Navegando por Palavras-chave "Radiopharmaceutical"

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    Present and Future of the Radio-Molecules used in Detection of Sentinel Lymphatic Nodes
    (Colegio Farmaceuticos Provincia De Buenos Aires, 2009-03-01) Fernandez Nunez, Eutimio Gustavo; Faintuch, Bluma Linkowski; Oliveira, Relma Tavares de; Wiecek, Danielle Pereira; Teodoro, Rodrigo; Oliveira Filho, Renato Santos de [UNIFESP]; Inst Energet & Nucl Res; Salvador Allende Hosp; Universidade Federal de São Paulo (UNIFESP)
    Detection of the sentinel lymph node has become a mainstay of certain surgical interventions for cancer. In this sense, physiological and biochemical properties of the molecules employed for early detection of such metastasis have become relevant in many specialties. Traditionally the main characteristics considered for such radiopharmaceuticals are particle size and surface features. In addition, design of radiolabeled molecules has to take in account anatomy of the vascular lymphatic epithelium and its interaction with such agents. The aim is to create more specific and effective drugs, thus precisely shaping and eventually remodelling the surgical strategy for a given patient. Advances in diagnostic imaging open perspectives for additional categories of agents, endowed with different physico-chemical features as required by positron-emission tomography and other sophisticated procedures. This review covers the molecules used in sentinel node finding as well as some related topics, which can help to understand their action mechanism and failures.
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    Size and specificity of radiopharmaceuticals for sentinel lymph node detection
    (Royal Soc Medicine Press Ltd, 2011-09-01) Fernandez Nunez, Eutimio Gustavo; Teodoro, Rodrigo; Wiecek, Danielle Pereira; Silva, Natanael Gomes da; Martinelli, Jose Roberto; Oliveira Filho, Renato Santos de [UNIFESP]; Inst Energet & Nucl Res; Universidade Federal de São Paulo (UNIFESP)
    Background: Biological performance of radiotracers for sentinel node detection analyzed in the light of molecular design and dimension is not widely available.Purpose: To evaluate the effect of dextran molecular size and the presence of tissue-binding units (mannose) within the model of (99m)Tc-carbonyl conjugate for sentinel lymph node detection.Material and Methods: Four dextran conjugates with and without mannose in the chemical backbone were included. All polymers were radiolabeled using the precursor [(99m)Tc(OH(2))(3)(CO)(3)](+). Radio labeling conditions targeted the best radiochemical purity and specific activity for each radiopharmaceutical, and partition coefficients were also defined. Lymphoscintigraphy and ex-vivo biodistribution in popliteal lymph node, liver and kidneys were performed in Wistar rats. the effects of molecular weight and mannose presence were assessed by a two-level factorial design.Results: Radiochemical purity was indirectly related to molecular weight and presence of mannose in the polymer structure. All products were able to detect popliteal lymph node, however, uptake was strongly influenced by use of mannose (4-fold higher). Excretion was similarly modulated by differences in molecular weight. Mannose-enhanced lymph node uptake and higher molecule size in the range under study benefitted lymphoscintigraphic performance.Conclusion: Screening of radiopharmaceuticals for lymphoscintigraphy might improve with attention to the mentioned physico-chemical features of the molecule.