Navegando por Palavras-chave "Pancreas"
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- ItemAcesso aberto (Open Access)Aneurisma de artéria hepática simulando lesão em cabeça de pâncreas: relato de caso(Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, 2005-12-01) Pinto, Oswaldo Luiz; Tornin, Olger De Souza; Botelho, Renato Assayag; Menezes, Marcelo Carneiro; Chagas, José Francisco de Sales [UNIFESP]; Camargo, José Gonzaga; Souza, Ricardo Pires De; Pontifícia Universidade Católica de Campinas Departamento de Cirurgia; Complexo Hospitalar Heliópolis; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)The aim of this study is to report a rare case of hepatic artery aneurysm simulating a lesion in the head of the pancreas. A precise evaluation using computed tomography and magnetic resonance imaging is important in the treatment planning, which will influence the prognosis.
- ItemRestritoEfeitos da fotobiomodulação (aplicada de maneira aguda) no pâncreas de ratos diabéticos(Universidade Federal de São Paulo, 2021-07-26) Burek, Adriane Marie Angri [UNIFESP]; Renno, Ana Claudia Muniz [UNIFESP]; Cruz, Matheus de Almeida [UNIFESP]; http://lattes.cnpq.br/7546924431469938; http://lattes.cnpq.br/4106611304688552; http://lattes.cnpq.br/5416581734263265; Universidade Federal de São Paulo (UNIFESP)A diabetes mellitus tipo 1 (DM1) é uma doença metabólica crônica, caracterizada pela insuficiência na secreção da insulina, decorrente de uma destruição autoimune das células β do pâncreas. A fim de estudar a DM1, usa- se com frequência o modelo de indução por estreptozotocina (STZ) que leva à necrose específica das células β pancreáticas. De modo a fornecer uma estratégia terapêutica para o DM, encontramos na terapia por fotobiomodulação (FBM) um potencial promissor, promovendo a regeneração e a sobrevivência de células β pancreáticas. Assim, o objetivo do presente estudo consistiu em avaliar os efeitos de dois protocolos de FBM, aplicados de maneira aguda, na regeneração do pâncreas e parâmetros sorológico de tolerância à insulina e à glicose em um modelo experimental de DM em ratos. Para isso, foram utilizados 24 ratos machos da linhagem Wistar com três meses de idade, os quais foram distribuídos aleatoriamente em 3 grupos, sendo todos submetidos a DM1: grupo controle diabético (C) e grupos tratados com FBM a 30 J/cm2 (L30) e a 90 J/cm2 (L90). Após anestesia com excesso de anestésico foi aplicada, na veia peniana, uma dose de 60 mg/kg de STZ para indução de DM1. Após 15 dias da indução da doença foi verificado a glicemia dos animais para confirmação da DM1. E pelos próximos 3 dias os animais foram submetidos a FBM conforme parâmetros de cada grupo. Após o último dia de irradiação foi avaliado a tolerância à glicose e à insulina nos animais. Imediatamente após a eutanásia foi realizada a dissecção cirúrgica do pâncreas para processamento histológico (HE), análise histopatológica e análise imunohistoquímica da proteína 8-OhdG. Para as análises estatísticas foi utilizado ANOVA. Os resultados demonstraram que os grupos irradiados apresentaram diminuição na perda de massa corporal, bem como na concentração glicêmica. Os achados corroboram com estudos anteriores mostrando efeitos benéficos da irradiação por FBM no organismo do animal diabético. A fluência de 90J/cm2 foi demonstrada como promissora no tratamento do mesmo.
- ItemSomente MetadadadosEffects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia(Springer Japan Kk, 2018) Veloso, Aparecida Gabriela Bexiga; Lima, Nathalia Edviges Alves; Ornelas, Elisabete de Marco; Cardoso, Clever Gomes; Marques, Mara Rubia; Reis, Beatriz da Costa Aguiar Alves; Fonseca, Fernando Luiz Affonso [UNIFESP]; Maifrino, Laura Beatriz MesianoMenopausal women are at high risk of developing heart disease. However, physical exercise practice can reverse this scenario. We evaluated the biochemical, morphological, and physiological effects of moderate aerobic physical exercise on the pancreas of knockout mice for LDL receptor with estrogen deprivation by ovariectomy. Animals were divided into six groups (n = 5): sedentary non-ovariectomized control
- ItemSomente MetadadadosGastrectomy and Lymphadenectomy for Gastric Cancer: is the Pancreas Safe?(Springer, 2008-11-01) Herbella, Fernando A. [UNIFESP]; Tineli, Ana C. [UNIFESP]; Wilson, Jorge L. [UNIFESP]; Del Grande, Jose C. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Introduction Resection of the capsule of the pancreas is part of the radical operation proposed by oriental authors for the treatment of gastric cancer. It is unclear; however, if resection of the capsule is a safe procedure or even if it is necessary. This study aims to assess in patients treated for gastric cancer the occurrence of: (a) pancreatic fistula and (b) metastasis to the pancreatic capsule.Methods We studied 80 patients (mean age 61 years, 42 males) submitted to gastrectomy with resection of the pancreatic capsule by hydrodissection. Patients with pancreatic disease, tumoral invasion of the pancreas, submitted to concomitant splenectomy, or anastomotic leakage were excluded. the tumor was located in the distal third of the stomach in 60% of the patients, in the middle third in 27%, and proximally in 12%. Total gastrectomy was performed in 27% of the cases and partial gastrectomy in 73%. in all patients, amylase activity in the drainage fluid was measured on day 2. If initial measurement was abnormal, subsequent measurements were performed in alternated days until normalization. Pancreatic fistula was defined as amylase levels greater than 600. in 25 of these patients (mean age 53 years, 16 males), the pancreatic capsule was histologically analyzed for metastasis.Results Pancreatic fistula was diagnosed in eight (10%) patients. the mean amylase level was 5,863. Normalization of amylase levels was achieved within 7 days in all patients. No patient developed clinical signs of fistula besides abnormal amylase levels in the drainage fluid, such as intra-abdominal abscesses. Pancreatic fistula was associated to younger age (p = 0.03) but not to gender (p = 0.1), tumor location (p = 0.6), and type of gastrectomy (p = 0.8). Metastasis to the pancreatic capsule was not identified.Conclusion in conclusion, resection of the pancreatic capsule must be discouraged due to subclinical pancreatic fistula in a significant number of the cases and absence of metastasis.
- ItemAcesso aberto (Open Access)Papel atual dos métodos de imagem no diagnóstico das neoplasias císticas e sólidas do pâncreas: 1ª parte(Colégio Brasileiro de Cirurgiões, 2011-04-01) Ardengh, José Celso; Goldman, Suzan Menasce [UNIFESP]; Lima-filho, Éder Rios De; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Hospital dos Servidores do Estado do Rio de Janeiro Departamento de Cirurgia Geral IIThe authors address the value of endoscopic retrograde cholangiopancreatography, ultrasonography, computed tomography, magnetic resonance imaging and endoscopic ultrasound for the diagnosis of cystic and solid neoplasms of the pancreas, demonstrating that each of them is of great importance to undoubtedly increase the diagnostic accuracy of the biliopancreatic system diseases. The best method for each of several tumors is then determined.
- ItemAcesso aberto (Open Access)Papel atual dos métodos de imagem no diagnóstico das neoplasias císticas e sólidas do pâncreas: 2ªparte(Colégio Brasileiro de Cirurgiões, 2011-06-01) Ardengh, José Celso; Goldman, Suzan Menasce [UNIFESP]; Lima-filho, Éder Rios De; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Hospital dos Servidores do Estado do Rio de Janeiro Departamento de Cirurgia Geral IIThe authors address the value of endoscopic retrograde cholangiopancreatography, ultrasonography, computed tomography, magnetic resonance imaging and endoscopic ultrasound for the diagnosis of cystic and solid neoplasms of the pancreas, demonstrating that each of them is of great importance to undoubtedly increase the diagnostic accuracy of the biliopancreatic system diseases. The best method for each of several tumors is then determined.
- ItemAcesso aberto (Open Access)Repercussões da interposição ileal isolada em ratos com dismetabolismo glicídico induzido por dieta(Universidade Federal de São Paulo (UNIFESP), 2017-07-31) Leal, Lucas Pedroso Fernandes Ferreira [UNIFESP]; Azevedo, João Luiz Moreira Coutinho de [UNIFESP]; Lapchik, Milton Soibelmann [UNIFESP]; Gagliardi, Antonio Ricardo de Toledo; Milton Soibelmann Lapchik: http://lattes.cnpq.br/7871854683321407; Antonio Ricardo de Toledo Gagliardi: http://lattes.cnpq.br/3795666743699103; http://lattes.cnpq.br/2507285909783854; http://lattes.cnpq.br/4910203611295452; Universidade Federal de São Paulo (UNIFESP)INTRODUCTION: The clinical management of type 2 diabetes mellitus (T2DM) is complex and permanent. In this moment, it is necessary a surgical procedure considered effective for the treatment of this disease among individuals with body mass index above morbid obesity. The isolated ileal transposition (III) could become an alternative therapy in selected non-obese diabetic patients. There are no reports of III performed in wistar rats in an experimental model of diet-induced disglycemia without genetic or drug influences, nor its pancreas morphology evaluation. OBJECTIVE: This study aims to contribute to the treatment of T2DM, evaluating the physiological effects of III on glucose metabolism and investigating histological changes of the pancreas in an experimental model of diet-induced disglycemia. METHODS: Seventy two 12-week-old male Wistar rats were distributed into four groups - ileal transposition, sham-operated, diabetic controls and non-diabetic controls (NG). The NG group received usual rat feeding while the other groups received hypercaloric-hyperlipidic diets. III was carried out in obese disglycemic rats at the 30-week. All groups maintained their diets untill the 48-week. Glucose tolerance, insulin resistance, food-intake, body weight, adiposity, serum substances and pancreas morphology were evaluated. RESULTS: After a postoperative period of 18 weeks, the III improved glucose tolerance and insulin sensitivity in diet-induced disglycemic rats. III did not induced weight loss or food intake decrease, and did not affected fat mass. It did not promoted morphological pancreatic alterations. CONCLUSIONS: In rats with diet-induced disglycemia, III promotes beneficial changes in glucose metabolism and does not modify the morphology of the endocrine pancreas.
- ItemAcesso aberto (Open Access)Transplante de pâncreas e ilhotas em portadores de diabetes melito(Sociedade Brasileira de Endocrinologia e Metabologia, 2008-03-01) Sá, João Roberto de [UNIFESP]; Gonzalez, Adriano Miziara [UNIFESP]; Melaragno, Cláudio Santiago [UNIFESP]; Saitovich, David; Franco, Denise Reis; Rangel, Erika Bevilaqua [UNIFESP]; Noronha, Irene Lourdes; Pestana, Jose Osmar Medina [UNIFESP]; Bertoluci, Marcelo Casaccia; Linhares, Marcelo Moura [UNIFESP]; Miranda, Marcelo Perosa de; Monteagudo, Patricia [UNIFESP]; Genzini, Tércio; Eliaschewitz, Freddy Goldberg; Universidade Federal de São Paulo (UNIFESP); Pontifícia Universidade Católica do Rio Grande do Sul Hospital São Lucas Serviço de Nefrologia; Universidade de São Paulo (USP); Sistema de Saúde Centro de Pesquisa Médica Notre-Dame Intermédica; Universidade Federal do Rio Grande do Sul Departamento de Medicina Interna; Hospital Israelita Albert Einstein Serviço de Transplante de PâncreasPancreas and kidney transplants have specific indications, benefits and risks. The procedure has become more common and more often as long-term success has improved and risks have decreased. Compared with a patient being on dialysis, simultaneous pancreas-kidney transplant offers a distinct advantage when it comes to mortality, quality of life and diabetic complications. Since there can be a living-donor kidney transplant,, a possibly similar patient and graft survival by 10 years follow-up, this procedure should be considered. Pancreas after kidney transplants, when successful, can improve microvascular complications compared with kidney transplant alone, but immediate mortality may be higher. Solitary pancreas transplantation can improve the quality of life in selected patients, but it may also increase the immediate risk of mortality due to the complexity of the surgery and the risks of immunosupression. The results of Islet transplantation differ from the higher metabolic performance achieved by whole pancreas allotransplantation and its applicability is limited to selected adult diabetic patients.