Navegando por Palavras-chave "Thin melanoma"

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    Update on Thin Melanoma: Outcome of an International Workshop
    (Lippincott Williams & Wilkins, 2016) Mihic-Probst, Daniela; Shea, Chris; Duncan, Lyn; de la Fouchardiere, Arnaud; Landman, Gilles [UNIFESP]; Landsberg, Jennifer; ven den Oord, Joost; Lowe, Lori; Cook, Martin G.; Yun, Sook Jung; Clarke, Loren; Messina, Jane; Elder, David E.; Barnhill, Raymond L.; Universidade Federal de São Paulo (UNIFESP)
    The following communication summarizes the proceedings of a 1-day Workshop of the International Melanoma Pathology Study Group, which was devoted to thin melanoma. The definitions and histologic criteria for thin melanoma were reviewed. The principal differential diagnostic problems mentioned included the distinction of thin melanoma from nevi, especially from nevi of special site, irritated nevi, inflamed and regressing nevi, and dysplastic nevi. Histologic criteria for this analysis were discussed and the importance of clinico-pathologic correlation, especially in acral sites, was emphasized. Criteria for the minimal definition of invasion were also discussed. In addition, a new technique of m-RNA expression profiling with 14 genes was presented and facilitated the distinction of thin melanomas from nevus in histologically obvious cases. However, for particular nevi, it was not obvious why the results indicated a malignant lesion. Despite many molecular and other ancillary investigations, Breslow thickness remains the most important prognostic factor in thin melanoma. The prognostic significance of radial (horizontal) and vertical growth phases, Clark level, regression, and mitotic rate were also discussed. Because of the increasing frequency of thin melanomas, there is a great need to develop more refined predictors of thin melanomas with worse clinical outcome.
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    Vertical growth phase and positive sentinel node in thin melanoma
    (Associação Brasileira de Divulgação Científica, 2003-03-01) Oliveira Filho, Renato Santos de [UNIFESP]; Ferreira, Lydia Masako [UNIFESP]; Biasi, Luciano Jose [UNIFESP]; Enokihara, Mílvia Maria Simões e Silva [UNIFESP]; Paiva, Geruza Rezende [UNIFESP]; Wagner, Jairo; Universidade Federal de São Paulo (UNIFESP); Hospital Israelita Albert Einstein Serviço de Medicina Nuclear
    Sentinel node (SN) status is the most important prognostic factor for localized melanoma. Usually, patients with Breslow thickness of less than 1.0 mm are not included in SN protocols. However, the literature presents a rate ranging from 3 to 7% of nodal recurrence in thin melanoma. Ulceration, regression and high mitotic rate have been considered to be indications for an SN biopsy. The metastatic potential of the vertical growth phase is uncertain. To correlate pathological features in thin melanoma with SN metastasis, we reviewed 358 patients submitted to SN biopsy. Seventy-seven patients with lesions of 1 mm or smaller were included in the study group. Histological evaluation of the primary tumor included thickness, Clark level, mitotic rate, ulceration, regression, and growth phase. Lymphoscintigraphy was performed on all patients. Lymphatic mapping and gamma probe detection were both used for SN biopsy. Histological examination of SN consisted of hematoxylin-eosin and immunohistochemical staining. Median follow-up was 37 months. Six patients had micrometastases. Statistical analysis by the Fisher test showed that ulceration (P = 0.019), high mitotic rate (P = 0.008) and vertical growth phase (P = 0.002) were positively correlated with micrometastases. If other studies confirm these results, more melanoma patients must be submitted to SN biopsy.