Navegando por Palavras-chave "Pelvic organ prolapse"
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- ItemSomente MetadadadosCollagen XVIII and LOXL-4 polymorphisms in women with and without advanced pelvic organ prolapse(Springer London Ltd, 2018) Santos, Renata G. M. dos [UNIFESP]; Pepicelli, Fernanda C. A. [UNIFESP]; Batista, Nilce C. [UNIFESP]; Carvalho, Cristina Valletta de [UNIFESP]; Bortolini, Maria Augusta Tezelli [UNIFESP]; Castro, Rodrigo Aquino [UNIFESP]Introduction and hypothesis We verified the presence of single nucleotide polymorphisms (SNP) rs2236479 of the collagen 18 (COL18A1) and rs2862296 of the lysyl oxidase-like 4 (LOXL-4) genes and the association with pelvic organ prolapse (POP) in Brazilian women and determined risk factors for POP development. Methods We assessed 532 postmenopausal women divided into POP (stages III and IV) and control (stages 0 and I) groups by examination and peripheral blood sample collection. DNA sequences of interest were analyzed by real-time reverse-transcriptase polymerase chain reaction (RT-PCR). We used logistic regression models for the analyses, with p < 0.005 for significance. Results The frequency of homozygous polymorphic alleles (AA) in COL18A1 and (GG) in LOXL-4 were similar in both groups (17.5% and 15.4% for COL18A1 and 18.9% and 20.6% for LOXL-4, respectively). There were no associations between those polymorphisms or other genotypes and POP. Multiple logistic regression analysis identified age [odds ratio (OR) = 1.10, confidence interval (CI) 95% = 1.07
- ItemAcesso aberto (Open Access)Estudo da associação da atividade sexual com as disfunções do assoalho pélvico e suas implicações na qualidade de vida em mulheres(Universidade Federal de São Paulo (UNIFESP), 2018-05-08) Macedo, Sandra Reboucas [UNIFESP]; Castro, Rodrigo de Aquino [UNIFESP]; http://lattes.cnpq.br/9585387338656765; Bezerra, Leonardo Robson Pinheiro Sobreira; http://lattes.cnpq.br/6590913930590292; http://lattes.cnpq.br/8681235898667584; Universidade Federal de São Paulo (UNIFESP)Postmenopausal age and status are factors that negatively affect sexual activity. being married facilitates sexual activity in women, with dap. the presence of genital prolapse and urinary incontinence do not alter sexual activity. nsa women with genital prolapse present an important impairment of their quality of life when compared to sas...
- ItemAcesso aberto (Open Access)Estudo da imunogenicidade e segurança da vacina tríplice bacteriana acelular do adulto (dTpa) em crianças e adolescentes com artrite idiopática juvenil (AIJ)(Universidade Federal de São Paulo (UNIFESP), 2017-05-25) Nicacio, Aline Alencar Martins Fernandes [UNIFESP]; Terreri, Maria Teresa de Sande e Lemos Ramos Ascensão [UNIFESP]; Pinto, Maria Isabel de Moraes [UNIFESP]; http://lattes.cnpq.br/0967318191677557; http://lattes.cnpq.br/2661280959330284; http://lattes.cnpq.br/1618399462513631; Universidade Federal de São Paulo (UNIFESP)Introduction: Juvenile Idiopathic Arthritis (JIA) is the most common chronic rheumatic disease in childhood, accounting for varying degrees of physical disability. Protection of infections through active immunization is essential in patients with JIA using immunosuppressive drugs. However, there are still doubts about indication, safety and efficacy, as well as reactivation of the disease in this group of patients when using these vaccines. Objectives: The aim of this study was to evaluate the immunogenicity and safety of adult acellular bacterial triple vaccine (dTpa) in patients with JIA with or without use of anti-TNF agents. Methods: This is a prospective longitudinal experimental study in which three groups of individuals were assessed: one with patients with JIA according to ILAR criteria using anti-TNF agent (n=19), another with JIA patients without use of anti-TNF agent (n=19) and another from healthy individuals (Control, n=27), paired with case groups by age and gender. A 0.5 ml dose of the diphtheria, tetanus, acellular pertussis (dTpa) adsorbed vaccine (ADACEL® Sanofi Pasteur, Toronto, Canada) was administered intramuscularly in the non-dominant arm of the selected subjects. Samples of 10 mL of peripheral blood were collected on the day of vaccination (D0), after 14 days (D14) and 28 days after vaccination (D28). Serology for tetanus, diphtheria and pertussis and immunophenotyping of lymphocytes in peripheral blood were performed. Results: Patients with and without anti-TNF agents did not present significant differences in the frequency of ANA (anti-nuclear antibody), RF (rheumatoid factor) and presence of uveitis. There was only association between use of anti-TNF and course subtype (p = 0.009). Thus, it was observed that patients without anti-TNF had a higher percentage of persistent oligo (36.8% vs 0%) and lower ERA frequency (0.0% vs 21.1%) compared to the group onf anti-TNF. In the group on anti-TNF agent, about half were on fusion protein (etanercept), while the other half were on monoclonal antibody (adalimumab or infliximab). We did not observe reactivation of the disease after vaccination. We observed presence of adverse events in about one third of the individuals, being pain at the site of the vaccine the most prevalent. Differences in the immunophenotypic profile were observed, but without repercussion in the humoral immune response to the three antigens evaluated. Conclusion: The subjects with JIA with or without use of anti-TNF agents showed a good response to a booster dose for the three antigens studied in the absence of major adverse events and without reactivation of the disease.
- ItemAcesso aberto (Open Access)Estudo de polimorfismos de DNA em mulheres com e sem prolapso avançado de órgãos pélvicos(Universidade Federal de São Paulo (UNIFESP), 2017-05-30) Santos, Renata Gonçalves Martello dos [UNIFESP]; Castro, Rodrigo de Aquino [UNIFESP]; Bortolini, Maria Augusta Tezelli [UNIFESP]; Carvalho, Cristina Valletta de [UNIFESP]; Maria Augusta Tezelli Bortolini : http://lattes.cnpq.br/1150368284144393; Cristina Valletta de Carvalho : http://lattes.cnpq.br/6006653389006277; http://lattes.cnpq.br/6590913930590292; http://lattes.cnpq.br/5544814435283297; Universidade Federal de São Paulo (UNIFESP)Objective: To verify the presence of DNA polymorphisms rs2236479 (Col18A1) and rs2862296 (LOXL-4) and its association with POP in the Brazilian population. METHODS: 532 postmenopausal women divided into POP (stage III or IV by POP-Q) and control (stage 0 or I by POP-Q) were included. Women with previous hysterectomy or other pelvic surgery were excluded. The evaluation included clinical examination and blood collection. The genetic material was analyzed by RT-PCR. The statistical analysis of the data was performed according to the type of variable, using the chi-square test, mean and standard deviation, and median and 25th and 75th percentiles. For comparison between groups, the t test -Student for two independent samples and the Mann-Whitney test. The verification of the association between genotypes and the presence of prolapse was estimated by the odds ratio (OR) and respective 95% confidence intervals (95% CI) using binary logistic regression models. Results: A greater proportion of the genotypes with at least one polymorphic allele (AG and GG) of the LOXL-4 gene was verified in the control group compared to the POP group (73.2% and 67.3%, respectively, p = 0.465 ). As for the Col8A1 gene, a higher percentage of GA genotype was found in the control group (50.2% and 44.2%, respectively) and a higher number of women with POP and both polymorphic alleles (AA) (17.5% and 15.4% respectively), non-statistically significant results (p = 0.556). No associations were observed between presence of polymorphisms and POP. However, in the group of women homozygous for the polymorphic allele, both for LOXL-4 (GG) and Col18A1 (AA), OR less than 1 (OR = 0.84, 95% CI (0.47, 1.50 ) and (OR = 0.91, 95% CI (0.50, 1.65), respectively, suggest that these genotypes may be protective factors for POPs. In addition, the variables age, higher number of pregnancies, normal and presence of family history of POP were associated with the presence of dysfunction. Conclusion: There was no association between the presence of polymorphisms rs2862296, of the LOXL-4 gene, and rs2236479, of the Col18A1 mole, and the development of genital prolapse degrees III or IV in this sample of patients.
- ItemAcesso aberto (Open Access)Expressão de genes e de proteínas envolvidos na biossíntese da matriz extracelular no tecido vaginal de mulheres com e sem prolapso de órgãos pélvicos(Universidade Federal de São Paulo (UNIFESP), 2011-05-25) Bortolini, Maria Augusta Tezelli [UNIFESP]; Sartori, Marair Gracio Ferreira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: Pelvic organ prolapse (POP) results from the failure of pelvic floor support, and connective tissue abnormalities may be involved in the etiology and/or progression of the dysfunction. We aimed to analyze the differential expression of genes and proteins related to the collagen and elastin biogenesis: lysyl oxidases (LOXs), fibulin-5, fibrillin -1 and -2, and procollagen C proteinase (PCP/BMP1) in vaginal tissue of women without and with advanced POP controlled by hormonal status. Materials and Methods: During total hysterectomy, anterior vaginal wall biopsies were obtained from Caucasian premenopausal women (proliferative phase of menstrual cycle) and postmenopausal women with severe POP (POPQ stage III and IV) and asymptomatic controls (POPQ 0). Total mRNA and protein were extracted using Trizol and RIPA buffer, and the genes and proteins of interest were quantified by real-time RT-PCR and Immunoblotting, respectively. The following analysis were performed: (1) expression of LOX family genes and proteins (LOX and LOXL1-4), fibulin-5, fibrillin-1 and -2 in premenopausal women with and without POP; (2) PCP/BMP1 gene and protein expression in vaginal tissue of pre- and postmenopausal POP women, and respective controls. Wilcoxon signed-rank and Fisher tests were used for statistical analysis (p<0.05). Results: Samples from 15 premenopausal patients and 11 controls were obtained for study (1); 39 premenopausal (POP=23 and Control=16) and 18 postmenopausal women samples (POP=13 and Control=5) for study (2). We observed: (1) significant decrease in expression of LOX, LOXL1 and LOXL3 genes, as well as LOX and LOXL3 proteins in vaginal tissue of premenopausal POP patients compared with asymptomatic women (p<0.05); (2) PCP/BMP1 gene downregulation in the vagina of women with severe POP compared with controls, in both premenopausal and postmenopausal phase (both p=0.01); significant reduction of 130 kDa, 92.5 kDa and 82.5 kDa PCP/BMP1 isoforms in vaginal tissue of postmenopausal patients (p=0.01), and 130 kDa isoform upregulation in premenopausal women with severe POP (p=0.009), compared with their respective controls. Conclusion: The expression of LOXs enzymes and PCP/BMP1 are altered in vaginal tissue of women with severe POP, and are modulated by hormonal status. Dysregulation of these enzymes involved in the extracellular matrix biogenesis may contribute to impaired tissue and vaginal support, and may be involved in POP development.
- ItemSomente MetadadadosExpression of Bone Morphogenetic Protein-1 in vaginal tissue of women with severe pelvic organ prolapse(Elsevier B.V., 2011-06-01) Bortolini, Maria Augusta Tezelli [UNIFESP]; Shynlova, Oksana; Drutz, Harold P.; Girão, Manoel João Batista Castello [UNIFESP]; Castro, Rodrigo de Aquino [UNIFESP]; Lye, Stephen; Alarab, May; Univ Toronto; Mt Sinai Hosp; Universidade Federal de São Paulo (UNIFESP)OBJECTIVES: To analyze the differential gene and protein expression of Bone Morphogenetic Protein-1 in vaginal tissue of women with advanced pelvic organ prolapse and controls.STUDY DESIGN: We sampled the anterior vaginal wall of 39 premenopausal (23 patients and 16 controls), and 18 postmenopausal women (13 patients and 5 controls) during hysterectomy. Total mRNAs and proteins were quantified by real-time RT-PCR and immunoblotting.RESULTS: Bone Morphogenetic Protein-1 gene expression was decreased in pre- and postmenopausal pelvic organ prolapse patients compared with asymptomatic women (P = .01). the expression of 130 kDa, 92.5 kDa, and 82.5 kDa isoforms of Bone Morphogenetic Protein-1 were down-regulated in postmenopausal patients (P = .01), whereas the 130 kDa isoform expression was up-regulated in premenopausal patients (P = .009), when compared with respective controls.CONCLUSION: the Bone Morphogenetic Protein-1 expression in human vagina was altered in patients with severe pelvic organ prolapse and influenced by menopausal status. Dysregulation of Bone Morphogenetic Protein-1 may contribute for a deficient vaginal connective tissue and support.
- ItemSomente MetadadadosGenetics of pelvic organ prolapse: crossing the bridge between bench and bedside in urogynecologic research(Springer, 2011-10-01) Bortolini, Maria Augusta Tezelli [UNIFESP]; Rizk, Diaa E. E.; Universidade Federal de São Paulo (UNIFESP); Ain Shams UnivAn increasing number of scientists have studied the molecular and biochemical basis of pelvic organ prolapse (POP). the extracellular matrix content of the pelvic floor is the major focus of those investigations and pointed for potential molecular markers of the dysfunction. the identification of women predisposed to develop POP would help in the patients' management and care. This article includes a critical analysis of the literature up to now; discusses implications for future research and the role of the genetics in POP.
- ItemSomente MetadadadosHysteropreservation versus hysterectomy in the surgical treatment of uterine prolapse: systematic review and meta-analysis(Springer London Ltd, 2017) Oliveira, Sofia Andrade de [UNIFESP]; Fonseca, Marcelo Cunio Machado [UNIFESP]; Bortolini, Maria Augusta Tezelli [UNIFESP]; Girão, Manoel João Batista Castello [UNIFESP]; Roque, Matheus T.; Castro, Rodrigo de Aquino [UNIFESP]Introduction and hypothesis The efficacy and safety of removing or preserving the uterus during reconstructive pelvic surgery is a matter of debate. Methods We performed a systematic review and meta-analysis of studies that compared hysteropreservation and hysterectomy in the management of uterine prolapse. PubMed, Medline, SciELO and LILACS databases were searched from inception until January 2017. We selected only randomized controlled trials and observational cohort prospective comparative studies. Primary outcomes were recurrence and reoperation rates. Secondary outcomes were: operative time, blood loss, visceral injury, voiding dysfunction, duration of catheterization, length of hospital stay, mesh exposure, dyspareunia, malignant neoplasia and quality of life. Results Eleven studies (six randomized and five non-randomized) were included involving 910 patients (462 in the hysteropreservation group and 448 in the hysterectomy group). Pooled data including all surgical techniques showed no difference between the groups regarding recurrence of uterine prolapse (RR 1.65, 95% CI 0.88-3.10; p = 0.12), but the risk of recurrence following hysterectomy was lower when the vaginal route was used with native tissue repair (RR 10.61; 95% CI 1.26-88.94; p = 0.03). Hysterectomy was associated with a lower reoperation rate for any prolapse compartment than hysteropreservation (RR 2.05; 95% CI 1.13-3.74; p = 0.02). Hysteropreservation was associated with a shorter operative time (mean difference -12.43 min; 95% CI -14.11 to -10.74 ; p < 0.00001) and less blood loss (mean difference -60.42 ml; 95% CI -71.31 to -49.53 ml; p < 0.00001). Other variables were similar between the groups. Conclusions Overall, the rate of recurrence of uterine prolapse was not lower but the rate of reoperation for prolapse was lower following hysterectomy, while operative time was shorter and blood loss was less with hysteropreservation. The limitations of this analysis were the inclusion of nonrandomized studies and the variety of surgical techniques. The results should be interpreted with caution due to potential biases.
- ItemSomente MetadadadosMonoprosthesis for anterior vaginal prolapse and stress urinary incontinence: midterm results of an international multicentre prospective study(Springer, 2011-12-01) Palma, Paulo; Riccetto, Cassio; Prudente, Alessandro; Dalphorno, Fernanda; Delroy, Carlos; Castro, Rodrigo [UNIFESP]; Tcherniakovsky, Marcos; Salvador, Marcia; Bartos, Paul; Paladini, Mario; Adile, Biagi; Cianci, Antonio; Bandiera, Sebastiano; Universidade Estadual de Campinas (UNICAMP); Metropolitan Hosp; Universidade Federal de São Paulo (UNIFESP); Mater Hosp; JG Mendel Canc Ctr; Villa Sofia Hosp; Univ CataniaStress urinary incontinence (SUI) can occur simultaneously with anterior vaginal prolapse (AVP) in up to 30% of patients. We studied a monoprosthesis that combines prepubic and transobturator arms for simultaneous treatment of AVP and SUI.One hundred four women with AVP underwent surgical treatment using a monoprosthesis (NAZCA TCA (R)). POP-Q was used for anatomical evaluation. Functional results were evaluated by quality of life questionnaires, stress test and Stamey score. Patients were evaluated at 1, 3, 6 and 12 months postoperatively.There were significant and sustained improvements in points Aa, Ba and C. Positive stress test was observed in 29.8% preoperatively and decreased to 1.9% after 12 months. There was no significant impact in sexual symptoms. Mesh exposure was noted in 5.7% of patients.Monoprosthesis with combined prepubic and transobturator arms presented high success rates for AVP repair and simultaneous SUI treatment. It has also been shown to be safe and appears to preserve sexual function.
- ItemSomente MetadadadosPelvic floor disorders among indigenous women living in Xingu Indian Park, Brazil(Springer, 2009-09-01) Araujo, Maita Poli de; Takano, Claudia Cristina [UNIFESP]; Batista Castello Girao, Manoel Joao [UNIFESP]; Ferreira Sartori, Marair Gracio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Current assessment for pelvic floor disorders (PFDs) allows comparison between different communities.A total of 377 indigenous women living in Xingu Indian Park were evaluated. the pelvic organ prolapse quantification (POP-Q) was the system used to quantification the staging of pelvic support. the pelvic floor muscle strength was assessed by a perineometer. Logistic regression analysis was used to determine risk factors that were associated with prolapse.Only 5.8% of women reported urinary incontinence. the overall distribution of POP-Q stage system was the following: 15.6% stage 0, 19.4% stage I, 63.9% stage II and 0.8% stage III. Parity and age were the risk factors for pelvic organ prolapse (p < 0.0001).Urinary incontinence was uncommon in Xingu indigenous women. Like non-indigenous communities, age and parity were the most important risk factors to the genital prolapse.
- ItemSomente MetadadadosPelvic floor muscle training for treatment of pelvic organ prolapse: an assessor-blinded randomized controlled trial(Springer, 2011-10-01) Stuepp, Liliana [UNIFESP]; Magalhaes Resende, Ana Paula [UNIFESP]; Oliveira, Emerson [UNIFESP]; Castro, Rodrigo Aquino [UNIFESP]; Batista Castello Girao, Manoel Joao [UNIFESP]; Ferreira Sartori, Marair Gracio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)This pilot study aimed to investigate the effectiveness of pelvic floor muscle training (PFMT) for the treatment of pelvic organ prolapse.Thirty-seven women with stage II prolapse were randomized to either the intervention group (n = 21) or the control group (n = 16). the evaluation included assessments of pelvic floor muscle function and surface electromyography at baseline and post 14 weeks of treatment. the severity of prolapse was quantified by the POP-Q method and symptoms by P-QoL questionnaire.The intervention group showed significantly greater anatomic improvements in the anterior and posterior vaginal wall prolapses than did the control group (P < 0.001 and 0.025, respectively) and a decrease of symptoms. in addition, the intervention group had greater improvements in muscle strength (P < 0.001), endurance (P < 0.001), and electromyography parameters (P = 0.008) compared to the control group.PFMT is effective in the treatment of pelvic organ prolapse.
- ItemAcesso aberto (Open Access)Tradução, adaptação cultural e validação do Australian Pelvic Floor Questionnaire para o português brasileiro e sintomas de disfunções do assoalho pélvico durante a gestação e pós-parto(Universidade Federal de São Paulo, 2023-12-08) Cruz, Amanda Amorim [UNIFESP]; Sartori, Marair Gracio Ferreira [UNIFESP]; http://lattes.cnpq.br/2545470341657690; http://lattes.cnpq.br/3362770743372198Disfunções do Assoalho Pélvico (DAP) são uma preocupação significativa durante a gravidez e o período pós-parto. Objetivos: (i) traduzir, adaptar e validar o Australian Pelvic Floor Questionnaire (APFQ) para o português brasileiro na população de gestantes e mulheres no pós parto; e (ii) monitorar os sintomas de DAP ao longo da gestação e no pós-parto. Métodos: Para responder ao primeiro objetivo foram recrutadas 150 mulheres (75 gestantes e 75 mulheres no pós-parto). Foi avaliada a consistência interna, a validade do construto e a reprodutibilidade nos domínios: função urinária, função intestinal, prolapso e função sexual. Para responder ao segundo objetivo, monitoramos os sintomas de DAP aplicando o APFQ em gestantes e no pós-parto. As gestantes foram divididas em dois períodos: até 28 semanas (Período 1) e de 28 a 40 semanas gestacionais (Período 2), enquanto as mulheres pós-parto foram divididas em três períodos: até 6 semanas (Período 3), de 7 a 24 semanas (Período 4) e mais de 24 semanas pós-parto (Período 5). Resultados: Apenas 1% da amostra obteve pontuação no domínio de prolapso, portanto, ele foi excluído das análises de validação. Foram obtidos valores de Alfa de Cronbach superiores a 0,70 para os domínios da bexiga e intestino, e 0,69 para a função sexual. Quanto à reprodutibilidade, o Intraclass Correlation (ICC) foi superior a 0,75 para todos os domínios. A correlação de Spearman foi boa para intestino (r=0,74), moderada para bexiga (r=0,58) e fraca para função sexual (r=0,23). Os resultados da Análise Fatorial Confirmatória (AFC) mostraram adesão não ideal: apesar do valor de x² ser significativo (p<0,001), o valor de CMIN foi inferior a 3. Foram obtidas sensibilidades acima de 80%, e especificidades de 43%, 16% e 12% para os domínios intestino, bexiga e função sexual, respectivamente. Para os sintomas de DAP nos períodos 1 ao 5, foram incluídas 46 e 44 gestantes (períodos 1 e 2, respectivamente) e 65, 53 e 39 mulheres pós-parto (períodos 3, 4 e 5, respectivamente),. Foram observadas diferenças significativas nos sintomas de DAP ao longo do tempo. Para as gestantes, a função sexual variou significativamente entre os dois períodos, enquanto as mulheres pós-parto exibiram diferenças significativas nas funções urinárias e sexuais entre os diferentes períodos pós-parto. Houve associação entre os sintomas de DAP e gravidez, paridade e idade. Conclusão: Este estudo traduziu, adaptou culturalmente e validou o APFQ para gestantes e mulheres no pós-parto brasileiras, demonstrando boa consistência interna, validade de construto, reprodutibilidade e sensibilidade. Além disso, o acompanhamento de gestantes e mulheres no pós-parto mostrou variações nos sintomas de DAP durante diferentes períodos de gravidez e pós-parto, enfatizando a importância de monitorar esses sintomas para fornecer intervenções oportunas às mulheres afetadas.
- ItemAcesso aberto (Open Access)The use of transvaginal synthetic mesh for anterior vaginal wall prolapse repair: a randomized controlled trial(Springer, 2013-11-01) Delroy, Carlos Antonio [UNIFESP]; Castro, Rodrigo de Aquino [UNIFESP]; Dias, Marcia M. [UNIFESP]; Feldner Junior, Paulo Cezar [UNIFESP]; Bortolini, Maria Augusta Tezelli [UNIFESP]; Girão, Manoel João Batista Castello [UNIFESP]; Sartori, Marair Gracio Ferreira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The aim of the study was to compare the efficacy and safety of transvaginal trocar-guided polypropylene mesh insertion with traditional colporrhaphy for treatment of anterior vaginal wall prolapse.This is a randomized controlled trial in which women with advanced anterior vaginal wall prolapse, at least stage II with Ba a parts per thousand yenaEuro parts per thousand+1 cm according to the Pelvic Organ Prolapse Quantification (POP-Q) classification, were randomly assigned to have either anterior colporrhaphy (n = 39) or repair using trocar-guided transvaginal mesh (n = 40). the primary outcome was objective cure rate of the anterior compartment (point Ba) assessed at the 12-month follow-up visit, with stages 0 and I defined as anatomical success. Secondary outcomes included quantification of other vaginal compartments (POP-Q points), comparison of quality of life by the prolapse quality of life (P-QOL) questionnaire, and complication rate between the groups after 1 year. Study power was fixed as 80 % with 5 % cutoff point (p < 0.05) for statistical significance.The groups were similar regarding demographic and clinical preoperative parameters. Anatomical success rates for colporrhaphy and repair with mesh placement groups were 56.4 vs 82.5 % (95 % confidence interval 0.068-0.54), respectively, and the difference between the groups was statistically significant (p = 0.018). Similar total complication rates were observed in both groups, with tape exposure observed in 5 % of the patients. There was a significant improvement in all P-QOL domains as a result of both procedures (p < 0.001), but they were not distinct between groups (p > 0.05).Trocar-guided transvaginal synthetic mesh for advanced anterior POP repair is associated with a higher anatomical success rate for the anterior compartment compared with traditional colporrhaphy. Quality of life equally improved after both techniques. However, the trial failed to detect differences in P-QOL scores and complication rates between the groups.