Navegando por Palavras-chave "Poly-Butylene Adipate-Co-Terephthalate"

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    Produção, por rotofiação, de fibras poliméricas bioabsorvíveis ultrafinas de poli (butileno adipato cotereftalato) reforçadas com nanotubos de carbono e nanohidroxiapatita para preenchimento ósseo
    (Universidade Federal de São Paulo (UNIFESP), 2017-03-13) Andrade, Patricia Oliveira de [UNIFESP]; Santo, Ana Maria do Espírito [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Bone grafting is performed for numerous reasons, including injuries and diseases. The use of bioabsorbable polymers rises as an alternative for treating hard tissue damages, including as three-dimensional porous scaffolds for the growth of tissue cells. Some properties can be improved adding nanoparticles fillers into the polymeric fibers as nanohydroxyapatite (nHap) and superhydrophilic multi-walled carbon nanotubes (nMWCNT-O2) forming a nanocomposite (nHap/ nMWCNT-O2) as reinforcement into the polymeric fibers. The current work describes the production of the bioabsorbable polymeric fibers of poly-butylene adipate-co-terephthalate (PBAT) matrix filled with (nHap/ nMWCNT-O2) as biological and mechanical reinforcements, respectively. This investigation aims the attainment of proper fibers as biomaterial for hard tissue engineering and orthodontics applications. Ultrathin polymeric fibers were produced by Rotary Jet Spinning technique (RJS). This method has proved be quite effective to produce porous matrices of PBAT. The experimental groups were divided as: Pure PBAT; PBAT filled with nMWCNT-O2; PBAT filled with nHap and PBAT filled with nanocomposite nHap/ nMWCNT-O2 under different concentrations of nMWCNT-O2 in NHap (nHap/nMWCNT-O2 1%, 2% and 3%). The scaffolds reinforcement was set at 1% wt content in polymer matrix. The physical and chemical properties of the samples were characterized by FT-IR, FT-RAMAN, DSC, TG, DMA, DRX, μEDX and Wettability. The fibers were also biologically evaluated by LDH, SBF and adhesion. The main results indicated that adding nMWCNT-O2 into the polymeric fiber matrix produced minor effect to improve the mechanical properties than nHap nanoparticles. All produced fibers, independently of the nanoparticle, showed be suitable to cellular adhesion as well to apoptosis level. Adding nHap particles favored cell growth along the fibers. This material shows as brand-new solution as scaffold in alloplastic bone grafting.