Navegando por Palavras-chave "Therapy"

Agora exibindo 1 - 20 de 46
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Abordagem dietética da alergia ao leite de vaca em crianças na perspectiva e nos estágios de mudança de comportamento de seus cuidadores
    (Universidade Federal de São Paulo (UNIFESP), 2020-05-28) Ullmann, Gabriela Rodrigues [UNIFESP]; Speridião, Patrícia da Graça Leite [UNIFESP]; Universidade Federal de São Paulo
    To know and understand the practices of the dietary approach from the perspective of children caregivers with ALV and to verify if the stages of behavior change of these caregivers correspond to their practices. Method: it´s a qualitative and quantitative, observational and cross-sectional study involving 30 children caregivers with CMA between 0 to 24 months old, attended in a specialized outpatient clinic, from July 2018 to May 2019. The data collection was performed by using a structured form with sociodemographic aspects, social classification, interview based on 4 guiding questions and an algorithm for classifying the stages of behavior change according to the transtheoretical model. Results: the caregivers are mostly (26/30) women, aged between 20 to 48 years old and belong to social classes C, D and E. Children with CMA are mostly women, do not attend school and live in a two-parent family model and the caregiver is the mother herself. More than half of the number of caregivers (18/30) reported seeking additional information about the treatment of CMA from other sources, for example, the internet (15/18). Of these, (11/18) consider the internet to be a very reliable source. Regarding the orientation of reading labels, (19/30) answered yes and the rest (11/30) replied that they had never received this information. The caregivers (22/30) reported not having adequate financial condaition to meet the demand for dietary management of CMA and 56,6% (17/30) feel distressed about it. According to the transtheoretical model, 80% of caregivers (24/30) are in the action stage in relation to behavior change. Conclusions: the practices related to the dietary approach in CMA by children caregivers are influenced by many feelings and emotions that can cause noise in the communication with the team professionals. The stage of behavior change in which the caregivers are found corresponds to the practices. The stage of behavior change in which the caregivers are found corresponds to the practices.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients
    (Czech Acad Sci, Inst Entomology, 2016) Cadegiani, Flavio A. [UNIFESP]; Silva, Osvalmir Sa
    Objective: Acarbose is a glucosidase inhibitor that slows carbohydrate digestion. It could thus be effective to promote remission of dumping syndrome (DS). Previous studies associating acarbose and late dumping, although not early dumping, have been reported. Herein, we aimed to evaluate the role of acarbose in dumping syndrome prevention and treatment and in resistive exercises resistance in bariatric subjects. Methods: Bariatric patients with DS and complete adherence to diet plan and resistive exercises were included (n=25). Number of early and late episodes, self-referred intensity of each episode, and ability to increase intensity of resistive exercise were evaluated, on a 0-10 scale. Acarbose was administered orally (50 mg) for 6 months, 4-5 times a day before meals. Results: Acarbose administration was associated with a decrease in the number of early (2.18-0.31) and late (2.79-0.12) episodes per week and intensity of each episode (6.10-1.65) and an increase in the ability to perform resistive exercises (3.03-7.12). Complete remission of DS was seen in 21 patients (84%), which persisted for 6 months with the use of acarbose. Conclusion: Acarbose prevented dumping in almost all studied subjects and helped improve exercise capacity.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Applicability of cone beam computed tomography to the assessment of the vocal tract before and after vocal exercises in normal subjects
    (Soc Brasil Cirurgia Cardiovasc, 2016) Garcia, Elisangela Zacanti [UNIFESP]; Yamashita, Helio Kiitiro [UNIFESP]; Garcia, Davi Sousa; Pereira Padovani, Marina Martins; Azevedo, Renata Rangel [UNIFESP]; Chiari, Brasilia Maria [UNIFESP]
    Background/Aims: Cone beam computed tomography (CBCT), which represents an alternative to traditional computed tomography and magnetic resonance imaging, may be a useful instrument to study vocal tract physiology related to vocal exercises. This study aims to evaluate the applicability of CBCT to the assessment of variations in the vocal tract of healthy individuals before and after vocal exercises. Methods: Voice recordings and CBCT images before and after vocal exercises performed by 3 speech-language pathologists without vocal complaints were collected and compared. Each participant performed 1 type of exercise, i.e., Finnish resonance tube technique, prolonged consonant "b" technique, or chewing technique. The analysis consisted of an acoustic analysis and tomographic imaging. Results: Modifications of the vocal tract settings following vocal exercises were properly detected by CBCT, and changes in the acoustic parameters were, for the most part, compatible with the variations detected in image measurements. Conclusion: CBCT was shown to be capable of properly assessing the changes in vocal tract settings promoted by vocal exercises. (C) 2017 S. Karger AG, Basel
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Atitudes de nutricionistas em relação a indivíduos obesos – um estudo exploratório
    (ABRASCO - Associação Brasileira de Saúde Coletiva, 2015-02-01) Cori, Giuliana Da Costa; Petty, Maria Luiza Blanques; Alvarenga, Marle Dos Santos; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    The scope of this study was to assess attitudes of dietitians in relation to obesity; involving beliefs about the characteristics attributed to obese people, the reasons that lead to obesity and obesity itself. Dietitians (N = 344; 97.1% women) were contacted via their professional council and filled out the online survey. The survey questions were translated and adapted from international studies on this subject and the responses were analyzed for concordance rate. The results pointed to strong stigmatization of obesity and prejudice against the obese, attributing characteristics such as greed (67.4%), unattractiveness (52.0%), ungainliness (55.1%), lack of willpower (43.6%) and laziness (42.3%). The most important causal factors were considered to be emotional and mood changes, food addiction and low self-esteem. Research on this topic should be enhanced since these attitudes can affect the efficacy of treatment and also to foster broad discussion and training regarding the significance of obesity and to ensure more individualized and humanized treatment for obese patients.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Atorvastatin reduced soluble receptors of tnf-alpha in systemic lupus erythematosus
    (Clinical & exper rheumatology, 2016) Ferreira, G. A.; Teixeira, A. L.; Calderaro, D. C.; Sato, E. I. [UNIFESP]
    Objective The aim of this study was to evaluate the efficacy of atorvastatin to reduce the plasma levels of TNF system molecules (TNF-alpha, sTNFR1 and sTNFR2) and to assess their association with risk factors for accelerate atherosclerosis and clinical disease activity scores in SLE patients. Methods In a previous study, 64 female SLE patients received 20 mg/day of atorvastatin and 24 SLE patients (non-treated group) were followed for 8 weeks. Plasma levels of TNF-alpha, sTNFR 1 and sTNFR 2 were measured by ELISA, at baseline and at the end of the study. Results The plasma levels of sTNFR1 and sTNFR 2 showed a positive correlation with SLEDAI score. We also found a positive correlation between TNF-alpha and sTNFR 1 levels and SLICC score. Patients with current nephritis and patients with anti-dsDNA antibodies presented higher sTNFR1 and sTNFR2 levels. Patients with abdominal obesity and arterial hypertension also had higher plasma levels of soluble receptors. At the end of 8 weeks, we observed a significant decrease in sTNFR1 plasma levels in patients receiving atorvastatin [median (percentile), 876.5 (717-1284 pg/ml) vs. 748 (629.6-917.3 pg/ml), p=0.03], without difference regarding TNF-alpha and sTNFR2 plasma levels. The SLEDAI and SLICC scores were independent determinants of the plasma levels of sRTNF1. Conclusion Atorvastatin reduced soluble receptors of TNF-alpha. The plasma levels of TNF-alpha, sTNFR1 and sTNFR2 may play a role in SLE activity and atherosclerosis, and might be evaluated as targets for new therapies.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Avaliação neurocognitiva no abuso e dependência do álcool: implicações para o tratamento
    (Associação Brasileira de Psiquiatria - ABP, 2004-05-01) Cunha, Paulo J; Novaes, Maria Alice [UNIFESP]; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    The aim of the Neuropsychology applied to the Alcohol Dependence field is the comprehension of the effects of brain dysfunction on cognition and human behavior. It investigates neurocognitive impairments and associates them to structural and functional neuroimaging findings (CT, MRI, PET and SPECT). Acute use of alcohol impairs attention, memory, executive functions and visuospatial skills, while chronic abuse causes neurocognitive deficits in memory, learning, visuospatial functions, psychomotor speed processing, executive functions and decision-making, and may lead to persistent amnesic disorder and alcoholic dementia. Executive Dysfunction related to frontal lobe has direct implications on treatment, by the choosing of strategies and for prognostic evaluation. It is presented an easy tool to screen cognitive impairments, the Frontal Assessment Battery - FAB.15 Neuropsychological Assessment is useful for early detection of impairments and evaluation of their evolution and Cognitive Rehabilitation has a significant role on deficits recovery and psychosocial adjustment of these patients.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    The biphosphinic paladacycle complex induces melanoma cell death through lysosomal-mitochondrial axis modulation and impaired autophagy
    (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016) Gigli, Rafael [UNIFESP]; Pereira, Gustavo J. S. [UNIFESP]; Antunes, Fernanda [UNIFESP]; Bechara, Alexandre [UNIFESP]; Garcia, Daniel M. [UNIFESP]; Spindola, Daniel G. [UNIFESP]; Jasiulionis, Mirian G. [UNIFESP]; Caires, Antonio C. F.; Smaili, Soraya Soubhi [UNIFESP]; Bincoletto, Claudia [UNIFESP]
    Recently, palladium complexes have been extensively studied as cyclization of these complexes by cyclometallation reactions increased their stability making them promising antitumor compounds. In this study, we have investigated apoptosis induced by the Biphosphinic Paladacycle Complex (BPC11) and possible cross talk between apoptosis and autophagy in cell line models of metastatic (Tm5) and non-metastatic (4C11-) melanoma. The BPC11-induced cell death in melanoma involved the lysosomal mitochondrial axis, which is characterized by LMP, CatB activation and increased Bax protein levels following its translocation to mitochondria. Mitochondrial hyperpolarization, followed by membrane potential dissipation and cleavage of caspase-3, also resulted in cell death after 24 h of incubation. We also found that BPC11-mediated LC3II formation and increased p62 protein levels, suggesting blocked autophagy, probably due to LMP. Interestingly, the treatment of Tm5 and 4C11(-) cells with 3-methyladenine (3-MA), an inhibitor of the initial stage of autophagy, potentiated the effects of BPC11. We conclude that BPC11 is an anti-melanoma agent and that autophagy may be acting as a mechanism of melanoma cells resistance. Also, these data highlight the importance of studies involving autophagy and apoptosis during pre-clinical studies of new drugs with anticancer properties. (C) 2015 Elsevier Masson SAS. All rights reserved.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    The biphosphinic paladacycle complex induces melanoma cell death through lysosomal-mitochondrial axis modulation and impaired autophagy
    (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016) Gigli, Rafael [UNIFESP]; Pereira, Gustavo J. S. [UNIFESP]; Antunes, Fernanda [UNIFESP]; Bechara, Alexandre [UNIFESP]; Garcia, Daniel M. [UNIFESP]; Spindola, Daniel G. [UNIFESP]; Jasiulionis, Mirian G. [UNIFESP]; Caires, Antonio C. F.; Smaili, Soraya S. [UNIFESP]; Bincoletto, Claudia [UNIFESP]
    Recently, palladium complexes have been extensively studied as cyclization of these complexes by cyclometallation reactions increased their stability making them promising antitumor compounds. In this study, we have investigated apoptosis induced by the Biphosphinic Paladacycle Complex (BPC11) and possible cross talk between apoptosis and autophagy in cell line models of metastatic (Tm5) and non-metastatic (4C11-) melanoma. The BPC11-induced cell death in melanoma involved the lysosomal mitochondrial axis, which is characterized by LMP, CatB activation and increased Bax protein levels following its translocation to mitochondria. Mitochondrial hyperpolarization, followed by membrane potential dissipation and cleavage of caspase-3, also resulted in cell death after 24 h of incubation. We also found that BPC11-mediated LC3II formation and increased p62 protein levels, suggesting blocked autophagy, probably due to LMP. Interestingly, the treatment of Tm5 and 4C11(-) cells with 3-methyladenine (3-MA), an inhibitor of the initial stage of autophagy, potentiated the effects of BPC11. We conclude that BPC11 is an anti-melanoma agent and that autophagy may be acting as a mechanism of melanoma cells resistance. Also, these data highlight the importance of studies involving autophagy and apoptosis during pre-clinical studies of new drugs with anticancer properties. (C) 2015 Elsevier Masson SAS. All rights reserved.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Blocking fgf2 with a new specific monoclonal antibody impairs angiogenesis and experimental metastatic melanoma, suggesting a potential role in adjuvant settings
    (Elsevier ireland ltd, 2016) de Aguiar, Rodrigo Barbosa [UNIFESP]; Parise, Carolina Bellini [UNIFESP]; Teixeira Souza, Carolina Rosal; Braggion, Camila [UNIFESP]; Quintilio, Wagner; Moro, Ana Maria; Navarro Marques, Fabio Luiz; Buchpiguel, Carlos Alberto; Chammas, Roger; de Moraes, Jane Zveiter [UNIFESP]
    Compelling evidence suggests that fibroblast growth factor 2 (FGF2), overexpressed in melanomas, plays an important role in tumor growth, angiogenesis and metastasis. In this study, we evaluated the therapeutic use of a new anti-FGF2 monoclonal antibody (mAb), 3F12E7, using for that the B16-F10 melanoma model. The FGF2 neutralizing effect of this antibody was certified by in vitro assays, which allowed the further track of its possible in vivo application. 3F12E7 mAb could be retained in B16-F10 tumors, as shown by antibody low-pH elution and nuclear medicine studies, and also led to reduction in number and size of metastatic foci in lungs, when treatment starts one day after intravenous injection of B16-F10 cells. Such data were accompanied by decreased CD34(+) tumor vascular density and impaired subcutaneous tumor outgrowth. Treatments starting one week after melanoma cell intravenous injection did not reduce tumor burden, remaining the therapeutic effectiveness restricted to early-adopted regimens. Altogether, the presented anti-FGF2 3F12E7 mAb stands as a promising agent to treat metastatic melanoma tumors in adjuvant settings. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Cicatri-Press: Dispositivo Para A Compressão Do Queloide
    (Universidade Federal de São Paulo (UNIFESP), 2018-02-16) Isoldi, Felipe Contoli [UNIFESP]; Ferreira, Lydia Masako [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction: Compression Therapy Of Keloid (Pressure Therapy) Is An Adjuvant Treatment Of Pathological Scarring, Especially To Reduce Its Elevation Feature And Ease Its Symptoms. Objective: To Create A Device To Apply Compression On Keloid. Methods: A Review Of Existing Patents Was Made Through The Anteriority Search In The Main National (Inpi) And International Databases (Epo, Uspto, Espacenet, Wipo, Google Patent Search And Jpo). Design Thinking Was Used For The Elaboration Of Prototypes To Validate The Concepts And The Functionality Of The Device. The Prototype Was Divided Into Three Parts: The First One Was Kept In Contact With The Scar; The Second, Contained The Compressive Mechanism; And The Third Included The System That Attached All Parts Together. The Industrial Design And Final Version Of The Device Were Made. Results: Eleven Patents Were Found In The Anteriority Search. The Device For Keloid Compression Was Developed Using A Spring Mechanism, Comprised By Three Structural Units, Which Were Attache
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Conhecimento, prática e percepção de mães sobre o tratamento dietético da alergia às proteínas do leite de vaca de seus filhos atendidos em ambulatório especializado
    (Universidade Federal de São Paulo (UNIFESP), 2017-06-30) Pinto, Fernanda Lopes [UNIFESP]; Speridião, Patrícia da Graça Leite [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objective: to verify the knowledge, practice and perception of mothers about the dietary treatment of their children with allergy to cow's milk proteins (APLV) attended at a specialized medical outpatient clinic. Material and Methods: Observational, quantitative-qualitative cross-sectional study with 30 mothers of APLV children attended at a specialized outpatient clinic from September to December 2016. A structured questionnaire was used to obtain sociodemographic data of mothers and their children, social classification Of the family and objective questions regarding knowledge and practice about the dietary treatment of APLV. Qualitative data were obtained through a semistructured interview about the mothers knowledge and perception about the dietary treatment of APLV. The interviews were transcribed and analyzed using the content analysis method. Results: the median age of the mothers was 29 years and that of their children was 15.5 months. Receipt of information and understanding about APLV treatment was reported by 83.3% of mothers. They also referred to information on APLV on the Internet (60%) and reading of industrialized food labels (76%). Most mothers know that breast milk can trigger APLV (93.3%) and feel safe to perform the dietary treatment of their children (90.0%). As for food groups, mothers report that their children can eat fruits and vegetables, meats, fish and eggs, sweets and treats, but also point out that rice, pasta and wheat, as well as peanuts and nuts, are not allowed. Regarding the substitute drinks of cow's milk, 28 mothers reported that they only offer those recommended by the specialized outpatient team. Regarding the practice of breastfeeding during the period of APLV, 25 mothers answered positively about the continuity of this, along with the diet of exclusion of cow's milk and derivatives. The mothers pointed out feelings of insecurity and fear regarding the diagnosis of APLV and the conduction of dietary treatment. Conclusion: Mothers have reasonable knowledge about the dietary treatment of APLV, allowing the proper conduction of the cow's milk exclusion diet.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Crescimento intra-uterino retardado: aspectos atuais
    (Associação Médica Brasileira, 1997-06-01) Ragonesi, S.m.a. [UNIFESP]; Bertini, A.m. [UNIFESP]; Camano, L. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Dispositivo de terapia por pressão negativa com sistema de irrigação para fluidos e visualização da ferida
    (Universidade Federal de São Paulo (UNIFESP), 2017-06-29) Gomes, Daniel Teixeira [UNIFESP]; Ferreira, Lydia Masako [UNIFESP]; Blanes, Leila [UNIFESP]; http://lattes.cnpq.br/1898450330418640; http://lattes.cnpq.br/1619822351741819; http://lattes.cnpq.br/3765827988960543; Universidade Federal de São Paulo (UNIFESP)
    Introdução: A terapia de pressão negativa tópica, auxiliada pela instilação de fluidos no leito das feridas, é comumente utilizada para tratar feridas complexas, especialmente, aquelas que contêm exsudato espesso e colonização bacteriana importante. No mercado, existem equipamentos industriais que aplicam essa terapia, porém, de alto custo, impossibilitando o seu uso na rede pública de saúde. Desse modo, o desenvolvimento de tecnologias, que promovam essa terapia com baixo custo, torna-se necessário. Objetivo: Desenvolver um dispositivo de terapia por pressão negativa com sistema de irrigação para fluidos e visualização da ferida de baixo custo. Métodos: Revisão das patentes existentes por meio da busca de anterioridade e comparação com o dispositivo do estudo. Na confecção dos protótipos, foi empregada como metodologia o Design Thinking para Patentes, aplicada à experimentação, por meio de protótipos de baixo custo para validar os conceitos. Esses protótipos necessitaram de equipamentos e técnicas, entre eles, ferramentas de design gráfico, impressão em três dimensões e soldagem de polímeros termoplásticos para desenvolver o curativo e registro da patente. Resultados: A patente desenvolvida configura um modelo de utilidade que se refere a um curativo de terapia por pressão negativa, compreendendo duas unidades estruturais, que se unem com o auxílio de dois anéis de pressão. Possui duas tubulações, inserindo uma oposta à outra, simetricamente e detém uma placa de resina sintética para fixação adequada no leito da ferida. Conclusão: Foi desenvolvido um dispositivo de baixo custo para o tratamento de feridas que utiliza a pressão negativa e a irrigação de fluidos.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Efetividade do tratamento clínico em mulheres com diagnóstico de endometriose e dor pélvica crônica
    (Universidade Federal de São Paulo (UNIFESP), 2021) Mello, Thais Farias Koch [UNIFESP]; Schor, Eduardo [UNIFESP]; Universidade Federal de São Paulo
    Introduction: Endometriosis is a chronic disease that preferentially affects young women and at reproductive age, whose delay in diagnosis and, consequently, in treatment, can significantly affect patients' quality of life. Clinical treatment of symptoms related to endometriosis is a valid option as a first line of therapeutic approach, with good results on pain symptoms relief and as an alternative for when the surgical approach is not possible immediately. Objective: To evaluate the effectiveness of clinical treatment in relieving the symptoms of with chronic pelvic pain and endometriosis. Methods: Retrospective study with review of the medical records of patients with clinical and radiological diagnosis of endometriosis, with symptoms for more than six months and followed up at the Pelvic Pain and Endometriosis outpatient clinic (UNIFESP), with care beginning between January 2010 and December 2012. Patients were divided according to the classification of endometriosis by imaging exams; aspects of the clinical treatment used (type of drug treatment, number of medications, length of follow-up) were evaluated in relation to its effectiveness (improvement in the symptoms reported by the patients). Data on the care and follow-up of these patients were extracted until 12/31/2016. Results: Among the 316 patients seen during the study period, 169 were considered eligible. Significant improvement of symptoms was observed in 69,8% of women who underwent through clinical treatment, of which 87% used hormonal medication and 13% non-hormonal medication. Conclusion: Our study demonstrated that clinical treatment in patients with endometriosis, for a maximum period of six years of follow-up, is effective, with improvement in the symptoms reported by the patients and with rates similar to those described in the literature.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    A efetividade do tratamento fisioterapêutico em crianças com torcicolo congênito: revisão sistemática
    (Universidade Federal de São Paulo (UNIFESP), 2020-10-07) Almeida, Fabiana Corrêa de [UNIFESP]; Carvalho, Raquel de Paula [UNIFESP]; http://lattes.cnpq.br/7980384093582831; http://lattes.cnpq.br/0885567230221276; Universidade Federal de São Paulo (UNIFESP)
    O torcicolo muscular congênito (TMC) é uma deformidade musculoesquelética evidente ao nascimento ou nas primeiras semanas de vida, e é tipicamente caracterizado pela flexão lateral homolateral e rotação cervical contralateral ao músculo esternocleidomastoideo (ECM) acometido, devido contratura muscular não progressiva. Atualmente, a literatura mostra que o tratamento conservador é o padrão ouro para o tratamento do TMC, sendo o alongamento manual o método terapêutico mais comum. Assim, o objetivo do presente estudo foi: avaliar as intervenções fisioterapêuticas efetivas baseadas em evidência no tratamento do TMC através de uma revisão sistemática. O presente estudo é uma revisão sistemática. Os critérios de inclusão foram: estudos com intervenções fisioterapêuticas em crianças ≤ 6 meses de idade ao início do tratamento, com diagnóstico de torcicolo muscular congênito, escritos em inglês, com o desenho do estudo sendo ensaio clínico controlado ou não controlado, randomizado ou não randomizado. Os critérios de exclusão foram: estudos que não realizaram nenhuma intervenção fisioterapêutica, crianças > 6 meses de idade ao início do tratamento, com torcicolo de origem não muscular, tais como instabilidade rotatória atlantoaxial, hemivértebras, subluxação cervical, tumores de fossa posterior, malformação de Chiari, anormalidades oculares e vestibulares, e síndrome de Grisel. A seleção dos estudos ocorreu através do software Rayyan QCRI, após inserção dos resultados das buscas nos seguintes bancos de dados bibliográficos: PubMed, Cochrane Library, Open Grey, Lilacs e PEDro. Foram selecionados 26 estudos para leitura completa e extração de dados, destes apenas 10 foram se encaixaram nos critérios de inclusão desta revisão. As intervenções terapêuticas que foram efetivas no tratamento do torcicolo muscular congênito foram o alongamento manual, a associação de exercícios terapêuticos com microcorrentes ou com a mobilização de tecidos moles, além da educação dos pais e cuidadores em relação aos exercícios domiciliares, as estratégias de manuseio, posicionamento e adaptações no ambiente. Podemos concluir que a intervenção fisioterapêutica mais efetiva no tratamento do TMC é o alongamento manual, porém, existem outras modalidades terapêuticas que podem ser associadas e interferem positivamente na duração do tratamento e nos desfechos do sistema musculoesquelético.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Eficácia da Psicoterapia Psicanalítica no tratamento dos Transtornos de ansiedade: Uma revisão sistemática da literatura
    (Universidade Federal de São Paulo, 2023-11-24) Mauger, Vivian Sbrama [UNIFESP]; Lambertucci, Rafael Herling [UNIFESP]; http://lattes.cnpq.br/5826005580515987; Universidade Federal de São Paulo (UNIFESP)
    Introdução: Os transtornos de ansiedade têm o segundo maior número de diagnósticos de doenças mentais ao redor do mundo. O conhecimento da eficácia adequada do tratamento dessas doenças é atualmente uma direção importante para profissionais da área de saúde mental. Objetivo: Determinar se a psicoterapia psicanalítica é um tratamento eficaz para pacientes diagnosticados com transtornos de ansiedade. Métodos: Trata-se de uma revisão sistemática da literatura de ensaios clínicos randomizados, publicados no idioma inglês ou português, no qual os estudos selecionados utilizaram psicoterapia com abordagem psicanalítica como intervenção em adultos diagnosticados com transtorno de ansiedade e avaliaram os resultados antes e depois por meio de instrumentos psicométricos. As bases de dados eletrônicas Pubmed, Web of Science, Embase e PsycINFO foram utilizadas para seleção dos estudos. Resultados: 16 estudos foram incluídos na revisão, totalizando 1623 sujeitos com idade entre 18 e 70 anos. Os estudos foram publicados entre os anos de 1994 e 2020. A duração dos protocolos de intervenção variou de 8 - 31 sessões com duração de 10 - 37 semanas. Conclusão: Os resultados sugerem que adultos submetidos a psicoterapia psicanalítica podem ter redução significativa dos sintomas causados pelos transtornos de ansiedade investigados em nosso estudo (transtorno de ansiedade generalizada, transtorno de ansiedade social, transtorno de pânico com ou sem agorafobia). No geral, também demonstrou ser uma intervenção tão eficaz quanto outros tratamentos ativos investigados.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Emergence of polymyxin B resistance in a polymyxin B-susceptible KPC-producing Klebsiella pneumoniae causing bloodstream infection in a neutropenic patient during polymyxin B therapy
    (Elsevier Science Inc, 2018) Zavascki, Alexandre P.; Girardello, Raquel [UNIFESP]; Magagnin, Cibele M.; Antochevis, Laura C.; Maciel, Rafael A.; Palmeiro, Jussara K. [UNIFESP]; Gales, Ana C. [UNIFESP]
    The emergence of resistance to polymyxins in KPC-producing Klebsiella pneumoniae isolates has been a major clinical problem. This study evaluated the molecular mechanisms associated with polymyxin B (PMB) resistance that emerged in a previously PMB-susceptible KPC-2-producing K. pneumoniae during PMB therapy for a bloodstream infection in a neutropenic patient. The first isolate (PMB-susceptible) was obtained while the patient was receiving meropenem and other isolates were recovered from 2 sets of blood cultures in different dates while the patient was receiving PMB therapy (4 of 6 blood cultures bottles yielded isolates with full PMB resistance). The population analysis profile of the first isolate revealed the growth of resistant subpopulations with PFGE profile distinct from the parental isolate but undistinguishable from those obtained in subsequent days under PMB exposure. Resistant subpopulations were obtained from all parental PMB-susceptible and in one PMB-resistant isolate recovered from the patient. The molecular mechanism observed in the hetero-resistant subpopulations (IS1-like in mgrB-promoter region, increased rstB transcription with no mutation and non-identified mechanism) differed from those found in the PMB-resistant isolates, in which no mutation or transcriptional alterations were detected. This study showed that the mechanism of resistance to PMB that emerged during PMB therapy was not related to those observed in subpopulations selected in vitro from PMB-susceptible isolates recovered from the patient. The absence of mutations in the former isolates may be due to adaptive resistance occurred because of sub-optimal PMB levels as well as amikacin and meropenem used in combination. (C) 2017 Elsevier Inc. All rights reserved.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Evaluation of antioxidant treatment in presbyacusis: prospective, placebo-controlled, double-blind, randomised trial
    (Cambridge Univ Press, 2013-02-01) Polanski, J. F. [UNIFESP]; Cruz, O. L. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objective: There are many well-known aetiological mechanisms of presbyacusis, and free radicals have been shown to play an important role. This study aimed to evaluate the effect of antioxidant agents on the hearing threshold of patients with presbyacusis.Methods: One hundred and twenty individuals were divided into four groups and received one of the following treatment schemes: ginkgo biloba dry extract, a-lipoic acid plus vitamin C, papaverine chlorhydrate plus vitamin E, or placebo. All participants were evaluated at recruitment and after six months, using pure tone audiometry (at isolated and average frequencies), speech recognition threshold and percentage index of speech recognition.Results: the various treatments had no effect on any of the evaluated measures of hearing, either between groups or over time.Conclusion: There was no statistically significant change in the hearing threshold after treatment with any of the tested drugs, during the study period.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    A evolução da insulinoterapia no diabetes melito tipo 1
    (Sociedade Brasileira de Endocrinologia e Metabologia, 2008-03-01) Pires, Antonio Carlos; Chacra, Antonio Roberto [UNIFESP]; Faculdade de Medicina de São José do Rio Preto; Universidade Federal de São Paulo (UNIFESP)
    The discovery of insulin can be considered the milestone of diabetes mellitus history and a great achievement for its treatment. The first insulin available was the regular. Afterwards, Hagedorn added the protamine to the insulin, thus, creating the NPH insulin. In the 1950s an insulin free of protamine was synthesized: the lente insulin. With the advent of molecular biology, synthetic human insulin was synthesized using recombinant DNA technology. Most recently several types of insulin analogues were available, providing the patients with better metabolic control. Type 1 diabetes mellitus treatment includes plain substitution and individualization for short-acting plus long-acting insulin according to the physician's assistance, besides regular practice of physical activities and diet orientations. In type 1 diabetes mellitus the insulin of low variability is the best choice since basal/bolus insulin therapy or continuous subcutaneous insulin infusion pump can mimetize the physiological release of insulin by beta cells.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Fisiopatologia da menopausa e o manejo terapêutico dos seus sintomas associados
    (Universidade Federal de São Paulo, 2023-06-26) Braz, Naomi Matsura [UNIFESP]; Telles, Monica Marques [UNIFESP]; http://lattes.cnpq.br/8143359335123923; http://lattes.cnpq.br/4202281074464071
    A menopausa, um processo fisiológico que marca o final da fase reprodutiva feminino. Sua ocorrência é determinada quando há pelo menos 12 meses seguidos de amenorreia decorrente da exaustão folicular completa, significando o fim da capacidade de reprodução da mulher. A transição entre a perimenopausa até a menopausa, pode durar meses ou até mesmo de 4 a 6 anos. Neste período, a mulher passa por diversas mudanças hormonais, como a diminuição dos níveis de estradiol e aumento de hormônio folículo estimulante (FSH), que levam à ocorrência de sintomas fisiológicos, principalmente suores noturnos e ondas de calor, alterações emocionais do tipo depressão e/ou ansiedade, sobrepeso/obesidade, entre outros. Tendo em vista os diferentes aspectos que podem afetar a qualidade de vida da mulher no período de transição perimenopausa, o presente estudo tem como objetivo abordar e revisar a literatura sobre as opções farmacológicas disponíveis para o manejo dos diversos sintomas associados ao processo fisiológico da menopausa.