Navegando por Palavras-chave "Peritoneal macrophages"

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    Changes in the pro-inflammatory cytokine production and peritoneal macrophage function in rats with chronic heart failure
    (Elsevier B.V., 2006-06-01) Batista, M. L.; Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]; Cunha, L. M.; Mattos, K.; Oliveira, E. M.; Seelaender, M. C. L.; Rosa, L. F. B. P. Costa; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Chronic heart failure (CHF) is a state of immune activation, and pro-inflammatory cytokines play an important role in its development and progression. Macrophages (M phi s), when activated, are the main source of pro-inflammatory cytokines. We measured interjeukin-6 (IL-6), interleukin (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) production after lipopolysaccharide (LPS)-stimulation, as well as peritoneal M phi s migration, phagocytic capacity, chemotaxis index, and hydrogen peroxide production, in an attempt to clarify the role of this cell in an animal model of CHF. Ligature of the left coronary artery or sham operation was performed in adult Wistar rats. After 12 weeks, resident and total cell number, phagocytic capacity, chemotaxis index, and hydrogen peroxide production in M phi s were significantly higher in CHF than in control rats. the production of IL-6 and TNF-alpha was similarly significantly enhanced in CHF as compared with controls. M phi s obtained from CHF rats were more responsive to LPS, suggesting the existence, in vivo, of possible factor(s) modulating the production of pro-inflammatory cytokines. the results demonstrated that there is modification of peritoneal M phi s function along CHF development, possibly contributing to the pathophysiological process in the establishment of CHF. (c) 2006 Elsevier B.V. All rights reserved.
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    Immunomodulation and nitric oxide restoration by a probiotic and its activity in gut and peritoneal macrophages in diabetic rats
    (Churchill Livingstone, 2016) Maciel, Fabiane Romano [UNIFESP]; Punaro, Giovana Rita [UNIFESP]; Rodrigues, Adelson Marçal [UNIFESP]; Bogsan, Cristina Stewart Bittencourt; Rogero, Marcelo M.; Oliveira, Marice N.; Mouro, Margaret Gori [UNIFESP]; Higa, Elisa Mieko Suemitsu [UNIFESP]
    Background: The hyperglycemia leads to increased oxidative stress, causing lipid peroxidation and imbalance in the immune system. Aims: To investigate the effect of Kefir - a probiotic containing different strains on metabolic parameters, cytokines, nitric oxide (NO) production, phagocytic activity of peritoneal macrophages and intestinal modulation in diabetes. Methods: Wistar rats received injection of streptozotocin (45 mg/kg, intravenously) and diabetes was defined as glycemia >= 200 mg/dL. The animals were distributed in four groups: control (CTL)