Navegando por Palavras-chave "adenocarcinoma"
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- ItemAcesso aberto (Open Access)Avaliação dos fatores prognósticos clínicos, laboratoriais, cirúrgicos, anatomopatológicos e imuno-histoquímicos no carcinoma de vesícula biliar ressecado(Universidade Federal de São Paulo (UNIFESP), 2014-08-27) Costa, Sergio Renato Pais [UNIFESP]; Goldenberg, Alberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Aims: To evaluate prognostic factors for survival in cases of gallbladder adenocarcinoma. Method: Clinical, laboratory, surgical, anatomopathological and, immunohistochemical (tissue expression of the proteins P53, E-cadherin, Cox-2 and EGFR) data on a series of 42 resected patients due to gallbladder adenocarcinoma from January 1995 to January 2006 were gathered. The sample comprised 7 men and 35 women. The median age 71 years (range: 35-87 years). The lesion distribution according to the TNM-AJCC classification was: T1 (n = 2), T2 (n = 5), T3 (n = 31) and T4 (n = 4). Twenty patients underwent curative resection (R0), while 22 had palliative surgery (R1-R2). These results were correlated with the final prognosis and with the patients’ survival. Uni and multivariate statistical analyses were conducted using the PASW statistical software, version 17 (SPSS Inc., 2009) for Windows; p < 0.05 was considered to be statistically significant. The survival analysis was performed using Kaplan-Meier curves, and the outcome from comparisons between the curves was calculated using the log-rank test. Results: The estimated five-year survival was 26%, while the median was 8 months. Multivariate analysis identified four independent prognostic factors: serum albumin (< 3.0 ng/ml), gallbladder perforation, tumor necrosis and tissue overexpression of the protein EGFR. Conclusion: The final prognosis in the gallbladder cancer cases was affected by serum albumin, perforation of the surgical specimen, tumor necrosis and tissue overexpression of the protein EGFR.
- ItemSomente MetadadadosBronchioloalveolar carcinoma arising in a congenital pulmonary airway malformation in a child: case report with an update of this association(Elsevier B.V., 2007-05-01) Ramos, Simone G.; Barbosa, Gustavo H.; Tavora, Fabio Rocha Fernandes [UNIFESP]; Jeudy, Jean; Torres, Lidia A. G. M.; Tone, Luiz Gonzaga; Trad, Clovis S.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Univ MarylandAn 9-year-old girl was evaluated for a mass in the left pulmonary lobe. Her clinical history was remarkable for an intermittent dry cough since the age of 2, with recurrent episodes of purulent sputum and fever. She underwent left lower lobectomy, which was found to be a bronchioloalveolar carcinoma arising in a type 1 congenital pulmonary airway malformation at pathologic examination. No additional therapies were undertaken. Two years after resection, imaging studies showed 5 contralateral pulmonary nodules suggestive of disseminated disease with a poor outcome. A review of presentation, treatment, and outcome of this association was made. (C) 2007 Elsevier Inc. All rights reserved.
- ItemSomente MetadadadosHow accurate is cytological diagnosis of cervical glandular lesions?(Wiley-Blackwell, 2008-04-01) Moreira, Marise A. R.; Filho, Adhemar Longatto; Castelo, Adauto [UNIFESP]; Evangelista de Barros, Maria Rita; Silva, Ana Paula da; Thomann, Patricia; Mattosinho de Castro Ferraz, Maria da Gloria [UNIFESP]; das Dores, Gerson Botacini; Universidade Federal de Goiás (UFG); Atalaia Lab; Univ Minho; Adolfo Lutz Inst; Universidade Federal de São Paulo (UNIFESP); Digene BrasilGynecological cytology has some inaccurate morphological categorization and poor interobserver reproducibility especially for glandular lesions. Liquid-based cytology (LBC) preparations are presumed to reduce artifacts that interfere in diagnosis performance, but its value to correctly identify glandular alterations has not been sufficiently reported. the objective of this study was to compare the diagnostic performance and interobserver agreement of LBC and conventional Pap smear to identify, histologically confirmed glandular lesions according to five cytologists. Sensitivity ranged from 55.8 to 73.1% and 32.7 to 48.1% for Pap smear and LBC, respectively. Specificity ranged from 66.1 to 87.1% and 69.4 to 94.4%, respectively. in general, agreement between pairs of cytologists was poor with K-values around 0.45. in conclusion, relying entirely on cervical cytology to rule out glandular lesions may be risky. the use of HPV DNA test alone or combined to screening glandular lesions may contribute to minimize the limitations of both conventional and LBC preparations to diagnose glandular abnormalities.
- ItemSomente MetadadadosImunoexpressão dos biomarcadores ts, cox-2, egfr, msh6, mlh1 no adenocarcinoma colorretal e sua correlação com o grau de diferenciação tumoral e os fatores prognósticos(Universidade Federal de São Paulo (UNIFESP), 2013-09-25) Batista, Wilson Roberto [UNIFESP]; Matos, Delcio Matos [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: To study the immunoexpression of biomarkers TS, p53, COX2, EGFR, MSH6, MLH1 in patients with colorectal carcinoma, correlating with the degree of tumor differentiation and clinical prognostic factors patolólogicos. Methods: We analyzed tissues fixed in formalin and embedded in paraffin blocks of tumors from 107 patients, for immunohistochemistry by the streptavidin-biotin method using the technique of matrix arrangement of tissue samples (tissue-microarray). In the evaluation of positive markers was used categorical scores that determined the cutoff value in the percentage of stained tumor cells. Tissue expression of the proteins were correlated with the variables of degree of cell differentiation, staging, disease-free, recurrence, survival and specific mortality. We employed the Fisher exact test (Agresti, 1990) to study the association between tumor grade and TS, Cox-2, EGFR, MSH1, MSH6 and p53, and tumor staging correlated with TS, Cox-2, EGFR, MSH1, MSH6 and p53. Estimation of Kaplan-Meier (Collett, 2003), Log-rank test (Collett, 2003) and adjusting the Cox regression model (Cox, 1972) to investigate the behavior of the overall survival of patients (months) according to TS, COX-2, EGFR, MSH6, MLH1 and p53 and disease-free interval of subjects (months), according to TS, COX-2, EGFR, MSH6, MLH1 and p53. Results: The degree of tumor differentiation of individuals is not associated with TS (p = 0.138), COX-2 (p = 0.428), EGFR (p = 0.103), MSH6 (p = 0.876), MLH1 (p = 0.792) and p53 (p = 0.884). The staging is not associated with TS (p = 0.817), COX-2 (p = 0.842), EGFR (p = 0.344), MSH6 (p = 0.923) and p53 (p = 0.666). The same behavior was not observed for MLH1 (p = 0.021) in which the group of patients with stage III or IV is a higher percentage of MLH1 negative (27.4%) than in the group of patients with stage 0, I, or II (2.2%). The survival time of individuals is not related to TS (p = 0.480), COX-2 (p = 0.998), EGFR (p = 0.600), MSH6 (p = 0.318), MLH1 (p = 0.798) and p53 (p = 0.695). The disease-free interval of subjects is not related to TS (p = 0.356), COX-2 (p = 0.885), EGFR (p = 0.786), MSH6 (p = 0.178), MLH1 (p = 0.691) and p53 (p = 0.441). Conclusion: There was no correlation of the association between the degree of tumor differentiation, staging, survival time and disease-free interval with markers TS, p53, COX2, EGFR, MSH6. In advanced cases of RCC with stage III and IV, there was a higher percentage of MLH1 negative.
- ItemAcesso aberto (Open Access)A relação da caderina-E com o prognóstico do adenocarcinoma colorretal(Colégio Brasileiro de Cirurgiões, 2005-08-01) Leme, Marcelo Betim Paes; Waitzberg, Angela Flávia Logullo [UNIFESP]; Artigiani Neto, Ricardo [UNIFESP]; Matos, Delcio [UNIFESP]; Centro Universitário de Volta Redonda; Universidade Federal de São Paulo (UNIFESP)BACKGROUND: To evaluate the relationship between E-cadherin and recurrence, relapse free survival, overall survival and TNM system in patients operated on for colorectal adenocarcinoma. METHODS: This study included 89 patients (41 men and 48 women, mean age 62.3 years) who underwent colorectal ressection for adenocarcinoma. Of these patients, 13 (14.6%) had TNM stage I disease, 29 (32.6%) stage II, 23 (25.8%) stage III and 24 (27.0%) stage IV. Sixty-seven patients had been treated by curative resection and their mean follow-up was 37.9 months. Paraffin-embedded tumor specimens were immunohistochemically stained to cadherin-E and assessed as positive and negative. RESULTS: E-cadherin was positive in 49.4% of the patients and negative for the remaining 50.6%. The disease recurred in 22.4% of the patients and there was no relation with E-cadherin expression. Likewise, there was no relationship between E-cadherin and relapse free survival or overall survival. No significant association has been show between E-cadherin (p = 0.958) and TNM system. CONCLUSION: These results do not allow us to associate Ecadherin with the TNM system and prognosis of patients with colorectal adenocarcinoma.
- ItemSomente MetadadadosRelationship between angiogenesis and grade of histologic differentiation in endometrial adenocarcinoma(I R O G Canada, Inc, 2005-01-01) Speck, Neila Maria de Góis [UNIFESP]; Focchi, José [UNIFESP]; Alves, A. C.; Ribalta, Julisa Chamorro Lascasas [UNIFESP]; Osório, Cintia Aparecida Bueno [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Inst Brasileiro Controle CancThe objective of the study was to quantity vessels and to relate them to the degree of histologic differentiation in endometrial adenocarcinoma. We studied 35 cases of which ten were G1, 13 G2 and 12 G3 adenocarcinonias. The control group consisted of 11 atrophic and 10 proliferative endometria. From each case two histologic sections were obtained: one for hematoxylin-eosin staining and the other for immunohistochemical study with anti-CD34. Vessel count was performed by morphometric study. Mean vessel count was 15.3 for G 1: 19 for G2 and 22.7 for G3 adenocarcinomas; in the control group it was 11.6 for atrophic and 13.2 for proliferative endometria. Slightly differentiated adenocarcinoma presented greater angiogenesis than normal and well-differentiated carcinoma. In contrast. moderately differentiated carcinoma showed greater angiogenicity as related to normal endometrium, but did not differ from other tumoral endometria.