Navegando por Palavras-chave "Renal function"

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    Albuminuria, renal function and blood pressure in undernourished children and recovered from undernutrition
    (Springer, 2017) Martins, Vinicius J. B.; Sesso, Ricardo [UNIFESP]; Clemente, Ana P. G.; Fernandes, Mariana B. F. [UNIFESP]; Sawaya, Ana L. [UNIFESP]
    Background The objective of this study was to investigate some biomarkers of renal function and blood pressure in children who had recovered from undernutrition. Methods This was cross-sectional, comparative study in which a convenience sample of children of both genders (n = 126
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    Determination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levels
    (Associação Brasileira de Divulgação Científica, 2006-10-01) Chinen, Rogerio [UNIFESP]; Câmara, Niels Olsen Saraiva [UNIFESP]; Nishida, Sonia Kiyomi [UNIFESP]; Silva, Marcelo de Souza [UNIFESP]; Rodrigues, Dirceu Almeida [UNIFESP]; Pereira, Aparecido Bernardo [UNIFESP]; Pacheco-Silva, Alvaro [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Significant improvements have been noted in heart transplantation with the advent of cyclosporine. However, cyclosporine use is associated with significant side effects, such as chronic renal failure. We were interested in evaluating the incidence of long-term renal dysfunction in heart transplant recipients. Fifty-three heart transplant recipients were enrolled in the study. Forty-three patients completed the entire evaluation and follow-up. Glomerular (serum creatinine, creatinine clearance measured, and creatinine clearance calculated) and tubular functions (urinary retinol-binding protein, uRBP) were re-analyzed after 18 months. At the enrollment time, the prevalence of renal failure ranged from 37.7 to 54% according to criteria used to define it (serum creatinine> or = 1.5 mg/dL and creatinine clearance <60 mL/min). Mean serum creatinine was 1.61 ± 1.31 mg/dL (range 0.7 to 9.8 mg/dL) and calculated and measured creatinine clearances were 67.7 ± 25.9 and 61.18 ± 25.04 mL min-1 (1.73 m²)-1, respectively. Sixteen of the 43 patients who completed the follow-up (37.2%) had tubular dysfunction detected by increased levels of uRBP (median 1.06, 0.412-6.396 mg/dL). Eleven of the 16 patients (68.7%) with elevated uRBP had poorer renal function after 18 months of follow-up, compared with only eight of the 27 patients (29.6%) with normal uRBP (RR = 3.47, P = 0.0095). Interestingly, cyclosporine trough levels were not different between patients with or without tubular and glomerular dysfunction. Renal function impairment is common after heart transplantation. Tubular dysfunction, assessed by uRBP, correlates with a worsening of glomerular filtration and can be a useful tool for early detection of renal dysfunction.
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    Donor-Specific Anti-Human Leukocyte Antigens Antibodies, Acute Rejection, Renal Function, and Histology in Kidney Transplant Recipients Receiving Tacrolimus and Everolimus
    (Karger, 2017) Ferreira, Alexandra Nicolau [UNIFESP]; Felipe, Claudia Rosso [UNIFESP]; Cristelli, Marina Pontello [UNIFESP]; Viana, Laila [UNIFESP]; Basso, Geovana [UNIFESP]; Stopa, Suelen[UNIFESP]; Mansur, Juliana Busato [UNIFESP]; Paula, Mayara Ivani de [UNIFESP]; Bessa, Adrieli Barros [UNIFESP]; Ruiz, Priscila Ruppel [UNIFESP]; Aguiar, Wilson Ferreira [UNIFESP]; Campos, Erika Fernandes [UNIFESP]; Gerbase-Lima, Maria [UNIFESP]; Proença, Henrique [UNIFESP]; Tedesco-Silva, Helio [UNIFESP]; Pestana, Jose Osmar Medina [UNIFESP]
    Background: This analysis compared efficacy, renal function, and histology in kidney transplant recipients receiving tacrolimus (TAC) combined with everolimus (EVR) or mycophenolate (MPS). Methods: This was a retrospective analysis from a randomized trial in kidney transplant recipients who received a single 3 mg/kg dose of rabbit antithymocyte globulin (r-ATG), TAC, EVR, and prednisone (PRED
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    Efeito terapêutico das isoflavonas no metabolismo e na função renal em animais submetidos à dieta hiperlipídica rica em frutose
    (Universidade Federal de São Paulo (UNIFESP), 2017-07-31) Pessoa, Edson de Andrade [UNIFESP]; Borges, Fernanda Teixeira [UNIFESP]; http://lattes.cnpq.br/4206613998602417; http://lattes.cnpq.br/1831498061607525; Universidade Federal de São Paulo (UNIFESP)
    A obesidade é considerada uma epidemia mundial e um fator de risco para inúmeras patologias como diabetes, hipertensão e doença renal. A dieta hiperlipídica, rica em carboidratos, como a frutose, mimetiza muitas das alterações associadas a obesidade. O objetivo deste trabalho foi avaliar o efeito da dieta hiperlipídica rica em frutose sobre o metabolismo e função renal em ratos e elucidar o possível efeito terapêutico das isoflavonas nestas condições. Ratos Wistar foram divididos em: animais controle (CTL), submetidos a dieta controle por 120 dias (17,70% lipídios, 61,74% carboidratos e 20,56% proteína), animais submetidos a dieta hiperlipídica (DH) rica em frutose (68,27% lipídios, 16,41% de frutose e 15,32% proteína) durante 120 dias e grupo de animais submetidos a DH por 120 e nos últimos 60 dias tratados com isoflavonas (300 mg/kg, por gavage). A DH induziu aumento de consumo de calorias, no peso e acúmulo de gordura visceral. Causou aumento na glicemia, hemoglobina glicada, uricemia e promoveu resistência à insulina. Houve elevação no colesterol total, triglicérides, diminuição no HDL-C. Na função renal observamos aumento na creatinina e ureia plasmáticas, fração de excreção de sódio, proteinúria e diminuição no clearance de creatinina, associados ao aumento na marcação para KIM-1 tubular. Houve aumento na pressão arterial sistêmica, enquanto na hemodinâmica renal observamos diminuição no fluxo sanguíneo renal e aumento na resistência vascular renal. A DH induziu uma inflamação renal subclínica com aumento no TNFα, IL1-β e IL-6 e infiltração de macrófagos. Estes efeitos foram mediados pelo estresse oxidativo (aumento na peroxidação lipídica) e nitrosilativo (aumento no NO) renal. As isoflavonas reverteu praticamente todas estas alterações sem interferir no consumo de calorias, principalmente via efeitos antioxidantes e anti-inflamatórios. As isoflavonas pode ser uma opção terapêutica no tratamento ou prevenção das alterações metabólicas e renais associadas a obesidade.
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    Efeitos da suplementação de vitamina D sobre a pressão arterial, metabolismo glicídico, responsividade vascular e função renal de ratos espontaneamente hipertensos submetidos à dieta hiperlipídica palatável
    (Universidade Federal de São Paulo (UNIFESP), 2016-10-31) Geraldini, Simone [UNIFESP]; Cesaretti, Mario Luis Ribeiro [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Background: Vitamin D insufficiency has been associated with several diseases such as obesity, diabetes mellitus and hypertension. However, the cause-effect relationship of vitamin D supplementation on dysfunctions and abnormalities of metabolic syndrome has not been clearly elucidated. Objective: Analyze the effects of cholecalciferol supplementation on blood pressure, glucose metabolism, body weight, renal function and vascular relaxation in spontaneously hypertensive rats (SHR), with palatable hyperlipidic diet (PHD)-fed. Methods: Male 12-weeks-old SHR rats were divided into four groups: control SHR (SHR-C), SHR+PHD (SHR-OB), SHR+vit.D (SHR-VD), SHR+PHD+vit.D (SHR-OBVD). Cholecalciferol supplementation was performed by gavage (1000 UI/kg/daily), and the animals were treated for 12 weeks. Weekly, body weight and tail blood pressure (TAP) were measured. At the end of 12 weeks, Oral Glucose Tolerance Test (GTT) and Insulin Tolerance Test (ITT) were performed. Proteinuria was determined in the baseline and the end period, 25-hidroxivitamina D serum and clearance of creatinine were determined in the end of treatment. The vascular endothelium-dependent function was evaluated in isolated rings of the thoracic aortas, also the relative visceral fat weight was performed. Results: The SHR-OB group presented lower body weight gain compared to the SHR-C and SHR-OBVD groups (p=0,02). However, both treated groups with PHD showed higher epididimal fat than the groups standard rat chow-fed (p<0,001). The vitamin D was not able to reduce final TAP as well as shift maximal responses of endothelium-dependent vascular relaxation. Besides, vitamin D treatment attenuated insulin resistance only on SHR-VD group, in the same way decreased the proteinuria only in this group (p=0,001). Conclusion: An oral supplementation of vitamin D can be an adequate strategy for delay the development of glucose metabolism dysfunctions in metabolic syndrome when associated with a balanced diet, avoiding therefore the loss of renal function.
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    Efeitos do exercício físico na qualidade de vida e nas alterações fisiológicas de pacientes com doença renal crônica avançada
    (Universidade Federal de São Paulo (UNIFESP), 2017-12-13) Araújo, Cássio Luis da Silva [UNIFESP]; Medeiros, Alessandra [UNIFESP]; http://lattes.cnpq.br/0071198026371230; http://lattes.cnpq.br/2924040906282549; Universidade Federal de São Paulo (UNIFESP)
    Introdução: A doença renal crônica (DRC) é definida pela perda lenta, gradual e irreversível da função renal. Atualmente essa doença é considerada como um problema de saúde pública devido suas elevadas taxas de morbi/mortalidade tendo impacto negativo na qualidade de vida (QV). Um planejamento de exercícios é essencial nesses pacientes, já que os mesmos se apresentam em acentuada redução da capacidade funcional e física. Objetivos: Realizar uma revisão de literatura sobre os efeitos do exercício físico na qualidade de vida e nas alterações fisiológicas de pacientes com DRC avançada. Materiais e métodos: Foram realizadas buscas nas bases LILACS, SCIELO e PUBMED, a partir das seguintes palavras-chave: treinamento físico; atividade física; função renal; dialise; qualidade de vida, encontrados a partir dos Descritores em Ciências da Saúde (DeCS) e Medical Subject Headings (MeSH), sendo selecionados artigos (ensaios clínicos controlados randomizados, experimentais e revisão de literatura) nos idiomas português, inglês e espanhol, publicados entre 1997 e 2016. Resultados: Foram localizados 84 artigos, sendo 37 da base de dados PUBMED, 14 LILACS e 33 da base SCIELO. Desses artigos encontrados, 68 observaram melhora da qualidade de vida e apenas 2 não encontraram alteração da capacidade funcional e qualidade de vida dos pacientes que foram submetidos ao programa de exercício. O principal método utilizado para avaliar a qualidade de vida foi o questionário SF-36. Conclusão: Por meio de programas de exercícios físicos pode-se ter melhoras na capacidade funcional dos indivíduos com DRC. Esses exercícios exercem efeitos benéficos sobre pacientes também em hemodiálise, contudo, deve-se considerar que a DRC, desempenha amplo impacto na QV, ocasionando inúmeras alterações e constantes desafios na vida diária desses doentes. É importante ressaltar que a melhora da QV é meta comum, e que refletir sobre estas práticas com objetivo de melhorá-las é um dos caminhos para a qualidade da assistência e um objetivo a ser alcançado.
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    Effect of an isotonic rehydration sports drink and exercise on urolithiasis in rats
    (Associação Brasileira de Divulgação Científica, 2005-04-01) Abreu, Nayda Parisio de [UNIFESP]; Bergamaschi, Cassia Toledo [UNIFESP]; Di Marco, Giovana Seno [UNIFESP]; Razvickas, Clara Versolato [UNIFESP]; Schor, Nestor [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The objective of the present study was to evaluate the role of physical exercise as well as the influence of hydration with an isotonic sports drink on renal function in male Wistar rats. Four groups were studied over a period of 42 days: 1) control (N = 9); 2) physical exercise (Exe, N = 7); 3) isotonic drink (Drink, N = 8); 4) physical exercise + isotonic drink (Exe + Drink, N = 8). Physical exercise consisted of running on a motor-driven treadmill for 1 h/day, at 20 m/min, 5 days a week. The isotonic sports drink was a commercial solution used by athletes for rehydration after physical activity, 2 ml administered by gavage twice a day. Urine cultures were performed in all animals. Twenty-four-hour urine samples were collected in metabolic cages at the beginning and at the end of the protocol period. Urinary and plasma parameters (sodium, potassium, urea, creatinine, calcium) did not differ among groups. However, an amorphous material was observed in the bladders of animals in the Exe + Drink and Drink groups. Characterization of the material by Western blot revealed the presence of Tamm-Horsfall protein and angiotensin converting enzyme. Physical exercise and the isotonic drink did not change the plasma or urinary parameters measured. However, the isotonic drink induced the formation of intravesical matrix, suggesting a potential lithogenic risk.
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    Effect of D-alpha-tocopherol on tubular nephron acidification by rats with induced diabetes mellitus
    (Associação Brasileira de Divulgação Científica, 2005-07-01) Gomes, G. Nascimento [UNIFESP]; Barbosa, F.t. [UNIFESP]; Radaeli, R.f. [UNIFESP]; Cavanal, Maria de Fátima [UNIFESP]; Aires, M. Mello; Gil, Frida Zaladek [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    The objective of the present study was to determine if treatment of diabetic rats with D-alpha-tocopherol could prevent the changes in glomerular and tubular function commonly observed in this disease. Sixty male Wistar rats divided into four groups were studied: control (C), control treated with D-alpha-tocopherol (C + T), diabetic (D), and diabetic treated with D-alpha-tocopherol (D + T). Treatment with D-alpha-tocopherol (40 mg/kg every other day, ip) was started three days after diabetes induction with streptozotocin (60 mg/kg, ip). Renal function studies and microperfusion measurements were performed 30 days after diabetes induction and the kidneys were removed for morphometric analyses. Data are reported as means ± SEM. Glomerular filtration rate increased in D rats but decreased in D + T rats (C: 6.43 ± 0.21; D: 7.74 ± 0.45; D + T: 3.86 ± 0.18 ml min-1 kg-1). Alterations of tubular acidification observed in bicarbonate absorption flux (JHCO3) and in acidification half-time (t/2) in group D were reversed in group D + T (JHCO3, C: 2.30 ± 0.10; D: 3.28 ± 0.22; D + T: 1.87 ± 0.08 nmol cm-2 s-1; t/2, C: 4.75 ± 0.20; D: 3.52 ± 0.15; D + T: 5.92 ± 0.19 s). Glomerular area was significantly increased in D, while D + T rats exhibited values similar to C, suggesting that the vitamin prevented the hypertrophic effect of hyperglycemia (C: 8334.21 ± 112.05; D: 10,217.55 ± 100.66; D + T: 8478.21 ± 119.81µm²). These results suggest that D-alpha-tocopherol is able to protect rats, at least in part, from the harmful effects of diabetes on renal function.
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    Evaluation of the Antihypertensive Properties of Yellow Passion Fruit Pulp (Passiflora edulis Sims f. flavicarpa Deg.) in Spontaneously Hypertensive Rats
    (Wiley-Blackwell, 2014-01-01) Konta, Eliziane Mieko; Almeida, Mara Ribeiro; Amaral, Catia Lira do; Castania Darin, Joana Darc; Rosso, Veridiana Vera de [UNIFESP]; Mercadante, Adriana Zerlotti; Greggi Antunes, Lusania Maria; Pires Bianchi, Maria Lourdes; Univ Estadual Paulista UNESP; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Universidade Estadual de Campinas (UNICAMP)
    Various species of the genus Passiflora have been extensively used in traditional medicine as sedatives, anxiolytics, diuretics and analgesics. in the present study, after the identification and quantification of phytochemical compounds from yellow passion fruit pulp by liquid chromatography-photodiode array-mass spectrometry (HPLC-PDA-MS/MS), its antihypertensive effect was investigated on spontaneously hypertensive rats. Additionally, the renal function, evaluated by kidney/body weight, serum creatinine, proteinuria, urinary flow, reduced glutathione (GSH) levels and thiobarbituric acid-reactive substances (TBARS) and mutagenicity in bone marrow cells were assessed to evaluate the safety of passion fruit consumption. Yellow passion fruit pulp (5, 6 or 8g/kg b.w.) was administered by gavage once a day for 5 consecutive days. HLPC-PDA-MS/MS analysis revealed that yellow passion fruit pulp contains phenolic compounds, ascorbic acid, carotenoids and flavonoids. the highest dose of passion fruit pulp significantly reduced the systolic blood pressure, increased the GSH levels and decreased TBARS. There were no changes in renal function parameters or the frequency of micronuclei in bone marrow cells. in conclusion, the antihypertensive effect of yellow passion fruit pulp, at least in part, might be due to the enhancement of the antioxidant status. the exact mechanisms responsible by this effect need further investigation. Copyright (c) 2013 John Wiley & Sons, Ltd.
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    Heme oxygenase 1 improves glucoses metabolism and kidney histological alterations in diabetic rats
    (Biomed Central Ltd, 2013-01-16) Ptilovanciv, Ellen O. N. [UNIFESP]; Fernandes, Gabryelle S. [UNIFESP]; Teixeira, Luciana C. [UNIFESP]; Reis, Luciana A. [UNIFESP]; Pessoa, Edson A. [UNIFESP]; Convento, Marcia B. [UNIFESP]; Simoes, Manuel J. [UNIFESP]; Albertoni, Guilherme A. [UNIFESP]; Schor, Nestor [UNIFESP]; Borges, Fernanda T. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    One important concern in the treatment of diabetes is the maintenance of glycemic levels and the prevention of diabetic nephropathy. Inducible heme oxygenase 1 (HO-1) is a rate-limiting enzyme thought to have antioxidant and cytoprotective roles. the goal of the present study was to analyze the effect of HO-1 induction in chronically hyperglycemic rats. the hyperglycemic rats were divided into two groups: one group, called STZ, was given a single injection of streptozotocin; and the other group was given a single streptozotocin injection as well as daily injections of hemin, an HO-1 inducer, over 60 days (STZ + HEME). A group of normoglycemic, untreated rats was used as the control (CTL).Body weight, diuresis, serum glucose levels, microalbuminuria, creatinine clearance rate, urea levels, sodium excretion, and lipid peroxidation were analyzed. Histological alterations and immunohistochemistry for HO-1 and inducible nitric oxide synthase (iNOS) were assessed. After 60 days, the STZ group exhibited an increase in blood glucose, diuresis, urea, microalbuminuria, and sodium excretion. There was no weight gain, and there was a decrease in creatinine clearance in comparison to the CTL group. in the STZ + HEME group there was an improvement in the metabolic parameters and kidney function, a decrease in blood glucose, serum urea, and microalbuminuria, and an increase of creatinine clearance, in comparison to the STZ group.There was glomerulosclerosis, collagen deposition in the STZ rats and increase in iNOS and HO-1 expression. in the STZ + HEME group, the glomerulosclerosis and fibrosis was prevented and there was an increase in the expression of HO-1, but decrease in iNOS expression and lipid peroxidation. in conclusion, our data suggest that chronic induction of HO-1 reduces hyperglycemia, improves glucose metabolism and, at least in part, protects the renal tissue from hyperglycemic injury, possibly through the antioxidant activity of HO-1.
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    Impact of Radial and Partial Nephrectomy on Rental Function in Patients with Renal Cancer
    (Karger, 2014-01-01) Krebs, Rodrigo Ketzer [UNIFESP]; Andreoni, Cássio [UNIFESP]; Ortiz, Valdemar [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objective: To evaluate renal function in renal cancer patients undergoing radical nephrectomy (RN) or partial nephrectomy (PN) (open or laparoscopic ORN, OPN, LRN or LPN) and to identify risk factors contributing to renal function loss. Methods: We analysed 228 consecutive renal cancer patients admitted for OPN, LPN, ORN or LRN. the variables analysed were age, gender, weight, type of surgery (radical versus partial), type of surgical access (open versus laparoscopic), preoperative renal function and history of hypertension, diabetes or malignancy. Absolute renal function was calculated as the difference in glomerular filtration rate (AGFR) between the renal function before (GFR(0)) and 12 months after surgery (GFR(12)). the relative renal function of patients undergoing PN and RN was evaluated by the change in chronic kidney disease stage. Results: LRN caused the greatest loss in absolute renal function, followed by ORN, LPN and OPN. A GFR of >= 60 ml/min was noted for 90(68.7%) patients before and 65 (49.6%) patients after RN and for 80 (82.5%) patients before and 74 (76.3%) patients after PN. the chronic kidney disease stage dropped to 4 or 5 in the case preoperative weight and type of surgery (radical versus partial) had a significant impact on renal function. Conclusion: Renal function significantly decreased in patients undergoing RN, irrespective of the access route. Patients With preoperative poor renal function are at risk of postoperative end-stage renal disease. (c) 2014 S. Karger AG, Basel
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    Nitric oxide (NO) is associated with gentamicin (GENTA) nephrotoxicity and the renal function recovery after suspension of GENTA treatment in rats
    (Elsevier B.V., 2011-03-15) Christo, Joelma Santina [UNIFESP]; Rodrigues, Adelson Marçal [UNIFESP]; Mouro, Margaret Gori [UNIFESP]; Cenedeze, Marcos Antonio [UNIFESP]; Simoes, Manuel de Jesus [UNIFESP]; Schor, Nestor [UNIFESP]; Suemitsu Higa, Elisa Mieko [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    GENTA nephrotoxicity is likely to be caused, among other factors, by an increase of vasoconstrictors or a decrease of vasodilators such as NO. Few days after discontinuing GENTA treatment, the renal function is recovered, but if risk factors like advanced age, previous renal dysfunction, simultaneous use of other nephrotoxic drugs or dehydration are present, severe and progressive renal disease occurs. the aim of this study was to evaluate the renal function in rats during GENTA treatment and after its suspension as well as its relationship with NO. Rats were treated with water (vehicle, CTL) or GENTA (100 mg/kg BW) intraperitonially during 10 days; both n = 24. Twelve animals of each group were sacrificed after blood and 24 h urine were collected, and their kidneys were removed for histology. in another rats this procedure underwent after 20 or 30 days of GENTA suspension. GENTA treated group developed a marked decrease in renal function, characterized by an increased serum urea and decreased creatinine clearance; NO was increased in the serum and decreased in the urine; all P < 0.01 vs CTL. Acute tubular necrosis was confirmed in GENTA treated group. After GENTA suspension we observed a normalization of urea, creatinine clearance and serum and urinary NO; the histological lesions were also attenuated. We suggest that NO could play a role in GENTA induced nephrotoxicity and recovery. the understanding of this physiopathology could be an useful tool to prevent or blunt the nephrotoxicity progression, mainly when risk factors are present. (C) 2010 Elsevier Inc. All rights reserved.