Navegando por Palavras-chave "Pro-inflammatory cytokines"

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    Changes in the pro-inflammatory cytokine production and peritoneal macrophage function in rats with chronic heart failure
    (Elsevier B.V., 2006-06-01) Batista, M. L.; Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]; Cunha, L. M.; Mattos, K.; Oliveira, E. M.; Seelaender, M. C. L.; Rosa, L. F. B. P. Costa; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Chronic heart failure (CHF) is a state of immune activation, and pro-inflammatory cytokines play an important role in its development and progression. Macrophages (M phi s), when activated, are the main source of pro-inflammatory cytokines. We measured interjeukin-6 (IL-6), interleukin (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) production after lipopolysaccharide (LPS)-stimulation, as well as peritoneal M phi s migration, phagocytic capacity, chemotaxis index, and hydrogen peroxide production, in an attempt to clarify the role of this cell in an animal model of CHF. Ligature of the left coronary artery or sham operation was performed in adult Wistar rats. After 12 weeks, resident and total cell number, phagocytic capacity, chemotaxis index, and hydrogen peroxide production in M phi s were significantly higher in CHF than in control rats. the production of IL-6 and TNF-alpha was similarly significantly enhanced in CHF as compared with controls. M phi s obtained from CHF rats were more responsive to LPS, suggesting the existence, in vivo, of possible factor(s) modulating the production of pro-inflammatory cytokines. the results demonstrated that there is modification of peritoneal M phi s function along CHF development, possibly contributing to the pathophysiological process in the establishment of CHF. (c) 2006 Elsevier B.V. All rights reserved.
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    Endurance training restores peritoneal macrophage function in post-MI congestive heart failure rats
    (Amer Physiological Soc, 2007-05-01) Batista, M. L.; Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]; Oliveira, E. M.; Seelaender, M. C. L.; Rosa, L. F. B. P. Costa; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Univ Mogi das Cruzes
    Congestive heart failure (CHF) induces a state of immune activation, and peritoneal macrophages (M Phi s) may play an important role in the development and progression of one such condition. Moderate endurance training modulates peritoneal M Phi function. We evaluated the effect of endurance training on different stages of the phagocytic process and in the production of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) after LPS stimulation. Either ligation of the left coronary artery or Sham operations were performed in adult Wistar rats. After 4 wk, control (Sham operated) and MI (ligation of the left coronary artery) animals were randomly assigned to either a sedentary (Sham-operated sedentary, n = 7 and MI sedentary, n = 10) or a trained group (Sham-operated trained, n = 8 and MI trained, n = 8). Trained rats ran on a treadmill (0% grade at 13-20 m/min) for 60 min/day, 5 days/wk, for 8-10 wk, whereas sedentary rats had only limited activity. Training increased maximal oxygen uptake normalized for body weight (ml . kg(-1). min(-1)), as well as skeletal muscle citrate synthase maximal activity, when compared with sedentary groups. the resident and total cell number, the chemotaxis index, and the production of TNF-alpha stimulated by LPS were significantly higher in the MI sedentary group when compared with the Sham sedentary group. Moderate endurance training reversed these alterations promoted by post-MI. These results demonstrate that moderate intensity exercise training modulates peritoneal M Phi function and induces beneficial metabolic effects in rats with post-MI CHF.
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    Exercise, sleep and cytokines: Is there a relation?
    (W B Saunders Co Ltd, 2007-06-01) Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]; Tufik, Sergio [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Physical exercise is a modality of non-pharmacological treatment for sleep disorders. Contradicting results are still found in studies of the effect of exercise on steep. Among the substances that have been described as steep modulators, cytokines produced during the recovery period after an acute exercise session are very important. Various studies have verified that physical exercise may alter the plasma concentration of the many pro-inflammatory cytokines that may in turn modulate steep. A number of factors seem to mediate this effect of exercise, including duration, intensity, and form of exercise, in addition to temperature and metabolic alterations. the mechanisms through which exercise promotes alterations in steep architecture remain to be clarified. Researchers speculate that many hormones and substances produced by metabolism may affect steep. Therefore, the object of this review is to discuss the effects of exercise and cytokines on steep, and the relation between these two steep-regulating components, raising the hypothesis that the alterations in steep promoted by exercise are mediated by cytokines, which, by increasing the nREM steep phase, would stimulate the regenerating characteristics of steep. (c) 2007 Published by Elsevier B.V.