Navegando por Palavras-chave "anti-inflammatory"
Agora exibindo 1 - 6 de 6
Resultados por página
Opções de Ordenação
- ItemAcesso aberto (Open Access)Analgesic activity of a triterpene isolated from Scoparia dulcis L. (vassourinha)(Instituto Oswaldo Cruz, Ministério da Saúde, 1991-01-01) Freire, Sonia Maria de Farias; Torres, Luce Maria Brandão [UNIFESP]; Roque, Nidia Franca; Souccar, Caden [UNIFESP]; Lapa, Antonio José [UNIFESP]; UFMA Departamento de Fisiologia; UFMA Departamento de Química; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)Analgesic and anti-inflammatory activities of water (WE) and ethanolic (EE) extracts of Scoparia dulcis L. were investigated in rats and mice, and compared to the effects induced by Glutinol, a triterpene isolated by purification of EE. Oral adminsitration (p.o.) of either WE or EE(up to 2 g/Kg) did not alter the normal spontaneous activity of mice and rats. The sleeping time induced by sodium pentobarbital (50 mg/Kg, i.p.) was prolonged by 2 fold in mice pretreated with 0.5 g/Kg EE, p.o. Neither extract altered the tail flick response of mice in immersion test, but previous administration of EE (0.5 g/Kg, p.o.) reduced writhings induced by 0.8% acetic acid (0.1 ml/10 g, i.p.) in mice by 47% EE (0.5 and 1 g/Kg, p.o.) inhibited the paw edema induced by carrageenan in rats by respectively 46% and 58% after 2 h, being ineffective on the paw edema induced by dextran. No significant analgesic or anti-edema effects were detected in animals pretreated with WE (1 g/Kg, p.o.). Administration of Glutinol (30 mg/Kg, p.o.) reduced writhing induced by acetic acid in mice by 40% and the carrageenan induced paw edema in rats by 73%. The results indicate that the analgesic activity of S dulcis L. may be explained by explained by an anti-inflammatory activity probably related to the triterpene Glutinol.
- ItemAcesso aberto (Open Access)Chemical composition and anti-inflammatory evaluation of essential oils from leaves and stem barks from Drimys brasiliensis Miers (Winteraceae)(Sociedade Brasileira de Química, 2010-01-01) Lago, Joao Henrique Ghilardi [UNIFESP]; Carvalho, Larissa A. C; Silva, Flávia S. da; Toyama, Daniela de O; Fávero, Oriana A; Romoff, Paulete; Universidade Federal de São Paulo (UNIFESP); Universidade Presbiteriana Mackenzie Departamento de Ciências Exatas e da Terra Centro de Ciências e Humanidades Centro de Ciências Biológicas e da Saúde; Universidade Presbiteriana Mackenzie Centro de Ciências Biológicas e da SaúdeThe essential oils from leaves and stem barks from Drimys brasiliensis Miers (Winteraceae) were individually obtained by hydrodistillation and their compounds characterized by use of GC/FID and GC/MS. The main identified derivatives were monoterpenes (leaves 4.31% and stem barks 90.02%) and sesquiterpenes (leaves 52.31% and stem barks 6.35%). Additionally, the sesquiterpene polygodial was isolated from hexane extract from stem barks of D. brasiliensis after chromatographic steps and characterized by spectroscopic means, mainly NMR. Aiming the evaluation of anti-inflammatory potential, the crude essential oils and the sesquiterpene polygodial were subjected to bioassays to evaluate the acute toxicity of these compounds as well as the anti-inflammatory and antinociceptive activities induced by carrageenan and formalin in mices. Ours results showed that essential oil obtained from the stem barks significantly reduced the oedema induced by carrageenan. The anti-inflammatory effect induced by stem barks oil (at 200 mg kg-1) was similar to observed for indomethacin (at 10 mg kg-1) and superior for polygodial (at 200 mg kg-1) in 30 and 60 min after the administration of essential oils. The inflammatory response induced by formalin was effective to the stem barks oil (62.5%) in comparison to polygodial (50.0%).
- ItemSomente MetadadadosCytokines in schizophrenia: Possible role of anti-inflammatory medications in clinical and preclinical stages(Wiley-Blackwell, 2012-06-01) Mansur, Rodrigo Barbachan [UNIFESP]; Zugman, Andre [UNIFESP]; Asevedo, Elson de Miranda [UNIFESP]; Cunha, Graccielle Rodrigues da [UNIFESP]; Bressan, Rodrigo Affonseca [UNIFESP]; Brietzke, Elisa [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Aims: in this paper, we review the literature on the efficacy of anti-inflammatory agents as neuroprotectors in clinical and preclinical stages of schizophrenia. Method: A synthetic and integrative approach was applied to review studies stemming from epidemiology, phenomenology, cognition, genetics and neuroimaging data. We provide conclusions and future directions of research on early-onset schizophrenia. Results: Abnormal inflammatory activation has been demonstrated in schizophrenia. Increases or imbalances in cytokines before birth or during childhood may impact neurodevelopment and produce vulnerability to schizophrenia. the specificity of inflammatory abnormalities in psychiatric disorders is controversial. Similar increases in pro-inflammatory cytokines have been described in other disorders, especially mood and anxiety disorders. One of the most important challenges at this point is the understanding of neurobiological correlates of prodromal stages of schizophrenia. Conclusion: Although future research should investigate the exact role of different cytokines in pathophysiology of schizophrenia, these mediators emerge as promising molecular targets to its prevention and treatment.
- ItemSomente MetadadadosEvaluation of anti-inflammatory activity of derivatives from aerial parts of Baccharis uncinella(Informa Healthcare, 2011-06-01) Zalewski, Cynthia A. [UNIFESP]; Passero, Luiz Felipe D.; Melo, Alexis S. R. B.; Corbett, Carlos Eduardo P.; Laurenti, Marcia D.; Toyama, Marcos H.; Toyama, Daniela O.; Romoff, Paulete; Favero, Oriana A.; Lago, Joao Henrique G. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Univ Estadual Paulista Julio de Mesquito Filho; Univ Presbiteriana MackenzieContext: Species of Baccharis exhibit antibiotic, antiseptic, and wound-healing properties, and have been used in the traditional medicine of South America for the treatment of inflammation, headaches, diabetes, and hepatobiliary disorders.Objective: To investigate the anti-inflammatory activity of organic phases from EtOH extract of the aerial parts of Baccharis uncinella DC (Asteraceae).Materials and methods: the crude EtOH extract from the aerial parts of B. uncinella was subjected to partition procedures and the corresponding CH(2)Cl(2) and EtOAc phases were subjected to several chromatographic separation procedures. Thus, these phases and their purified compounds were assayed for evaluation of anti-inflammatory activity.Results: the CH(2)Cl(2) phase from EtOH extract from B. uncinella contained two triterpenoids (oleanolic and ursolic acids) and one flavonoid (pectolinaringenin), whereas the respective EtOAc phase showed to be composed mainly by two phenylpropanoid derivatives (caffeic and ferulic acids). the CH(2)Cl(2) and EtOAc phases as well as their isolated compounds exhibited anti-inflammatory effects against inflammatory reactions induced by phospholipase A2 (from Crotalus durissus terrificus venom) and by carrageenan.Discussion and conclusion: the results suggested that the components obtained from partition phases of EtOH extract of B. uncinella could represent lead molecules for the development of anti-inflammatory agents. Additionally, the results confirmed the use of Baccharis genus in the traditional medicine of South America for the treatment of inflammation and other heath disorders. To date, the present work describes for the first time the anti-inflammatory effects of compounds isolated from B. uncinella.
- ItemAcesso aberto (Open Access)Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2(Mdpi Ag, 2017) Belchor, Mariana Novo [UNIFESP]; Gaeta, Henrique Hessel; Bittencourt Rodrigues, Caroline Fabri; da Cruz Costa, Caroline Ramos; Toyama, Daniela de Oliveira; Domingues Passero, Luiz Felipe; Laurenti, Marcia Dalastra; Toyama, Marcos HikariRhamnetin (Rhm), 3-O-methylquercetin (3MQ), and Rhamnazin (Rhz) are methylated derivatives of quercetin commonly found in fruits and vegetables that possess antioxidant and anti-inflammatory properties. Phospholipase A2 (PLA2) displays several important roles during acute inflammation
- ItemAcesso aberto (Open Access)A Possible role for Platelet-Activating Factor receptor in Amyotrophic Lateral sclerosis treatment(Frontiers Media Sa, 2018) Briones, Marcelo R. S. [UNIFESP]; Snyder, Amanda M.; Ferreira, Renata C. [UNIFESP]; Neely, Elizabeth B.; Connor, James R.; Broach, James R.Amyotrophic lateral sclerosis (ALS) is the third most prevalent neurodegenerative disease affecting upper and lower motor neurons. An important pathway that may lead to motor neuron degeneration is neuroinflammation. Cerebrospinal Fluids of ALS patients have increased levels of the inflammatory cytokine IL-18. Because IL-18 is produced by dendritic cells stimulated by the platelet-activating factor (PAF), a major neuroinflammatory mediator, it is expected that PAF is involved in ALS. Here we show pilot experimental data on amplification of PAF receptor (PAFR) mRNA by RT-PCR. PAFR is overexpressed, as compared to age matched controls, in the spinal cords of transgenic ALS SOD1-G93A mice, suggesting PAF mediation. Although anti-inflammatory drugs have been tested for ALS before, no clinical trial has been conducted using PAFR specific inhibitors. Therefore, we hypothesize that administration of PAFR inhibitors, such as Ginkgolide B, PCA 4248 and WEB 2086, have potential to function as a novel therapy for ALS, particularly in SOD1 familial ALS forms. Because currently there are only two approved drugs with modest effectiveness for ALS therapy, a search for novel drugs and targets is essential.