Repositório Institucional - Unifesp :: Navegando por Palavras-chave "Postmenopause"

Navegando por Palavras-chave "Postmenopause"

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Acesso aberto (Open Access)
Associação entre os polimorfismos HaeIII e MspI do gene para o receptor alfa de estrogênio e densidade mamográfica em mulheres após a menopausa
(Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2006-10-01) Ramos, Eduardo Henrique de Moura [UNIFESP]; Kemp, Claudio [UNIFESP]; Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
PURPOSE: To assess the presence of estrogen receptor gene polymorphisms HaeIII and MspI as well as clinical factors, and their possible associations with high mammographic density in post-menopausal women. METHODS: One hundred and fifteen post-menopausal women, not in use of hormonal therapy and without clinical or mammographic lesions were evaluated. Three independent observers have determined the mammographic density pattern based on the ACR-BIRADS® 2003 (two subjective and one objective evaluations - Adobe Photoshop 7.0 software). Oral swabs (Cytobrush) were obtained to extract DNA and the polymerase chain reaction - restriction fragment length polymorphism) was performed to assess the presence of polymorphisms in intron 1 and exon 1 from estrogen receptor gene (HaeIII and MspI). RESULTS: The HaeIII polymorphism was found in 43 (37.4%) of the 115 women, while MspI was found in 96 (83.5%) of them. There was a good agreement among determinations of the three observers with regard to mammographic density. Thirty-four (29.6%) women had dense breasts and eighty-one (70.4%) had non-dense breasts. CONCLUSION: The estrogen receptor gene polymorphism Haelll showed no association with mammographic density (Fisher = 0.712), while the association between estrogen receptor gene polymorphism Mspl and mammographic density was near significance (Fisher = 0.098). The associations among age, parity and body mass index revealed statistical significance.
Somente Metadadados
Association between obesity and sleep disorders in postmenopausal women
(Lippincott Williams & Wilkins, 2018) Naufel, Maria Fernanda [UNIFESP]; Frange, Cristina [UNIFESP]; Andersen, Monica Levy [UNIFESP]; Batista Castello Girao, Manoel Joao [UNIFESP]; Tufik, Sergio [UNIFESP]; Ribeiro, Eliane Beraldi [UNIFESP]; Hachul, Helena [UNIFESP]
Objective:To investigate the relationship between obesity and sleep architecture in postmenopausal women.Methods:One hundred seven postmenopausal women from the Ambulatory of Integrative Treatment for Female Sleep Disorders were invited by telephone to participate in this study. Fifty-three completed the study. We included women aged 50 to 70 years, and excluded women on hormone therapy or missing data. The study consisted of two meetings, including a full-night polysomnography. Menopause status was confirmed by amenorrhea for at least 1 year. Anthropometric measurements included: body mass, height, body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio (WHR), and neck circumference. Participants were allocated into two groups according to BMI: nonobese group (BMI <30kg/m(2)) and obese group (BMI 30kg/m(2)).Results:The obese group had significantly (P<0.01) increased values of BMI, neck circumference, waist circumference, and hip circumference. WHR was similar between the groups (P=0.77). Obese participants had significantly increased values of respiratory disturbance index (16.4 vs 9.3n degrees/h) and apnea-hypopnea index (14.2 vs 5.6n degrees/h). Rapid eye movement sleep latency was positively correlated to body mass (r=P<0.01), BMI (P<0.01), and hip circumference (P=0.01). WHR was negatively correlated to sleep efficiency (P=0.03). The linear regression model showed that BMI (P<0.01) and WHR (P<0.01) were positive predictors of rapid eye movement sleep latency.Conclusion:In postmenopausal women, high BMI and abdominal obesity are sources of sleep disturbances, decreasing deep sleep, and sleep efficiency, while increasing the risk of obstructive sleep apnea.
Acesso aberto (Open Access)
Avaliação da Memória Prospectiva antes e após o uso do extrato concentrado de soja, em mulheres na pós-menopausa com queixa de alteração de memória
(Universidade Federal de São Paulo (UNIFESP), 2013) Laprano Vieira, Lucia Helena [UNIFESP]; Silva, Ivaldo [UNIFESP]; Haidar, Mauro Abi [UNIFESP]; Dardes, Rita de Cassia de Maio [UNIFESP]; http://lattes.cnpq.br/3864318683297398; http://lattes.cnpq.br/3773357188654076; http://lattes.cnpq.br/9948402316193744; http://lattes.cnpq.br/4605481134945295
O objetivo deste estudo foi analisar os efeitos do extrato concentrado de soja na memoria prospectiva (MP), apos a menopausa, por meio de avaliacao neuropsicologica. Correlacionou-se o desempenho no teste de MP, com testes de funcoes cognitivas. (funcoes atencionais, executivas, memoria, viso-motora, abstracao e linguagem), escalas de autopercepcao e depressao. Realizou-se estudo randomizado, duplo-cego, prospectivo, com 84 pacientes na posmenopausa, atendidas no Setor de Transicao Menopausal e Pos-Menopausa da Disciplina de Endocrinologia Ginecologia, do Departamento de Ginecologia da Universidade Federal de São Paulo u Escola Paulista de Medicina (UNIFESPEPM). As pacientes foram divididas, conforme programa de randomizacao, em dois grupos Grupo I - receberam 150mg de extrato concentrado de soja sob a forma de uma capsula com 60mg de isoflavonas totais, por via oral/dia; Grupo II - receberam uma capsula contendo substancia inativa (placebo), durante seis meses. Os nossos resultados demonstraram que as mulheres em uso de extrato de isoflavonas tiveram melhora clinicamente (autopercepcao) no desempenho da memoria prospectiva (MP), entretanto nao foi possivel estabelecer correlacao destes resultados com o desempenho cognitivo. O extrato concentrado de soja teve um efeito favoravel sobre a funcao cognitiva, dentre todas as funcoes, somente na memoria verbal e tarefas da funcao executiva de planejamento e flexibilidade mental, nas demais nao teve melhora. Concluimos que o extrato concentrado tem acao somente em algumas funcoes cognitivas
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The benefits of a high-intensity aquatic exercise program (HydrOS) for bone metabolism and bone mass of postmenopausal women
(Springer, 2014-07-01) Moreira, Linda Denise Fernandes [UNIFESP]; Fronza, Fernanda Cerveira Abuana Osorio; Santos, Rodrigo Nolasco dos [UNIFESP]; Zach, Patricia Lins [UNIFESP]; Kunii, Ilda Sizue [UNIFESP]; Hayashi, Lilian Fukusima [UNIFESP]; Teixeira, Luzimar Raimundo; Martins Kruel, Luis Fernando; Lazaretti-Castro, Marise [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Univ Fed Rio Grande do Sul
This study aimed to evaluate the 24-week effects of a high-intensity aquatic exercise program on bone remodeling markers and bone mass of postmenopausal women. in this randomized, controlled trial we studied 108 women (58.8 +/- A 6.4 years), randomized into Aquatic Exercise Group (AEG), n = 64, performing 24 weeks of aquatic exercises, and Control Group (CG), n = 44, sedentary. They had their fasting morning blood sample collected for the measures of intact parathyroid hormone (iPTH), procollagen type 1 amino-terminal propeptide (P1NP) and carboxy-terminal cross-linking telopeptide of type I collagen (CTx). Bone mass was measured by dual-energy X-ray absorptiometry before and after the intervention. Participants of both groups received a daily supplementation of 500 mg of elementary calcium and 1,000 IU of vitamin D (cholecalciferol). Results showed an augment in bone formation marker (P1NP) only in the AEG (15.8 %; p = 0.001), and although both groups experienced significant enhancements in bone resorption marker (CTx), this increase was less considerable in the AEG (15 % in the AEG and 29 % in the CG). IPTH was increased by 19 % in the CG (p = 0.003) at the end. the femoral trochanter BMD presented a 1.2 % reduction in the CG (p = 0.009), whereas in the AEG no change was observed (p = 0.069). the proposed aquatic exercise program was efficient in attenuating bone resorption raise and enhancing bone formation, which prevented the participants in the AEG from reducing the femoral trochanter BMD, as happened in the CG.
Acesso aberto (Open Access)
Canonical and noncanonical Wnt pathways: a comparison between endometrial cancer type I and atrophic endometrium in Brazil
(Associacao Paulista Medicina, 2011-01-01) Menezes, Marina de Pádua Nogueira [UNIFESP]; Oshima, Celina Tizuko Fujiyama [UNIFESP]; Badiglian Filho, Levon [UNIFESP]; Gomes, Thiago Simao [UNIFESP]; Barrezueta, Luis Fernando Mesias [UNIFESP]; Stávale, João Norberto [UNIFESP]; Goncalves, Wagner Jose [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
CONTEXT AND OBJECTIVE: The Wnt pathway is involved in tumorigenesis of several tissues. For this reason, we proposed to evaluate Wnt gene expression in endometrial cancer type I.DESIGN AND SETTING: Cross-sectional study on materials gathered from the tissue bank of the Department of Pathology, Universidade Federal de Sao Paulo.METHODS: Endometrial specimens were obtained from surgeries performed between 1995 and 2005 at Sao Paulo Hospital, Universidade Federal de Sao Paulo. The material was divided into two groups according to tissue type: Group A, atrophic endometrium (n = 15); and Group B, endometrial adenocarcinoma (n = 45). We compared the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and beta-catenin between endometrial cancer type I and atrophic endometrium.RESULTS: Regarding Wnt1, FZD1 and Wnt5a expression, no significant association was observed between the groups. A significant association was observed between the groups in relation to FZD5 expression (P = 0.001). The proportion of FZD5-positive samples was significantly higher in group A (80.0%) than in group B (31.1%). Regarding the survival curve for FZD5 in group B, we did not find any significant association between atrophic endometrium and endometrial adenocarcinoma. We also did not find any significant association regarding beta-catenin expression (P = 1.000).CONCLUSION: FZD5 is downregulated in endometrial adenocarcinoma, in comparison with atrophic endometrium.
Somente Metadadados
Chiropractic intervention in the treatment of postmenopausal climacteric symptoms and insomnia: A review
(Elsevier B.V., 2014-05-01) Goto, Viviane [UNIFESP]; Frange, Cristina [UNIFESP]; Andersen, Monica L. [UNIFESP]; Junior, Jose M. S. [UNIFESP]; Tufik, Sergio [UNIFESP]; Hachul, Helena [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Introduction: Insomnia is a frequent postmenopausal symptom and may be due to hormonal changes, depressive states related to this period of life, hot flashes or nocturia. Chiropractic care has been demonstrated to be effective in the treatment of these symptoms.Objectives: the aim of this study was to review chiropractic interventions in postmenopausal women as a possible management approach to menopausal symptoms and insomnia.Methods: A PubMed search was conducted by cross-referencing the key words insomnia, sleep, and menopause with chiropractic. the search used an end date of January 2014 and retrieved 17 articles.Results: Three articles were eligible for the study. All epidemiological data from large surveys demonstrated a lack of evidence for chiropractic intervention as a complementary and alternative therapeutic method in the management of menopausal symptoms and insomnia.Conclusions: There is no evidence for the effectiveness of chiropractic intervention as a complementary and alternative therapy for menopausal symptoms and insomnia. Further studies with proper methodological designs are warranted. (C) 2014 Published by Elsevier Ireland Ltd.
Acesso aberto (Open Access)
O efeito da massagem terapêutica nos sintomas climatéricos em mulheres pós-menopausadas com insônia: um estudo clínico randomizado
(Universidade Federal de São Paulo (UNIFESP), 2011-06-29) Oliveira, Denise de Souza [UNIFESP]; Bittencourt, Lia Rita Azeredo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
In the climacteric period, approximately 80% of women are affected by consequences of hypoestrogenism: physiological and psychological alterations, hot flashes, nycturia, mood alterations. These changes contribute to the increase of insomnia prevalence in this phase, which affects approximately 28% to 63% of postmenopausal women. The presence of such symptoms associated with socio-cultural conditions, such as retirement, appreciation of youth, aging, reflect directly on quality of life of this population. As hormone therapy is indicated in certain cases and is not indicated for some patients, there has been an increase in the demand for complementary or alternative therapies, including therapeutic massage, which may relieve insomnia symptoms in the climacteric period. The present study is presented in two studies. The first one, a pilot study with seven individuals, evaluated the effects of therapeutic massage on post-menopausal insomniac women and demonstrated subjective and objective sleep improvement. The results of this study led us to conduct a second one, now a randomized and controlled trial, including 44 women, distributed into 3 groups (control, passive movement and therapeutic massage). The results of the questionnaires demonstrated improvement in sleep, climacteric symptoms and quality of life.
Acesso aberto (Open Access)
Efeito de suplementação de complexo B na concentração de homocisteína e perfil lipídico na pós-menopausa
(Universidade Federal de São Paulo (UNIFESP), 2018-09-27) Banzoli, Carolina Vicente [UNIFESP]; Campos, Helena Hachul de [UNIFESP]; D'Almeida, Vânia [UNIFESP]; http://lattes.cnpq.br/7220411418339421; http://lattes.cnpq.br/0292346083994904; http://lattes.cnpq.br/4575473016156394; Universidade Federal de São Paulo (UNIFESP)
Introduction: Cardiovascular diseases (CVD) are the main cause of death in Western countries. A homocysteine (Hcy) is an important risk factor for coronary artery disease. With population growth, life expectancy for women in Brazil rose from 79.1 years, according to the 2015 census (IBGE, 2010). Given this scenario women will spend 1/3 of their lives in the postmenopausal and consequently without estrogen protection, which is already a risk factor for hyperhomocysteinemia. It is known that the vitamins pyridoxine, cyanocobalamin and folic acid are important co-factors in the metabolism of Hcy, and their deficiency may lead to an increase in Hcy plasma levels. Objective: To evaluate the effects of to assess the effects of multivitamin (pyridoxine hydrochloride 4.00 mg + folic acid 0.80 mg + cyanocobalamin 0.40 mg) on plasma Hcy plasma concentrations and lipid profile of postmenopausal women. Methods: A double-blind randomized clinical trial with an unqualified mask of convenience selected 60 postmenopausal women from the Climateric outpatient clinic at Casa de Saúde Santa Marcelina, who routinely consulted and met the inclusion criteria. Women were randomly assigned to the control or intervention group (30 in each group). The group will be delivered daily and the control group will be compressed with the organoleptic characteristics of the compound for a period of 4 months. The women were evaluated before and after 4 months of the beginning of the intervention. The following variables were analyzed in health worksheets: anthropometric measures, total cholesterol and fractions, triglycerides, fasting glycemia, Hcy, and analyzed by SPPS version 21, using the GEE test, with a significance level of 5%. Results: There was a significant decrease in Hcy in the intervention group compared to the control group when patients with HDL <50 μg / dL (p=0,01 IC= [0,133 – 0,518]). were analyzed. Conclusions: Multivitamin supplementation consisting of pyridoxine, cyanocobalamin, and folic acid was effective in decreasing plasma Hcy levels in women with decreased HDL. We conclude that B complex supplementation may be beneficial in postmenopausal patients in order to decrease the plasma Hcy level.
Acesso aberto (Open Access)
Efeitos da isoflavona e dos estrogênios conjugados eqüinos sobre a qualidade de vida na pós-menopausa
(Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2007-05-01) Vieira, Lúcia Helena Laprano [UNIFESP]; Soares Júnior, José Maria [UNIFESP]; Nunes, Márcia Gaspar [UNIFESP]; Simões, Ricardo Santos [UNIFESP]; Kaari, Cristina [UNIFESP]; Haidar, Mauro Abi [UNIFESP]; Baracat, Edmund Chada [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
PURPOSE: to analyze the isoflavone and estrogen effects on the postmenopausal quality of life. METHODS: this is a randomized and double-blind study with 79 postmenopausal patients, 12 months of amenorrhea, 40 years old or more and body mass index (BMI) above 30 kg/m². The participants were randomly divided into two treatment groups: GECP received orally two capsules, every 12 hours, one contained 0.625 mg conjugated equine estrogen and another placebo (n=33); GECS received two capsules of 150 mg extract of soy, with 60 mg isoflavone (n=32). Both treatments were administered for six months. The Quality Menopause Specific Questionnaire of Life was applied before and after one, three and six months of treatment. The parameters of gynecological cancer risk were evaluated. ANOVA and the Tukey test were used for data analysis. RESULTS: there was a reduction in the values of the vasomotor parameters after six months of treatment, 1.6±0.8 and 2.4±1.6, compared to before therapy, 4.0±2.2 and 4.2±2.3 in GECP and GECS, respectively. The psychological aspects showed reduction in values after six months of therapy, 2.5±1.2 and 2.9±1.4, compared to before treatment, 3.6±1.6 and 4.1±1.9 in GECP and GECS, respectively. Similar results were obtained on the physical aspects and in the sexual symptoms. CONCLUSIONS: isoflavones may positively act on life quality of postmenopausal women. This effect was similar to conjugated equine estrogen.
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Efeitos da isoflavona e o estrogênio na qualidade de vida na pós-menopausa
(Universidade Federal de São Paulo (UNIFESP), 2005) Laprano Vieira, Lucia Helena [UNIFESP]; Haidar, Mauro Abi [UNIFESP]
0 objetivo deste estudo é analisar os efeitos da isoflavona e do estrogênio na qualidade de vida, de mulheres na pós-menopausa, durante seis meses, utilizando-se de questionário específico construído para a menopausa (MENQOL ou Menopause-Specific Quality of Life) e critério de classificação sócio econômica. Realizou-se estudo randomizado, duplo-cego, prospectivo, com 79 pacientes na pós-menopausa, atendidas no Setor de Climatério, da Disciplina de Endocrinologia Ginecologia, do Departamento de Ginecologia da Universidade Federal de São Paulo - Escola Paulista de Medicina (UNIFESP-EPM), no período de seis meses. As pacientes foram divididas, conforme programa de randomização, em dois grupos: o grupo I recebeu estrogênio, por via oral (uma cápsula de 0,625mg de estrogênios conjugados eqüinos e, outra, era de placebo) e o grupo II recebeu isoflavona, por via oral (uma cápsula com 60 mg de isoflavonas cada, duas vezes ao dia).
Acesso aberto (Open Access)
Efeitos das isoflavonas sobre o assoalho pélvico e a vascularização peri-uretral de mulheres na pós-menopausa
(Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2006-09-01) Accorsi, Leni Aparecida Spagna [UNIFESP]; Haidar, Mauro Abi [UNIFESP]; Simões, Ricardo Santos [UNIFESP]; Accorsi Neto, Alfeu Cornélio; Mosquette, Rejane [UNIFESP]; Soares Júnior, José Maria [UNIFESP]; Baracat, Edmund Chada [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Faculdade de Medicina de Catanduva Departamento de Ginecologia; Universidade de São Paulo (USP)
PURPOSE: to evaluate muscular strength of the pelvic floor and the periurethral vessels of postmenopausal women before and after six months of soybean extract treatment. METHODS: the study was conducted on 30 postmenopausal women before and after six consecutive months of soyabean extract (100 mg/day) administration. Urinary loss and muscular strength of the pelvic floor were investigated through digital perineometer and functional evaluation. Digital color Doppler in the periurethral region was used to count the number of vessels. For statistical analysis, the paired Student t test was applied to compare the results before and after the treatment. RESULTS: twenty women reported urinary incontinence before the treatment period. The amelioration of this symptom was observed in 15 (75%) women after the treatment. Vaginal pressure (muscular strength of the pelvic floor) was 12.95±1.73 and 15.86±1.86 Sauers, before and after the treatment, respectively (p<0.001). Twenty-two women (73.3%) presented an increase in the pressure at the end of this study. In relation to the function evaluation, 18 (60%) had improvement in muscular strength and 12 women did not present any change. On ultrasonography (Doppler), the number of vessels was 2.20±0.15 blood vessels/field in the beginning of this study and 3.46±0.25 blood vessels/field at the end of the treatment (p<0.001). An increase in the number of periurethral vessels was detected in 21 women (70%). CONCLUSION: it is important to emphasize that these are preliminary results. A double blind randomized and placebo-controlled clinical trial with a high number of participants is necessary. However, the treatment with concentrated soybean extract (100 mg per day) for six consecutive months may determine an improvement in pelvic floor muscular strength and an increase in the number of periurethral vessels in postmenopausal women.
Acesso aberto (Open Access)
Efeitos do óleo essencial de lavanda na qualidade de sono em mulheres na pós-menopausa com insônia
(Universidade Federal de São Paulo (UNIFESP), 2020-04-30) Lucena, Leandro dos Reis [UNIFESP]; Hachul de Campos, Helena [UNIFESP]; http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4791144E7; http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K8484267P6; Universidade Federal de São Paulo (UNIFESP)
Objective: This study aimed to evaluate the effect of Lavandula angustifolia essential oil inhalation on sleep and menopausal symptoms in postmenopausal women with insomnia. Methods: In this double-blind, randomized controlled trial, 35 women (aged 48-65) with a clinical diagnosis of insomnia were divided into two groups: Placebo, which inhaled sunflower oil before bed and Aroma, which inhaled Lavandula angustifolia essential oil before bed, for 29 days. Both groups received sleep hygiene guidelines before the intervention and weekly follow-up during it. Polysomnography and validated questionnaires, such as Epworth Sleepiness Scale, Insomnia Severity Index, and Pittsburgh Sleep Quality Index were used to evaluate sleep. In addition, the effect of the intervention on quality of life, anxiety and depression symptoms, and postmenopausal symptoms were assessed. Evaluations were performed before and after intervention in both groups. Statistical analyses were performed with SPSS 22 using the Generalized Estimated Equations test and intention-to-treat to impute missing data. Results: There were no significant differences between groups after intervention in the primary outcome; however, a tendency of improvement in wake after sleep onset (WASO) was observed. Both groups presented better sleep quality over time. Aroma group participants showed a significant decrease in sleep onset latency, depression levels, hot flashes, postmenopausal symptoms and, in polysomnography data, increased sleep efficiency (P=0.002) compared to baseline. Conclusion: Although no significant differences were observed between groups, our data presented a tendency of improvement in WASO. Moreover, Aroma group participants had enhanced overall sleep pattern, quality and sleep efficiency. Weekly follow-up and sleep hygiene instructions were essential for both groups to show improvement in almost all outcomes.
Somente Metadadados
Effects of long-term periodized resistance training on body composition, leptin, resistin and muscle strength in elderly post-menopausal women
(Edizioni Minerva Medica, 2013-06-01) Botero, João Paulo [UNIFESP]; Shiguemoto, Gilberto Eiji; Prestes, Jonato; Marin, Cecilia Tardivo; Prado, Wagner Luiz do [UNIFESP]; Pontes, Carmen Lucia Salla; Guerra, Ricardo Luís Fernandes [UNIFESP]; Ferreira, Fabiano Candido; Baldissera, Vilmar; Perez, Sergio Eduardo de Andrade; Universidade Federal de São Paulo (UNIFESP); Universidade Federal de São Carlos (UFSCar); UNICEP; Cathol Univ Brasilia; Univ Pernambuco
Objective of the study was to determine the effects of a periodized resistance training program on body composition, plasmatic levels of leptin and resistin, and muscle strength in elderly post-menopausal women.Methods. Twenty-three post-menopausal women (age=63.02 +/- 4.42 years; height 1.55 +/- 0.06 m; body mass 67.56 +/- 2.26 kg) were submitted to 12 months of periodized resistance training twice a week. The training program consisted of 3 sets of 6-14 repetitions maximal (RM). Body composition (DXA), muscle strength (bench press, leg press 45 and arm curl), plasmatic levels of resistin and leptin (ELISA method) were assessed before and after the training program. Paired Student's t test was used for comparison between pre- and post-training values.Results. There was a significant increase in muscle strength and lean body mass; decrease in body mass, body fat percentage and fat mass after 12 months of resistance training, a part from the decrease in leptin and resistin levels.Conclusion. Long-term periodized resistance training prevents aging sarcopenia, decreases body fat and systemic markers of inflammation in postmenopausal elderly women.
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The effects of topical isoflavones on postmenopausal skin: Double-blind and randomized clinical trial of efficacy
(Elsevier B.V., 2009-10-01) Moraes, Andrea B. [UNIFESP]; Haidar, Mauro Abi [UNIFESP]; Soares Junior, Jose Maria [UNIFESP]; Simoes, Manuel J. [UNIFESP]; Baracat, Edmund C.; Patriarca, Marisa T. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
Objective: the aim of this study was to evaluate the effects of estrogen and isoflavones on postmenopausal skin morphological parameters.Study design: A randomized, double-blind, estrogen-controlled trial was performed on postmenopausal women treated in the Gynecology Department of the Federal University of São Paulo. This study was designed to analyze the effects of topical administration of estradiol and isoflavones on facial skin for 24 weeks. the participants were divided into two groups: G1-17-betaestradiol 0.01% (n = 18) and G2-isoflavones 40% (genistein 4%, n = 18). Skin biopsies were performed on each patient before and after the treatment. the skin samples were processed for histological analysis, stained with haematoxylin and eosin, and examined using light microscopy.Results: After 24 weeks of treatment, the estradiol group had a significant increase in skin parameters analyzed compared to the isoflavone group and to the baseline measurements: epidermal thickness (a 75% increase in the estrogen group and 20% in the isoflavone group), number of dermal papillae (a rise of 125% with estrogen, no significant gain with isoflavones), fibroblasts (a 123% accretion with estradiol, no significant gain with isoflavones), and vessels (a 77% increase with estrogen and 36% with isoflavones).Conclusion: Our data suggest that estrogens may have a stronger effect on histomorphometrical parameters than isoflavones. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Somente Metadadados
Estrogen therapy influence on periurethral vessels in postmenopausal incontinent women using Dopplervelocimetry analysis
(Elsevier B.V., 2008-11-20) Kobata, S. A. [UNIFESP]; Girao, M. J. B. C. [UNIFESP]; Baracat, E. C. [UNIFESP]; Kajikawa, M. [UNIFESP]; Di Bella, V. [UNIFESP]; Sartori, M. G. F. [UNIFESP]; Bella, Z. I. K. Jarmy-Di [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Lack of estrogen affects the urinary tract mainly by diminishing vascular, muscular and epithelial trophism, resulting in negative effects on continence in postmenopausal women. Therefore, the use of estrogens in these patients may revert these alterations and lead to an expressive improvement of the urinary symptoms.Objective: Study the effect of topical estrogen therapy (conjugated equine estrogens, estriol or promestriene) in periurethral vessels detected by Dopplervelocimetric analysis using, as parameters: the number of vessels, resistance and pulsatility indexes, as well as the minimum diastolic value.Methods: Forty-one postmenopausal women with stress urinary incontinence were randomized into three groups according to different types of topical estrogen received during 3 months. Group I received conjugated equine estrogens, group 2 received estriol and group 3 received promestriene. Periurethral Dopplervelocimetry analysis was done before estrogen administration and during treatment in all groups.Results: We observed an increase in the number of the periurethral vessels in group 1 and group 2, being higher in group I than in group 2. the pulsatility index remained unchanged in all three groups. the resistance index at the periurethral vessels reduced only at the conjugated estrogen group (group 1). in this same group we noticed an increase in the mean minimal diastolic value, meaning a better periurethral vascularization.Conclusion: Topical conjugated equine estrogens and estriol were effective in increasing the number of periurethral vessels in postmenopausal women with Urinary stress incontinence, with the Conjugated equine estrogens being the most effective intervention studied. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Acesso aberto (Open Access)
Estudo da via Wnt no endométrio normal e no câncer de endométrio, em mulheres após a menopausa
(Universidade Federal de São Paulo (UNIFESP), 2011-06-29) Menezes, Marina de Pádua Nogueira [UNIFESP]; Goncalves, Wagner Jose [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
The Wnt family is involved in tumorigenesis of several tissues as well in embriogenesis. In order to analize the canonical and noncanonical Wnt pathway in atrophic endometrium and endometrial adenocarcinoma, we evaluated the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and ƒÀ-catenin. Endometrial specimens were obtained from surgeries performed between 1995 and 2005 and the patients were divided in two groups: Group A, atrophic endometrium (N = 15); Group B, endometrial adenocarcinoma (N = 45). Immunoreactivity for Wnt1, FZD1, Wnt5a, FZD5 and ƒÀ-catenin was scored for each group. For the expression of Wnt1, FZD1 and Wnt5a, no significant association was observed between the groups. A significant association was observed between the groups for the FZD5 expression (p = 0.001). The proportion of FZD5 positive women was significantly higher for group A (80.0%) compared to group B (31.1%). Regarding the survival curve for FZD5 at group B, we found no significant association between positive and negative women. No significant association was observed between s-catenin expression and the patient group since the expression for groups A and B were 100% and 95.6%, respectively (p = 1.000). FZD5 is downregulated in type I endometrial adenocarcinoma when compared to atrophic endometrium.
Acesso aberto (Open Access)
Estudo do binômio insônia-dor musculoesquelética crônica na pós-menopausa
(Universidade Federal de São Paulo (UNIFESP), 2017-11-30) Frange, Cristina Mattos Pereira [UNIFESP]; Andersen, Monica Levy [UNIFESP]; Hachul, Helena [UNIFESP]; http://lattes.cnpq.br/0292346083994904; http://lattes.cnpq.br/4951931552005515; http://lattes.cnpq.br/5507825991578153; Universidade Federal de São Paulo (UNIFESP)
Sleep and pain are assumed to share a reciprocal relationship. Chronic musculoskeletal pain, and sleep disorders such as insomnia are two central symptoms of menopause symptomatology. Although postmenopausal women often suffer from both, there is a lack of studies addressing these two factors and their interaction. The objectives of this study were therefore to investigate the relationship between these two factors and their effect on sleep quality and pattern; chronic musculoskeletal pain severity, intensity and interference in daily function, the number of pain sites; menopausal and mood symptoms; and quality of life. We examined this relationship between sleep and chronic musculoskeletal pain, through a 10-day temporal analysis. Our sample was composed of 4 groups: CTRL - control group, absence of diagnosis of insomnia and musculoskeletal pain; CMP Group - absence of insomnia and complaint of chronic musculoskeletal pain; INS Group - clinical diagnosis of insomnia and absence of chronic musculoskeletal pain and CMP+INS Group - clinical diagnosis of insomnia and presence of complaint of chronic musculoskeletal pain. We performed two analyzes: coss sectional and microlongitudinal. All volunteers answered questionnaires about pain, quality of sleep and life, climacteric, anxiety and depression symptoms, and blood samples were collected for confirmation of postmenopausal status, and we performed polysomnography and actigraphy exams. Our results indicate that insomnia by itself was associated with more self-reported pain. The presence of chronic musculoskeletal pain alone does not modify sleep, either subjectively or objectively. However, the association of both comorbidities was related to worsening menopausal and anxiety symptoms, higher sleep fragmentation, worse severity of chronic musculoskeletal pain, as well as more interference in daily activities and more pain sites, and also lower quality of life. Our findings indicated that the higher the sleep duration, the higher the pain intensity upon waking, while increased pain at bedtime predicted longer sleep duration and also time in bed in postmenopausal women. These results strongly suggest that sleep and pain conditions should both be targeted in the treatment of postmenopausal women in order to improve quality of life and reduce the possible development of comorbidities, such as anxiety and depression.
Somente Metadadados
Estudo histológico do endométrio de pacientes com carcinoma mamário na pós-menopausa
(Universidade Federal de São Paulo (UNIFESP), 1989) Nazário, Afonso Celso Pinto [UNIFESP]; Lima, Geraldo Rodrigues de [UNIFESP]
Somente Metadadados
Expression of p53 protein in the endometrial polyp in postmenopausal women
(I R O G Canada, Inc, 2013-01-01) Albuquerque Neto, Luiz Cavalcanti de [UNIFESP]; Soares, Jose Maria [UNIFESP]; Giusa-Chiferi, Maria Gabriela [UNIFESP]; Goncalves, Wagner Jose [UNIFESP]; Baracat, Edmund Chada [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
Objective: To evaluate p53 protein expression in the endometrial polyp and compare with adenocarcinoma and atrophic endometrium of postmenopausal women. Materials and Methods: Ninety-eight postmenopausal women were included in this study and divided into three groups related to histopathologic diagnosis: Group A - endometrial adenocarcinoma (n = 40), Group B - endometrial polyp (n = 38), and Group C - endometrial atrophy (n = 20). The length of this study was from 1990 to 2004. The endometrial samples were collected from hysteroscopic biopsy or surgery then processed for histopathologic routine. One thousand cells of each histological section were evaluated for immunohistochemical analysis using p53 antibodies. The ANOVA test was performed for the statistical analysis. Results: The expression of p53 in adenocarcinoma samples was the highest. The expression of polyp was positive when associated to hyperplasia without atypia. All samples of atrophic endometrial were negative. Conclusions: The present data suggested that presence of hyperplasia in the endometrial polyp is factor to increase the expression of p53.
Acesso aberto (Open Access)
Frequencia dos disturbios de sono em mulheres na pos-menopausa com sobrepeso/obesidade
(Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2014-02-01) Correa, Karin Mitiyo; Bittencourt, Lia Rita Azeredo [UNIFESP]; Tufik, Sergio [UNIFESP]; Hachul, Helena; Universidade Federal de São Paulo (UNIFESP)
PURPOSE:To evaluate the frequency of sleep disorders, such as obstructive sleep apnea, restless leg syndrome and insomnia in overweight/obese postmenopausal women seen in a climacteric sleep disorders clinic.METHODS:Thirty-four postmenopausal women were selected using the following inclusion criteria: age between 50 and 70 years; at least 12 months of amenorrhea; body mass index (BMI) greater than or equal to 25 kg/m2; and sleep-related complaints with at least one previous polysomnography. Patients provided responses to 6 questionnaires related to sleep characteristics and menopausal symptoms. Weight and height were measured using standardized scales, and abdomen and hip circumferences were also measured. The statistical analyses were performed using the χ2 test for qualitative variables and using Student's t-test for quantitative variables.RESULTS:Patients' characteristics were as follows: mean age of 60.35 years; mean BMI of 31.62; an average of 11.61 postmenopausal years and an average Kupperman Index of 19. A total of 85.2% of the patients had a waist/hip ratio of less than 0.8. The Epworth Scale score was greater than or equal to 9 in 50% of patients; 68% had sleep disturbances according to the Pittsburgh Index, and 68% were classified as high-risk for sleep apnea by the Berlin Questionnaire. On polysomnography, 70.58% of the patients had a sleep efficiency lower than 85%; 79.41% had a sleep latency of less than 30 min; 58.82% had a REM sleep latency of less than 90 min, and 44.11% had mild apnea. When the groups were compared, a linear association was identified between BMI and the AHI average, and a relationship between high BMI and use of drugs for thyroid treatment was found.CONCLUSION:There was a high prevalence of sleep-disordered breathing, initial insomnia, fragmented sleep, and thyroid disorders in the group with higher BMI.

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