Repositório Institucional - Unifesp :: Navegando por Palavras-chave "Pathology"

Navegando por Palavras-chave "Pathology"

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Análise crítica das linhas de pesquisa em neuropatologia e patologia tocoginecológica
(Universidade Federal de São Paulo (UNIFESP), 2005) Stávale, João Norberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Acesso aberto (Open Access)
Análise semiquantitativa de biópsias cirúrgicas de diferentes lobos pulmonares de pacientes com pneumonia intersticial usual/fibrose pulmonar idiopática
(Sociedade Brasileira de Pneumologia e Tisiologia, 2009-07-01) Gonçalves, José Júlio Saraiva; Leao, Luiz Eduardo Villaca [UNIFESP]; Ferreira, Rimarcs Gomes [UNIFESP]; Oliveira, Renato [UNIFESP]; Ota, Luiz Hirotoshi [UNIFESP]; Santos, Ricardo Sales Dos; Universidade para o Desenvolvimento do Estado e da Região do Pantanal; Universidade Federal de São Paulo (UNIFESP); Boston University School of Medicine
OBJECTIVE: To evaluate the differences between surgical biopsies of distinct lung lobes in terms of the histopathological features of usual interstitial pneumonia, using a semiquantitative score. METHODS: We selected all of the patients diagnosed with idiopathic pulmonary fibrosis and submitted to surgical biopsy in two distinct lobes between 1995 and 2005 at the Hospital São Paulo and other hospitals operated by the Federal University of São Paulo. In the histological evaluation of the specimens, we used a semiquantitative method based on previous studies, assigning a score to each of the biopsied sites. RESULTS: In this sample of patients, we found no statistically significant differences that would alter the stage of the disease, based on the score used. This finding was independent of the biopsy site (middle lobe or lingular segment). CONCLUSIONS: No significant histological differences were found between the lung lobes studied. The definitive histological diagnosis of usual interstitial pneumonia did not alter the stage of the disease.
Acesso aberto (Open Access)
Avaliação do comprometimento da pele no câncer de mama: ultrassonografia pré-operatória e correlação anatomopatológica
(Universidade Federal de São Paulo (UNIFESP), 2016-05-31) Brandão, Rodrigo Gregório [UNIFESP]; Nazário, Afonso Celso Pinto [UNIFESP]; http://lattes.cnpq.br/0266384667983727; http://lattes.cnpq.br/4289185300875541; Universidade Federal de São Paulo (UNIFESP)
Introduction: The removal of the overlying skin carcinoma is often unnecessary and can compromise the aesthetic result of breast surgery. In the presence of a tumor, the distance between the lesion and epidermis is given relevance in deciding between preserving or resection of skin overlying the cancer, in conservative surgery such as mastectomy. Objectives: To correlate the tumorskin distance obtained in ultrasound and pathological examinations and to establish a relationship between these parameters. Methods: This was a prospective study conducted on 39 women presenting 41 breast tumors who were diagnosed with invasive cancer and were candidates for conservative or radical surgery. Distance measurements between the tumor and skin were performed using preoperative ultrasound examinations and an anatomopathological specimen. Results: The mean distance between the tumour and skin obtained from the ultrasound examinations was 0.8 cm, with a minimum of 0.15 cm and a maximum of 2.43 cm. In the pathological examinations, the mean was 2.21 cm, with values ranging between 0.5 and 5.0 cm. The Pearson correlation between the methods was r = 0.75. Conclusion: The tumour-skin measurements observed during ultrasound examinations were well correlated with those observed during pathological examinations. The distance between the tumor and skin of the breast obtained by sonography is always lower than that obtained in pathology specimen, on average 3.1 times smaller. The intraobserver and interobserver variability in achieving tumor-skin distance through ultrasound and pathology analysis was not significant. The anatomopathological distance between tumor and skin can be estimated by the model: Dpathology = 0.69 + 1.89 x Dultrasound, where D is distance. Breast cancer. Skin. Breast ultrasound. Pathology.
Acesso aberto (Open Access)
Correlação entre tomografia de coerência óptica e histopatologia da região macular em olhos post mortem
(Universidade Federal de São Paulo (UNIFESP), 2017-02-28) Moreira Neto, Carlos Augusto [UNIFESP]; Burnier, Miguel Noel Nascentes [UNIFESP]; Mattos Neto, Rubens Belfort [UNIFESP]; http://lattes.cnpq.br/4120061586520703; http://lattes.cnpq.br/4487521900423032; http://lattes.cnpq.br/7462211121032251; Universidade Federal de São Paulo (UNIFESP)
Introdução: Tomografia de coerência óptica (OCT) é um método não invasivo de imagem diagnóstica usado por oftalmologistas. Apesar de fornecer imagens de alta resolução da anatomia ocular, a OCT não é capaz de apresentar o mesmo nível de detalhe celular oferecido pela histopatologia. Dúvidas sobre a interpretação da imagem da OCT são comuns na rotina do retinólogo. Objetivos: Estabelecer uma metodologia que permita a precisa correlação entre OCT e histopatologia no mesmo olho humano post mortem na região macular, e demonstrar como esta metodologia pode ser usada para validar ou reprovar hipóteses criadas sem comprovação histopatológica. Métodos: Dezenove olhos humanos post mortem foram escaneados usando OCT en face. Um dispositivo óptico customizado foi utilizado para a aquisição de imagens na OCT. Foi realizado um controle da orientação do tecido durante o processamento histopatológico para aquisição dos cortes seriados de tecido, que foram identificados com seu scan correspondente na OCT. Resultados: A acurácia da metodologia foi provada com a correspondência histopatológica mostrando as mesmas características e/ou alterações observadas na OCT, tais como drusas, micro-hemorragias, exsudatos e membranas epirretinianas. Esta metodologia foi então empregada para validar a hipótese de que a junção dos segmentos internos e externos dos fotorreceptores é representada por uma linha hiperrefletiva na imagem da OCT. Conclusão: Este estudo mostra um protocolo acurado e reprodutível para correlacionar imagens de OCT com cortes histopatológicos de olhos humanos. Esta metodologia pode ser usada para um melhor entendimento de achados não bem definidos à OCT, e também pode auxiliar oftalmologistas a ter um melhor entendimento das imagens, diminuindo a necessidade de biópsias. Pela primeira vez, foi provado que a junção dos segmentos externos e internos dos fotorreceptores é hiperrefletiva na OCT.
Acesso aberto (Open Access)
Estudo comparativo entre a classificação radiológica e análise macro e microscópica das lesões na osteoartrose do joelho
(Sociedade Brasileira de Ortopedia e Traumatologia, 2011-04-01) Garrido, Carlos Antonio [UNIFESP]; Sampaio, Tania Clarete Fonseca Vieira Sales [UNIFESP]; Ferreira, Frederico de Souza; Universidade Federal de São Paulo (UNIFESP); Hospital São Bento Cardioclínica S/A Serviço de Residência; UFMG; Hospital São Bento Cardioclínica S/A
OBJECTIVES: To compare the modified Ahlbäck radiological classification with macroscopic analysis of knee injuries and locate a chondral lesion in the tibial plateau, and to correlate this with integrity or lack of integrity of the anterior cruciate ligament. MATERIAL AND METHODS: Between July and December 2009, 40 patients of mean age 67.1 years with an indication for total knee arthroplasty were selected. The modified Ahlbäck radiological classification was used. The International Cartilage Repair Society classification was used for macroscopic analysis of the lesions. Chondral injuries were correlated with the integrity or lack of integrity of the anterior cruciate ligament. RESULTS: Regarding the radiological classification of the knees, three (7.5%) were classified as grade 1, two (5%) as grade 2, 17 (42.5%) as grade 3, 16 (40%) as grade 4 and two (5%) as grade 5. The macroscopic analysis of the knee showed that 25 patients (62.5%) had very severe injury and 15 (37.5%), severe. In eight knees (20%) with ruptured ACL, the lesion extended to the posterior region of the medial tibial plateau. When the ACL was intact, the lesion was located in the anterior-central region. CONCLUSION: Knee osteoarthrosis of grades 4 and 5 in the radiological classification, showed agreement with the macroscopic analysis, i.e. very severe chondral injury. However, grades 1, 2 and 3 were discordant. In the cases of osteoarthrosis with intact ACL, the lesion was located in the anterior-central region of the medial tibial plateau, and those with ruptured ACL had the lesion extending to the posterior region of the plateau.
Somente Metadadados
Evolução histológica de reativações da hanseníase durante ou após o tratamento
(Universidade Federal de São Paulo (UNIFESP), 1996) Trindade, Maria Angela Bianconcini [UNIFESP]; Fleury, Raul Negrão [UNIFESP]
Acesso aberto (Open Access)
Giant atypical lipoma
(Soc Brasileira Dermatologia, 2017) Mascarenhas, Marta Regina Machado [UNIFESP]; Mutti, Lais de Abreu [UNIFESP]; Paiva, Joao Marcos Goes de [UNIFESP]; Enokihara, Mílvia Maria Simões e Silva [UNIFESP]; Rosa, Ival Peres [UNIFESP]; Enokihara, Mauro Yoshiaki [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Liposarcomas correspond to the most common histological subtype of soft tissue sarcomas. They can be subdivided into: well differentiated or atypical lipoma, undifferentiated, myxoid, round, and pleomorphic cells. Atypical lipomas are the most prevalent and usually appear as asymptomatic softened tumors. They are locally aggressive but rarely lead to distant metastases. The diagnosis of this tumor is based on the imaging and histopathologic findings. Treatment consists of excision surgery with complete tumor removal. It has a good prognosis due to the low percentage of distant metastases. We report a rare case of giant atypical lipoma as well as the adopted therapy and evolution.
Acesso aberto (Open Access)
Granuloma faciale: a rare disease from a dermoscopy perspective
(Sociedade Brasileira de Dermatologia, 2013-12-01) Teixeira, Danilo Augusto; Estrozi, Bruna; Ianhez, Mayra; Federal University of Goiás Department of Dermatology; Pathologist at the Pathology Consulting Service - Botucatu (SP); Universidade Federal de São Paulo (UNIFESP); Federal University of Goiás
The granuloma faciale is a rare and benign skin disease of unknown etiology, characterized by chronic leukocitoclastic vasculitis. It is characterized by skin lesions predominantly facial whose course is chronic and slowly progressive. The diagnosis is based on clinical features, histopathology and, more recently, in dermoscopy. We describe the case of a male patient, 40 years old, with a sarcoid lesion on the malar site, whose histopathological examination revealed a mixed inflammatory infiltrate with presence of Grenz zone. Dermoscopy revealed a pink background with white striations. The definitive diagnosis is made by histopathologic evaluation, and dermatoscopy can be helpful. It is known to be resistant to therapy, oral medications, intralesional and surgical procedures are options.
Acesso aberto (Open Access)
Histological classification of 1,025 cases of Hodgkin's lymphoma from the State of São Paulo, Brazil
(Associação Paulista de Medicina - APM, 2005-05-01) Vassallo, José; Paes, Roberto Pinto; Soares, Fernando Augusto; Menezes, Yara; Aldred, Vera; Ribeiro, Karina De Cássia Braga; Alves, Antonio Correa [UNIFESP]; Universidade Estadual de Campinas (UNICAMP); Santa Casa de Misericórdia de São Paulo; Fundação Antônio Prudente Hospital do Câncer de São Paulo; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
CONTEXT AND OBJECTIVE: It is currently asserted that, in industrialized countries, nodular sclerosis is the most frequent type of Hodgkin's lymphoma, in contrast to developing countries, where mixed cellularity and lymphocyte depletion are more frequently seen. The objective was to review histological data from cases of Hodgkin's lymphoma from São Paulo and Campinas cities. DESIGN AND SETTING: Cross-sectional histopathological analysis, in four university hospitals and one cancer care center. METHODS: 1,025 cases diagnosed as Hodgkin's lymphoma between 1990 and 2000 were collected from five institutions; 631 of them (61.5%) had been immunophenotyped using antibodies to CD20, CD3, CD15 and CD30. The relative frequencies of histological types (as informed by the contributing authors, who are hematopathologists in their institutions) were determined according to age and gender. RESULTS: The Hodgkin's lymphoma types were distributed as follows: lymphocyte predominance 4.8%, nodular sclerosis 69.2%, mixed cellularity 21.1% and lymphocyte depletion 4.6%. CONCLUSIONS: The controversy regarding the frequencies of Hodgkin's lymphoma types within the Brazilian setting seems to be due to the small number of cases in previous studies. The present data show a picture close to the situation in the industrialized countries.
Somente Metadadados
Human Schistosoma mansoni-associated glomerulopathy in Brazil
(Oxford Univ Press, 2002-01-01) Nussenzveig, Israel; Brito, Thales de; Carneiro, Celia Regina Whitaker [UNIFESP]; Silva, Ana Maria G; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
Embargo
Imunoexpressão de marcadores de superfície leucocitários e moléculas de adesão no estudo das lesões vasculares graves (v3) da rejeição aguda do transplante renal
(Universidade Federal de São Paulo (UNIFESP), 2010-08-25) Soares, Maria Fernanda Sanches [UNIFESP]; Franco, Marcello Fabiano de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Objetives: Acute tubulo-interstitial and mild vascular rejection (Banff types I e IIA) are tipically T-cell mediated processes. Acute severe vascular rejection (Banff type III) however may be mediated by receptor antibodies directed to donor cells and is histologically characterized by transmural arteritis and/or fibrinoid necrosis of the vessel wall. It is still object of debate if transmural arteritis and fibrinoid necrosis are pathogenetically distinct entities. This study tries to shed some light over this question by analyzing the immunoexpression of adhesion molecules and the inflammatory cell immunophenotypic profile in renal allografts with type III rejection. Methods: Seventy explanted renal allografts with acute severe vascular rejection were analyzed. Vascular lesions were classified as i) “FN”- fibrinoid necrosis and ii) “TA”- transmural arteritis . Formalin-fixed, paraffin-embeded tissue underwent immunoperoxidase testing for: i) Presence of CD4, CD8, CD20 and CD68 in vessel wall and interstitial inflammatory cells; ii) Positivity for C4d in peritubular capillaries; iii) Presence of ICAM-1 and VCAM-1 in vessel walls. Groups were compared by Fisher Exact Test, chi-square test for independence and one-way ANOVA with Bonferroni correction (p£0.05). Results: TA lesions revealed marked presence of CD4+ and CD8+ T cells and macrophages and positivity of ICAM-1 e VCAM-1 in the tunica media and endothelium. Positivity of C4d in the PTC was detected in 58% of the cases with no statistically significant differences between the groups. Conclusions: The results suggest that T-cell interactions are involved in the increased positivity of vascular adhesion molecules ICAM-1 and VCAM- 1 in type III renal allograft rejection. Peritubular capillary C4d positivity in grafts with TA, FN or both lesions indicate antibody-mediated injury mechanisms in the pathogenesis of both TA and FN.
Acesso aberto (Open Access)
Non-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus
(Sociedade Brasileira de Dermatologia, 2014-01-01) Porro, Adriana Maria [UNIFESP]; Caetano, Livia De Vasconcelos Nasser; Maehara, Laura De Sena Nogueira; Enokihara, Milvia Maria Dos Santos; Universidade Federal de São Paulo (UNIFESP)
The pemphigus group comprises the autoimmune intraepidermal blistering diseases classically divided into two major types: pemphigus vulgaris and pemphigus foliaceous. Pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus are rarer forms that present some clinical, histological and immunopathological characteristics that are different from the classical types. These are reviewed in this article. Future research may help definitively to locate the position of these forms in the pemphigus group, especially with regard to pemphigus herpetiformis and the IgG/ IgA pemphigus.
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Prenatal diagnosis of congenital syngnathia by 3D ultrasound and pathological correlation
(Springer, 2013-01-01) Rezende, Guilherme de Castro; Pereira, Alamanda Kfoury; Nogueira Reis, Zilma Silveira; Parola, Aluana Rezende; Bastos, Fernando Macedo; Araujo Junior, Edward [UNIFESP]; Machado Nardozza, Luciano Marcondes [UNIFESP]; Vieira Cabral, Antonio Carlos; Universidade Federal de Minas Gerais (UFMG); Minist Educ Brazil; Universidade Federal de São Paulo (UNIFESP)
Congenital syngnathia is a maxillomandibular fusion, and it can vary in severity from single mucosal bands (synechiae) to complete bony fusion (synostosis). Cases of combinations of bony or soft tissue adhesions between the mandible and maxilla with cleft of the lip or palate, aglossia, popliteal pterygium, and van der Woude syndrome have been reported. It is a very rare condition, with only one case report of prenatal diagnosis using two-dimensional ultrasound in the literature. We present the first case of prenatal diagnosis of congenital syngnathia by three-dimensional ultrasound and the postnatal pathology correlation.
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Prenatal diagnosis of Nager syndrome in the third trimester of pregnancy and anatomopathological correlation
(Springer, 2012-10-01) Moreira Rios, Livia Teresa; Araujo Junior, Edward [UNIFESP]; Machado Nardozza, Luciano Marcondes [UNIFESP]; Bruns, Rafael Frederico; Moron, Antonio Fernandes [UNIFESP]; Martins, Marilia da Gloria; Universidade Federal de São Paulo (UNIFESP); Fed Univ Maranhao UFMA; Universidade Federal do Paraná (UFPR)
Nager syndrome or acrofacial dysostosis is a rare and complex malformation characterized by ear anomalies, micrognathia, radial limb hypoplasia, and absence of the thumb or other fingers. Since the original description of the syndrome in 1948, there have only been four reports of prenatal diagnoses in the literature, all during the second trimester, and only two of them had anatomopathological correlations. We describe a case of Nager syndrome that was suspected in the third trimester of gestation and confirmed postnatally through pathology. the mother was white, 27 years old, and G5P2A2, with a family history of a brother with a harelip. She was referred to our service at 33 weeks of pregnancy with an ultrasound fetal diagnosis of musculoskeletal dysplasia associated with severe micrognathia and severe polyhydramnios. Birth was by means of cesarean section because of suspected fetal distress, which resulted in extraction of a live male fetus with Apgar 1/4, weight of 1,505 g, severe mandibular hypoplasia, low-set ears, severe upper-limb shortening, and absent left thumb. Death occurred 4 h after birth. Anatomopathological examination confirmed the diagnosis of Nager syndrome.
Acesso aberto (Open Access)
Repercussões da interposição ileal isolada em ratos com dismetabolismo glicídico induzido por dieta
(Universidade Federal de São Paulo (UNIFESP), 2017-07-31) Leal, Lucas Pedroso Fernandes Ferreira [UNIFESP]; Azevedo, João Luiz Moreira Coutinho de [UNIFESP]; Lapchik, Milton Soibelmann [UNIFESP]; Gagliardi, Antonio Ricardo de Toledo; Milton Soibelmann Lapchik: http://lattes.cnpq.br/7871854683321407; Antonio Ricardo de Toledo Gagliardi: http://lattes.cnpq.br/3795666743699103; http://lattes.cnpq.br/2507285909783854; http://lattes.cnpq.br/4910203611295452; Universidade Federal de São Paulo (UNIFESP)
INTRODUCTION: The clinical management of type 2 diabetes mellitus (T2DM) is complex and permanent. In this moment, it is necessary a surgical procedure considered effective for the treatment of this disease among individuals with body mass index above morbid obesity. The isolated ileal transposition (III) could become an alternative therapy in selected non-obese diabetic patients. There are no reports of III performed in wistar rats in an experimental model of diet-induced disglycemia without genetic or drug influences, nor its pancreas morphology evaluation. OBJECTIVE: This study aims to contribute to the treatment of T2DM, evaluating the physiological effects of III on glucose metabolism and investigating histological changes of the pancreas in an experimental model of diet-induced disglycemia. METHODS: Seventy two 12-week-old male Wistar rats were distributed into four groups - ileal transposition, sham-operated, diabetic controls and non-diabetic controls (NG). The NG group received usual rat feeding while the other groups received hypercaloric-hyperlipidic diets. III was carried out in obese disglycemic rats at the 30-week. All groups maintained their diets untill the 48-week. Glucose tolerance, insulin resistance, food-intake, body weight, adiposity, serum substances and pancreas morphology were evaluated. RESULTS: After a postoperative period of 18 weeks, the III improved glucose tolerance and insulin sensitivity in diet-induced disglycemic rats. III did not induced weight loss or food intake decrease, and did not affected fat mass. It did not promoted morphological pancreatic alterations. CONCLUSIONS: In rats with diet-induced disglycemia, III promotes beneficial changes in glucose metabolism and does not modify the morphology of the endocrine pancreas.
Acesso aberto (Open Access)
Simulação de sinais de EMG e modelagem de impedância muscular no LTSpice
(Universidade Federal de São Paulo, 2023-07-13) Mello, Caio Henrique Silva; Polli, Roberson Saraiva; http://lattes.cnpq.br/6933632737044678
Os biopotenciais são sinais elétricos produzidos por células e tecidos vivos do corpo humano, que podem ser medidos e analisados para fins médicos, de pesquisa ou de diagnóstico. Esses sinais são gerados pela atividade elétrica nas células nervosas, musculares e cardíacas, e podem ser detectados e registrados através de eletrodos colocados na pele ou dentro do corpo. A modelagem de circuitos é uma etapa fundamental para obter uma boa aproximação dos parâmetros e sinais dos biopotenciais musculares. Através da modelagem, é possível equivaler os tecidos do corpo humano a componentes elétricos, como resistores e capacitores, devido às propriedades de impedância e condutividade dos tecidos. Assim, o trabalho se baseia na utilização do software de uso livre LTSpice para modelagem e simulação do tecido muscular e visualizar os efeitos que o tecido com características saudáveis ou patológicas causam em um sinal de EMG retirado de um banco de dados. Levando em consideração como principal parâmetro o circuito equivalente ao tecido condutor, foi possível verificar a influência deste tanto na amplitude quanto na frequência do sinal. Com a ausência de trabalhos que disponibilizem dados como capacitância e resistência do tecido muscular patológicos, tais valores foram sugeridos pelos autores e posteriormente analisados. As simulações permitiram observar o quanto o tecido condutor pode influenciar no sinal de EMG, demonstrando ser uma ferramenta de aplicação de análise de sinais biológicos para estudantes de áreas afins.
Acesso aberto (Open Access)
O transplante hepático por hepatocarcinoma na era MELD em São Paulo: avaliação de 414 casos transplantados pelo critério de Milão/Brasil
(Universidade Federal de São Paulo (UNIFESP), 2015-11-30) Sá, Gustavo Pilotto Domingues [UNIFESP]; Gonzalez, Adriano Miziara [UNIFESP]; Salzedas Netto, Alcides Augusto [UNIFESP]; http://lattes.cnpq.br/2580534578039797; http://lattes.cnpq.br/6234829429056217; http://lattes.cnpq.br/9311192779485846; Universidade Federal de São Paulo (UNIFESP)
Introdução: O critério de Milão (CM) vem sendo utilizado como padrão para indicação do transplante hepático (TxH) por hepatocarcinoma (HCC) em todo o mundo, há quase 20 anos. Diversos centros têm adotado critérios expandidos com o intuito de aumentar o número de pacientes candidatos ao TxH, mantendo bons índices de sobrevida. No Brasil, desde 2006, o critério de Milão/Brasil (CMB), que desconsidera nódulos menor que 2 cm, é adotado, incluindo maior número de pacientes com nódulos pequenos. O objetivo deste estudo foi avaliar o resultado do transplante hepático de acordo com o CMB e a forma de controle da fila de espera, enquanto os pacientes aguardam pelo transplante. Métodos: Foram analisados os prontuários dos pacientes com HCC submetidos ao TxH na cidade de São Paulo, entre 2007 e 2011, em relação à recidiva e sobrevida. Foram comparados os exames de imagens préoperatórios com o anatomopatológico do fígado explantado (BX) e sua relação com o resultado dos transplantes. Resultados: Em 414 TxH por HCC, a sobrevida em 1 e 5 anos foi de 84,1 e 72,7%. Destes, 7% atingiram o CMB através de Downstaging, com sobrevida em 1 e 5 anos, de 93,1 e 71,9%. O grupo de pacientes do CMB que excedeu o CM (8,6%) teve sobrevida de 58,1% em 5 anos. Não houve diferença estatística na sobrevida entre os grupos CM, CMB e Downstaging. A invasão vascular (p < 0,001), tamanho do maior nódulo (p = 0,001) e n de nódulos maiores que 2 cm (p = 0,028) se associaram com recidiva. A idade (p = 0,001), sexo feminino (p < 0,001), MELD real (p < 0,001), invasão vascular (p = 0,045) e o n de nódulos maiores que 2 cm (p < 0,014) estiveram associados a piora na sobrevida. Os exames de imagem diferiram da BX em cerca de 30% dos casos. 11,3% dos pacientes transplantados estavam fora do CMB de acordo com a BX. Conclusões: O CMB aumentou em 8,6% as indicações de TxH e apresentou índices de sobrevida semelhantes ao CM. A margem de erro na indicação e acompanhamento na fila de espera foi de 11,3%.
Acesso aberto (Open Access)
Trissomia do cromossomo 9 associada com aumento da translucência nucal: correlação ultra-sonográfica e anatomopatológica ¾ relato de um caso
(Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, 2001-04-01) Murta, Carlos Geraldo Viana [UNIFESP]; Merçon-de-vargas, Paulo Roberto; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Espírito Santo; Universidade Federal do Espírito Santo Centro Biomédico Departamento de Patologia
We report a case of prenatal diagnosis of trisomy 9 in a fetus presenting increased translucency thickness (9.1 mm) observed on an ultrasound scan performed at 12 weeks pregnancy and confirmed by cariotype analysis of biopsy material obtained from the chorionic villi. Multiple trisomy 9 characteristic abnormalities were detected by ultrasound and confirmed by autopsy and histopathological examination. Although rare, trisomy 9 should be included in the list of chromosomic anomalies associated with increased translucency.
Acesso aberto (Open Access)
Uso da microscopia digital para comparação de espessura entre córneas normais e rejeitadas ex-vivo: ênfase na Membrana de Descemet
(Universidade Federal de São Paulo (UNIFESP), 2019-06-27) Tognon, Taise [UNIFESP]; Burnier Júnior, Miguel Noel Nascente [UNIFESP]; Sousa, Luciene Barbosa de [UNIFESP]; http://lattes.cnpq.br/2367491641205774; http://lattes.cnpq.br/8668472375424523; http://lattes.cnpq.br/4487521900423032; Universidade Federal de São Paulo (UNIFESP)
Objective: To analyze and compare thickness measurements of corneal layers, especially the Descemet membrane (DM), in normal corneas and in failed grafts due to rejection (FGRs) using a digital microscopy method. Methods: An experimental, cross-sectional, and analytical study was performed at the Henry C. Witelson Ocular Pathology Laboratory (McGill University Health Center and Research Institute, Montreal/Canada). Slides of 25 normal human corneas and 40 FGRs were examined using a Philips Ultra Fast Scanner® and the associated software. The inclusion criteria adopted were samples diagnosed as normal corneas or FGRs, all specimens were from patients older than 18 years of age. Slides with corneal structures that could not be adequately visualized and/or whose donor epidemiological information could not be obtained were excluded from the study. On each slide, the thickness of the corneal layers was measured, with 2 central measurements, 2 measurements at the nasal periphery, and 2 measurements at the temporal periphery using perpendicular planes as reference. Results: There were differences between the normal and FGR groups in the means of the central thickness of the epithelium (p<0.001), the nasal and temporal stroma regions (p<0.001), and the DM in the nasal and temporal regions (p<0.001). Comparing the mean thicknesses of the different regions (central, nasal and temporal) of the DM in the same group, the central region of the DM in the normal corneas had a lower mean thickness than the two peripheral regions (p<0.001), a difference that did not occur in the FGR group. Conclusions: Normal corneas had a lower epithelium thickness in the central region than did corneas in the FGR group. In addition, the stroma and DM thickness of the nasal and temporal periphery was significantly higher in normal corneas than in those from the FGR group.
Acesso aberto (Open Access)
Very, very late stent thrombosis triggered by in-stent neoatherosclerosis: optical coherence tomography findings
(Termedia publishing house ltd, 2016) Joao, Geovana A. [UNIFESP]; Portela, Carlos Eduardo S. [UNIFESP]; Ybarra, Luiz F. [UNIFESP]; Genereux, Philippe; Caixeta, Adriano [UNIFESP]

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