Navegando por Palavras-chave "Receptor P2X7"

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    O receptor P2X7 e a via de PGC-1A/PPAR como alvos na estratégia do desenvolvimento de terapias para a doença de Parkinson
    (Universidade Federal de São Paulo (UNIFESP), 2017-08-08) Ferrazoli, Enéas Galdini [UNIFESP]; Ulrich, Alexander Henning [UNIFESP]; Gomes, Telma Tiemi Schwindt Diniz [UNIFESP]; http://lattes.cnpq.br/8780348666074054; http://lattes.cnpq.br/9571481236686866; http://lattes.cnpq.br/7508889777108883; Universidade Federal de São Paulo (UNIFESP)
    Parkinson's Disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and their projections to the striatum, and there are no therapies that significantly delay its progression so far. Currently, the most common treatment for PD is the administration of Levodopa, but this drug has limited efficacy and many side effects, such as dyskinesias. Recently, several groups have demonstrated the participation of purinergic receptors, especially the P2X7 receptor (P2X7R), and the peroxisome proliferator activated receptor (PPAR), in neuroinflammatory and neurodegenerative pathways, suggesting that these might be important targets for therapies for neurodegenerative diseases. It is also known that the inflammation process is closely linked to the mechanisms of neuronal death in PD. Further, neural stem / progenitor cells express various chemokines and chemokine receptors that are involved in the homing of these cells to sites of injury in the central nervous system; thus transplantation of neural stem / progenitor cells is indicated as a promising strategy for the treatment of neurodegenerative diseases. The objective of the present study was to evaluate the therapeutic effect of the use of the P2X7R blocker Brilliant Blue G, the PPAR activator fenofibrate, and neural progenitor cell transplantation in an in vitro model for PD. For this purpose, we used the hemiparkinsonism model induced by 6-hydroxy-dopamine. The apomorphine-induced rotational behavior, characteristic of this model, and histological analysis of tyrosine hydroxylase expression were used as parameters to determine the effects of the used treatments. The obtained results obtained show that the blockade of P2X7R by BBG induced a significant decrease of apomorphine-evoked rotations and the recovery of dopaminergic neurons in the substantia nigra. However, treatments with fenofibrate and neural progenitor cells did not promote any improvement compared to animals treated with saline. In summary, we can conclude that P2X7R may be an important therapeutic target in Parkinson's disease.
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    Tempos E Espaços Escolares: As Experiências De Duas Alunas Com Deficiência Múltipla Em Escola Da Rede Municipal
    (Universidade Federal de São Paulo (UNIFESP), 2017-06-12) Jacob, Rosangela Nezeiro Da Fonseca [UNIFESP]; Freitas, Marcos Cezar De [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    This thesis aims to investigate the experiences of two students with multiple disabilities, during school time and space. The study was carried out in a public school located on the north side of the city of São Paulo. Two elementary school first-grade female students attending the literacy cycle and enrolled in two different classes as well as the Specialized Educational Service (AEE – Atendimento Educacional Especializado) were followed closely by the researcher’s careful look throughout the academic year of 2015. The study was systematized according to Geertz’s proposal (2012), particularly the drafting of dense descriptions with the purpose of understanding specific everyday environments, or, in the instance of this study, the everyday reality of public schools. The data for the analysis, including the observations of physical manifestations in school times and spaces, were recorded in a journal. The school was described through concrete situations. In order to know (or to recognize) the microcosm of children both in close proximity to them and from inside, the study required an ethnographic journey. The theoretical basis for the microscopic social research had Woods (1999; 2013) as reference, a researcher specialized in investigating schools from within and with an in-depth approach to their daily functionings. Also considered were the face-to-face relationships and interactions as investigated by Goffman (2010; 2012; 2013; 2015). For the complexity of the study of multiple disabilities, the following were considered: Jacob (2012); Cormedi (2015; 2011); Mantoan (2015a; 2015b); Mantoan; Santos (2010); Mazotta (2011); Prieto (2011); Prieto et al. (2015a; 2015b), and others. The list of references included the current legislation and specific SME-SP documents in order to analyze and discuss the educational inclusion of disabled students. The recording method was based on the ethnographic research model proposed by Geertz (2012) and Woods (1999; 2013) with the use of a journal and field notes. Face-to-face interactions were analyzed in a number of different settings and school environments, including the collaborative work between the Specialized Educational Service and the regular classroom. The students’ interactions with professionals from support services, family members and other educators were also recorded. The study found several discrepancies between public policies and the daily practice in the educational process of the students who are the target audience of special education. It also found almost complete absence of the territories of the self, and the lack of proper articulation between the Specialized Educational Service and the regular classroom.