Navegando por Palavras-chave "Sclerotherapy"
Agora exibindo 1 - 10 de 10
Resultados por página
Opções de Ordenação
- ItemEmbargoComparação da eficiência do laser de diodo 980 nm versus glicose a 75% na oclusão de veias da orelha de coelhos(Universidade Federal de São Paulo (UNIFESP), 2010-09-29) Lima, Paulo Roberto da Silva [UNIFESP]; Baptista-Silva, José Carlos Costa [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Contexto. Por ser o laser um método novo no tratamento das varizes, há muitos mitos e dúvidas com relação à sua eficácia; veio a necessidade de compará-lo às substâncias esclerosantes mais utilizadas em nosso meio. Assim, é relevante responder a pergunta de pesquisa: qual a eficiência do laser de diodo 980 nm em comparação à glicose 75% na oclusão de veias em orelha de coelho? Objetivo. Comparar a eficiência do laser de diodo 980 nm à glicose 75% na oclusão de veias em orelha de coelho. A hipótese é que o laser de diodo 980 nm tenha uma eficiência de 30% em relação à glicose 75%. Tipo de estudo. Ensaio aleatório em animais de laboratório por 21 dias. Local. Biotério do Laboratório de Tecnologia Farmacêutica (LTF) do Campus I da Universidade Federal da Paraíba, João Pessoa – PB. Amostra. Orelhas de coelhos machos. Procedimentos. Grupo L (LASER): 15 orelhas tratadas com laser e grupo G (glicose 75%): 15 orelhas tratadas com glicose 75%. Variáveis. Primárias: veias esclerosadas e/ou ocluídas. Secundárias: segurança. Complementares: volume da substância administrada, calibre e tamanho do vaso, peso e idade do coelho. Método estatístico. O tamanho da amostra foi estimado em 30 orelhas com base na literatura e para respeitar as normas da COBEA. A análise estatística será realizada com o teste exato de Fisher associado ao Risco Relativo (RR) e calculando o intervalo de confiança (IC) de 95% para cada ponto estimado Resultados. Característica da amostra. Congestão vascular no grupo G foi 87% (13/15, IC 95% 60 a 98) e no grupo L de 67% (10/15, IC 95% 38 a 88) com P = 0,3898 e RR de 1,30 (IC 95% 0,86 a 1,96). Hiperplasia intimal no grupo G foi 13% (2/15, IC 95% 2 a 40); e no grupo L 7% (1/14, IC 95% 0 a 32) com P = 1 e RR de 2,00 (IC 95% 0,20 a 19,79). Variáveis. A incidência de esclerose ou oclusão venosa foi no grupo G foi de 53% (8/15, IC 95% 27 a 79) e no grupo L 20% (3/15, IC 95% 4 a 49) com de P bicaudal foi de 0,1281, seu RR (risco relativo) usando a aproximação de Katz foi igual a 2,66 IC 95% 0,87 a 8,15 Conclusão. A eficiência do laser de diodo 980 nm em comparação à glicose 75% na oclusão de veias é a mesma.
- ItemAcesso aberto (Open Access)Efeito da espuma de polidocanol no parênquima pulmonar após administração em veia periférica de ratos(Universidade Federal de São Paulo (UNIFESP), 2016-04-29) Silva, Melissa Andreia de Moraes [UNIFESP]; Miranda Junior, Fausto [UNIFESP]; http://lattes.cnpq.br/0032704511396445; http://lattes.cnpq.br/6749209338440036; Universidade Federal de São Paulo (UNIFESP)Background: Sclerotherapy has been gaining increased acceptance and popularity as an effective therapy for the treatment of varicose veins. This attention has fed growing interest into the safety and potential complications of this procedure. There is no evidence of pulmonary complications from foam sclerotherapy in humans; however, animal studies have shown possible damage. Objective: The aim of this study is to show the changes in rat pulmonary parenchyma after the injection of 1% polidocanol foam into the peripheral vein using histological analysis of the inflammatory and fibrosis processes. Method: Twenty-four Wistar albino rats were divided into the following four groups: 24 h Polidocanol, 7 day Polidocanol, 28 day Polidocanol, and control. After foam was injected into the lateral saphenous vein, the lungs of the rats were removed for histological analysis. Results: Alveolar edema was observed in only the 24 h group (p <0.005). Vessel thickening was observed in the 7 and 28 day groups (p <0.001). Interstitial fibrosis was found in only the 28 day group (p=0.006). There was no evidence of venous or arterial thrombosis in either group. Conclusions: Polidocanol foam injection into rat peripheral veins causes alveolar edema, vessel thickening and interstitial fibrosis.
- ItemAcesso aberto (Open Access)Efeitos do etil-cianoacrilato na parede venosa, de cães(Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2002-02-01) Maia, Celso Costa [UNIFESP]; Cruz Filho, Milton [UNIFESP]; Abrahão, Silvio [UNIFESP]; Baptista-Silva, José Carlos Costa [UNIFESP]; Gomes, Paulo Oliveira [UNIFESP]; Soufen, Marco Antônio; Novo, Neil Ferreira [UNIFESP]; Juliano, Yara [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de Mogi das Cruzes; Faculdade de Medicina de Santo AmaroChemical drugs for vein sclerosis and / or obliteration has been used in esophagogastric varices endoscopic management, trying to treat and prevent digestive hemorrhage as an alternative for surgical treatment. The synthetic adhesive ethyl-cyanoacrylate showing fast polymerization, low cost, commercial availability and good fluidity for intravenous injection, was useful for that purpose. OBJECTIVE: To study the ethyl-cyanoacrylate effects on venous wall, in dogs. METHODS: The cephalic vein wall changes were evaluated in 42 male adults mongrel dogs, weighing 10-13 Kg, randomly distributed in three groups (group 1 = 7 days, group 2 = 14 days and group 3 = 21 days). Single punction and injection of 1 ml of ethyl-cyanoacrilate, and 7, 14 and 21 days later operative specimen excision, having inside the polymer. The non-injected contralateral vein remained as control. Histopathological parameters evaluated (hematoxylin-eosin) were: venous obliteration by adhesive polymerization, acute and chronic inflammatory process, venous wall lesion and granulation tissue degree. RESULTS: Statistical analysis showed lumen complete obliteration and venous wall lesion in all injected animals on 7, 14 and 21 days; prominent acute and chronic inflammation on 14 and 21 days and granulation tissue found only on 21 day. CONCLUSION: Complete obliteration and venous wall injury in all injected animals was shown on 7, 14 and 21 days. Prominent acute and chronic inflammation occurred after 14th day, and granulation tissue only after the 21st day.
- ItemAcesso aberto (Open Access)Efeitos do oleato de etanolamina na parede venosa, de cães(Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2002-09-01) Cruz Filho, Milton [UNIFESP]; Maia, Celso Costa [UNIFESP]; Abrahão, Silvio [UNIFESP]; Baptista-Silva, José Carlos Costa [UNIFESP]; Gomes, Paulo Oliveira [UNIFESP]; Soufen, Marco Antônio; Novo, Neil Ferreira [UNIFESP]; Juliano, Yara [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de Mogi das Cruzes (UMC) Curso de Medicina Disciplina de Patologia Geral; Faculdade de Medicina de Santo AmaroOBJECTIVE: Evaluate the ethanolamine oleate effects on venous dog wall. METHODS: The cephalic vein wall changes were evaluated in 39 male adults mongrel dogs, weighing 10-18 kg, randomly distributed in three groups (group 1 = 7 days, group 2 = 14 days and group 3, 21 days). Single punction and injection of 2 mL of 5 % ethanolamine oleate and 7, 14 and 21 days later operative specimen excision were compared to non-injected contralateral control vein. Histological parameters evaluated (hematoxylin-eosin and Masson's trichrome staining methods) were: venous thrombosis and organization, thrombus recanalization, media layer lesion and inflammatory process, outer wall inflammatory process, hemossiderin, sclerosant spillage outside the outer layer and hyaline amorphous material deposition. RESULTS: Venous thrombosis and thrombus organization were seen in all animals. Thrombus recanalization was not shown until 21 days. Media layer lesion occurred without inflammatory process. Outer wall inflammatory process was seen in all three time periods. Hemossiderin phagocytes occurred on 14th and 21st days. Sclerosant spillage outside the outer layer was seen only on the 7th day. Hyaline amorphous material deposition was seen only on the 21st day. CONCLUSIONS: Ethanolamin oleate in contact with the inner vein wall produced venous thrombosis, organized in all cases. During this study no significant recanalization was observed. Media layer vein lesion was seen in all animals without any correlate inflammatory reactive process. Reactive inflammatory process, hemossiderin phagocytosis, sclerosant spillage and hyaline amorphous material deposition was shown in the adventitia layer.
- ItemSomente MetadadadosEfetividade do 5-fluorouracil e da glicose hipertônica 75% na prevenção de seroma: estudo experimental em modelo animal.(Universidade Federal de São Paulo (UNIFESP), 2019-11-30) Cartaxo, Sidney Bandeira [UNIFESP]; Nahas, Fabio Xerfan [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Introduction: Seroma is a frequent complication that may evolve with compromised final outcome of the surgical procedure. Objective: To evaluate the effectiveness of 5-Fluorouracil and 75% hypertonic glucose in the prevention of seroma in an animal model. Method: primary, experimental, prospective, analytical, controlled, randomized study. 60 rats were mastectomized, with left lymphadenectomy and divided into three groups. Group I (Control) - (n = 20). Group II (Glucose) - (n = 20) received at the operative site one mL of 75% hypertonic glucose. Group III (5-FU) - (n = 20) received one mL of 5-FU at the operative site. The skin of the animals of the three groups was sutured with 4-0 black monofilament yarn (Procare®) with simple stitches. All groups of animals had clinical followup and physical examination to observe the appearance of seroma 24, 48, 72 hours, 7th and 12th postoperative day. Results: different percentages of seroma occurrence were observed over time for both Group I - Control (p = 0.041) and Group II - Glucose (p <0.001), unlike Group III - 5-FU for no differences were observed in the incidence of seroma over the evaluation moments (p = 0.627). In the histological analysis, Group III - 5-FU presented the lowest inflammatory process (23.8%), unlike Group II - Glucose which presented mild inflammatory process (66.7%) and Group I - Control presented the lowest inflammatory process. intense inflammatory process (61.1%). Conclusion: 5-FU was effective in preventing seroma formation in this animal experiment.
- ItemAcesso aberto (Open Access)Esclerose de pequenos vasos venosos com corrente elétrica galvânica ponteada, em orelhas de coelhos(Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2001-12-01) Santiago, Sergio [UNIFESP]; Taha, Murched Omar [UNIFESP]; Fagundes, Djalma José [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Telangiectases, in accordance with current concepts, must be treated in a surgical way. The most commons surgicals treatments included the electrosurgery, electocauterization and electrolysis. The injury to the peripherical dermal tissue was a problem as the insatisfactory results in the vessels scleroses. Therefore, the aim of this study was estimated the value of one electrical device planned with care and exactness to provide a galvanic electric sharp stream to be used in a animal model. Thus, 45 white New Zealand adults male rabbits received a electrical galvanic pulse(marginal vein of the right ear) or only the mechanical puncture(marginal vein of the left ear) in three consecutives times at first, second and third weeks. The animals of group I (n=15) received doses of 100m A, group II (n=15) doses of 200m A and group III(n=15) doses of 300m A. Fourteen days after the last application the redness, exudates and ulcers in skin was evaluate.Samples of the vessels and peripherical skin was prepared and stained with hematoxylin-eosin for leukocyte exudates and granulation tissue. Both, electric and mechanical treatment showed no statistical differences,actually the galvanic eletric sharp stream was ineffective to produce sclerosis in the vessels. Another survey, probably using an stronger eletric flow or different means of study, must be provide.
- ItemAcesso aberto (Open Access)High-resolution Manometry Findings in Patients After Sclerotherapy for Esophageal Varices(Korean Soc Neurogastroenterology & Motility, 2016) Herbella, Fernando Augusto Mardiros [UNIFESP]; Colleoni, Ramiro [UNIFESP]; Bot, Luiz [UNIFESP]; Vicentine, Fernando Pompeu Piza [UNIFESP]; Patti, Marco G.Background/Aims Endoscopic therapy for esophageal varices may lead to esophageal dysmotility. High-resolution manometry is probably the more adequate tool to measure esophageal motility in these patients. This study aimed to evaluate esophageal motility using high resolution manometry following eradication of esophageal varices by endoscopic sclerotherapy. Methods We studied 21 patients (11 women, age 52 [45-59] years). All patients underwent eradication of esophageal varices with endoscopic sclerotherapy and subsequent high resolution manometry. Results A significant percentage of defective lower esophageal sphincter (basal pressure 14.3 [8.0-20.0] mmHg
- ItemAcesso aberto (Open Access)Injeção percutânea de etanol no tratamento de nódulos tiroidianos sólidos, císticos e autônomos(Sociedade Brasileira de Endocrinologia e Metabologia, 2003-10-01) Bianchini, Elizabeth X. [UNIFESP]; Ikejiri, Elza S. [UNIFESP]; Mamone, Maria Conceição [UNIFESP]; Paiva, Elias R. [UNIFESP]; Maciel, Rui Monteiro de Barros [UNIFESP]; Furlanetto, Reinaldo P. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Percutaneous ethanol injection (PEI) guided by ultrasound has been used for the treatment of cystic, solid and autonomous thyroid nodules. We present our experience in the treatment of 50 patients with thyroid nodules: 26 solid, 17 cystic and 7 autonomous (AN). Patients were evaluated 1 week, 1, 3, and 6 months and 1 year after PEI. After one year, solid nodules showed a mean 74% volume reduction, and cysts a volume reduction of 92%, with no recurrences. After one year, 5 patients with AN reached clinical and laboratory euthyroidism; the other 2 also became euthyroid, but with subnormal TSH. Recurrence of thyrotoxicosis was not observed and mean nodular reduction was 66%. The procedure was well tolerated by all patients. The results confirm that PEI is a good therapeutic alternative for reduction of solid and cystic thyroid nodules and for the treatment of autonomous nodules.
- ItemSomente MetadadadosLigadura elástica ou escleroterapia para tratamento das varizes de esôfago: resultados de um estudo prospectivo, randomizado, duplo cego em pacientes portadores da forma hepatoesplênica da Esquistossomose Mansoni(Universidade Federal de São Paulo (UNIFESP), 1996) Siqueira, Eduardo Sampaio [UNIFESP]; Ferrari, Angelo Paulo [UNIFESP]
- ItemAcesso aberto (Open Access)Prospective study of bacteremia rate after elective band ligation and sclerotherapy with cyanoacrylate for esophageal varices in patients with advanced liver disease(Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED, 2011-12-01) Bonilha, Danielle Queiroz [UNIFESP]; Correia, Lucianna Motta [UNIFESP]; Monaghan, Marie; Lenz, Luciano [UNIFESP]; Santos, Marcus [UNIFESP]; Libera, Ermelindo Della [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); King's College London School of Medicine; Laboratório FleuryCONTEXT: Band ligation (BL) is the most appropriate endoscopic treatment for acute bleeding or prophylaxis of esophageal variceal bleeding. Sclerotherapy with N-butyl-2-cyanoacrylate (CY) can be an alternative for patients with advanced liver disease. Bacteremia is an infrequent complication after BL while the bacteremia rate following treatment with CY for esophageal varices remains unknown. OBJECTIVES: To evaluate and compare the incidence of transient bacteremia between cirrhotic patients submitted to diagnostic endoscopy, CY and BL for treatment of esophageal varices. METHODS: A prospective study comprising the period from 2004 to 2007 was conducted at Hospital of Universidade Federal de São Paulo (UNIFESP), UNIFESP, SP, Brazil. Cirrhotic patients with advanced liver disease (Child-Pugh B or C) were enrolled. The patients were divided into two groups according treatment: BL Group (patients undergoing band ligation, n = 20) and CY Group (patients receiving cyanoacrylate injection for esophageal variceal, n = 18). Cirrhotic patients with no esophageal varices or without indication for endoscopic treatment were recruited as control (diagnostic group n = 20). Bacteremia was evaluated by blood culture at baseline and 30 minutes after the procedure. RESULTS: After 137 scheduled endoscopic procedures, none of the 58 patients had fever or any sign suggestive of infection. All baseline cultures were negative. No positive cultures were observed after CY or in the control group - diagnostic endoscopy. Three (4.6 %) positive cultures were found out of the 65 sessions of band ligation (P = 0.187). Two of these samples were positive for coagulase-negative staphylococcus, which could be regarded as a contaminant. The isolated microorganism in the other case was Klebsiella oxytoca. The patient in this case presented no evidence of immunodeficiency except liver disease. CONCLUSIONS: There was no significant difference in bacteremia rate between these three groups. BL or CY injection for non-bleeding esophageal varices may be considered as low-risk procedures regarding bacteremia even when performed on patients with advanced liver disease.