Navegando por Palavras-chave "Reference values"
Agora exibindo 1 - 20 de 25
Resultados por página
Opções de Ordenação
- ItemAcesso aberto (Open Access)Age norms for monocular grating acuity measured by sweep-VEP in the first three years of age(Conselho Brasileiro de Oftalmologia, 2008-08-01) Salomão, Solange Rios [UNIFESP]; Ejzenbaum, Fábio [UNIFESP]; Berezovsky, Adriana [UNIFESP]; Sacai, Paula Yuri [UNIFESP]; Pereira, Josenilson Martins [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)PURPOSE: To determine age norms for grating visual acuity and interocular acuity differences measured by the sweep-visually evoked potentials (VEP) technique in the first three years of life. METHODS: Monocular grating visual acuity was measured using the sweep-VEP in 67 healthy normal infants and children in the first 36 months of life. RESULTS: Sweep-VEP grating acuity ranged from 0.80 logMAR (20/125 Snellen equivalent) in the first month of life to 0.06 logMAR (20/20 Snellen equivalent) at 36 months of age. Lower normal limits (95th percentile limit) ranged from 0.95 logMAR (20/180) to 0.12 logMAR (20/25) with a progression of approximately 3 octaves in the first 36 months of age. The largest acceptable interocular acuity difference for clinical purposes was 0.10 logMAR. CONCLUSIONS: Age norms for grating acuity along with interocular acuity differences were determined using the sweep-VEP technique. These norms should be incorporated in clinical practice for precise diagnosis of visual status in infants and preverbal children.
- ItemAcesso aberto (Open Access)Avaliação do comprimento e área do corpo caloso fetal por meio da ultrassonografia tridimensional(Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2010-12-01) Visentainer, Milena [UNIFESP]; Araujo Júnior, Edward [UNIFESP]; Rolo, Liliam Cristine [UNIFESP]; Nardozza, Luciano Marcondes Machado [UNIFESP]; Moron, Antonio Fernandes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)PURPOSE: to establish reference values for the length and area of the fetal corpus callosum between the 20th and 33rd weeks of gestation using three-dimensional ultrasound (3DUS). METHODS: this cross-sectional study involved 70 normal pregnancies with gestational age between 20 and 33 weeks. An Accuvix XQ instrument with a convex volumetric transducer (3 to 5 MHz) was used. To assess the corpus callosum, a transfrontal plane was obtained using the metopic suture as an acoustic window. Length was obtained by measuring the distance between the proximal and distal extremities of the corpus callosum. Area was obtained by manual tracing of the external corpus callosum surface. The means, medians, standard deviations, and maximum and minimum values were calculated for the corpus callosum length and area. Scatter graphs were created to analyze the correlation between corpus callosum length and area and gestational age and biparietal diameter, the quality adjustments was verified according to the determination coefficient (R²). The intraclass correlation coefficient (ICC) was used to assess the intraobserver variability. RESULTS: mean corpus callosum length increased from 21.7 (18.6 - 25.2 mm) to 38.7 mm (32.6 - 43.3 mm) between 20 and 33 weeks of pregnancy, respectively. Mean corpus callosum area increased from 55.2 (41.0 - 80.0 mm²) to 142.2 mm² (114.0 - 160.0 mm²), between 20 to 33 weeks of pregnancy, respectively. There was a strong correlation between corpus callosum length and area and gestational age (R² = 0.7 and 0.7, respectively) and biparietal diameter (R² = 0.7 and 0.6, respectively). Intraobserver variability was appropriate, with an ICC of 0.9 and 0.9 for length and area, respectively. CONCLUSIONS: reference values for corpus callosum length and area were established for fetuses between 20 and 33 weeks gestation. Intraobserver variability was appropriate.
- ItemAcesso aberto (Open Access)Avaliação dos valores séricos de troponina I cardíaca em crianças menores de 1 ano de idade(Sociedade Brasileira de Cirurgia Cardiovascular, 2008-09-01) Souto, Antonio Carlos Arruda [UNIFESP]; Carvalho, Werther Brunow de [UNIFESP]; Hospital Padre Albino UTI pediátrica; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: The objective is to verify the cardiac troponin I values in children less than 1 year of age without clinical cardiac dysfunction. METHODS: The cardiac troponin I values were determined in 99 children less than 1 year of age, including term infants without diseases related to cardiac dysfunction using the specific kit Opus T Troponin I (cTn) (Dade Behring Inc. -Newalk, DE 19714, USA). RESULTS: All children have values of cardiac troponin I less than 0.1 ng/ml. CONCLUSION: We verified that the cardiac troponin I value is less than 0.1 ng/ml in children less than 1 year, including term infants without cardiac dysfunction, when analized by the kit Opus T Troponin I (cTn) test modules.
- ItemAcesso aberto (Open Access)Cálcio ionizado no soro: estimativa do intervalo de referência e condições de coleta(Sociedade Brasileira de Patologia ClínicaSociedade Brasileira de PatologiaSociedade Brasileira de Citopatologia, 2004-04-01) Andriolo, Adagmar [UNIFESP]; Moreira, Silvia Regina; Silva, Luciene Alves; Carvalho, Aluizio Barbosa de [UNIFESP]; Vieira, José Gilberto H. [UNIFESP]; Ghiringhello, Maria Teresa; Juliano, Yara; Universidade Federal de São Paulo (UNIFESP); Centro de Medicina DiagnósticaINTRODUCTION: The ionized serum calcium determination has become frequent replacing the total calcium with advantages: it is the physiologically active fraction, and the availability of robust methodology with favorable cost/benefice ratio. The use of this methodology implies in reference interval estimation. OBJECTIVE: To estimate the reference interval for serum ionized calcium, and to evaluate interferences in tourniquet time application, and interferences in sample refrigeration before analysis. MATERIAL AND METHOD: to estimate the reference interval we included the results of 11,320 consecutive calcium ionized determinations accomplished from January 2000 to November 2002; in order to evaluate the effect of sample refrigeration, 16 samples were collected in duplicate, so that one tube was placed in ice bath and the other was maintained in room temperature. To evaluate the effect of tourniquet application time, we collected blood samples from one arm of 6 normal subjects, immediately after, and from the other arm, after 3 minutes of the tourniquet application. The blood was collected in evacuated tubes with gel separator and centrifuged up to 30 minutes after collection. All determinations were performed up to 4 hours after the centrifugation by ion-selective electrode. RESULTS: regarding to the central 95% data distribution, the inferior and superior limits were, respectively, 1.11 (confidence interval of 90%: 1.1 to 1.11) and 1.4mmol/l (confidence interval of 90%: 1.39 to 1.41). No significant differences were detected between results with and without refrigeration and between samples with less than 1 and after 3 minutes of tourniquet application.
- ItemAcesso aberto (Open Access)Comparação das equações de valores de referência da função pulmonar mais utilizadas no Brasil: impacto no estadiamento da DPOC(Universidade Federal de São Paulo (UNIFESP), 2010-06-30) Pereira, Marcella Cristiane Silveira [UNIFESP]; Jardim, José Roberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: To compare the absolute values of FVC and FEV1 found in a random sample of a Brazilian population over 40 years of age with values of equations most used in Brazil. To compare the values in percentage of predicted of FVC and FEV1 of the selected equations with the PLATINO equation ones. To evaluate the change in COPD staying when using different reference equations. Material and Methods: We conducted a retrospective study from a representative sample of residents in the metropolitan region of Sao Paulo, aged .40 years, from the PLATINO study. For comparison of the FVC and FEV1, were subtracted from the predicted values of each equation the absolute values obtained from each individual, considering the equation inadequate wherever there was a difference of up to 0.15 L as defined by ATS. We also evaluated the difference between the values of FVC and VEF1 in percentage of predicted of the equations with the PLATINO equation, considering as a limit a difference .3% (ATS). The diagnosis of COPD was defined as FEV1/FVC <0.70 after bronchodilator, and the comparison of staging was performed using the FEB1 in percentage of predicted in each equation, with reference to the percentage expected from the PLATINO equation. T-student test, chi-squared and the intraclass correlation coefficient were used to evaluate the performance of FVC and FEV1 in different equations and data are presented as mean, standard deviation, standard error and confidence interval of 95%. Results: After evaluating 178 healthy subjects, we observed that the equations that show less difference between the predicted value and the absolute value for both FEV1 and FVC in both sexes were Roca et al., Pereira et al. 2006, Enright et al. and PLATINO. The Knudson et al. equation underestimated the absolute values for both FVC and FEV1. In comparison with PLATINO equation, the percentage of predicted for FVC and FEV1, the equation showing the lowest difference was NHANES III, except for FVC male, who showed a wide variability. We evaluated 152 patients with COPD, observing staging changes in 29.6% in relation to the difference equations, being Knudson et al. the equation that showed the greatest number of changes. Conclusion: There is a great variability among the reference equations. The equations showing less variability and better intraclass correlation coefficient were Roca et al., Caucasian NHANES III et al., Enright et al. and PLATINO, which are the ones that should be recommended to be used for the Brazilian population. There is a change in the COPD staging when different equations are applied, suggesting that the use of a single equation for the treatment of the patient would avoid possible alterations in treatment.
- ItemAcesso aberto (Open Access)Comparison between reference values for FVC, FEV1, and FEV1/FVC ratio in White adults in Brazil and those suggested by the Global Lung Function Initiative 2012(Sociedade Brasileira de Pneumologia e Tisiologia, 2014-08-01) Pereira, Carlos Alberto de Castro [UNIFESP]; Duarte, Andrezza Araujo Oliveira; Gimenez, Andrea; Soares, Maria Raquel; Universidade Federal de São Paulo (UNIFESP); Federal University of Campina Grande; Centro Diagnóstico BrasilOBJECTIVE:To evaluate the spirometry values predicted by the 2012 Global Lung Function Initiative (GLI) equations, which are recommended for international use, in comparison with those obtained for a sample of White adults used for the establishment of reference equations for spirometry in Brazil.METHODS:The sample comprised 270 and 373 healthy males and females, respectively. The mean differences between the values found in this sample and the predicted values calculated from the GLI equations for FVC, FEV1, and VEF1/FVC, as well as their lower limits, were compared by paired t-test. The predicted values by each pair of equations were compared in various combinations of age and height.RESULTS:For the males in our study sample, the values obtained for all of the variables studied were significantly higher than those predicted by the GLI equations (p < 0.01 for all). These differences become more evident in subjects who were shorter in stature and older. For the females in our study sample, only the lower limit of the FEV1/FVC ratio was significantly higher than that predicted by the GLI equation.CONCLUSIONS:The predicted values suggested by the GLI equations for White adults were significantly lower than those used as reference values for males in Brazil. For both genders, the lower limit of the FEV1/FVC ratio is significantly lower than that predicted by the GLI equations.
- ItemAcesso aberto (Open Access)Desenvolvimento das fissuras cerebrais fetais: avaliação com ultrassonografia tridimensional(Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2011-03-01) Alves, Cynthia Maria Soares [UNIFESP]; Araujo Júnior, Edward [UNIFESP]; Nardozza, Luciano Marcondes Machado [UNIFESP]; Oliveira, Patrícia Soares de [UNIFESP]; Goldman, Suzan Menasce [UNIFESP]; Ajzen, Sergio Aron [UNIFESP]; Moron, Antonio Fernandes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)PURPOSE: to assess the distance of the fetal cerebral fissures from the inner edge of the skull by three-dimensional ultrasonography (3DUS). METHODS: this cross-sectional study included 80 women with normal pregnancies between 21st and 34th weeks. The distances between the Sylvian, parieto-occiptal, hippocampus and calcarine fissures and the internal surface of the fetal skull were measured. For the evaluation of the distance of the first three fissures, an axial three-dimensional scan was obtained (at the level of the lateral ventricles). To obtain the calcarine fissure measurement, a coronal scan was used (at the level of the occipital lobes). First degree regressions were performed to assess the correlation between fissure measurements and gestational age, using the determination coefficient (R²) for adjustment. The 5th, 50th and 95th percentiles were calculated for each fissure measurement. Pearson's correlation coefficient (r) was used to assess the correlation between fissure measurements and the biparietal diameter (BPD) and head circumference (HC). RESULTS: all fissure measurements were linearly correlated with gestational age (Sylvian: R²=0.5; parieto-occiptal: R²= 0.7; hippocampus: R²= 0.3 and calcarine: R²= 0.3). Mean fissure measurement ranged from 7.0 to 14.0 mm, 15.9 to 28.7 mm, 15.4 to 25.4 mm and 15.7 to 24.8 mm for the Sylvian, parieto-occiptal, hippocampus and calcarine fissures, respectively. The Sylvian and parieto-occiptal fissure measurements had the highest correlations with the BPD (r=0.8 and 0.7, respectively) and HC (r=0.7 and 0.8, respectively). CONCLUSION: the distance from the fetal cerebral fissures to the inner edge of the skull measured by 3DUS was positively correlated with gestational age.
- ItemAcesso aberto (Open Access)Eletrorretinografia focal em adultos jovens normais(Conselho Brasileiro de Oftalmologia, 2005-12-01) Punaro, Elizabete [UNIFESP]; Berezovsky, Adriana [UNIFESP]; Salomão, Solange Rios [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)PURPOSE: To determine normative values for focal electroretinography in normal young adults, according to the standard protocol recommended by the International Society for Clinical Electrophysiology of Vision - IsCEV. METHODS: 33 normal volunteers aged from 14 to 38 years (mean 22.96±5.73) were included in this study. Focal electroretinography was recorded by corneal electrode after white flicker light stimulation in the macula at high temporal frequencies -42Hz and 31.25Hz. Focal electroretinography parameters as amplitude (nanovolts) and latency (milliseconds) were extracted and analyzed after discrete Fourier transformation. Median, values below 95% and above 95%; maximum; minimum and percentiles were calculated for both parameters; a t test was calculated between amplitudes and latencies for both frequencies. RESULTS: For 42Hz. Amplitude: median 614nV; below 95% 529nV; above 95% 650nV; minimum 370 nV; maximum 794 nV; 2.5th percentile 378.8nV; 97.5th percentile 779.6nV. Latency: median 26.4ms; below 95% 25.4ms; above 95% 26.8ms; minimum 23.4ms; maximum 28.2ms; 2.5th percentile 23.8ms; 97.5th percentile 27.88ms. For 31.25Hz. Amplitude: median 632nV; below 95% 429nV; above 95% 750nV; minimum 364nV; maximum 1036nV; 2.5th percentile 364.8nV; 97.5th percentile 1018.4nV. Latency: median 30.1ms; below 95% 29.3ms; above 95% 31.2ms; minimum 25.9ms; maximum 33.9ms; 2.5th percentile 27.18ms; 97.5th percentile 33.34ms. CONCLUSIONS: Normal limits for focal electroretinography according to the International Society for Clinical Electrophysiology of Vision, guidelines were established in a cohort of young adults. Comparable amplitude values were found for both 42 Hz and 31.25 Hz temporal frequencies. However, latencies was significantly faster for 42 Hz stimuli.
- ItemSomente MetadadadosEquação de referência para o incremental shuttle walk test em crianças e adolescentes saudáveis(Universidade Federal de São Paulo (UNIFESP), 2018-07-03) Toledo Filho, Marcos de [UNIFESP]; Vidotto, Milena Carlos [UNIFESP]; http://lattes.cnpq.br/0334734747375995; http://lattes.cnpq.br/0697850987655003; Universidade Federal de São Paulo (UNIFESP)Introduction: The Incremental Shuttle Walk Test (Iswt) Is Widely Used To Evaluate The Functional Capacity Of Patients With Chronic Diseases. This Test Shows Excellent Correlation With The Gold Standard Assessment Of Exercise Capacity, Besides Being Affordable And Most Representative Of The Activities Of Daily Living. Few Studies Used Iswt To Evaluate The Functional Capacity Of Children And Adolescents And There Is Currently No Reference Value For This Population Using The Original Test Protocol. Objective: Develop A Reference Equation For Iswt Based On Demographic And Anthropometric Variables For Healthy Children And Adolescents. Methodology: A Survey Composed Of 161 Individuals Aged 6 To 18 Years (96 Female). The Volunteers Underwent Two Iswt To Determine The Variables That Influence The Walked Distance. The Longest Walked Distance In Both Tests Was Analyzed. Results: The Data From 109 Subjects (59 Girls) Were Analyzed To Develop The Reference Equation. There Was No Significant Difference Between Individuals
- ItemAcesso aberto (Open Access)Equações de referência para a predição das principais relações fisiológicas submáximas em adultos submetidos ao teste de exercício cardiopulmonar incremental em esteira rolante(Universidade Federal de São Paulo, 2021-02-26) Gonze, Bárbara de Barros [UNIFESP]; Dourado, Victor Zuniga [UNIFESP]; Ostolin, Thatiane Lopes Valentim Di Paschoale [UNIFESP]; http://lattes.cnpq.br/4675570734968007; http://lattes.cnpq.br/1919368500743497; http://lattes.cnpq.br/2303420787732563INTRODUÇÃO: O Teste de Exercício Cardiopulmonar (TECP) é amplamente utilizado na prática clínica para identificar tolerância ao exercício e seus fatores limitantes. As respostas obtidas no pico do exercício são utilizadas para expressar a aptidão cardiorrespiratória deadultos. Apesar da importância dos valores de pico, a interpretação e o valor prognóstico do TECP podem ser aprimorados por meio da análise das relações submáximas de variáveis-chave, como eficiência cardiovascular (ΔFC/ΔVO2, eficiência ventilatória (∆VE/∆ VCO2), padrão ventilatório (∆VC/∆lnVE) e eficiência do consumo de oxigênio (OUES). Além da inclinação dessas relações, seus interceptos em y também foram identificados, mais recentemente, como clinicamente importantes. Embora valores de referência dessas variáveis no TECP realizado em cicloergômetro já existam, sob nosso conhecimento, tais informações não estão disponíveis em esteira rolante. OBJETIVO: Propor valores e equações de referência para a predição das principais relações fisiológicas submáximas dinâmicas em adultos submetidos ao teste de exercício cardiopulmonar incremental em esteira rolante. MÉTODOS: Submetemos 1.517 indivíduos adultos (60% mulheres) ao TECP realizado em esteira rolante, sob protocolo de rampa. Indivíduos com distúrbios cardiopulmonares ou eletrocardiográficos foram excluídos da amostra final (n=1.295). Dados demográficos, antropométricos e fatores de risco cardiovascular (RCV) foram obtidos. Elaboramos equações de regressão múltipla linear do tipo enter, para a predição das respostas fisiológicas submáximas, considerarando idade, sexo, massa corporal, estatura e inatividade física como potenciais preditores. RESULTADOS: Idade, sexo, massa corporal, estatura e inatividade física explicaram entre 2,9 e 57% da variabilidade total das variáveis estudadas. Estes preditores influenciaram 33, 47 e 57% da variabilidade do padrão respiratório, eficiência cardiovascular e OUES, respectivamente. Por outro lado, apresentaram influência limitada para eficiência ventilatória (6,4%) e para os interceptos em y. CONCLUSÃO: Eficiência cardiovascular e OUES, bem como padrão ventilatório durante o esforço, podem ser adequadamente preditos por variáveis demográficas, antropométricas e RCV.
- ItemAcesso aberto (Open Access)Equações de referência para o teste de caminhada de seis minutos em indivíduos saudáveis(Sociedade Brasileira de Cardiologia - SBC, 2011-06-01) Dourado, Victor Zuniga [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The six-minute walk test (6MWT) has been broadly used in clinical settings. Several reference equations for prediction of the total distance walked during the test (6MWD) are available in literature. The present review aimed to critically discuss studies, published in Portuguese and English (LILACS, SCIELO, MEDLINE, PUBMED), which evaluated normal values and created reference equations for predicting 6MWD in healthy subjects, comparing them with the results that were recently obtained in Brazilian individuals. Age, sex, weight, height and body mass index were the main demographic and anthropometric features more often correlated with 6MWD. The equations derived from these characteristics were able to explain between 25 and 66% of the total variability in the 6MWD. Unfortunately, the foreign equations were not applicable to the Brazilian population. Even when the 6MWT was performed following strict standardization, the difference in 6MWT performance between foreign and Brazilian individuals remains, indicating the necessity of providing specific reference equations for each population and/or ethnic group. Accordingly, these equations developed in Brazil are probably the most appropriate for interpreting 6MWT performance in Brazilian patients with chronic diseases affecting the exercise capacity. Future studies are necessary with larger sample sizes (e.g. multicentric ones) and randomized design for the reference values of the 6MWD to be considered reliable.
- ItemAcesso aberto (Open Access)Estudo normativo do eletrorretinograma de campo total em adultos jovens(Conselho Brasileiro de Oftalmologia, 2003-01-01) Pereira, Josenilson Martins [UNIFESP]; Mendieta, Luana [UNIFESP]; Sacai, Paula Yuri [UNIFESP]; Salomão, Solange Rios [UNIFESP]; Berezovsky, Adriana [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)PURPOSE: To determine normative data for full-field electroretinogram (ERG) in a healthy young adult group, according to the guidelines of a standard protocol recommended by the International Society for Clinical Electrophysiology of Vision (ISCEV). METHODS: A group of 42 healthy normal volunteers aged from 15 to 26 years (mean=20.8 ± 2.9 years) was recruited. Full-field electroretinogram (ERG) was recorded using a bipolar contact lens electrode according to the International Society for Clinical Electrophysiology of Vision standard protocol, including the following responses: a) scotopic rod response; b) scotopic maximal response; c) scotopic response for oscillatory potentials; d) photopic single-flash cone response and e) photopic 30 Hz flicker for cone response. RESULTS: Mean (± 1 SD) peak-to-peak amplitude was 241.1 ± 66.9 µV for rod response; 385.4 ± 71.8 µV for maximal response; 180.6 ± 48.6 µV for oscillatory potentials; 102.6 ± 36.3 µV for single-flash cone response and 69.2 ± 26.6 µV for light adapted 30 Hz flicker response. Mean b-wave implicit time was 85.2 ± 7.6 ms for rod response; 45.6 ± 2.0 ms for maximal response; 27.8 ± 1.2 ms for single-flash cone response and 27.9 ± 1.2 ms for 30 Hz flicker response. Comparable values were obtained from males and females, but the scotopic maximal response of females showed statistically larger amplitudes (t=2.06; P=0.04). CONCLUSIONS: The results obtained in this study are comparable to those previously reported in the literature and will be helpful to evaluate patients with several retinal disorders. Inclusion of other age groups will provide extended normative data.
- ItemAcesso aberto (Open Access)Estudo normativo do eletrorretinograma por padrões (PERG) em adultos(Conselho Brasileiro de Oftalmologia, 2010-06-01) Alves, Letícia Dourado [UNIFESP]; Berezovsky, Adriana [UNIFESP]; Sacai, Paula Yuri [UNIFESP]; Pereira, Josenilson Martins [UNIFESP]; Salomão, Solange Rios [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Purpose: To determine normative values for pattern-reversal electroretinogram (PERG) in healthy adult volunteers according to the standard protocol recommended by the International Society for Clinical Electrophysiology of Vision-ISCEV. Methods: Participants were 30 healthy volunteers (15 males) with ages from 18 to 61 years (mean= 30.8 ± 8.7 yrs.; median= 29.5 yrs). Inclusion criteria were: visual acuity of 0.0 logMAR (20/20 Snellen) in each eye, absence of visual complaints, absence of media opacities, negative history for ocular or neurological diseases, negative family history for ocular and informed consent. PERG was recorded from each eye in a darkened room at 1 m from a high resolution display monitor. Stimuli were monochromatic checkerboards subtending 60, 15 e 7.5 minutes of visual angle reversing at 1.9 Hz. Responses were obtained from modified disposable fiber electrodes developed at UNIFESP. Latency (ms) for N35, P50 and N95 components as well as peak-to-peak amplitudes (µV) for N35-P50 and P50-N95 were determined. For normative values only one randomly chosen eye was included. Normal limits were calculated as 97.5% percentiles for latency and 2.5% percentile for amplitudes for each stimulus size. Results: Normal limits for N35, P50 and N95 latencies for 60', 15' and 7.5' stimuli were respectively: N35 - 40.1; 39.9 and 41.3 ms; P50 - 60.5; 64.4 and 65.6 ms and N95 - 103.4; 104.6 and 104.6 ms. For amplitude the normative values for N35-P50 and P50-N95 for 60', 15' and 7.5' were respectively: N35-P50 - 1.7; 1.6 and 0.9 µV; P50-N95 - 3.8; 2.8 and 1.5 µV. No gender differences were found either for latency or for amplitude in the three stimulus sizes. There was no correlation between PERG latency and amplitude with age, except for P50 amplitude for stimulus 15'(r=0.39; P=0.035). Conclusions: Normative values were determined for PERG parameters of amplitude and latency for three stimulus sizes. These parameters are important for evaluating the normal functioning of retinal ganglion cells and the macula. The normative values obtained in this study are comparable to previous studies in the literature.
- ItemSomente MetadadadosThe Incremental Shuttle Walk Test in Older Brazilian Adults(Karger, 2011-01-01) Jürgensen, Soraia Pilon [UNIFESP]; Antunes, Letícia Cláudia de Oliveira; Tanni, Suzana Erico; Banov, Marcos Carraro; Lucheta, Paulo Adolfo; Bucceroni, Alessandra Freire; Godoy, Irma; Dourado, Victor Zuniga [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)Background: Despite widespread use of the incremental shuttle walk distance (ISWD), there are no reference equations for predicting it. Objectives: We aimed to evaluate ISWD in healthy subjects and to establish a reference equation for its prediction. Methods: 131 Brazilian individuals (61 males; 59 +/- 10 years) performed 2 walk tests in a 10-m long corridor. We assessed height, weight, body mass index, forced expiratory volume in 1 s, forced vital capacity and self-reported physical activity. Results: Mean ISWD was greater in males than in females (606 +/- 167 vs. 443 +/- 117 m; p < 0.001). ISWD correlated significantly (p < 0.05) with age (r = -0.51), height (r = 0.54) and weight (r = 0.20). A predictive model including age, height, weight and gender explained 50.3% of the ISWD variance. in an additional group of 20 subjects prospectively studied, the difference between measured and predicted ISWD was not statistically significant (534 +/- 84 vs. 552 +/- 87 m, respectively), representing 97 +/- 12% of the predicted value calculated with our reference equation for ISWD. Conclusions: This reference equation including demographic and anthropomorphic attributes could be useful for interpreting the walking performance of patients with chronic diseases that affect exercise capacity. Copyright (C) 2010 S. Karger AG, Basel
- ItemAcesso aberto (Open Access)Learning effect of standard automated perimetry in healthy individuals(Conselho Brasileiro de Oftalmologia, 2008-08-01) Castro, Dinorah Piacentini Engel [UNIFESP]; Kawase, Juliana [UNIFESP]; Melo Jr., Luiz Alberto Soares [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)PURPOSE: To evaluate the learning effect in standard automated perimetry using SITA strategy, central 24-2 program, possible associated factors and spatial distribution in individuals with no perimetry experience. METHODS: A total of 55 healthy subjects were submitted to Humphrey perimetry in two different sessions in one day. Reliability and global indices, and threshold sensitivity at each point were compared between the two examinations. The influence of potential factors (age, gender, and educational level) and the spatial distribution were evaluated regarding alterations between these two examinations. RESULTS: The duration of the test was longer in the first session (median, 5.7 min; interquartile range [IQR], 1.7 min) than in the second (median, 5.3; IQR, 1.1 min) (p=0.002). The median (IQR) of false negative errors was 2% (6%) in the first examination and 0% (6%) in the second (p=0.04). The mean (standard deviation) in the mean deviation (MD) global index was -2.31 (1.86) dB in the first examination and -1.73 (1.69) dB in the second (p=0.07). No association was observed between the change in MD and age (p=0.29), gender (p=0.69) and educational level (p=0.27). The changes in threshold sensitivity were greater at the peripheral points than at the central points (p<0.001). CONCLUSION: The threshold sensitivity increased in the second examination compared to the first. No factors were associated with this change. The changes in threshold sensitivity were more evident at the peripheral points.
- ItemAcesso aberto (Open Access)Padronização normativa de eletro-oculografia em adultos(Conselho Brasileiro de Oftalmologia, 2004-04-01) Munhoz, Juliana Simões; Salomão, Solange Rios [UNIFESP]; Berezovsky, Adriana [UNIFESP]; Sacai, Paula Yuri [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)PURPOSE: To determine normative values for EOG in a group of healthy adult volunteers, according to the standard protocol recommended by the International Society for Clinical Eletrophisiology of Vision - ISCEV. METHODS: 33 volunteers aging from 18 to 55 years (mean=26.75±10.50) were included in the study. EOG was recorded by skin electrodes positioned in the external canthi of the eyes, with LED stimulus presented in a Ganzfeld dome. Subject's task was to fix the LED stimulus either straight ahead or with saccadic horizontal movements. The potential difference between the cornea and posterior pole of the eye was recorded each minute. The examination was done in 3 phases: 1- pre-adaptation; 2- dark (scotopic) and 3- light (photopic). The Arden ratio was calculated as the proportion between the maximum peak amplitude in the light phase divided by the minimum peak amplitude in the dark. RESULTS: At the scotopic phase, the minimum peak amplitude occurred between 14 and 21 minutes after the beginning of the stimulation (mean=17.82±2.11 min) and the amplitude ranged from 206 to 635 µV (mean 365.73±122.52 µV). At the photopic phase the maximun peak amplitude occurred between 27 and 34 minutes (mean=30.06±1.80 min); the amplitude ranged from 646 to 1250 µV (mean= 950.70±179.16 µV). Arden ratio ranged from 1.85 to 4.02 with a lower normal limit of 1.92 and the upper limit of 4.00. CONCLUSION: The results obtained in this study are comparable to those previously reported in the literature, with a lower normal limit of 1.92 for Arden ratio. These values will be helpful to evaluate patients with several retinal disorders. Inclusion of other age groups will provide extended normative data.
- ItemAcesso aberto (Open Access)Phonemic verbal fluency task in adults with high-level literacy(Inst Israelita Ensino & Pesquisa Albert Einstein, 2016) Opasso, Patricia Romano [UNIFESP]; Barreto, Simone dos Santos; Ortiz, Karin Zazo [UNIFESP]Objective: To establish normative parameters for the F-A-S form of the phonemic verbal fluency test, in a population of Brazilian Portuguese speaking adults with high-level literacy. Methods: The sample comprised 40 male and female volunteers aged 19 to 59 years, and at least 8 years of formal education. Volunteers were first submitted to the Mini-Mental State Examination and the Clock Drawing cognitive screening tests, then to the F-A-S Verbal Phonemic Fluency Test in this test, examinees were given 60 seconds to generate as many words as possible beginning with each of the three test letters. Results: The means for number of words beginning the letters F, A and S and for total number of words beginning with either letter generated per minute corresponded to 15.3, 14.4, 13.9 and 43.5, respectively. Conclusion: Reference values obtained from young adults with high levels of literacy submitted to the F-A-S Verbal Phonemic Fluency Test in this study were similar to those reported in the international literature. These reference values can be used for clinical assessment of language disorder and neuropsychological evaluation.
- ItemSomente MetadadadosPontos de corte da resposta ao broncodilatador e valores de referência para VEF 0,75 em espirometria de pré-escolares(Soc Brasileira Pneumologia Tisiologia, 2016) Burity, Edjane Figueiredo; de Castro Pereira, Carlos Alberto [UNIFESP]; Jones, Marcus Herbert; Sayao, Larissa Bouwman; de Andrade, Armele Dornelas; Amorim de Britto, Murilo CarlosObjective: To determine the cut-off points for FEV1, FEV0.75, FEV0.5, and FEF25-75% bronchodilator responses in healthy preschool children and to generate reference values for FEV0.75. Methods: This was a cross-sectional community-based study involving children 3-5 years of age. Healthy preschool children were selected by a standardized questionnaire. Spirometry was performed before and after bronchodilator use. The cut-off point of the response was defined as the 95th percentile of the change in each parameter. Results: We recruited 266 children, 160 (60%) of whom were able to perform acceptable, reproducible expiratory maneuvers before and after bronchodilator use. The mean age and height were 57.78 ± 7.86 months and 106.56 ± 6.43 cm, respectively. The success rate for FEV0.5 was 35%, 68%, and 70% in the 3-, 4-, and 5-year-olds, respectively. The 95th percentile of the change in the percentage of the predicted value in response to bronchodilator use was 11.6%, 16.0%, 8.5%, and 35.5% for FEV1, FEV0.75, FEV0.5, and FEF25-75%, respectively. Conclusions: Our results provide cut-off points for bronchodilator responsiveness for FEV1, FEV0.75, FEV0.5, and FEF25-75% in healthy preschool children. In addition, we proposed gender-specific reference equations for FEV0.75. Our findings could improve the physiological assessment of respiratory function in preschool children.
- ItemSomente MetadadadosReference values for spirometry in preschool children(Soc Brasil Pediatria, 2013-07-01) Burity, Edjane F.; Pereira, Carlos A. C. [UNIFESP]; Rizzo, Jose A.; Brito, Murilo C. A.; Sarinho, Emanuel S. C.; Universidade Federal de Pernambuco (UFPE); Universidade Federal de São Paulo (UNIFESP); Fundacao Oswaldo Cruz FiocruzObjectives: Reference values for lung function tests differ in samples from different countries, including values for preschoolers. the main objective of this study was to derive reference values in this population.Methods: A prospective study was conducted through a questionnaire applied to 425 preschool children aged 3 to 6 years, from schools and day-care centers in a metropolitan city in Brazil. Children were selected by simple random sampling from the aforementioned schools. Peak expiratory flow (PEF), forced vital capacity (FVC), forced expiratory volumes (FEV,, FEV0.50), forced expiratory flow (FEF25.75) and FEV1/FVC, FEV0.5/FVC and FEF25.75/FVC ratios were evaluated.Results: of the 425 children enrolled, 321 (75.6%) underwent the tests. of these, 135 (42.0%) showed acceptable results with full expiratory curves and thus were included in the regression analysis to define the reference values. Height and gender significantly influenced FVC valuesthrough linear and logarithmic regression analysis. in males, R-2 increased with the logarithmic model for FVC and FEV1, but the linear model was retained for its simplicity. the lower limits were calculated by measuring the fifth percentile residues.Conclusion: Full expiratory curves are more difficult to obtain in preschoolers. in addition to height, gender also influences the measures of FVC and FEV1. Reference values were defined for spirometry in preschool children in this population, which are applicable to similar populations. (C) 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
- ItemSomente MetadadadosSpirometry reference values after inhalation of 200 mu g of Salbutamol(Ediciones Doyma S/l, 2007-10-01) Perez-Padilla, Rogelio; Torre Bouscoulet, Luis; Vazquez-Garcia, Juan Carlos; Muino, Adriana; Marquez, Maria Nelly; Lopez, Maria Victorina; Oca, Maria Montes de; Talamo, Carlos; Valdivia, Gonzalo; Pertuze, Julio; Jardim, José Roberto de Brito [UNIFESP]; Menezes, Ana Maria Baptista; Grp PLATINO; Inst Nacl Enfermedades Resp; Univ Republica; Cent Univ Venezuela; Pontificia Univ Catolica Chile; Universidade Federal de São Paulo (UNIFESP); Univ Fed PelotasOBJECTIVE: the criteria for disease severity established by the Global Initiative for Chronic Obstructive Lung Disease are based on forced expiratory volume in I second (FEV) expressed as a percentage of the predicted value after application of a bronchodilator. This study aims to determine postbronchodilator spirometry reference values.SUBJECTS and METHODS: A cluster sample of subjects aged 40 years or over was chosen to be representative of the metropolitan areas of 5 Latin American cities (São Paulo, Mexico City, Montevideo, Santiago, and Caracas). Spirometry was performed on 5183 subjects following the recommendations of the American Thoracic Society before and after inhalation of 200 mu g of salbutamol. Multiple linear regression equations were fitted for the postbronchodilator spirometric values-FEV1, forced expiratory volume in 6 seconds (FEV6), peak expiratory flow rate, forced vital capacity (FVC), FEV1/FEV6, FEV1/FVC and forced expiratory flow between 25% and 75% of vital capacity (FEF25-75). These were adjusted for sex, age, and height in 887 asymptomatic subjects with no history of lung disease.RESULTS: the postbronchodilator reference values for FEV, FEV1/FVC, and FEV1/FEV6 were on average 3% higher than those obtained before bronchodilation. This apparently small difference caused an upward shift in the 5th percentile (lower limit of normal) of the predicted values. When prebronchodilation instead of postbronchodilation reference values were used, 3.2% of the results for airflow obstruction in our population of over-40-year-olds were false negatives.CONCLUSIONS: the reported reference values are more appropriate for postbronchodilator spirometry and make it possible to reduce the number of misclassifications.