Navegando por Palavras-chave "SPONDYLOARTHRITIS"

Agora exibindo 1 - 3 de 3
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Effect of Enthesitis on 1505 Brazilian Patients with Spondyloarthritis
    (J Rheumatol Publ Co, 2013-10-01) Carneiro, Sueli; Bortoluzzo, Adriana; Goncalves, Celio; Braga da Silva, Jose Antonio; Ximenes, Antonio C.; Bertolo, Manoel; Ribeiro, Sandra Lucia; Keiserman, Mauro; Skare, Thelma; Menin, Rita; Azevedo, Valderilio; Vieira, Walber; Albuquerque, Elisa; Bianchi, Washington; Bonfiglioli, Rubens; Campanholo, Cristiano; Carvalho, Hellen Mary de; Costa, Izaias da; Duarte, Angela; Kohem, Charles; Leite, Nocy; Lima, Sonia A. L.; Meirelles, Eduardo S.; Pereira, Ivanio A.; Pinheiro, Marcelo M. [UNIFESP]; Polito, Elizandra; Resende, Gustavo G.; Rocha, Francisco Airton C.; Santiago, Mittermayer B.; Sauma, Maria de Fatima L. C.; Valim, Valeria; Sampaio-Barros, Percival D.; Universidade Federal do Rio de Janeiro (UFRJ); Universidade do Estado do Rio de Janeiro (UERJ); Universidade de São Paulo (USP); Universidade de Brasília (UnB); Hosp Geral Goiania; Universidade Estadual de Campinas (UNICAMP); Univ Fed Amazonas; Pontificia Univ Catolica; Fac Med Sao Jose Rio Preto; Univ Fed Parana; Hosp Geral Fortaleza; Santa Casa Rio de Janeiro; Santa Casa São Paulo; Universidade Federal de Pernambuco (UFPE); Univ Fed Rio Grande do Sul; Universidade Federal de Santa Catarina (UFSC); Universidade Federal de São Paulo (UNIFESP); Santa Casa Belo Horizonte; Universidade Federal de Minas Gerais (UFMG); Fed Univ Para
    Objective. To analyze the clinical effect of enthesitis in a large Brazilian cohort of patients with spondyloarthritis (SpA).Methods. A common protocol of investigation was prospectively applied to 1505 patients with SpA in 29 centers in Brazil. Clinical and demographic variables and disease indexes were investigated. the Maastricht Ankylosing Spondylitis Enthesitis Score was used to investigate the enthesitis component. Ankylosing spondylitis was the most frequent disease in the group (65.4%). Others were psoriatic arthritis (18.4%), undifferentiated SpA (6.7%), reactive arthritis (3.3%), and enteropathic arthritis (3.2%).Results. At least 1 affected enthesis was observed in 54% of the patients with SpA, with a mean of 2.12 +/- 2.98 entheses affected. According to the clinical presentation, enthesitis was significantly more frequent in patients with axial + peripheral joint involvement compared to isolated axial or peripheral involvement (p < 0.001). There was a statistical association between the presence of enthesites and axial symptoms (buttock pain, cervical pain, and hip pain), and peripheral symptoms (lower limb arthritis, number of painful and swollen joints; p < 0.05). Patients with enthesitis also presented higher mean scores of Bath Ankylosing Spondylitis Functional Index (BASFI; p < 0.001), Bath Ankylosing Spondylitis Disease Activity Index (p < 0.001), and Ankylosing Spondylitis Quality of Life (ASQoL; p < 0.001). Multivariate logistic regression showed that BASFI (p < 0.0001; OR 74.839), ASQoL (p = 0.0001; OR 14.645), and Achilles tendonitis (p = 0.0059; OR 7.593) were associated with work incapacity.Conclusion. the clinical presence of enthesitis in this large cohort of patients with SpA was frequent and was associated with a significant increase in disease activity and decline in functional capacity and quality of life.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Ethnic Influence in Clinical and Functional Measures of Brazilian Patients with Spondyloarthritis
    (J Rheumatol Publ Co, 2012-01-01) Skare, Thelma L.; Bortoluzzo, Adriana B.; Goncalves, Celio R.; Braga da Silva, Jose Antonio; Ximenes, Antonio Carlos; Bertolo, Manoel B.; Ribeiro, Sandra L. E.; Keiserman, Mauro; Menin, Rita; Carneiro, Sueli; Azevedo, Valderilio F.; Vieira, Walber P.; Albuquerque, Elisa N.; Bianchi, Washington A.; Bonfiglioli, Rubens; Campanholo, Cristiano; Carvalho, Hellen M. S.; Costa, Izaias P.; Duarte, Angela P.; Gavi, Maria Bernadete O.; Kohem, Charles L.; Leite, Nocy H.; Lima, Sonia A. L.; Meirelles, Eduardo S.; Pereira, Ivanio A.; Pinheiro, Marcelo M. [UNIFESP]; Polito, Elizandra; Resende, Gustavo G.; Rocha, Francisco Airton C.; Santiago, Mittermayer B.; Sauma, Maria de Fatima L. C.; Sampaio-Barros, Percival D.; Universidade de São Paulo (USP); Hosp Evangel Curitiba; Insper Inst Educ & Res; Universidade de Brasília (UnB); Hosp Geral Goiania; Universidade Estadual de Campinas (UNICAMP); Univ Fed Amazonas; Pontificia Univ Catolica Porto Alegre; Universidade Federal do Rio de Janeiro (UFRJ); Universidade do Estado do Rio de Janeiro (UERJ); Univ Fed Parana; Hosp Geral Fortaleza; Santa Casa Rio de Janeiro; Pontificia Univ Catolica Campinas; Santa Casa São Paulo; Universidade Federal de Mato Grosso do Sul (UFMS); Universidade Federal de Pernambuco (UFPE); Univ Fed Espirito Santo; Univ Fed Rio Grande do Sul; Universidade Federal de Santa Catarina (UFSC); Universidade Federal de São Paulo (UNIFESP); Santa Casa Belo Horizonte; Universidade Federal de Minas Gerais (UFMG); Univ Fed Ceara; Escola Med & Saude Publ Salvador; Fed Univ Para
    Objective. Spondyloarthritides (SpA) can present different disease spectra according to ethnic background. the Brazilian Registry of Spondyloarthritis (RBE) is a nationwide registry that comprises a large databank on clinical, functional, and treatment data on Brazilian patients with SpA. the aim of our study was to analyze the influence of ethnic background in SpA disease patterns in a large series of Brazilian patients.Methods. A common protocol of investigation was prospectively applied to 1318 SpA patients in 29 centers distributed through the main geographical regions in Brazil. the group comprised whites (65%), African Brazilians (31.3%), and people of mixed origins (3.7%). Clinical and demographic variables and various disease index scores were compiled. Ankylosing spondylitis (AS) was the most frequent disease in the group (65.1%); others were psoriatic arthritis (18.3%), undifferentiated SpA (6.8%), enteropathic arthritis (3.7%), and reactive arthritis (3.4%).Results. White patients were significantly associated with psoriasis (p = 0.002), positive HLA-B27 (p = 0.014), and use of corticosteroids (p < 0.0001). Hip involvement (p = 0.02), axial inflammatory pain (p = 0.04), and radiographic sacroiliitis (p = 0.025) were associated with African Brazilian descent. Sex distribution, family history, and presence of peripheral arthritis, uveitis, dactylitis, urethritis, and inflammatory bowel disease were similar in the 3 groups, as well as age at disease onset, time from first symptom until diagnosis, and use of anti-tumor necrosis factor-a agents (p > 0.05). Schober test and thoracic expansion were similar in the 3 groups, whereas African Brazilians had higher Maastricht Ankylasing Spondylitis Enthesitis Scores (p = 0.005) and decreased lateral lumbar flexion (p = 0.003), while whites had a higher occiput-to-wall distance (p = 0.02). African Brazilians reported a worse patient global assessment of disease (p = 0.011). Other index scores and prevalence of work incapacity were similar in the 3 groups, although African Brazilians had worse performance in the Ankylosing Spondylitis Quality of Life questionnaire (p < 0.001).Conclusion. Ethnic background is associated with distinct clinical aspects of SpA in Brazilian patients. African Brazilian patients with SpA have a poorer quality of life and report worse disease compared to whites, (First Release Nov 1 2011; J Rheumatol 2012;39:141-7; doi:10.3899/jrheum.110372)
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Sacroiliac Joint Magnetic Resonance Imaging in Asymptomatic Patients with Recurrent Acute Anterior Uveitis: A Proof-of-concept Study
    (J Rheumatol Publ Co, 2017) Oliveira, Thauana L. [UNIFESP]; Maksymowych, Walter P.; Lambert, Robert G. W.; Muccioli, Cristina [UNIFESP]; Fernandes, Artur R. C. [UNIFESP]; Pinheiro, Marcelo M. [UNIFESP]
    Objective. Our aim was to quantify bone marrow edema (BME) and/or structural lesions in the sacroiliac joints (SIJ) of patients with recurrent acute anterior uveitis (rAAU) with or without back pain, to evaluate the frequency of axial (axSpA) and peripheral spondyloarthritis (pSpA) and to establish which criterion for magnetic resonance imaging (MRI) positivity best reflected the global assessment of SIJ MRI. Methods. A total of 50 patients with rAAU without prior rheumatologic diagnosis were included in our cross-sectional study, and these patients were compared to 21 healthy volunteers. SIJ MRI scans were read by 2 rheumatologists according to the Spondyloarthritis Research Consortium of Canada (SPARCC/MORPHO) protocol. Discrepant cases were adjudicated by a radiologist. Results. Patients with rAAU were diagnosed with axSpA (Group 1, n = 20, 40%) and nonspecific back pain (Group 2, n = 6, 12%), or as being asymptomatic (Group 3, n = 24, 48%). Group 3 results showed 9 patients (37.5%) had SIJ MRI and/or were radiography-positive for axSpA (5 MRI and radiograph, 1 MRI, 3 radiograph). SIJ MRI scans that were compatible with SpA in groups 1 (n = 12) and 3 (n = 6) were similar in acute and structural lesions that were analyzed according to SPARCC/MORPHO. The best sensitivity/specificity criterion for defining a positive global MRI assessment was a BME score = 3 (88%/94%). Conclusion. This is the first study evaluating SIJ MRI in patients with rAAU without back symptoms, showing positive findings for sacroiliitis. Moreover, a BME score >= 3 had better performance to define an SIJ MRI as positive for axSpA.