Navegando por Palavras-chave "REM sleep"
Agora exibindo 1 - 11 de 11
Resultados por página
Opções de Ordenação
- ItemAcesso aberto (Open Access)Aspectos do sono em pacientes com cirrose hepática(Universidade Federal de São Paulo (UNIFESP), 2009-05-27) Teodoro, Vinicius Vasconcelos [UNIFESP]; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Hepatic cirrhosis is a serious public health issue in the world, since it was a very common disease, with a great impact. The occurrence of liver structural alterations has various consequences, including neurological ones. The patient with cirrhosis presents several clinical manifestations that involve alterations on his biological functions such as sleep and waking. Study objective: The aim of this study was to characterize sleep parameters and sleepiness in cirrhotic patients and to assess a possible influence the severity level of this disease on these parameters. Design: It was a case-control study. Setting: The hepatology outpatient service of Hospital São Paulo (UNIFESP/EPM) and Sleep Institute and diagnostic center of Associação Fundo de Incentivo à Psicofarmacologia (AFIP). 42 cirrhotic patients and 42 volunteers without hepatic disease were submitted to an all night polysomnographic evaluation. They also answered sleep questionnaires as well as the Epworth Sleepiness Scale. The severity of the illness was assessed by the prognostic model of Child-Turcotte-Pugh and MELD scores. Results: There was no difference in age, gender and BMI between cirrhotic patients and volunteers. However, the polysomnographic findings showed lower sleep efficiency, as well as an increase in the REM sleep latency and a lower REM sleep percentage in the cirrhotic group when compared with the control group. The cirrhotic patients also showed higher frequency of Periodic Limb Movements in Sleep than the controls. There was a significant difference among Child-Turcotte-Pugh groups in regard to REM sleep percentage, significantly lower in group C when compared to group B and group A. No significant differences were detected between the scores of both groups in the Epworth Scale. Conclusion: The findings suggest that cirrhotic patients had a worse quality of sleep when compared with the control group and higher occurrence of PLMS. There was also an influence of the severity of liver failure in some sleep parameters.
- ItemSomente MetadadadosAssociation between body mass index and sleep duration assessed by objective methods in a representative sample of the adult population(Elsevier B.V., 2013-04-01) Moraes, Walter André dos Santos [UNIFESP]; Poyares, Dalva [UNIFESP]; Zimberg, Ioná Zalcman [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Bittencourt, Lia Rita Azeredo [UNIFESP]; Santos-Silva, Rogerio [UNIFESP]; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Introduction: Sleep duration has been associated with overweight individuals in many epidemiological studies; however, few studies have assessed sleep using objective methods. Our study was designed to evaluate the association between body mass index (BMI) and sleep duration measured by actigraphy (Acti), polysomnography (PSG) and the Pittsburgh Sleep Quality Index questionnaire (PSQIO). Furthermore, we evaluated other biochemical and polysomnographic parameters.Methods: A representative sample of 1042 individuals from São Paulo, Brazil, including both genders (20-80 yrs), participated in our protocol. Weight and other anthropometric parameters were measured at the onset of the study. Sleep duration was calculated by Acti, PSG, and the PSQIQ. the population was sorted by sleep duration, body, slow wave sleep (SWS) and REM sleep (REMS) duration subsets. in addition, other biochemical and polysomnographic parameters were analyzed. Differences between population subsets were analyzed by one-way analysis of variance (ANOVA). Linear regression analysis was performed between sleep and anthropometric parameters.Results: Shorter sleep duration was associated with higher BMI and waist and neck circumference when measured by Acti and PSG (p < 0.05). Lower leptin levels were associated with short sleep in normal-weight (BMI > 18 and <= 25) individuals (p < 0.01). the association between short sleep duration Acti and higher BMI was present when apnea-hypopnea index (AHI) was less than 15 (p = 0.049). Shorter REMS and SWS also were associated with higher BMI (p < 0.01). Normal-weight individuals tended to sleep longer, have higher sleep efficiency and longer SWS and REMS than obese individuals (Acti, PSG; p = 0.05). Sleep duration was negatively correlated with BMI (Acti, PSG; p < 0.05). Short SWS and REMS were associated with higher cardiovascular risk factors (p < 0.05).Conclusion: Shorter sleep, SWS, and REMS duration were associated with higher BMI, central adiposity measurements, and cardiovascular risk factors when measured by objective methods. (c) 2012 Elsevier B.V. All rights reserved.
- ItemSomente MetadadadosEffects of different sleep deprivation protocols on sleep perception in healthy volunteers(Elsevier B.V., 2014-10-01) Goulart, Leonardo I.; Pinto, Luciano R. [UNIFESP]; Perlis, Michael L.; Martins, Raquel [UNIFESP]; Caboclo, Luis Otavio; Tufik, Sergio [UNIFESP]; Andersen, Monica L. [UNIFESP]; Hosp Israelita Albert Einstein; Univ Penn; Universidade Federal de São Paulo (UNIFESP)Objectives: To investigate whether different protocols of sleep deprivation modify sleep perception.Methods: the effects of total sleep deprivation (TD) and selective rapid eye movement (REM) sleep deprivation (RD) on sleep perception were analyzed in normal volunteers. Thirty- one healthy males with normal sleep were randomized to one of three conditions: (i) normal uninterrupted sleep; (ii) four nights of RD; or (iii) two nights of TD. Morning perception of total sleep time was evaluated for each condition. Sleep perception was estimated using total sleep time (in hours) as perceived by the volunteer divided by the total sleep time (in hours) measured by polysomnography (PSG). the final value of this calculation was defined as the perception index (PI).Results: There were no significant differences among the three groups of volunteers in the total sleep time measured by PSG or in the perception of total sleep time at baseline condition. Volunteers submitted to RD exhibited lower sleep PI scores as compared with controls during the sleep deprivation period (P < 0.05). Both RD and TD groups showed PI similar to controls during the recovery period.Conclusion: Selective REM sleep deprivation reduced the ability of healthy young volunteers to perceive their total sleep time when compared with time measured by PSG. the data reinforce the influence of sleep deprivation on sleep perception. (C) 2014 Elsevier B. V. All rights reserved.
- ItemSomente MetadadadosHeart rate variability during sleep in patients with vasovagal syncope(Blackwell Publishing, 2005-12-01) Cintra, Fátima Dumas [UNIFESP]; Poyares, Dalva [UNIFESP]; Amaral, Alessandro do [UNIFESP]; Marchi, Guilherme de [UNIFESP]; Barreto, Simone [UNIFESP]; Tufik, Sergio [UNIFESP]; De Paola, Angelo Amato Vincenzo [UNIFESP]; Guilleminault, Christian; Universidade Federal de São Paulo (UNIFESP); Sleep Disorders CtrBackground: There are a few studies showing no significant heart rate variability (HRV) over a 24-hour period in vasovagal syncope (VVS) patients, but no research has examined HRV and its sympathetic and parasympathetic components during rapid eye movement (REM) and non-REM sleep. the authors hypothesized that REM sleep might be a critical state in which VVS patients would show abnormal responses.Objectives: To analyze the sympathetic and parasympathetic components of HRV during REM and SWS in patients with VVS compared to normal subjects, and in patients with positive HUTT compared to negative ones. Methods: Thirty-seven VVS patients and 20 normal age-matched controls were submitted to polysomnography with 24-hour Holter monitoring to assess HRV Time and frequency domain techniques were carefully performed for 24 hours and during Stages 3 and 4 of REM and non-REM sleep. Variation of sympathetic activity index (VSAI) was defined as the difference in the low frequency (LF) component of HRV between REM and Stages 3 and 4 of non-REM sleep. An analysis of variance was performed to compare patients and controls; patients with positive and negative head-up tilt testing.Results: the LF component was lower in syncope compared to normal patients (1,769.54 +/- 1,738.17, 3,225.37 +/- 2,585.05, respectively, P = 0.03). There was a significant decrease in VSAI in the syncope group compared to the control group (-539.39 +/- 1,930.78, 1,268.10 +/- 2,420.20, respectively, P = 0.01). the other sleep variables analyzed including very LF, high frequency, low frequency/high frequency and time domain parameters did not reach statistical significance. Syncope patients also showed an increase in slow wave sleep (28.2 +/- 10.5, 19.7 +/- 7.8, P = 0.01).Conclusions: VVS patients exhibited sympathetic suppression during REM sleep. Possible mechanisms are discussed in this article.
- ItemSomente MetadadadosIncreased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivation(Elsevier B.V., 2004-01-02) Pedrazzoli, M.; D'Almeida, V; Martins, PJF; Machado, R. B.; Ling, L.; Nishino, S.; Tufik, S.; Mignot, E.; Universidade Federal de São Paulo (UNIFESP); Stanford UnivRat cisternal (CSF) hypocretin-1 in cerebrospinal fluid was measured after 6 or 96 It of REM sleep deprivation and following 24 It of REM sleep rebound. REM deprivation was found to increase CSF hypocretin-1 collected at zeitgeber time (ZT) 8 but not ZT0. Decreased CSF hypocretin levels were also observed at ZT8 after 24 It of REM sleep rebound. These results suggest that REM sleep deprivation activates and REM sleep rebound inhibits the hypocretin system. Increased hypocretin tone during REM deprivation may be important in mediating some of the effects of REM sleep deprivation such as antidepressant effects, hyperphagia and increased sympathetic activity. (C) 2003 Elsevier B.V All rights reserved.
- ItemSomente MetadadadosLong lasting alteration in REM sleep of female rats submitted to long maternal separation(Elsevier B.V., 2008-02-27) Tiba, Paula Ayako [UNIFESP]; Tufik, Sergio [UNIFESP]; Suchecki, Deborah [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Early adverse experiences represent risk factors for the development of anxiety and mood disorders. Maternal separation can induce biobehavioral alterations in male rodents similar to those seen in depressed humans, such as hyperresponsiveness to stress and sleep disturbances. Nonetheless, no study has yet explored the effects of early life events on the relationship between stress and sleep in female rats. Whole litters of Wistar rats were submitted to brief- or long maternal separations (15 [BMS] or 180 min/day [LMS], from postnatal days 2-14) or kept undisturbed with their mothers (CTL). When adults, female rats were sleep-recorded for 22 h before (baseline) and after a 1 h exposure to cold stress (post-stress). Additional subsets of animals were sacrificed before, 1 or 3 h after the stressor for plasma corticosterone determination. No differences in baseline sleep were observed among the groups. Female rats submitted to LMS exhibited a significant increase of REM sleep on the night following a 1 h exposure to cold stress, whereas the sleep of BMS rats was barely altered by stress. All groups exhibited similar basal and stress-induced corticosterone levels. the present results are compared to a previous study performed in male rats, and corroborate that manipulations applied during infancy modify the expression of stress-induced sleep rebound. (C) 2007 Elsevier Inc. All rights reserved.
- ItemAcesso aberto (Open Access)Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound(Frontiers Media Sa, 2016) Machado, Ricardo Borges [UNIFESP]; Suchecki, Deborah [UNIFESP]Sleep homeostasis depends on the length and quality (occurrence of stressful events, for instance) of the preceding waking time. Forced wakefulness (sleep deprivation or sleep restriction) is one of the main tools used for the understanding of mechanisms that play a role in homeostatic processes involved in sleep regulation and their interrelations. Interestingly, forced wakefulness for periods longer than 24 h activates stress response systems, whereas stressful events impact on sleep pattern. Hypothalamic peptides (corticotropin-releasing hormone, prolactin, and the CLIP/ACTH (18-39)) play an important role in the expression of stress-induced sleep effects, essentially by modulating rapid eye movement sleep, which has been claimed to affect the organism resilience to the deleterious effects of stress. Some of the mechanisms involved in the generation and regulation of sleep and the main peptides/hypothalamic hormones involved in these responses will be discussed in this review.
- ItemSomente MetadadadosOpposite effects of sleep rebound on orexin OX1 and OX2 receptor expression in rat brain(Elsevier B.V., 2005-05-20) D'Almeida, V; Hipolide, D. C.; Raymond, R.; Barlow, KBL; Parkes, J. H.; Pedrazzoli, M.; Tufik, S.; Nobrega, J. N.; Ctr Addict & Mental Hlth; Universidade Federal de São Paulo (UNIFESP)Orexins (hypocretins) have been implicated in the regulation of the normal sleep-wake cycle, in sensorimotor programming, and in other homeostatic and neuroregulatory processes. the present study examined the effects of sleep deprivation (SD) and sleep recovery on the expression of orexin 1 receptors (OX1R) and orexin 2 receptors (OX2R) throughout the brain. Rats were sacrificed either immediately after 96 h of sleep deprivation (SD group) or after SD followed by 24 h of sleep recovery (Rebound group). Prepro-orexin mRNA showed a nonsignificant increase in the SD group relative to controls, but a pronounced and significant increase in the Rebound group (+88%, P < 0.007). Similarly, sleep deprivation produced no effect on OX1R or OX2R mRNA levels. However, in the Rebound group, OX1R mRNA levels increased significantly, compared to either control or SD groups, in 37 of 92 brain regions analyzed, with particularly strong effects in the amygdala and hypothalamus. Changes in OX2R mRNA levels were also seen only in the sleep Rebound group, but they were fewer in number (10 out of 86 regions), were in the direction of decreased rather than increased expression, and were predominantly confined to cerebral cortical areas. These observations indicate that some factor associated with sleep recovery, possibly the compensatory increase in REM sleep, has strong effects on the orexin system at the mRNA level. They further indicate that OX1 and OX2 receptors are affected in opposite way and that the former are more vulnerable to these effects than the latter. (c) 2005 Elsevier B.V. All rights reserved.
- ItemSomente MetadadadosRapid Eye Movement Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy(Amer Acad Sleep Medicine, 2016) Vale, Thiago Cardoso; Prado, Lucila Bizari Fernandes do [UNIFESP]; Prado, Gilmar Fernandes do [UNIFESP]; Barsottini, Orlando Graziani Povoas [UNIFESP]; Pedroso, Jose Luiz [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Study Objectives: To report two female patients with paraneoplastic cerebellar degeneration (PCD) related to breast cancer that presented with rapid eye movement-sleep behavior disorder (RBD) and improved sleep symptoms with immunotherapy. Methods: The two patients were evaluated through clinical scale and polysomnography before and after therapy with intravenous immunoglobulin. Results: RBD was successfully treated with immunotherapy in both patients. Score on the RBD screening questionnaire dropped from 10 to 1 or 0, allied with the normalization of polysomnographic findings. Conclusions: A marked improvement in RBD after immunotherapy in PCD raises the hypothesis that secondary RBD may be an immune-mediated sleep disorder.
- ItemSomente MetadadadosRapid Eye Movement Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy(Amer Acad Sleep Medicine, 2016) Vale, Thiago Cardoso; Fernandes do Prado, Lucila Bizari [UNIFESP]; do Prado, Gilmar Fernandes [UNIFESP]; Povoas Barsottini, Orlando Graziani [UNIFESP]; Pedroso, Jose Luiz [UNIFESP]Study Objectives: To report two female patients with paraneoplastic cerebellar degeneration (PCD) related to breast cancer that presented with rapid eye movement-sleep behavior disorder (RBD) and improved sleep symptoms with immunotherapy. Methods: The two patients were evaluated through clinical scale and polysomnography before and after therapy with intravenous immunoglobulin. Results: RBD was successfully treated with immunotherapy in both patients. Score on the RBD screening questionnaire dropped from 10 to 1 or 0, allied with the normalization of polysomnographic findings. Conclusions: A marked improvement in RBD after immunotherapy in PCD raises the hypothesis that secondary RBD may be an immune-mediated sleep disorder.
- ItemAcesso aberto (Open Access)Sawtooth waves during REM sleep after administration of haloperidol combined with total sleep deprivation in healthy young subjects(Associação Brasileira de Divulgação Científica, 2002-05-01) Pinto Junior, L.R. [UNIFESP]; Peres, Clovis de Araujo [UNIFESP]; Russo, Regina Helena [UNIFESP]; Remesar-Lopez, Alberto Jorge [UNIFESP]; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)We sought to examine the possible participation of dopaminergic receptors in the phasic events that occur during rapid eye movement (REM) sleep, known as sawtooth waves (STW). These phasic phenomena of REM sleep exhibit a unique morphology and, although they represent a characteristic feature of REM sleep, little is known about the mechanisms which generate them and which are apparently different from rapid eye movements. STW behavior was studied in 10 male volunteers aged 20 to 35 years, who were submitted to polysomnographic monitoring (PSG). On the adaptation night they were submitted to the first PSG and on the second night, to the basal PSG. On the third night the volunteers received placebo or haloperidol and spent the whole night awake. On the fourth night they were submitted to the third PSG. After a 15-day rest period, the volunteers returned to the sleep laboratory and, according to a double-blind crossover randomized design, received haloperidol or placebo and spent the whole night awake, after which they were submitted to the fourth PSG. The volunteers who were given haloperidol combined with sleep deprivation exhibited an elevation of the duration and density of the STW, without significant alterations of the other REM sleep phasic phenomena such as rapid eye movement. These findings suggest that sawtooth waves must have their own generating mechanisms and that the dopaminergic receptors must exert a modulating role since REM sleep deprivation, as well as administration of neuroleptics, produces supersensitivity of dopaminergic receptors.