Navegando por Palavras-chave "Seizure"

Agora exibindo 1 - 14 de 14
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Cardiorespiratory and electroencephalographic responses to exhaustive acute physical exercise in people with temporal lobe epilepsy
    (Elsevier B.V., 2010-11-01) Vancini, Rodrigo Luiz [UNIFESP]; Barbosa de Lira, Claudio Andre; Scorza, Fulvio Alexandre [UNIFESP]; Albuquerque, Manly de; Sousa, Bolivar Saldanha [UNIFESP]; Lima, Cristiano de [UNIFESP]; Cavalheiro, Esper Abrao [UNIFESP]; Silva, Antonio Carlos da [UNIFESP]; Arida, Ricardo Mario [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal de Goiás (UFG); UMC
    We evaluated physiological and electroencephalographic responses during a cardiopulmonary exercise test (CPET) in people with epilepsy. Behavioral outcomes of people with epilepsy were also compared with those of healthy controls. Thirty-eight subjects (19 people with epilepsy and 19 controls) participated in this study. Poor outcomes in the behavioral analyses (habitual level of physical activity and quality of life) were observed in the people with epilepsy. With respect to the CPET, VO(2max) (14.6%) and VO(2) at anaerobic threshold (16.1%) were significantly lower in the epilepsy group than in the control group. Although not statistically significant, a decrease in the number of epileptiform discharges was observed between the rest state and exercise (82%) and between the rest state and recovery period (74%). in conclusion, the lower aerobic fitness in people with epilepsy observed may be associated with their sedentary habits. Moreover, our findings reinforce the hypothesis that exhaustive exercise is not a seizure-inducing factor. (C) 2010 Elsevier Inc. All rights reserved.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Early physical exercise and seizure susceptibility later in life
    (Elsevier B.V., 2011-12-01) Silva, Sergio Gomes da [UNIFESP]; Almeida, Alexandre Aparecido de [UNIFESP]; Silva Araujo, Bruno Henrique [UNIFESP]; Scorza, Fulvio Alexandre [UNIFESP]; Cavalheiro, Esper Abrao [UNIFESP]; Arida, Ricardo Mario [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    We conducted a study to examine whether physical exercise undertaken during the period of postnatal brain development could modify seizure susceptibility later in life. Male Wistar rats aged 21 postnatal days (P21) were divided into two groups: exercise and control. Animals in the exercise group were submitted to daily exercise on the treadmill between P21 and P60. Running time and speed gradually increased over this period, reaching a maximum of 18 m/min for 60min. After the final exercise session (P60), animals from exercise group were maintained non-trained for 90 days. This period without stimulus was used to observe the influence of early physical exercise on susceptibility to seizures induced by the pilocarpine model of epilepsy at P150. the results showed that the exercise program undertaken during the period of postnatal brain development delayed the onset and reduced the intensity of pilocarpine-induced motor symptoms in midlife rats. These findings suggest that early exercise interferes positively in the later ictogenesis process, and support the hypothesis that physical activity in early life may build a neural reserve against brain disorders. (C) 2011 ISDN. Published by Elsevier B.V. All rights reserved.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Experimental and clinical findings from physical exercise as complementary therapy for epilepsy
    (Elsevier B.V., 2013-03-01) Arida, Ricardo Mario [UNIFESP]; Almeida, Antonio-Carlos Guimaraes de; Cavalheiro, Esper Abrão [UNIFESP]; Scorza, Fulvio Alexandre [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Fed Sao Joao del Rei
    Complementary therapies for preventing or treating epilepsy have been extensively used. This review focuses on the positive effects of physical exercise programs observed in clinical studies and experimental models of epilepsy and their significance as a complementary therapy for epilepsy. Information about the antiepileptogenic and neuroprotective effects of exercise is highlighted. Considering that exercise can exert beneficial actions such as reduction of seizure susceptibility, reduction of anxiety and depression, and consequently, improvement of quality of life of individuals with epilepsy, exercise can be a potential candidate as non-pharmacological treatment of epilepsy.This article is part of a Special Issue entitled the Future of Translational Epilepsy Research. (c) 2012 Elsevier Inc. All rights reserved.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Favorable effects of physical activity for recovery in temporal lobe epilepsy
    (Wiley-Blackwell, 2010-01-01) Arida, Ricardo Mario [UNIFESP]; Scorza, Fulvio Alexandre [UNIFESP]; Cavalheiro, Esper Abrao [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    P>Strategies that are efficacious for preventing or treating of epilepsy have been extensively used. This review discusses the positive effects of physical exercise program in experimental models of epilepsy, and considerations of the potential application of physical exercise strategy for preventing or treating temporal lobe epilepsy (TLE) are highlighted. Findings from animal studies indicate that exercise can modulate neuronal vulnerability to epileptic insults. Exercise treatment before a precipitating brain insult demonstrates a reduced brain susceptibility in the kindling or the pilocarpine model of epilepsy. in view of the beneficial effect of exercise during the epileptogenesis process, studies analyzed the influence of exercise after the development of chronic epilepsy. Behavioral analysis showed a reduced frequency of seizures during physical exercise program. Metabolic, electrophysiologic, and immunohistochemical studies have confirmed the positive influence of exercise on epilepsy. Taken into account that exercise can exert beneficial actions such as reduction of seizure susceptibility as observed in animal studies, and improvement of quality of life and reduction of anxiety and depression of individuals with epilepsy, physical exercise can be a potential candidate to be integrated with conventional therapy for epilepsy.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Fish oil attenuates methylmalonate-induced seizures
    (Elsevier B.V., 2013-07-01) Reschke Bandero, Cristina Ruedell; Salvadori, Mirian G. S. S.; Gomes, Anajara Teixeira; Dal Ri, Nadja M. K.; Furian, Ana Flavia; Oliveira, Mauro Schneider; Rambo, Leonardo Magno; Scorza, Fulvio A. [UNIFESP]; Cysneiros, Roberta M.; Emanuelli, Tatiana; Mello, Carlos Fernando; Universidade Federal de Sergipe (UFS); Universidade Federal de São Paulo (UNIFESP); Univ Presbiteriana Mackenzie
    Methylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurological dysfunction, including seizures. Dietary fatty acids are known as an important energy source and reduce seizure activity in selected acute animal models. This study investigated whether chronic treatment with fish oil or with oleic acid attenuates MMA-induced seizures and whether maintenance of Na+,K+-ATPase activity was involved in such an effect. Adult male Wistar rats were given fish oil (85 mg/kg), oleic acid (85 mg/kg) or vehicle (0.42% aqueous Cremophor EL (TM), 4 mL/kg/body weight/day), p.o., for 75 days. On the 73th day a cannula was implanted in the right lateral ventricle with electrodes over the parietal cortex for EEG recording. On the 76th day the animals were injected with NaCl (2.5 mu Lmol/2.5 mu L, i.c.v.), or with MMA (2.5 mu mol/2.5 mu L, i.c.v.), and seizure activity was measured by electroencephagraphic (EEG) recording with concomitant behavior monitoring. the effect of prostaglandin E-2 (PGE(2)) on Na+,K+-ATPase activity of slices of cerebral cortex from NaCl-injected animals was determined. Fish oil increased the latency to MMA-induced tonic-clonic seizures, reduced the mean amplitude of ictal EEG recordings, and prevented PGE(2)-induced decrease of Na+,K+-ATPase activity in cortical slices in vitro. Oleic acid decreased mean amplitude of ictal EEG recordings. the results support that fish oil decreases MMA-induced seizures. the decreased sensitivity of Na+,K+-ATPase to the inhibitory effect of PGE(2) in fish oil-treated animals may be related to the currently reported anticonvulsant activity. (C) 2013 Elsevier B.V. All rights reserved.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    From depressive symptoms to depression in people with epilepsy: Contribution of physical exercise to improve this picture
    (Elsevier B.V., 2012-03-01) Arida, Ricardo M. [UNIFESP]; Cavalheiro, Esper A. [UNIFESP]; Scorza, Fulvio A. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objectives: Epilepsy is a chronic condition that may be associated with several other diseases. Psychiatric comorbidities are highly prevalent and depression is the most common type of psychiatric comorbidity in people with epilepsy. the beneficial effects of exercise for people with epilepsy have been increasingly reported, including reduction of seizure susceptibility, improvement of quality of life and reduction of depression. in this regard, we propose in this article the potential role of physical exercise to minimize depression in people with epilepsy.Methods and results: We summarized the most relevant data on the complex relationship between neurotransmitters and epilepsy, depression, physical exercise and subsequently proposed how a regular program of exercise can regulate depression associated with epilepsy.Conclusions: the significance of such a relationship has a marked impact on the development and implementation of appropriate coadjutant treatments to improve functional outcomes and quality of life in people with epilepsy. (C) 2011 Elsevier B.V. All rights reserved.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Impairment of Sexual Function in Rats with Epilepsy
    (Wiley-Blackwell, 2012-09-01) Andersen, Monica L. [UNIFESP]; Alvarenga, Tathiana A. [UNIFESP]; Scorza, Fulvio A. [UNIFESP]; Matos, Gabriela [UNIFESP]; Sonoda, Eliza Y. [UNIFESP]; Hirotsu, Camila [UNIFESP]; Cavalheiro, Esper A. [UNIFESP]; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction. Epilepsy is a chronic disease that affects men and women of all ages, with different levels of severity. Many individuals with epilepsy also suffer from impairments in sexual function. However, it is difficult to differentiate between the impact of the disease and the impact of antiepileptic drugs on sexual function in human subjects. Aims. To evaluate sexual behavior in adult male rats submitted to chronic pilocarpine-induced epilepsy. Methods. First, non-epileptic rats were exposed to nine training sessions to acquire sexual experience, and their baseline sexual performance was evaluated. Then, the same rats were given pilocarpine to induce status epilepticus followed by chronic epilepsy. Once the animals had developed spontaneous recurrent seizures, their sexual behavior was evaluated during three sessions. Main Outcome Measures. Examine changes in latencies to first mount, intromission, and ejaculation, and the total number of mounts, intromissions, and ejaculations. Results. All outcome measures related to sexual motivation and sexual performance were markedly impaired during chronic epilepsy compared with the baseline and the control group. Conclusion. These findings will aid in understanding the interaction between sexual behavior and epilepsy, as well as encouraging further experimental studies in human patients with epilepsy suffering from sexual dysfunction. Andersen ML, Alvarenga TA, Scorza FA, Matos G, Sonoda EY, Hirotsu C, Cavalheiro EA, and Tufik S. Impairment of sexual function in rats with epilepsy. J Sex Med 2012;9:22662272.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Maximal electroshock-induced seizures are able to induce Homer1a mRNA expression but not pentylenetetrazole-induced seizures
    (Elsevier B.V., 2015-03-01) Cavarsan, Clarissa F. [UNIFESP]; Matsuo, Alisson [UNIFESP]; Blanco, Miriam M. [UNIFESP]; Mello, Luiz E. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objective: Homer1a is a protein that regulates metabotropic glutamate receptors involved in neural plasticity processes. Recently, we demonstrated that Homer1a mRNA is enhanced after pilocarpine-induced status epilepticus. Here, we investigated whether a single acute seizure triggered by means of pentylenetetrazole (PTZ) injection or maximal electroshock (MES) stimulation (2 different seizure models) would alter Homer1a expression in the hippocampus.Methods: Male Wistar rats subjected to the PTZ or MES model were analyzed 2 h, 8 h, 24 h, and 7 days after seizure induction. Homer1a, mGluR1, and mGluR5 mRNA expression levels in hippocampal extracts were analyzed by quantitative PCR.Results: Quantitative PCR revealed Homer1a overexpression at 2 h after MES-induced tonic-clonic seizures compared to control, but the overexpression did not remain elevated after 8 h. Pentylenetetrazole-induced seizures, in contrast, were not able to change Homer1a mRNA expression. No differences were observed at these time points after seizures for mGluR1 and mGluR5 mRNA expression in any of the models.Significance: Our data indicate that the levels of Homer1a mRNA were transiently increased only after MES induced tonic-clonic seizures (and not after PTZ-induced seizures). We suggest that Homer1a expression may be dependent on seizure intensity or on specific brain circuit activation. We suggest that Homer1a may contribute to counteract hyperexcitability processes. (C) 2015 Elsevier Inc. All rights reserved.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Neurocysticercosis: A natural human model of epileptogenesis
    (Wiley-Blackwell, 2015-02-01) Nash, Theodore E.; Mahanty, Siddhartha; Loeb, Jeffrey A.; Theodore, William H.; Friedman, Alon; Sander, Josemir W.; Singh, Gagandeep; Cavalheiro, Esper [UNIFESP]; Del Brutto, Oscar H.; Takayanagui, Osvaldo M.; Fleury, Agnes; Verastegui, Manuela; Preux, Pierre-Marie; Montano, Silvia; Pretell, E. Javier; White, A. Clinton; Gonzales, Armando E.; Gilman, Robert H.; Garcia, Hector H.; Natl Inst Allergy & Infect Dis; Univ Illinois; Natl Inst Neurol Disorders & Stroke; Ben Gurion Univ Negev; Dalhousie Univ; UCL Inst Neurol; Netherlands Fdn; Dept Neurol; Universidade Federal de São Paulo (UNIFESP); Univ Espiritu Santo; Universidade de São Paulo (USP); Natl Autonomous Univ Mexico & Natl Inst Neurol &; Univ Peruana Cayetano Heredia; Univ Limoges; US Naval Med Res Unit 6; Hosp Alberto Sabogal; Univ Texas; Natl Univ San Marcos; Johns Hopkins Bloomberg Sch Publ Hlth; Inst Neurol Dis
    ObjectiveTo develop a better understanding of mechanisms of seizures and long-term epileptogenesis using neurocysticercosis.MethodsA workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis.ResultsHuman neurocysticercosis and parallel animal models offer a unique opportunity to understand basic mechanisms of seizures. Inflammatory responses to degenerating forms and later-stage calcified parasite granulomas are associated with seizures and epilepsy. Other mechanisms may also be involved in epileptogenesis.SignificanceNaturally occurring brain infections with neurocysticercosis offer a unique opportunity to develop treatments for one of the world's most common causes of epilepsy and for the development of more general antiepileptogenic treatments. Key advantages stem from the time course in which an acute seizure heralds a start of the epileptogenic process, and radiographic changes of calcification and perilesional edema provide biomarkers of a chronic epileptic state.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    PDEI-5 for Erectile Dysfunction: A Potential Role in Seizure Susceptibility
    (Wiley-Blackwell, 2012-08-01) Matos, Gabriela [UNIFESP]; Scorza, Fulvio A. [UNIFESP]; Cavalheiro, Esper A. [UNIFESP]; Tufik, Sergio [UNIFESP]; Andersen, Monica L. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction. There is a high prevalence of erectile dysfunction (ED) in men with epilepsy; however, few studies have been conducted concerning the treatment of ED in this neurological group. Aim. the main purpose of this review is to highlight the influence of phosphodiesterase type 5 inhibitor (PDEI-5) for ED on seizure susceptibility. Methods. All available online articles with information pertaining to PDEI-5 and seizure susceptibility were included in this review. Main Outcome Measures. the main outcome assessed demonstrated the intriguing role of PDEI-5 and its metabolites on seizure susceptibility. Results. Case reports in men without epilepsy described seizure occurrence and electrophysiological changes following sildenafil, tadalafil, or vardenafil treatment. Consistent with these findings, preclinical studies suggested a proconvulsant effect of PDEI-5 on models of seizure induction. Conclusions. Evidence suggests an influence of PDEI-5 on seizure susceptibility in humans. in addition, preclinical studies have demonstrated the role of nitric oxide metabolites in the facilitation of paroxysmal phenomenon. Although there are many causes of seizures, medical professionals should be aware of the possible influence of PDEI-5 on seizure susceptibility. Further investigation by physicians and scientists is required to improve our understanding of this important topic. Matos G, Scorza FA, Cavalheiro EA, Tufik S, and Andersen ML. PDEI-5 for erectile dysfunction: A potential role in seizure susceptibility. J Sex Med 2012;9:21112121.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Physiological and electroencephalographic responses to acute exhaustive physical exercise in people with juvenile myoclonic epilepsy
    (Elsevier B.V., 2011-12-01) Lima, Cristiano de [UNIFESP]; Vancini, Rodrigo Luiz [UNIFESP]; Arida, Ricardo Mario [UNIFESP]; Guilhoto, Laura M. F. F. [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Barreto, Amaury Tavares [UNIFESP]; Bittar Guaranha, Mirian Salvadori [UNIFESP]; Targas Yacubian, Elza Marcia [UNIFESP]; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Although the available evidence suggests that exercise may positively affect epilepsy, whether this effect is applicable to different types of epilepsy has not been established. Physiological responses during rest, acute physical effort, and a recovery period were studied by concomitant analysis of cerebral electric activity using EEGs in subjects with juvenile myoclonic epilepsy (JME) and healthy controls. in addition, level of habitual physical activity, body composition, and 1 week of actigraphy monitoring data were evaluated. Twenty-four subjects (12 with JME and 12 controls) participated in this study. Compared with the control group, the JME group had a significantly lower (V) over dotO(2) at rest (13.3%) and resting metabolic rate (15.6%). the number of epileptiform discharges in the JME group was significantly reduced during the recovery period (72%) compared with the resting state. There were no significant differences between the JME and control groups in behavioral outcomes and sleep parameters evaluated by actigraphy monitoring. the positive findings of our study strengthen the evidence for the benefits of physical exercise for people with JME. (C) 2011 Published by Elsevier Inc.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    The potential role of physical exercise in the treatment of epilepsy
    (Elsevier B.V., 2010-04-01) Arida, Ricardo Mario [UNIFESP]; Scorza, Fulvio Alexandre [UNIFESP]; Silva, Sergio Gomes da [UNIFESP]; Schachter, Steven C.; Cavalheiro, Esper Abrao [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Harvard Univ
    The beneficial effects of exercise for people with epilepsy, including reduction of seizure susceptibility, improvement of quality of life, reduction of anxiety and depression, and better social integration, have increasingly been reported. We present data from human and animal studies supporting the role of exercise as a therapy for epilepsy complementary to standard treatments. (C) 2010 Elsevier Inc. All rights reserved.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Relationship between thresholds to convulsions induced by a benzodiazepine inverse agonist and [H-3]-L-glutamate binding in the membranes of brain regions
    (Springer, 2013-04-01) Contó, Marcos Brandão [UNIFESP]; Barbosa de Carvalho, Jose Gilberto [UNIFESP]; Venditti, Marco Antonio Campana [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Although some studies have investigated the influence of kindling model of epilepsy on the glutamatergic neurotransmission, the relation between glutamatergic receptors and seizure susceptibility remains unclear. the present study sought to determine if rats with high (HTR) and low (LTR) thresholds to clonic convulsions induced by the benzodiazepine inverse agonist DMCM differed in the [H-3]-l-glutamate binding to membranes from discrete brain regions. Compared to the HTR subgroup, the LTR subgroup presented a lower binding of [H-3]-l-glutamate in the hippocampus, frontal cortex and amygdala plus limbic cortex, suggesting that glutamatergic receptors in these brain regions may underlie the susceptibility to DMCM-induced convulsions.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    A strength exercise program in rats with epilepsy is protective against seizures
    (Elsevier B.V., 2012-11-01) Peixinho-Pena, Luiz Fernando [UNIFESP]; Fernandes, Jansen [UNIFESP]; Almeida, Alexandre Aparecido de [UNIFESP]; Gomes, Fabiano Guimaraes Novaes [UNIFESP]; Cassilhas, Ricardo Cardoso [UNIFESP]; Venancio, Daniel Paulino [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Scorza, Fulvio Alexandre [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Arida, Ricardo Mario [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The beneficial effects of physical exercise on epilepsy, such as a decreased seizure frequency, have been observed following aerobic exercise programs in both clinical and experimental studies. However, it is not well clarified whether other types of exercise, including strength exercise, can provide similar benefits for epilepsy. Forty four animals with epilepsy were continuously monitored 24 h a day for 60 days and divided into two periods of 30 days. the first period was used to determine the number of seizures before beginning the physical exercise program, and the second period was utilized to determine the number of seizures during the strength training. the mean frequency of seizures in the control and SHAM groups increased significantly from period 1 to period 2. Although the frequency of seizures did not change significantly between the two periods of 30 days of observation in the strength exercise group, a significant reduction in the seizure frequency was observed compared with the control and SHAM groups in period 2. Our study demonstrated that a strength exercise program exerted a significant influence on the seizure frequency in animals with epilepsy and strengthens the observed beneficial effect of exercise on epilepsy that has been demonstrated in animal studies. the finding of this nonclinical study can open a new window to verify the beneficial contribution of strength exercise in epilepsy. Further experimental and clinical investigations are necessary to explore the extent to which strength exercise interferes with the epileptic condition. (c) 2012 Elsevier Inc. All rights reserved.