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- ItemAcesso aberto (Open Access)Análise da postura corporal estática segundo o nivel de atividade fisica em idosos residentes no municipio de São Paulo(Universidade Federal de São Paulo (UNIFESP), 2009) Reis, Camila Costa Ibiapina [UNIFESP]; Ramos, Luiz Roberto [UNIFESP]; Ramos, Luiz Roberto [UNIFESP]The fast and intense ageing of the population leads to the necessity of a functional ageing. It is believed that the body posture and the physical activity can contribute to preserve the elderly’s autonomy and independence. Objectives: to analyze the elderly’static body posture with different levels of physical activity, controlling by sex and age, as well as to correlate body posture and quality of life level. Methods: It is a transversal, analytic-descriptive study, with blind assessment, because the body posture observers were not aware of the elderly’s physical activity and quality of life level. One hundred and sixty (160) elderly people were evaluated, being 104 women and 56 men, with an average age of 72.1 years old (± 7.1). In the body posture assessment, a symmetrograph and a plumb-bob were used, besides photographs in the anterior, posterior, right and left lateral views. This assessment counted on the participation of two observers simultaneously with no communication between them. The physical activity level was evaluated by means of the “International Physical Activity Questionnaire” (IPAQ), long version (transportation and leisure); and the quality of life by means of the SF-36 (Short-Form) questionnaire. As for the statistical analysis, a descriptive analysis of the sample was firstly carried out. After that, Student’s t test, chisquare test, unconditional logistic regression and kappa’s test were also used, being the adopted significance level p< 0,001. Results: 70.6% of the insufficiently active elderly showed the worst body posture, whereas in physically active elderly this frequency was of 44.6%, independently of sex. The oldest elderly have more chances to have a worse body posture than the youngest elderly. It was also observed an association between quality of life and body posture only in the field limitation due to physical aspects. A good agreement level between the postural evaluation observers was also observed. Conclusion: In relation to the sample studied, it was possible to conclude that the physically active elderly show a better body posture when compared to the insufficiently active elderly, independently of sex. The oldest elderly have a bigger chance of having worse body posture than the youngest elderly. Besides, the elderly with the worst body posture show more limitations due to physical aspects.
- ItemSomente MetadadadosApolipoprotein A-V gene polymorphism -1131T > C and Alzheimer's disease(Ios Press, 2006-12-01) Barbosa, Fabio Augusto Freiria; Labio, Roger Willian de; Rigolin, Valdeci Oliveira Santos [UNIFESP]; Minett, Thaís Soares Cianciarullo [UNIFESP]; Bertolucci, Paulo Henrique Ferreira [UNIFESP]; Smith, Marilia de Arruda Cardoso [UNIFESP]; Payão, Spencer Luiz Marques [UNIFESP]; Fac Med Marilia; Universidade Federal de São Paulo (UNIFESP); Univ Marilia; Univ Sagrado CoracaoAlzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly and is also considered a progeroid genetic syndrome. The etiology of AD is complex and the mechanisms underlying its pathophysiology remain to be claritied. It has been suggested that a high serum cholesterol level is a risk factor for (AD), and that some polymorphisms of genes encoding proteins regulating cholesterol metabolism are associated with AD development. APOA5 is a recently discovered apolipoprotein involved primarily with triglyceride JG) metabolism disorder. This study investigates the association of AD with the APOA5 gene - 1131T > C polymorphisms in samples of 106 patients with Alzheimer's disease (AD), 76 elderly healthy controls and 93 young healthy controls. DNA samples were isolated from blood cells, amplified by PCR and digested with Tru11. We observed that the genotype distributions of APOA5 variants were within Hardy-Weinberg equilibrium in all subject samples. Furthermore, chi-square test comparison for genotype distributions and allele frequencies did not reveal any significant difference among the three groups of subjects (P > 0.05). These results support the idea that these variants are not involved as a risk factor for developing AD.
- ItemSomente MetadadadosApolipoprotein E4 allele and ribosomal genes in Alzheimer's disease(Ios Press, 2004-08-01) Tavares, W. M.; Speranca, M. A.; Labio, Roger Willian de; Peres, Clovis de Araujo [UNIFESP]; Okamoto, Ivan Hideyo [UNIFESP]; Bertolucci, Paulo Henrique Ferreira [UNIFESP]; Smith, Marilia de Arruda Cardoso [UNIFESP]; Payão, Spencer Luiz Marques [UNIFESP]; FAMEMA; Universidade Federal de São Paulo (UNIFESP)Ribosomal genes are involved in cellular transcription, translation and gene expression modulation process. An association between 28S/18S rRNA ratio levels with apoptosis and aging has been reported. Moulder et al. [22] and Hashimoto et al. [8] showed an association between apolipoprotein E4 allele and neuronal cell apotosis through diverse mechanisms. The apoE 4 allele is considered a late-onset Alzheimer's disease (AD) risk factor associated with AD pathogenesis. We evaluated the association between apoE4 allele genotyping by PCR and rRNA 28S/18S ratio by slot blotting technique using peripheral blood samples of 18 Alzheimer's disease patients, 18 elderly controls and 18 young controls. A rRNA ratio decrease was observed in AD individuals confirming our previous results but this association is independently of the ApoE4 allele genotype. Thus our results pointed that two different mechanisms are involved in the etiology of Alzheimer disease each one leading independently to cell death. Further studies could investigate these factors.
- ItemSomente MetadadadosDown's syndrome, ageing and fragile sites(Elsevier B.V., 1998-03-16) Smith, Marilia de Arruda Cardoso [UNIFESP]; Borsatto, Bianca [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Fragile sites have been interesting for mapping chromosomal regions involved in disease and ageing. The chromosomal fragile site expression from 38 Down's syndrome (DS) individuals aged 0-48 years was investigated in blood peripheral lymphocytes. Fragile sites were statistically characterized as the minimum expected number of lesions per band based on a Poisson distribution. The results showed that the fragile site 2q11 was associated with the DS condition and fragile sites 5q31, 6p21 and 9q12 with ageing in DS subjects. Fragility in 6p21 has also been associated with Alzheimer's disease patients. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
- ItemSomente MetadadadosThe effect of age on the power/duration relationship and the intensity-domain limits in sedentary men(Springer, 2000-07-01) Neder, J. A.; Jones, P. W.; Nery, L. E.; Whipp, B. J.; Univ Glasgow; Univ London St Georges Hosp; Universidade Federal de São Paulo (UNIFESP)The time to fatigue (t) in response to high-intensity constant-load exercise decreases hyperbolically with increasing power ((W) over dot) at least in active and younger individuals [i.e. ((W) over dot - theta(F))t = W', where theta(F) is the critical power asymptote and W' is the curvature constant]. Little is known. however, about the combined effects of age and sedetarity on these parameters. We therefore evaluated 17 non-trained males (9 aged 60-75 years and 8 aged below 30 years) who underwent ramp-incremental cycle ergometry and, on different days, 4 high-intensity constant-load tests to t. Compared to their younger counterparts, the older subjects presented significantly lower maximum oxygen uptake (i.e. the maximum value of oxygen uptake attained at the end of a progressive exercise with the subject exerting a presumably maximal effort, mu(V) over dot O-2), estimated lactate threshold ((V) over dot O(2)theta(L)), (V) over dot O(2)theta(F), and W' (P < 0.05). Interestingly, however, both (V) over dot O(2)theta(L) and (V) over dot O(2)theta(F), when expressed as a percentage of mu(V) over dot O-2, were higher in older than in younger men [61.8 (6.2)% versus 45.4 (4.6)% and 87.8 (7.3)% versus 79.0 (8.2)%, P < 0.05, respectively]. Therefore, age was associated with an increase in the relative magnitude of the moderate, sub-theta(L) exercise-intensity domain (+30.4%), mainly at the expense of the very-heavy, supra-theta(F) domain (-56%). Our results demonstrate that age and sedentarity are associated with: (1) marked reductions in both the aerobic (theta(F)) and anaerobic (W') determinants of the (W) over dot /t relationship, and (2) changes in either the absolute or relative magnitudes of the exercise-intensity domains. These findings are consistent with the notion that endurance-related parameters are less diminished with ageing than the maximal capacity, thereby mitigating the deleterious effects or senescence in the functional capacity.
- ItemSomente MetadadadosEffects of ageing on the energy balance of food-restricted rats(Blackwell Publishing Ltd, 2004-06-01) Passadore, M. D.; Griggio, Mauro Antonio [UNIFESP]; Nunes, M. T.; Luz, J.; Universidade Federal de São Paulo (UNIFESP)Aims: Age can alter energy balance by decreasing the resting metabolic rate. Food restriction can also change energy balance by decreasing energy expenditure as a mechanism of energy conservation. We investigated the influence of food restriction on the energy balance of rats at different ages.Methods: Wistar EPM-1 female rats were used at ages of 3, 9, 15 and 21 months. At each age, two food intake schedules were provided: control (ad libitum) and food restriction (50%). Animals remained under these schedules for 30 days, and throughout this period body weight, food intake, and stool collection were controlled daily. On the 30th day, animals were killed, blood was collected and the carcasses and faeces were processed for analysis by pump calorimetry. Blood glucose, T-3, T-4 and rT(3) levels were determined.Results: Food restriction reduced energy gain and gross food efficiency of animals at different ages, but more so in older animals. Food-restricted rats also had lower energy expenditure than controls. This reduction was about 40% of the energy expenditure of control animals irrespective of age. Water content increased and fat content decreased in the carcass of food-restricted animals. Serum T-3 and T-4 levels were lower in food-restricted animals pointing out to a major role of thyroid hormones in the mechanism of energy conservation exhibited by food-restricted animals.Conclusions: the mechanism of energy conservation takes place in all restricted animals and is very important for survival and for species preservation, mainly in aged animals in which food restriction is frequently aggravated by senescence-related organic disorders.
- ItemSomente MetadadadosHeteropterys aphrodisiaca (extract BST0298): a Brazilian plant that improves memory in aged rats(Elsevier B.V., 2002-03-01) Galvao, SMP; Marques, L. C.; Oliveira, MGM; Carlini, E. A.; Universidade Federal de São Paulo (UNIFESP)Literature report is lacking on pharmacological studies of the plant Heteropterys aphrodisiaca, endemic to the scrublands of Brazil. the present study was carried out to investigate the effects of oral dosing with extract BST0298 from this plant, on learning and on memory, in young (3-6-month-old) and aged (20-28-month-old) rats. the aged animals presented significant memory deficits in both the passive avoidance and T-maze left/right discrimination tests. Treatment for 7 days (50 mg/kg) or 26 days (100 mg/kg) with extract BST0298 restored the memory deficits in the passive avoidance test. However, no improvement in memory was observed after acute administration of extract BST0298 (100 mg.kg) in aged rats. An improvement in learning was also observed in the left/right discrimination test in aged rats treated for 109 days with BST0298 at a dose of 50 mg/kg. These results suggest that treatment for 7 days or more with H. aphrodisiaca improves learning and memory deficits in aged rats. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
- ItemSomente MetadadadosInterleukin-8 gene polymorphism -251T > A and Alzheimer's disease(Ios Press, 2007-01-01) Vendramini, Alex Augusto; Labio, Roger Willian de; Rasmussen, Lucas Trevizani [UNIFESP]; Minett, Thaís Soares Cianciarullo [UNIFESP]; Bertolucci, Paulo Henrique Ferreira [UNIFESP]; Smith, Marilia de Arruda Cardoso [UNIFESP]; Payão, Spencer Luiz Marques [UNIFESP]; Famema; USC Univ Sagrado Coracao; Universidade Federal de São Paulo (UNIFESP)
- ItemSomente MetadadadosTelomere shortening, ageing, and chromosome damage(Elsevier B.V., 1996-07-31) KormannBortolotto, M. H.; Borsatto, B.; Smith, MDC; Universidade Federal de São Paulo (UNIFESP)A relationship between telomere shortening and ageing has been established. A series of young and elderly healthy donors, Alzheimer disease patients, young and old Down's syndrome individuals were cytogenetically analyzed. No preferential damage in distal bands was seen in age-related chromosome instability.
- ItemAcesso aberto (Open Access)Valores normais das velocidades de condução nervosa em um grupo de 101 pessoas(Academia Brasileira de Neurologia - ABNEURO, 1992-03-01) Grandini, Dalva Livramento [UNIFESP]; Nóbrega, J. A. Maciel [UNIFESP]; Juliano, Yara [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Motor and sensory nerve conduction velocities were analysed in a group of 101 normal Brazilians. The normal values were obtained considering the group age, the distal and proximal segments of each nerve, the differences in the right and left side for each nerve. A significant decline in the conduction was found for the elderly aged group.