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- ItemSomente Metadadados24 bp duplication of CHIT1 gene and determinants of human chitotriosidase activity among participants of EPISONO, a population-based cross-sectional study, São Paulo, Brazil(Elsevier B.V., 2013-08-01) Tamanaha, Priscila [UNIFESP]; D'Almeida, Vania [UNIFESP]; Calegare, Bruno F. A. [UNIFESP]; Tomita, Luciana Yuki [UNIFESP]; Bittencourt, Lia Rita A. [UNIFESP]; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objectives: We investigated whether plasma chitotriosidase activity is related to Obstructive Sleep Apnea (OSA) conditions and is correlated with biochemical variables present in the EPISONO database. This is the first study conducted in an epidemiological and nutritional transition country using subjects from the EPISONO population-based cross-sectional study.Design and methods: Chitotriosidase (CHIT) activity was determined by fluorimetric assay. OSA classification was defined as an apnea-hypopnea index. the correlations were investigated using a multiple regression linear model and statistical criteria, with CHIT as the dependent variable and correlated variables (from the EPISONO database) as independent variables, to access the contribution of each one to the variation in CHIT activity.Results: No significant difference was observed when comparing the mean CHIT activities of different apnea groups. the prevalence of the CHIT1 24-bp duplication from patients with severe apnea was higher than in controls. in a multiple regression linear model, CHIT concentration was positively associated with age, creatine and testosterone. Age was the strongest predictor of CHIT variation, followed by gender, waist circumference and TNF alpha. levels. the whole regression model explained 14% of the CHIT variation.Conclusion: Many variables are related to CHIT activity and show evidence of the multifactor and potentially synergistic character of this enzyme. in this study, we found that age, gender, TNF alpha, Hcy, sleep efficiency and waist circumference were responsible for approximately 14% of CHIT variation. Further studies are needed to elucidate additional parameters that may be related to CHIT activity. (C) 2013 the Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
- ItemAcesso aberto (Open Access)Diabetes mellitus tipo 2: fatores preditivos na população nipo-brasileira(Sociedade Brasileira de Endocrinologia e Metabologia, 2003-10-01) Nascimento, Rogéria do [UNIFESP]; Franco, Laercio Joel [UNIFESP]; Gimeno, Suely Godoy Agostinho [UNIFESP]; Hirai, Amélia Toyomi [UNIFESP]; Ferreira, Sandra Roberta Gouvea [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)In order to identify the main predictors for the development of type 2 diabetes mellitus (DM2) in a population with high prevalence of DM - the Japanese-Brazilians -, we evaluated 314 individuals with Japanese ancestry from Bauru, SP, aged 40 years or more, without miscegenation, in 1993 and 2000. The parameters evaluated, obtained in 1993, were sex, age, body mass index (BMI), waist and hip circumferences, fasting and 2h after 75g of glucose load glycemia, insulinemia and proinsulinemia, HOMA (function of the b cell and insulin resistance), lipid profile and blood pressure. The glycemic homeostasis evaluated in 2000 showed that individuals with impaired fasting glycemia or impaired glucose tolerance presented a higher risk for the progression to DM2 (60 and 70%, respectively) than normals (19%). The main variables involved in the progression to DM were BMI, waist circumference (only women), systolic blood pressure, fasting and 2h glycemia, and VLDL-cholesterol. These results showed the existing potential for the reduction in the incidence of DM2 in this population, because the main risk factors can be modified by interventions in lifestyle.
- ItemSomente MetadadadosPreditores de "Gaming Sisorder" em uma amostra escolar de crianças e adolescentes em São Paulo e Porto Alegre(Universidade Federal de São Paulo (UNIFESP), 2020-06-23) Ferreira, Felipe De Macedo [UNIFESP]; Araripe Neto, Ary Gadelha De Alencar [UNIFESP]; Universidade Federal de São PauloFollowing the appearance of videogames in the seventies, along with the popularization of internet in the early 2000s, the use of electronic games is has become increasingly common, especially amongst children and adolescents. The extensive, and sometimes excessive, use of such technologies, has raised parents and health professional concerns about it’s behavioral, psychological and neurological consequences. The DSM-5 has classified Internet Gaming Disorder, addiction to online gaming, in the “Conditions for Further Study” section. An increasing number of studies associate the excessive use of electronic games to impulse control impairment (similarly to other addictions) and orbitofrontal cortex activation differences in neuroimaging studies. In Brazil, around 66% of the population engage in electronic gaming of some kind - and the majority of gamers have around 25 to 34 years. It is still necessary to understand how the gaming pattern of the younger population is related to the emergence of addictive behaviours. The objective of this study is to investigate psychosocial and behavioral variables associates to Gaming Disorder (GD) in a population o children and adolescents. Socioeconomic (sex, age, social strata), preference for specific gaming genders, mean length of gaming session, proportion of online gaming and the presence of other mental health disorders were addressed. The sample is a subgroup of the Brazilian High-Risk Cohort, a communitary cohort comprised of children and adolescents. A questionnaire was used to investigate electronic gaming pattern. The Gaming Addiction Scale (translated to portuguese) foi used to diagnose Gaming Addiction. For 9 the other psychiatric diagnoses, we used the Development and Well-Being Behaviour Assessment (DAWBA). Out of 407 participants, 20.4% were diagnosed with GD. Male participants scored a higher GAS, and presented higher GD prevalence when compared to females. Furthermore, the prevalence of GD increased with the number of genres played by the participants. Higher proportion of online playing, longer gaming sessions, and presence of other mental disorders were deemed the best predictors of GD in our logistic regression model. Considering all the included variables in our study, high online gaming proportion, longer gaming sessions and the presence of other mental health disorders were the most relevant in diagnosing GD. Additionally, male participants had higher prevalence of GD and played more. Our data might aid mental health professionals, parents and politicians in creating strategies of health promotion and treatment of this novel disorder. This kind of study is still rare in brazilian sample s, and further understanding of children and adolescents pattern of electronic gaming and its relationship with GD is still necessary.
- ItemAcesso aberto (Open Access)Systematic head and neck physical examination as a predictor of obstructive sleep apnea in class III obese patients(Associação Brasileira de Divulgação Científica, 2008-12-01) Martinho, Fernanda Louise [UNIFESP]; Tangerina, Rodrigo de Paiva [UNIFESP]; Togeiro, Sonia Maria [UNIFESP]; Gregório, Luiz Carlos [UNIFESP]; Tufik, Sergio [UNIFESP]; Bittencourt, Lia Rita Azeredo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Our aim was to determine if anatomical abnormalities of the upper airway (UA) and facial skeleton of class III severely obese patients are related to the presence and severity of obstructive sleep apnea syndrome (OSAS). Forty-five patients (69% females, mean age 46.5 ± 10.8 years) with a body mass index (BMI) over 40 kg/m² underwent UA and facial skeletal examinations as well as polysomnography. Mean BMI was 49 ± 7 kg/m² and mean neck circumference was 43.4 ± 5.1 cm. Polysomnographic findings showed that 22% had a normal apnea-hypopnea index (AHI) and 78% had an AHI over 5. The presence of OSAS was associated with younger age (P = 0.02), larger neck circumference (P = 0.004), presence of a voluminous lateral wall (P = 0.0002), posteriorized soft palate (P = 0.0053), thick soft palate (P = 0.0014), long uvula (P = 0.04), thick uvula (P = 0.0052), and inferior turbinate hypertrophy (P = 0.04). A larger neck circumference (P = 0.02), presence of a voluminous lateral wall (P = 0.04), posteriorized soft palate (P = 0.03), and thick soft palate (P = 0.04) were all associated with OSAS severity. The prevalence of OSAS in this group was high. A larger neck circumference and soft tissue abnormalities of the UA were markers for both the presence and severity of OSAS. Conversely, no abnormalities in the facial skeleton were associated with OSAS in patients with morbid obesity.
- ItemSomente MetadadadosUpdate on Thin Melanoma: Outcome of an International Workshop(Lippincott Williams & Wilkins, 2016) Mihic-Probst, Daniela; Shea, Chris; Duncan, Lyn; de la Fouchardiere, Arnaud; Landman, Gilles [UNIFESP]; Landsberg, Jennifer; ven den Oord, Joost; Lowe, Lori; Cook, Martin G.; Yun, Sook Jung; Clarke, Loren; Messina, Jane; Elder, David E.; Barnhill, Raymond L.The following communication summarizes the proceedings of a 1-day Workshop of the International Melanoma Pathology Study Group, which was devoted to thin melanoma. The definitions and histologic criteria for thin melanoma were reviewed. The principal differential diagnostic problems mentioned included the distinction of thin melanoma from nevi, especially from nevi of special site, irritated nevi, inflamed and regressing nevi, and dysplastic nevi. Histologic criteria for this analysis were discussed and the importance of clinico-pathologic correlation, especially in acral sites, was emphasized. Criteria for the minimal definition of invasion were also discussed. In addition, a new technique of m-RNA expression profiling with 14 genes was presented and facilitated the distinction of thin melanomas from nevus in histologically obvious cases. However, for particular nevi, it was not obvious why the results indicated a malignant lesion. Despite many molecular and other ancillary investigations, Breslow thickness remains the most important prognostic factor in thin melanoma. The prognostic significance of radial (horizontal) and vertical growth phases, Clark level, regression, and mitotic rate were also discussed. Because of the increasing frequency of thin melanomas, there is a great need to develop more refined predictors of thin melanomas with worse clinical outcome.
- ItemSomente MetadadadosUpdate on Thin Melanoma: Outcome of an International Workshop(Lippincott Williams & Wilkins, 2016) Mihic-Probst, Daniela; Shea, Chris; Duncan, Lyn; de la Fouchardiere, Arnaud; Landman, Gilles [UNIFESP]; Landsberg, Jennifer; ven den Oord, Joost; Lowe, Lori; Cook, Martin G.; Yun, Sook Jung; Clarke, Loren; Messina, Jane; Elder, David E.; Barnhill, Raymond L.; Universidade Federal de São Paulo (UNIFESP)The following communication summarizes the proceedings of a 1-day Workshop of the International Melanoma Pathology Study Group, which was devoted to thin melanoma. The definitions and histologic criteria for thin melanoma were reviewed. The principal differential diagnostic problems mentioned included the distinction of thin melanoma from nevi, especially from nevi of special site, irritated nevi, inflamed and regressing nevi, and dysplastic nevi. Histologic criteria for this analysis were discussed and the importance of clinico-pathologic correlation, especially in acral sites, was emphasized. Criteria for the minimal definition of invasion were also discussed. In addition, a new technique of m-RNA expression profiling with 14 genes was presented and facilitated the distinction of thin melanomas from nevus in histologically obvious cases. However, for particular nevi, it was not obvious why the results indicated a malignant lesion. Despite many molecular and other ancillary investigations, Breslow thickness remains the most important prognostic factor in thin melanoma. The prognostic significance of radial (horizontal) and vertical growth phases, Clark level, regression, and mitotic rate were also discussed. Because of the increasing frequency of thin melanomas, there is a great need to develop more refined predictors of thin melanomas with worse clinical outcome.