Repositório Institucional - Unifesp :: Navegando por Palavras-chave "Vitamin A"

Navegando por Palavras-chave "Vitamin A"

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Assessment of Nutritional Status: Vitamin A and Zinc in Patients With Common Variable Immunodeficiency
(Esmon Publicidad S A, 2012-01-01) Calheiro dos Santos-Valente, E. [UNIFESP]; Silva, R. da [UNIFESP]; Moraes-Pinto, M. I. de [UNIFESP]; Oselka Saccardo Sarni, R. [UNIFESP]; Costa-Carvalho, B. T. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Fed Alfenas; ABC Univ
Background: Patients with common variable immunodeficiency (CVID) present with low antibody levels, impaired lymphocyte function, and chronic inflammation. Vitamin A and zinc are essential components of the immune system and can be redistributed in the body as a result of inflammation.Objective: To compare levels of retinol, beta-carotene, and zinc in patients with CVID and healthy controls after evaluating a series of parameters for each participant.Patients and Methods: We performed a cross-sectional study of CVID patients and healthy controls matched for age and gender. All participants underwent a nutritional and laboratory evaluation comprising a complete blood count and determination of levels of C-reactive protein (CRP), lipopolysaccharide (LPS), soluble CD14 (sCD14), retinol, beta-carotene, and serum and erythrocyte zinc.Results: We included 17 patients (mean age, 28.54 years) and 17 controls. Mean (SD) retinol levels were lower in patients: 1.99 (0.67) mu mol/L vs 2.72 (0.96) mu mol/L. Median beta-carotene levels were similar in both groups (0.30 mu mol/L). Median serum zinc levels were 50.0 mu g/dL (50-100 mu g/dL) in the patients and 100.0 mu g/dL (50-150 mu g/dL) in the controls. Mean levels of erythrocyte zinc were lower among patients: 37.32 (10.51) mu gZn/gHb vs 44.91 (7.67) mu gZn/gHb in the controls. Median CRP levels were significantly higher among patients: 4.99 (0.15-34.51) mg/L vs 0.55 (0.17-6.06) mg/L. No differences in translocation marker levels were observed between the groups.Conclusions: CVID patients had lower levels of retinol and zinc than controls. Since micronutrient deficiency could aggravate their disease and contribute to chronic inflammation, micronutrient status should always be assessed in patients with primary immunodeficiency.
Restrito
Avaliação do estado nutricional relativo a retinol, beta caroteno e zinco em pacientes com imunodeficiência comum variável
(Universidade Federal de São Paulo (UNIFESP), 2010-08-25) Santos-Valente, Elisangela Calheiro dos [UNIFESP]; Costa-Carvalho, Beatriz Tavares [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Introduction: Common Variable Immunodeficiency (CVI) patients presenting diarrhea and weight loss probably have impaired nutrient ingestion and absorption. Objectives: To compare vitamin A and zinc levels in CVI patients and healthy controls and also compare those levels with gastrointestinal (GI) symptoms and bacterial translocation. Methods: CVI patients from the Immunology outpatients clinic from the Federal University of Sao Paulo and age and gender-matched healthy controls underwent nutritional and laboratorial evaluation with CBC, C reactive protein (CRP), lipopolysaccharide (LPS), soluble CD14 (sCD14), retinol, beta carotene, serum and erythrocyte zinc. Results: Seventeen patients (mean age 28.54y) and 17 controls were included in the study. Retinol levels were lower in patients compared to controls: 1.99 ( }0.67) and 2.72ƒÊmol/L ( }0.96), respectively, p=0.014. Likewise, serum zinc levels were 50.0 (50-100) in the patients and 100.0ƒÊg/dL (50-150) in the control group, (p=0.020). For erythrocyte zinc the levels were 37.32 ( }10.51) for patients and 44.91ƒÊgZn/gHb ( }7.67) for controls, p=0.045. CRP levels were higher among patients: 4.99 (0.15-34.51), compared to controls: 0.55mg/L (0.17-6.06), p=0.004. There was no difference in the translocation marker levels between the groups. A tendency of lower retinol was seem in those patients with severe GI symptoms compared with those with mild/absent symptoms and health controls. Conclusions: CVI patients presented significant lower retinol and zinc levels and higher CRP levels than the healthy controls with no evidence of bacterial translocation. Nonetheless, those patients with severe GI symptoms tend to have lower retinol levels than the other patients.
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Determinação dos níveis urinários da proteína transportadora do retinol (RBP) em recém-nascidos pré-termo, lactantes e crianças maiores
(Universidade Federal de São Paulo (UNIFESP), 1992) Vaisbich, Maria Helena [UNIFESP]; Pereira, Aparecido Bernardo [UNIFESP]
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Doença hepática gordurosa não alcoólica em escolares com sobrepeso e obesidade
(Universidade Federal de São Paulo (UNIFESP), 2006) Souza, Fabíola Isabel Suano de [UNIFESP]; Amâncio, Olga Maria Silvério [UNIFESP]
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Estado nutricional relativo à vitamina A e zinco e sua relação com estresse oxidativo em pacientes com Ataxia-Telangiectasia
(Universidade Federal de São Paulo (UNIFESP), 2011-02-22) Silva, Rosangela da [UNIFESP]; Costa-Carvalho, Beatriz Tavares [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Ataxia-telangiectasia (A-T) is a rare and degenerative disease that leads to varying degrees of immunodeficiency, exacerbation of oxidative stress and malnutrition in over 50% of patients. Objectives: To evaluate the nutritional status, retinol and beta carotene plasmatic concentration and zinc serum and erythrocytes in patients with A-T. To correlate these concentrations with: malondialdehyde (MDA), T lymphocyte numbers (CD4+ e CD8+) and immunoglobulin (IgA). Methods: In a cross sectional study, prospective and controlled, we evaluated 14 patients with A-T and 14 healthy controls according to the Z score of BMI and height for age, body composition, dietary intake and laboratory tests. Results: The mean age of the groups was 13 years; 7 (50%) patients were malnourished. The patients exhibited lean body mass significantly lower compared to controls, p = 0.006. There was no difference between the concentrations of micronutrients or MDA between patients and controls. There was a negative correlation between MDA and the concentrations of retinol (r = - 0.628, p = 0.016) and a significant positive correlation between IgA levels and retinol (r = 0.633, p = 0.015). The average energy consumption and zinc was lower in patients compared to controls (p <0.05). Conclusion: The A-T patients showed a high percentage of malnutrition with a reduction of lean mass, however, changes in nutritional status concerning vitamin A and zinc wasn´t observed.
Acesso aberto (Open Access)
Estudio comparativo del estado nutricional de la vitamina A en mujeres embarazadas y en mujeres que quedaron embarazadas o no tras el bypass gástrico en Y de Roux
(Aula Medica Ediciones, 2018) Cruz, Sabrina; Machado, Suzana Nunes; Cruz, Suelem Pereira da; Pereira, Silvia; Saboya, Carlos [UNIFESP]; Ramalho, Andrea
Introduction: the changes in digestive physiology after Roux-en-Y gastric bypass (RYGB), as well as pregnancy, maximizes the risk of vitamin A deficiency (VAD) and both can result in harm to the mother and child health. Objective: to compare the nutritional status of vitamin A among women who became pregnant or did not after RYGB and in pregnant women who did not undergo surgery, and to assess the impact of VAD on the mother and child health. Methods: this is a cross-sectional study of the analytical type. The women were divided into: group 1 (G1) with 80 pregnant women
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IMPACT OF DIFFERENT PROTOCOLS OF NUTRITIONAL SUPPLEMENTS ON THE STATUS OF VITAMIN A IN CLASS III OBESE PATIENTS AFTER ROUX-EN-Y GASTRIC BYPASS
(Springer, 2016) Pereira, S. E.; Rodrigues, B. C.; Oliveira E Silva, L. G.; Goncalves, I. A. A.; Lavalle, L. R.; Saboya, C. [UNIFESP]; Ramlho, A.
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Lipodystrophy, lipid profile changes, and low serum retinol and carotenoid levels in children and adolescents with acquired immunodeficiency syndrome
(Elsevier B.V., 2010-06-01) Beraldo Battistini, Tania Regina; Sarni, Roseli Oselka Saccardo [UNIFESP]; Suano de Souza, Fabiola Isabel [UNIFESP]; Pitta, Tassiana Sacchi; Fernandes, Ana Paula; Hix, Sonia; Affonso Fonseca, Fernando Luiz; Tardini, Priscila Chemiotti; Santos, Valter Pinho dos; Lopez, Fabio Ancona [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Objective: To assess serum retinol and levels of carotenoids in children and adolescents with acquired immunodeficiency syndrome (AIDS) and to correlate low serum retinol and carotenoid levels with the presence of lipodystrophy, lipid profile changes, lipid peroxidation, and insulin resistance.Methods: A cross-sectional, controlled observational study was carried out with 30 children and adolescents with AIDS (mean age 9.1 y) receiving antiretroviral therapy (median length of treatment 28.4 mo), including 30 uninfected healthy controls matched forage and gender. Clinical and laboratory assessments were performed to determine nutritional status, presence of lipodystrophy, serum concentrations of retinol, beta-carotene, lycopene, lipid profile (high-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerols), lipid peroxidation (thiobarbituric acid-reactive substances), glycemia, and serum insulin (homeostasis model assessment for insulin resistance, cutoff point >3). Statistical analysis was done with chi-square test and Student's t test.Results: Lipodystrophy was observed in 53.3% of patients with AIDS, and dyslipidemia was detected in 60% and 23% of subjects with human immunodeficiency virus and control subjects, respectively (P = 0.004). A higher prevalence of retinol deficiency (60% versus 26.7%, P = 0.009) and beta-carotene deficiency (23.3% versus 3.3%, P = 0.026) was found in the group with human immunodeficiency virus than in the control group. No correlation was found for low retinol and beta-carotene levels, changes in lipid and glucose metabolism, or lipodystrophy in children and adolescents with AIDS.Conclusion: Despite the high frequency of dyslipidemia, lipodystrophy, and retinol and beta-carotene deficiencies, it was not possible to demonstrate a correlation of these findings with lipid peroxidation and insulin resistance. More studies are needed to investigate the causes of retinol and beta-carotene deficiencies in this population and the clinical consequences of these findings. (C) 2010 Elsevier Inc. All rights reserved.
Acesso aberto (Open Access)
Níveis plasmáticos de vitamina A em crianças carentes com pneumonia na fase aguda e após recuperação
(Sociedade Brasileira de Pediatria, 2005-04-01) Silva, Rosangela da; Lopes Jr., Emílio; Sarni, Roseli Oselka Saccardo [UNIFESP]; Taddei, Jose Augusto de Aguiar Carrazedo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Faculdade de Medicina do ABC Departamento de Saúde Materno Infantil; Universidade de Santo Amaro
OBJECTIVE: The aim of this study was to examine the plasma retinol of children in the acute phase of pneumonia and after recovery and to investigate the association between plasma levels of retinol after recovery with socioeconomic variables, nutritional status and severity of pneumonia. METHODS: A prospective cohort study which included 40 low-income hospitalized children with pneumonia, aged 6 months to 5 years. We evaluated: plasma retinol level during the acute phase and after recovery, years of schooling of the head of the family, per capita income, birth weight, nutritional status, hemoglobin levels and severity of pneumonia. RESULTS: Mean plasma retinol levels were significantly higher after recovery than during the acute phase of infection (1.4±0.6 vs. 1.7±0.6 µmol/l, p = 0.03). The frequency of inadequate plasma retinol levels (< 1.05 µmol/l) was 32.5 and 17.5% for the acute phase and after recovery, respectively. There were no statistically significant associations between plasma retinol deficiency and the clinical and epidemiological variables studied. More severe pneumonia was observed in 30/40 (75%) of the patients. There was no statistically significant association between plasma retinol inadequacy after recovery and severity of pneumonia (4/30 - 13.3% vs. 3/10 - 30.0%, p = 0.34). CONCLUSION: Serum retinol levels were significantly higher after recovery than during the acute phase of pneumonia. There was no statistically significant association between the deficiency of serum retinol and the clinical and epidemiological variables studied.
Acesso aberto (Open Access)
Nível sérico da vitamina A em crianças portadoras de leishmaniose visceral
(Sociedade Brasileira de Medicina Tropical - SBMT, 2001-08-01) Luz, Kleber Giovanni; Succi, Regina Célia de Menezes [UNIFESP]; Torres, Elizabeth; Universidade Federal do Rio Grande do Norte; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
Vitamin A is considered an anti-infectious disease vitamin, and its deficiency is associated with severe infections such as in measles. In developing countries the low concentrations of vitamin A are a public health problem. The aim of this study is to describe serum vitamin A concentrations among children with visceral leishmaniasis (VL). Blood sample was collected from 22 children with VL, and stored in a freezer, 9 siblings, with no clinical signs of the VL patients had their blood collected for a control group. Samples were assayed by high performance liquid chromatography. The median vitamin A concentration in the LV group was 21.38µg/100ml and in the control group it was 31.39µg/100. The mean in the LV was statistically lower than in the control group, using Student's t test, p<0.01.
Acesso aberto (Open Access)
Papel da Vitamina A na acuidade visual do lactente: uma revisão do estado da arte
(Universidade Federal de São Paulo, 2021-02-26) Santos, Gabriela Antunes da Costa [UNIFESP]; Speridião, Patrícia da Graça Leite [UNIFESP]; Rosso, Veridiana Vera de [UNIFESP]; http://lattes.cnpq.br/4938721558237749; http://lattes.cnpq.br/7520873457028761; http://lattes.cnpq.br/0770019269697366; Universidade Federal de São Paulo (UNIFESP)
Introdução: o leite materno é o alimento padrão ouro para o bebê, garantindo oferta nutricional para seu desenvolvimento e crescimento saudável. A vitamina A e os carotenóides presentes no leite materno são essenciais para o bebê, pois, são responsáveis pela acuidade e desenvolvimento visual. Objetivo: discutir e entender o papel da vitamina A na acuidade visual do lactente. Material e Método: o levantamento da literatura se deu por meio de busca nas bases eletrônicas de dados. Para discussão do tema, estabeleceu-se 4 dimensões norteadoras: 1) aspectos bioquímicos e fisiológicos da vitamina A; 2) acuidade visual do recém-nascido e do lactente; 3) leite materno versus vitamina A e, 4) fórmula infantil versus vitamina A. Resultados: a literatura é unânime em afirmar que o leite materno supre todas as necessidades do lactente e, sua composição varia ao longo da lactação. Lactentes alimentados com fórmulas infantis possuem menor concentração sérica de vitamina A em relação aos alimentados com leite materno. Caratenóides xantofílicos, luteína e zeaxantina, possuem papel importante na prevenção de doenças oculares, como a doença macular relacionada à idade. Conclusão: a vitamina A exerce papel fundamental na acuidade visual do lactente sendo que sua deficiência implica, principalmente, na doença macular relacionada à idade.
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USE of RETINYL ACETATE, RETINOIC ACID and INSULIN-LIKE GROWTH FACTOR-I (IGF-I) TO ENHANCE GOAT EMBRYO PRODUCTION
(Akademiai Kiado Rt, 2013-03-01) Chiamenti, Adauto; Aguiar Filho, Cristiano Rocha; Moura, Marcelo Tigre; Paula-Lopes, Fabiola Freitas [UNIFESP]; Neves, Jairo Pereira; Cavalcanti Neto, Cicero Cerqueira; Dias Goncalves, Paulo Bayard; Lima, Paulo Fernandes; Lemos Oliveira, Marcos Antonio; Univ Fed Rio Grande do Norte; Univ Fed Rural Pernambuco UFRPE; Universidade Federal de São Paulo (UNIFESP); Universidade de Brasília (UnB); Univ Fed Alagoas; Universidade Federal de Sergipe (UFS)
Experiments were carried out to investigate the beneficial effects of retinyl acetate (RAc) and retinoic acid (RA) on goat oocyte maturation as well as the effects of insulin-like growth factor-I (IGF-I), RAc and RA during embryo culture under chemically defined conditions. in Experiment 1, in vitro maturation (IVM) was performed in a chemically defined basic maturation medium (bMM) supplemented with 0.3 mu M RAc or 0.5 mu M RA. Presumptive zygotes and embryos (24 cells) were cultured in droplets of potassium simplex optimised medium (KSOM); however, none of the embryos reached the blastocyst stage. in Experiment 2, oocytes were matured in bMM + RAc or bMM + RA. Presumptive zygotes and 2- to 4-cell embryos were placed in fresh KSOM droplets supplemented with RAc, RA, IGF-I, RAc+IGF-I or RA+IGF-I. in Experiment 1, addition of RAc and RA to bMM increased (P < 0.05) the proportion of 2- to 4-cell embryos reaching the morula stage as compared to the control. in Experiment 2, supplementation of embryo culture media with retinoids and IGF-I increased (P < 0.05) the proportion of 2- to 4-cell stage embryos developing to the morula and blastocyst stage. Our data demonstrate that goat embryo production in chemically defined media could be improved by exogenous RAc or RA and by the interaction between retinoids and IGF-I, and that goat embryos can be produced in vitro from oocytes following protocols similar to those currently used for cattle.
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Vitamin A concentration in human milk and its relationship with liver reserve formation and compliance with the recommended daily intake of vitamin A in pre-term and term infants in exclusive breastfeeding
(Springer, 2015-02-01) Souza, Gisele; Dolinsky, Manoela [UNIFESP]; Matos, Andrea; Chagas, Cristiane; Ramalho, Andrea; Universidade Federal do Rio de Janeiro (UFRJ); Universidade Federal de São Paulo (UNIFESP); Universidade Federal Fluminense (UFF); Fiocruz MS
To evaluate vitamin A concentration in mature breast milk of nursing mothers aiming to meet the daily needs and the formation of liver reserve in pre-term (PT) and term infants (T) in comparison with the recommended intake for this nutrient in this group.We analyzed the retinol concentration in the milk of 120 nursing mothers (40 of PT infants and 80 of T infants) by collecting 10 mL of mature breast milk, held by a hand spray of one of the breasts 2 h after the last feeding in the morning. the cutoff points adopted for identification of vitamin A deficiency (VAD) and the liver reserve were < 1.05 and > 2.3 mu mol/L, respectively.The concentrations of retinol in the human milk of T infants were superior to concentrations in the milk of PT infants (1.87 + 0.81 > 1.38 + 0.67 mu mol/L, p < 0.0001). They were higher in T compared to PT (352.64 + 152.72 > 217.65 + 105.65 mu g, p < 0.0001), but both were below the recommendation. VAD was 20.0 % (T) and 27.5 % (PT). Only 40.0 % (T) and 22.5 % (PT) of the mothers had retinol concentrations in milk above 2.3 mmol/L.The milk of the nursing mothers studied did not have enough retinol to meet the daily needs and to form liver reserve in both groups, especially in PT newborns. This finding reinforces the idea that supplementation with massive doses of vitamin A in the immediate postpartum period can be used as a protective device of the infant against VAD.
Somente Metadadados
Vitamin A concentration in mature human milk
(Soc Brasil Pediatria, 2012-11-01) Souza, Gisele; Saunders, Claudia; Dolinsky, Manuela [UNIFESP]; Queiroz, Juliana; Campos, Aline; Ramalho, Andrea; Universidade Federal do Rio de Janeiro (UFRJ); Fundacao Oswaldo Cruz FIOCRUZ; Universidade Federal de São Paulo (UNIFESP); Universidade Federal Fluminense (UFF); Fiocruz MS
Objective: To quantify vitamin A levels in mature milk of 196 nursing women who were treated at the Maternity School of Rio de Janeiro and to evaluate its correlation with sociodemographic variables and degree of nutrition knowledge.Methods: To quantify retinol concentrations, 10 mL of mature milk were collected by manual expression of one breast, 2 hours after the last feed, in the morning period. Values below 1.05 mu mol/L and 2.3 mu mol/L were considered inadequate to meet satisfactory intake and to constitute vitamin A liver reserve, respectively. the following variables were also assessed: sex, age, familiar income, maternal education, basic sanitation conditions, number of people in the household, maternal age, prenatal care, and degree of nutrition knowledge.Results: Among the 196 lactating mothers analyzed, the average vitamin A concentration observed in mature milk was 1.76 +/- 0.85 mu mol/L and prevalence of vitamin A deficiency was observed in 20.5% mothers. There was no significant difference between vitamin A levels in maternal milk and the variables socioeconomic status and nutrition knowledge. Only 38.9% of lactating women presented enough vitamin A concentrations in milk for the infants' liver reserves (2.3 mu mol/L).Conclusion: These findings reveal high prevalence of inadequate vitamin A nutritional status of mothers and infants, consistent with the national prevalence reported in women of childbearing age and Brazilian children, and that the intervention measures to fight this shortage should be extended to all pregnant and postpartum women, regardless of sociodemographic conditions and degree of nutrition knowledge, in order to improve the health of mother and son. J Pediatr (Rio.7). 2012;88(6):496-502.
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Vitamin A Deficiency in Pregnancy: Perspectives after Bariatric Surgery
(Springer, 2013-02-01) Chagas, Cristiane Barbosa; Saunders, Claudia; Pereira, Silvia; Silva, Jacqueline; Saboya, Carlos [UNIFESP]; Ramalho, Andrea; Universidade Federal do Rio de Janeiro (UFRJ); Fiocruz MS; Clin Cirurg Carlos Saboya; Universidade Federal de São Paulo (UNIFESP); Brazilian Soc Bariatr & Metab Surg
This study aims to describe the clinical consequences of vitamin A deficiency (VAD) in pregnant women after bariatric surgery. Included are studies on VAD during pregnancy and after bariatric surgery conducted in humans from 1993 to 2011. There are few investigations on the relationship between pregnancy and bariatric surgery and on the damage to the binomial mother-child resulting from VAD in this relationship. the high percentage of VAD in the postoperative period is a cause for concern, especially considering the function of this vitamin in certain biological moments and in moments of intense nutritional demand. This vitamin serum evaluation is recommended during the prenatal period.

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