Cesar de [UNIFESP]; Martinez, José Antônio Baddini [UNIFESP]; Capelozzi, Vera Luiza; Simões, Manuel de Jesus [UNIFESP]; Beppu, Osvaldo Shigueomi [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)Aminoguanidine is a drug known for more than a century, which has been attracting increasing interest in recent years due to the discovery of new pharmacological properties. This study investigated the effects of aminoguanidine on the fibrotic response induced by intratracheal administration of bleomycin to rats. Three groups of animals were studied: Group A (n = 19) corresponded to the control group. Group B (n = 20) received 10 IU/kg bleomycin intratracheal, and Group C (n = 12) received the same amount of bleomycin as Group B Followed by 50 mg/kg/day aminoguanidine bicarbonate for 4 weeks. Aminoguanidine led to significant reductions in total hydroxyproline content of the longs in Group C compared to Group B (Group A: 1.83 +/- 0.14 mg x Group B: 3.46 +/- 0.36 mg x Group C: 2.09 +/- 22 mg). Morphometric collagen studies carried out on histological sections stained with Sirius red F3BA showed that aminoguanidine promoted a significant reduction of the area occupied by collagen in the axial and septal zones of the lungs (Axial region = Group A: 4.29 +/- 1.31% x Group B: 19.30 +/- 4.86% x Group C: 8.52 +/- 1.96%; Septal region = Group A: 0.15 +/- 0.06% x Group B: 0.61 +/- 0.21% x Group C: 0.15 +/- 0.06%). These results suggest that aminoguanidine is a potential therapeutic agent for the treatment and prevention of pulmonary fibrosis which is associated with different clinical conditions. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
- ItemSomente MetadadadosUse of interferon alpha in intratumoral chemotherapy for cystic craniopharyngioma(Springer, 2005-08-01) Cavalheiro, Sergio; Dastoli, Patricia A.; Silva, Nasjla Saba; Toledo, Silvia Regina Caminada de [UNIFESP]; Lederman, Henrique; Silva, M. C. da; Universidade Federal de São Paulo (UNIFESP)Objectives: This study analyzed the intratumoral activity of interferon alpha (IFN-alpha) in the treatment of cystic craniopharyngiomas. Patients and methods: From January 2000 to January 2004, nine patients presenting with cystic craniopharyngiomas were treated with intratumoral injection of IFN-alpha at the Pediatric Oncology Institute of the Federal University of São Paulo-Escola Paulista de Medicina. Age ranged from 1 year and 10 months to 18 years (mean 10 years). All intratumoral catheters were inserted by a subfrontal approach. Doses varied from 36 to 108 MU. Results: There was complete disappearance of the lesion in seven cases. in two cases, partial reduction of tumor size was observed at follow-up. Follow-up varied from 1 year to 3 years and 6 months (mean 1 year 8 months). Conclusions: IFN-alpha proved to be an effective drug in the control of cystic craniopharyngiomas. Additional studies should be carried out to determine the optimal dose of IFN-alpha in the treatment of cystic craniopharyngioma. in addition, other drugs possessing high efficacy and low neurotoxicity should be analyzed.