Navegando por Palavras-chave "Tomography, optical coherence"

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    Aspectos da tomografia de coerência óptica na doença de Stargardt: relato de caso
    (Conselho Brasileiro de Oftalmologia, 2006-08-01) Gouveia, Enéias Bezerra [UNIFESP]; Morales, Maira Saad De Ávila [UNIFESP]; Allemann, Norma [UNIFESP]; Matte, Guilherme [UNIFESP]; Berezovsky, Adriana [UNIFESP]; Sallum, Juliana Maria Ferraz [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The term fundus flavimaculatus (Stargardt disease) describes a group of inherited macular dystrophies characterized by multiple yellow to yellow-white flecks at the level of the retinal pigment epithelium. The authors describe findings in the patient with Stargardt's disease using optical coherence tomography (OCT), and suggest the examination to be valid as subsidiary method in the study of the characteristics of the retina in Stargardt's disease patients, but studies involving a series of patients should be able to show the most frequent findings in these cases.
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    Avaliação da reprodutibilidade das medidas da camada de fibras nervosas retiniana e da cabeça do nervo óptico pela tomografia de coerência óptica
    (Soc Brasileira Oftalmologia, 2012-09-01) Rau, Ricardo [UNIFESP]; Silva, André Luiz de Freitas [UNIFESP]; Salame, André Luiz Alves [UNIFESP]; Melo Junior, Luiz Alberto Soares [UNIFESP]; Hosp Servidor Publ Estadual Sao Paulo Francisco M; Universidade Federal de São Paulo (UNIFESP)
    Purpose: To determine the reproducibility of the peripapillary retinal nerve fiber layer thickness and optic nerve head parameters measured with the optical coherence tomography (SD-OCT) in normal eyes. Methods: Thirty-four eyes of 34 healthy patients were included in the study. The Cirrus OCT optic disc cube 200x200 protocol was used to obtain three scans from each eye to evaluate the reproducibility. Intraclass correlation coefficient (ICC) was calculated for the measurements of retinal nerve fiber layer thickness and optic nerve head parameters. Results: The correlation was excellent for all measures of retinal nerve fiber layer thickness (ICC between 0.87 and 0.98). The same happened with the optic nerve head parameters (ranging from 0.83 to 0.99), with the exception of E/D vertical ratio (0.56). Conclusion: Measurements of peripappilary retinal nerve fiber layer thickness and optic nerve head parameters showed excellent reproducibility with Cirrus OCT, indicating that this instrument may be useful in the study of glaucoma. This study has some limitations, including the small number of cases studied, further studies are needed to corroborate our findings.
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    Avaliação da tomografia de coerência óptica em pacientes portadores de degeneração macular relacionada à idade tratada com terapia fotodinâmica com verteporfina
    (Conselho Brasileiro de Oftalmologia, 2008-12-01) Bordon, Arnaldo Furman [UNIFESP]; Oshima, Akioshi [UNIFESP]; Guia, Tércio Alves [UNIFESP]; Calucci, Daniela [UNIFESP]; Sallum, Juliana Maria Ferraz [UNIFESP]; Farah, Michel Eid [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    PURPOSE: To identify the optical coherence tomography (OCT) findings in patients with age-related macular degeneration (ARMD) treated with photodynamic therapy (PDT). STUDY DESIGN: Open, non-randomized, interventional case series. METHODS: ARMD patients were submitted to a complete ophthalmological examination, fluorescein angiography, and OCT at baseline (V0), 3, 6, 9 and 12 months (V3, V6, V9 and V12, respectively). PDT was carried out according to the TAP study. Visual acuity (VA) was measured using the logMAR ETDRS chart. The following foveal measurements were performed: foveal intraretinal thickness (FIRT), foveal choriocapillaris - RPE complex thickness (FCC-RPET) and total foveal thickness (TFT). The extrafoveal thicknesses measured were: extrafoveal intraretinal thickness (EFIRT), extrafoveal choriocapillaris - RPE complex thickness (EFCC-RPET) and total extrafoveal thickness (TEFT). Statistical analysis was performed using the block variance analysis test. RESULTS: Twenty-three eyes of 23 patients were enrolled. This study identified nine OCT patterns: 1) thickening of the foveal intraretinal layers; 2) thickening of the extrafoveal intraretinal layers; 3) thickening of the foveal choriocapillaris - RPE complex; 4) thickening of the extrafoveal choriocapillaris - RPE complex; 5) intraretinal fluid; 6) subretinal fluid; 7) subretinal pigment epithelium (RPE) fluid; 8) vitreo-retinal adhesion; 9) foveal depression. At baseline, FIRT and TFT were 398.5 µ and 639.2 µ, respectively. At V12 they were 173.7 µ e 423.9 µ, respectively, and this change was statistical significant (p=0.008 e p=0.003, respectively). The variation of the other foveal and extrafoveal measurements were not statistically significant. Foveal depression was present at baseline in 36.4% of the eyes, whereas at V12 it was present in 78.3%. Subretinal fluid was present in 36.4% of eyes at V0 and in 8.7% at V12. VA at baseline was 0.93 and it V12 was 1.04 (p=0,127). CONCLUSIONS: Visual acuity was stable throughout the study. Foveal depression was reestablished in 78.3% at V12. FIRT and TFT decreased at a statistical significant level, from V0 to V12.
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    Comparação do efeito antiangiogênico do ranibizumab e do bevacizumab in vitro
    (Conselho Brasileiro de Oftalmologia, 2011-10-01) Souto, Alexandre Cupello [UNIFESP]; Maricato, Juliana Terzi [UNIFESP]; Denapoli, Priscila Martins Andrade [UNIFESP]; Sallum, Juliana Maria Ferraz [UNIFESP]; Han, Sang Won [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Purpose: To evaluate the comparative in-vitro antiangiogenic effect of Bevacizumab and Ranibizumab. Methods: Endothelial venous umbilical cells culture (ECV304) cultivated in F12 media with addition of 10% Fetal Bovine Serum, were plaqued and treated with clinically relevant concentrations of Bevacizumab and Ranibizumab just after the scratch done in the middle of the culture (scratch methodology). Measurements of the linear size of the area free of cell proliferation were done 24, 48 and 72 hours after the scratch day point. All the experiments were done in triplicate and statistical analysis were done with T-student test. Results: Inhibitory effect was observed just at the concentrations of 0.5 and 0.7 mg/ml in both drugs. At 0.7 mg/ml, Ranibizumab demonstrated a more potent proliferative inhibitory effect than Bevacizumab. At the same concentration, Ranibizumab was three times more potent than Ranibizumab. Inhibitory effect was observed just in the first 24 hours for both drugs. Conclusion: Ranibizumab demonstrates an increased effect when compared to Bevacizumab and this is related more to the different molar rate of each drug than related to a real better proliferative inhibitory effect.
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    Comparisons of choroidal nevus measurements obtained using 10-and 20-MHz ultrasound and spectral domain optical coherence tomography
    (Consel Brasil Oftalmologia, 2017) Martins, Maira de Franca [UNIFESP]; Kiefer, Kelcia [UNIFESP]; Andrade Kanecadan, Liliane Almeida [UNIFESP]; Garcia, Patricia Novita [UNIFESP]; Belfort, Rubens N. [UNIFESP]; Allemann, Norma [UNIFESP]
    Purpose: To compare measurements of lesions clinically diagnosed as choroidal nevi using spectral domain optical coherence tomography (SD-OCT) and 10- and 20-MHz ultrasound (US). Methods: This prospective study, which was conducted between May 2011 and December 2011, evaluated eyes diagnosed with choroidal nevus via photographic documentation using 10- or 20-MHz A- and B-mode US (experienced examiner using both the transpalpebral technique and direct contact) or SD-OCT in the enhanced depth imaging mode (performed by a different examiner blinded to the US results). Anteroposterior (AP) and transverse (T) US sections corresponded to sections adjusted perpendicularly on SD-OCT. Results: We evaluated 14 eyes from 12 patients (six males, mean patient age=64.5 years) diagnosed with choroidal nevus. The choroidal nevi of all samples had a melanocytic profile. Moreover, eight nevi were located at the equator, five nevi were located in the posterior pole (peripapillary in one sample), and one nevus shifted from the equator to the periphery. On SD-OCT, the maximum measurable dimension was 9 mm. The lesions in the posterior pole were easier to evaluate, and image acquisition of lesions located more peripherally was possible depending on patient cooperation. The accurate assessment of height was difficult. Baseline dimensions on 10- and 20-MHz US were larger than those determined via OCT. No significant differences in height were observed between US and SD-OCT. All parameters were statistically similar between 10- and 20-MHz US measurements. Conclusions: No significant difference in the AP and T diameters was observed between 10- and 20-MHz US measurements
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    Detecção de maculopatia hipotônica subclínica pelo OCT III após cirurgia filtrante
    (Conselho Brasileiro de Oftalmologia, 2006-12-01) Weyll, Mônica; Gilio, Adriana; Barbosa, Aline [UNIFESP]; Nicoli, Aguida Aparecida; Silveira, Regina Cele [UNIFESP]; Complexo Hospitalar Padre Bento; CHPB; Universidade Federal de São Paulo (UNIFESP); CHPB Setor de Glaucoma
    PURPOSE: To detect nondiagnostic hypotony maculopathy by OCT III after filtration surgery. METHODS: After surgery, patients with intraocular pressure less than 9 mmHg were submitted to OCT III examination. RESULTS: Seven (87.50%) patients with previous diagnosis of open angle glaucoma and one (12.50%) of them with acute angle closure glaucoma. Two patients (25.00%) presented hypotony maculopathy on OCT III examination. CONCLUSION: OCT III examination seems to be a good diagnostic method to detect subclinical hypotony maculopathy after filtration surgery.
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    Different presentations of intraretinal fluid collections in optic disc pits: OCT study of 3 cases
    (Conselho Brasileiro de Oftalmologia, 2006-10-01) Brasil, Oswaldo Ferreira Moura [UNIFESP]; Brasil, Maria Vitoria Oliveira Moura [UNIFESP]; Brasil, Oswaldo Moura; Universidade Federal de São Paulo (UNIFESP); IBOL Setor de Retina e Vítreo
    The congenital optic disc pit is a rare anomaly that can lead to major visual impairment associated with subretinal fluid accumulation. The authors describe the optical coherence tomography study of three cases of untreated congenital optic disc pits with different levels of visual impairment and its different presentations of intraretinal fluid collections.
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    Emprego das medidas anatômicas do buraco macular idiopático obtidas pela tomografia de coerência óptica como fator preditivo nos resultados visuais: um estudo piloto
    (Conselho Brasileiro de Oftalmologia, 2007-10-01) Negretto, Alan Diego; Gomes, André Marcelo Vieira; Gonçalves, Fernando Pistarini; Jiun, Huang Sheau [UNIFESP]; Abujamra, Suel; Nakashima, Yoshitaka; Universidade de São Paulo (USP); Instituto Suel Abujamra; Universidade Federal de São Paulo (UNIFESP); Universidade de Santo Amaro Faculdade de Medicina; Hospital das Clínicas Clínica Oftalmológica
    PURPOSE: To evaluate the anatomy of idiopathic macular hole (IMH) using Optical Coherence Tomography (OCT) and to construct a prognostic index that can be correlated with the visual outcomes and the anatomical closing. METHODS: Prospective study, in which 22 eyes with IMH had been evaluated through OCT in the daily postoperative period of IMH surgery. The Prognostic of Macular Hole Index (PMHI) was created which was correlated with the anatomical result and the postoperative visual acuity (VA) six months after surgery. RESULTS: Sixteen eyes (72.7%) got anatomical closing at the end of six months of follow-up. On analysis of PMHI, there was significant difference between group 1 (open MH) and group 2 (closed MH) (p=0.0018). The risk for failure of anatomical closing is 11 times greater when the diameter of the internal base is over 600 µm or IPBM is less than 0.6 (p=0.0495). Regarding final VA, it was observed that the IPBM had a significant negative correlation with AV (p=0.001). CONCLUSIONS: IPBM showed to be the best predictor of anatomical closing and postoperative visual acuity among the studied variables. It predicted 41% of the postoperative final visual acuity, leading us to believe that other factors, such as the time of history and the degeneration of photoreceptors in these older BM, can be involved in the visual outcomes.
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    In vivo ultrathin Descemet stripping automated endothelial keratoplasty with a low-energy and high-frequency femtosecond laser
    (Conselho Brasileiro de Oftalmologia, 2014-04-01) Victor, Gustavo; Nosé, Walton [UNIFESP]; Sousa, Sidney Júlio de Faria e; Forseto, Adriana dos Santos [UNIFESP]; Alves, Milton Ruiz; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    This case report describes the production of an ultrathin endothelial donor corneal lamella using a femtosecond laser with low energy and a high frequency. In addition, we report its use in vivo in an eye with pseudophakic bullous keratopathy. The outcomes were observed 3 months after surgery in terms of the change in endothelial donor lamella and full cornea thickness (including pachymetric mapping), visual acuity, and endothelial cell count.
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    Indocyanine green-mediated photothrombosis for choroidal neovascularization in angioid streaks
    (Conselho Brasileiro de Oftalmologia, 2008-06-01) Malerbi, Fernando Korn [UNIFESP]; Huang, Sheau Jiun [UNIFESP]; Aggio, Fabio Bom [UNIFESP]; Carvalho Jr., Edenilson [UNIFESP]; Bonomo, Pedro Paulo [UNIFESP]; Farah, Michel Eid [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    PURPOSE: To investigate the effect of indocyanine green-mediated photothrombosis on choroidal neovascularization secondary to angioid streaks. METHODS: Six eyes of 5 patients with an average age of 70 years were diagnosed to have subfoveal choroidal neovascularization secondary to angioid streaks. Therapy was indicated if choroidal neovascularization was considered to be active, according to evidence of fluorescein leakage on angiograms, as well as presence of intra- or subretinal fluid on optical coherence tomography. Patients received photothrombosis at baseline with retreatment as necessary at 3, 6 and 9 months follow-up. Fluorescein leakage was assessed at 3, 6 and 9 months, along with foveal thickness measured by optical coherence tomography. Indocyanine green angiography was performed initially and whenever retreatment was considered. Retreatment was performed whenever there was evidence of increased leakage on fluorescein angiograms at follow-up visits. RESULTS: The mean follow-up was 13.3 months. All eyes had at least 12 months follow-up. Two eyes underwent retreatment. Three eyes had visual acuity improvement and three eyes had stabilization. All patients showed less fluorescein leakage on final angiograms and reduced foveal thickness upon optical coherence tomography measurement. CONCLUSION: Photothrombosis is a feasible procedure for choroidal neovascularization secondary to angioid streaks. Lesion analysis showed anatomical improvement in most cases in this series. Further studies are warranted to evaluate long-term results of this treatment.
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    Injeção intravítrea de acetato de triancinolona no tratamento da síndrome de Vogt-Koyanagi-Harada
    (Conselho Brasileiro de Oftalmologia, 2004-06-01) Andrade, Rafael Ernane Almeida [UNIFESP]; Muccioli, Cristina [UNIFESP]; Farah, Michel Eid [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    PURPOSE: To report the use of intravitreal injection of triamcinolone acetonide in the acute phase of Vogt-Koyanagi-Harada's disease. METHODS: Nine eyes from five patients in the acute phase of Vogt-Koyanagi-Harada's disease with serous retinal detachments were treated with a single 4-mg intravitreal injection of triamcinolone acetonide. The following parameters were evaluated: visual acuity, intraocular pressure, as well as the height of the serous retinal detachment using optical coherence tomography. RESULTS: Optical coherence tomography images showed a marked decrease in the retinal detachment in the first week after the injection with subsequent return to normal retinal thickness in all eyes. Follow-up ranged from 5 to 12 months with a mean of 7.8 months. No complications were observed. CONCLUSIONS: Intravitreal triamcinolone acetonide provides short-term improvement in visual acuity and serous retinal detachments associated with Vogt-Koyanagi-Harada's disease. These findings should be followed by further studies to evaluate long-term effects.
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    Intraretinal worm documented by optical coherence tomography in a patient with diffuse unilateral subacute neuroretinitis: case report
    (Conselho Brasileiro de Oftalmologia, 2010-10-01) Cunha, Leonardo Provetti; Costa-cunha, Luciana Virgínia Ferreira; Souza, Eduardo Cunha De [UNIFESP]; Monteiro, Mário Luiz R.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Our purpose is to report a case of diffuse unilateral subacute neuroretinitis (DUSN) in which an ophthalmoscopically visible worm was found and optical coherence tomography (OCT) scans allowed the precise localization of the parasite in the intraretinal layers. Our findings suggest that the parasite moves in the inner portions of the retina possibly explaining the severe degenerative neural changes that it causes.
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    Optical coherence tomography in presumed subretinal Toxocara granuloma: case report
    (Conselho Brasileiro de Oftalmologia, 2006-06-01) Lago, Aline do [UNIFESP]; Andrade, Rafael [UNIFESP]; Muccioli, Cristina [UNIFESP]; Belfort, Rubens Junior [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Our aim was to study optical coherence tomographic findings in a case of Toxocara granuloma. A patient with a cicatricial macular lesion, diagnosed as ocular toxocariasis, was examined with optical coherence tomography. In optical coherence tomography images, the macular granuloma appeared as a highly reflective round mass protruding above the retinal pigment epithelium with two other surrounding masses. Optical coherence tomography may increase understanding of the pathophysiology of the retinal Toxocara granuloma and help in the clinical diagnosis and management of its macular complications.
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    Pattern of inner retinal layers involvement in pigmented paravenous retinochoroidal atrophy as determined by SD-OCT: case report
    (Consel Brasil Oftalmologia, 2013-11-01) Junqueira, Daniela Laura Melo; Lopes, Flavio Siqueira Santos [UNIFESP]; Biteli, Luis Gustavo [UNIFESP]; Prata, Tiago dos Santos [UNIFESP]; Hosp Med Olhos; Universidade Federal de São Paulo (UNIFESP)
    Pigmented paravenous retinochoroidal atrophy is an ocular disease characterized by outer retina and choroidal atrophy often with overlying intraretinal bone spicule pigment deposition along the retinal veins. As a rare condition, there is scant information in the literature regarding the pattern of inner retinal layers involvement. We present a case of a 41-year-old white man initially referred for a glaucoma evaluation. Fundoscopy revealed patches of retinochoroidal atrophy and light pigmentation extending from the optic nerve head along the inferior-temporal retinal veins in both eyes. Using different spectral-domain optical coherence tomography (SD-OCT) protocols we identified a significant thinning of the inner retinal layers along the inferior-temporal veins, but with a lucid interval surrounding the optic nerve head. Standard automated perimetry revealed a superior absolute arcuate scotoma sparing the central fixation (good structure-functional correlation). This pattern of inner retinal layers involvement was not previously described. We believe SD-OCT added significantly to the anatomical description of this case. Physicians should consider these new anatomical findings and correlate them with functional status while assessing these patients.
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    Spontaneous closure of pediatric traumatic macular hole: case report and spectral-domain OCT follow-up
    (Conselho Brasileiro de Oftalmologia, 2012-08-01) Sartori, Juliana de Filippi [UNIFESP]; Stefanini, Francisco [UNIFESP]; Moraes, Nilva Simeren Bueno de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Spontaneous closure of a traumatic macular hole (TMH) is an unusual outcome. Optical coherence tomography (OCT) and clinical follow-up enabled monitoring of this resolution during a period of a few weeks. We describe a case of spontaneous closure of a TMH with complete visual recovery in a 15 year-old boy and show the follow-up of the macular hole obtained using the Spectral Domain OCT.
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    Submacular hemorrhage secondary to congenital toxoplasmosis
    (Instituto Israelita de Ensino e Pesquisa Albert Einstein, 2014-03-01) Costa, Ana Luiza Fontes De Azevedo; Martins, Thiago Gonçalves Dos Santos; Moncada, Francisco Javier Solano; Motta, Mário Martins Dos Santos; Hospital Federal dos Servidores do Estado; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    We report the case of a patient with congenital toxoplasmosis and submacular hemorrhage caused by a neovascular membrane who underwent an intravitreal injection of C3F8 and bevacizumab, and had a good visual recovery.
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    Yellowish dots in the retina: a finding of ocular syphilis?
    (Conselho Brasileiro de Oftalmologia, 2014-10-01) Rodrigues, Renan Albert Mendonça [UNIFESP]; Nascimento, Heloisa Moraes do [UNIFESP]; Muccioli, Cristina [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Here we report the occurrence of pale yellowish perivascular preretinal dots in 12 patients with ocular syphilis. A case series of these patients was examined between March and October 2012 at the Uveitis Sector of Universidade Federal de São Paulo. After diagnostic confirmation of syphilis, fundus photographs and optical coherence tomography (OCT) were performed to verify the localization of the dots, and patients were treated with IV crystalline penicillin for 14 days. The study comprised 11 men (91.6%), 19 eyes, median presentation age of 38.1 years, and panuveitis as the main clinical manifestation (seven patients, 58.3%), being bilateral in four. Ten patients were taking oral prednisone (83.3%). Serum panels performed by the Venereal Disease Research Laboratory (VDRL) showed positive results in eight patients (66.7%), whereas VDRL cerebrospinal fluid (CSF) tests were negative in seven of nine collected (77.8%). However, serum FTA-Abs was positive in 100% of patients, and eight patients (66.7%) had HIV infection. The best corrected visual acuity (BCVA) presented after treatment improved in 10 eyes (55.6%), did not change in seven eyes (38.9%), and worsened in one eye (5.6%). Although not yet acknowledged in the literature as a typical manifestation of ocular syphilis, these are very common findings in clinical practice. We believe that preretinal dots are due to perivasculitis secondary to treponema infection. It is important recognize them and remember that syphilis can present in several forms, including the one presented in this study.