Navegando por Palavras-chave "Sleep Apnea"
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- ItemSomente MetadadadosAngiotensin-Converting Enzyme Polymorphism and Erectile Dysfunction Complaints in the Brazilian Population(Wiley-Blackwell, 2010-08-01) Andersen, Monica L. [UNIFESP]; Guindalini, Camila [UNIFESP]; Santos-Silva, Rogerio [UNIFESP]; Bittencourt, Lia R. A. [UNIFESP]; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Introduction. Angiotensin-converting enzyme (ACE) is the major regulator of circulatory homeostasis. An insertion/deletion (I/D) polymorphism in the ACE gene has been associated with marked differences in serum ACE levels and with various cardiovascular diseases. Limited and conflicting data have been published on the influence of this genetic variant on the pathophysiology of erectile dysfunction (ED).Aim. To evaluate a potential association between ACE gene polymorphism and ED complaints in a population-based sample in So Paulo, Brazil.Main Outcome Measures. the prevalence of ED complaints was estimated according to previously validated 8 item questionnaire.Methods. A total of 449 men were enrolled in the Epidemiologic Sleep Study and answered an 8-item questionnaire to ascertain sexual performance/ED and satisfaction. ACE gene polymorphism were genotyped using a standard polymerase chain reaction method.Results. No significant case control difference was observed for the ACE gene I/D polymorphism either by genotype or allele-wise. Because age is a significant risk factor for ED complaints in our sample, we carried out analyses stratifying the sample by age group. the ID and II genotypes were significantly more frequent in ED complaint cases (88.9%) compared with controls (57.1%) in the men between 40 and 55 years of age. the frequency of the I allele NUS also significantly higher in individuals complaining of Ell (66.7%) compared with men with no complaints (39.0%) (odds ratio = 3.12; 95% confidence interval = 1.48-6.59). Correction for potential confounding variables, including genetic ancestry, did not affect the strength of the association.Conclusions. the findings of the present study suggest that the I/D polymorphism or another variant in close linkage disequilibrium with it may play a role in the development of ED in a specific age group and provides progress towards the understanding of the interaction between genetic factors and the risk of ED. Andersen ML, Guindalini C, Santos-Silva R, Bittencourt LRA, and Tufik S. Angiotensin converting enzyme polymorphism and erectile dysfunction complaints in the Brazilian population. J Sex Med 2010;7:2791-2797.
- ItemSomente MetadadadosApneia Do Sono Na Doença De Machado-Joseph: Avaliação Clínica E Polissonográfica(Universidade Federal de São Paulo (UNIFESP), 2018-02-22) Santos, Felipe Augusto Folha [UNIFESP]; Pedroso, Jose Luiz [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Introduction: Machado-Joseph Disease (Mjd) Or Spinocerebellar Ataxia Type 3 (Sca3) Is The Most Common Type Of Autosomal Dominant Spinocerebellar Ataxia (Acs). The Onset Of Symptoms Is Around The 3rd Or 4th Decade, Leading To Progressive Degeneration Of The Nervous System. The Disease Causes Diffuse Neurological Impairment And Affects The Cerebellum, Brainstem, Basal Ganglia, Spinal Cord, Peripheral Nerves, And The Clinical Spectrum Of Dmj Includes Varying Degrees Of Cerebellar Ataxia, Ophthalmoplegia, Nystagmus, And Pyramidal Signs. Sleep Disorders Have Been Described As Frequent Non-Motor Symptoms In Jdm And With Marked Impairment In Quality Of Life. However, Few Studies Have Evaluated The Frequency And Characteristics Of Sleep Apnea In Jdm.Methodology: This Study Analyzed The Prevalence Of Sleep Apnea In 47 Jdm Patients Using Polysomnography. Clinical Variables Such As Age, Duration Of Illness, Bmi, Severity Of Ataxia Scales And Cag Repeat Length Were Compared With The Polysomnographic Findings. Results: Pa
- ItemSomente MetadadadosAssociation Analysis of Endothelial Nitric Oxide Synthase G894T Gene Polymorphism and Erectile Dysfunction Complaints in a Population-Based Survey(Wiley-Blackwell, 2010-03-01) Andersen, Monica L. [UNIFESP]; Guindalini, Camila [UNIFESP]; Santos-Silva, Rogerio [UNIFESP]; Bittencourt, Lia Rita A. [UNIFESP]; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Introduction.Erectile dysfunction (ED) is a common disorder leading to a serious, negative impact on the quality of the patient's life. the gene encoding endothelial nitric oxide synthase (eNOS) is an interesting candidate gene for understanding the physiopathology of ED, as it is involved in the catalytic production of nitric oxide (NO), the neurotransmitter that plays a critical role in penile tumescence and erection.Aim.To evaluate a potential association between the G894T polymorphism in the eNOS gene and ED complaints in a population-based sample in São Paulo, Brazil.Main Outcome Measures.The prevalence of ED complaints was estimated according to the answer to the question How would you describe your ability to get and keep an erection that is adequate for satisfactory intercourse? ED was considered to be present if the response was sometimes or never.Methods.A total of 449 men were enrolled in the study and answered an eight-item questionnaire to ascertain sexual performance/ED and satisfaction. the eNOS G894T polymorphism was genotyped using a standard polymerase chain reaction method.Results.Univariate analysis demonstrated that ED was associated with diabetes, hypertension, sleep apnea severity, increasing age and body mass index, as well as testosterone levels (P < 0.05). Forward multiple regression models indicated that age was the only independent factor associated with ED in this population (odds ratio = 1.09; 95% CI 1.06-1.11; P < 0.0001). Genotypic and allelic analyses provided no evidence for an association between this polymorphism and the risk for ED complaints in this sample. Population stratification did not affect the association test results.Conclusions.This is the first study to examine the effect of polymorphisms in the eNOS gene and the risk for ED utilizing a case-control approach in the Brazilian population. Our results do not support a major role for eNOS gene polymorphisms in ED in this population. Andersen ML, Guindalini C, Santos-Silva R, Bittencourt LRA, and Tufik S. Association analysis of endothelial nitric oxide synthase G894T gene polymorphism and erectile dysfunction complaints in a population-based survey. J Sex Med 2010;7:1229-1236.
- ItemAcesso aberto (Open Access)Cognition and biomarkers of oxidative stress in obstructive sleep apnea(Faculdade de Medicina / USP, 2013-04-01) Sales, Leticia Viana; Bruin, Veralice Meireles Sales de [UNIFESP]; D'Almeida, Vânia [UNIFESP]; Pompéia, Sabine [UNIFESP]; Bueno, Orlando Francisco Amodeo [UNIFESP]; Tufik, Sergio [UNIFESP]; Bittencourt, Lia Rita Azeredo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Ceará (UFC) Faculdade de MedicinaOBJECTIVES: The aim of this study was to investigate neuropsychological performance and biomarkers of oxidative stress in patients with obstructive sleep apnea and the relationships between these factors. METHODS: This was an observational, cross-sectional study of 14 patients (36.0±6.5 years old) with obstructive sleep apnea and 13 controls (37.3±6.9 years old). All of the participants were clinically evaluated and underwent full-night polysomnography as well as neuropsychological tests. Blood samples were used to assay superoxide dismutase, catalase, glutathione and homocysteine, as well as vitamins E, C, B11 and B12. RESULTS: The patients performed poorly relative to the controls on several neuropsychological tests, such as the attention test and tests of long-term memory and working memory/executive function. They also had lower levels of vitamin E (p<0.006), superoxide dismutase (p<0.001) and vitamin B11 (p<0.001), as well as higher concentrations of homocysteine (p<0.02). Serum concentrations of vitamin C, catalase, glutathione and vitamin B12 were unaltered. Vitamin E levels were related to performance in the backward digit span task (F = 15.9; p = 0.002) and this correlation remained after controlling for age and body mass index (F = 6.3, p = 0.01). A relationship between superoxide dismutase concentrations and executive non-perseveration errors in the Wisconsin Card Sorting Test (F = 7.9; p = 0.01) was also observed. CONCLUSIONS: Decreased levels of antioxidants and lower performance on the neuropsychological tasks were observed in patients with obstructive sleep apnea. This study suggests that an imbalance between antioxidants and pro-oxidants may contribute to neuropsychological alterations in this patient population.
- ItemAcesso aberto (Open Access)Correlação entre queixas de sono e ingestão de vitamina D em idosos(Universidade Federal de São Paulo (UNIFESP), 2018-12-05) Barbosa, Renata Ferracioli [UNIFESP]; Antunes, Hanna Karen Moreira [UNIFESP]; Guerra, Ricardo Luís Fernandes [UNIFESP]; http://lattes.cnpq.br/3856113753837921; http://lattes.cnpq.br/1464519773053362; http://lattes.cnpq.br/7588574804840671; Universidade Federal de São Paulo (UNIFESP)Idosos possuem maior propensão ao desenvolvimento de carências nutricionais e à queixas de sono. No Brasil em torno de 30% a 50% da população em geral apresenta défict de vitamina D, embora exista luz solar durante grande parte do ano e diversos tipos de alimentos fonte. Alguns estudos têm associado a carência desta vitamina com apnéia obstrutiva do sono e sonolência diurna excessiva, comprometendo a qualidade de vida destes indivíduos. Ditos isso, o objetivo do presente estudo foi correlacionar a possível carência da vitamina D com queixas de sono em idosos acima de 60 anos. Participaram 50 voluntários de ambos os sexos com média ± desvio-padrão da idade, estatura, massa corporal e índice de massa corporal 70,82±8,40 anos, 1,60±0,09 m, 72,23±17,02 kg, e 28,06±5,34 kg/m2 respectivamente. Em um estudo transversal, os voluntários responderam a uma bateria de questionários que avaliaram o sono (Qualidade, sonolência e cronotipo), o nível de atividade física, uma bateria antropométrica e um questionário de frequência alimentar. Os dados foram analisados utilizando Teste T para amostras independentes com significância de p≤0,05. Os resultados revelaram que homens apresentaram maiores índices de sonolência diurna, enquanto as mulheres apresentaram piores índices na qualidade do sono e que não houve correlação entre queixas de sono e carência de vitamina D em idosos de ambos os sexos. Conclui-se, portanto, neste estudo que não houve correlação entre queixas de sono e carência de vitamina D em idosos.