Navegando por Palavras-chave "POP"

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    Expression of genes encoding smooth muscle contractile proteins in vaginal tissue of women with and without pelvic organ prolapse
    (Wiley-Blackwell, 2012-01-01) Bortolini, Maria Augusta Tezelli [UNIFESP]; Shynlova, Oksana; Drutz, Harold P.; Castro, Rodrigo de Aquino [UNIFESP]; Girão, Manoel João Batista Castello [UNIFESP]; Lye, Stephen; Alarab, May; Univ Toronto; Universidade Federal de São Paulo (UNIFESP); Mt Sinai Hosp
    Aims We hypothesize that the expression of genes encoding vaginal smooth muscle (SM) contractile proteins is altered in patients with pelvic organ prolapse (POP) and is influenced by age and menopausal status. We aim to analyze the expression of SM-myosin heavy chain (MHY11), caldesmon (CALD1), SM gamma-actin (ACTG2), and tropomyosin (TPM1), in premenopausal and postmenopausal women with advanced POP and asymptomatic controls. Methods: During total hysterectomy we collected anterior vaginal wall biopsy samples from 55 women, 37 premenopausal (23 patients and 14 controls), and 18 postmenopausal women (13 patients and 5 controls). Total mRNA from the tissues was quantified by real-time RT-PCR. Results: MHY11 gene expression was down-regulated in premenopausal POP patients compared to premenopausal controls (fivefold, P = 0.002). in the postmenopausal groups, we observed a sixfold increase in the CALD1 gene expression in POP patients compared to asymptomatic controls (P = 0.03). the gene expression of CALD1, ACTG2, and TPM1 was significantly down-regulated in vaginal tissue of healthy women after menopause (P < 0.05). Conclusion: Dysregulation of the vaginal SM content in POP patients involves alteration of different cellular pathways according to age and menopausal status. Neurourol. Urodynam. 31:109-114, 2012. (C) 2011 Wiley Periodicals, Inc.
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    Neuropeptidases in psychiatric disorders
    (Elsevier, 2021) Nani, João Victor; Almeida, Priscila G. C.; Hayashi, Mirian [UNIFESP]; http://lattes.cnpq.br/5559309395232147; http://lattes.cnpq.br/1198445675076270; http://lattes.cnpq.br/2938015553073591
    Psychiatric disorders (PDs), such as schizophrenia (SCZ), bipolar disorder (BD), and major depression disorder (MDD) are characterized by disturbances in the functioning of the CNS. These mental disorders have attracted the attention of researchers from different areas due to their high prevalence and extremely debilitating clinical characteristics. In spite of the many similarities observed among the PDs, not only in symptoms but also in the etiology as well, there is still a lack of knowledge in the biochemical and/or molecular pathways underlying each of these pathologies, in which better understanding could potentially help improve the diagnosis and possibilities for treatment. Several groups, including ours, have demonstrated that neuropeptidases and neuropeptidergic systems could play a fundamental role for the susceptibility of PDs such as SCZ, due to their involvement in the neurodevelopmental process (and consequent brain formation) and their recent association to disease progression. In this article, we bring an update of the main findings on neuropeptidases, such as Nuclear distribution element like-1 (NDEL1), angiotensin I-converting enzyme (ACE), and prolyl oligopeptidase (POP), with a detailed discussion on how they could be involved in the etiology of PDs. The main findings in the literature regarding alterations in neuropeptidase activity in different biological samples of patients with PDs, as well as in animal models, are presented here in order to draw the attention of general readers to the possibility of targeting this system for the discovery of new targets and/or development of novel therapies and gaining a deeper understanding of the molecular mechanisms underlying complex diseases such as PDs.
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    Neuropeptides and oligopeptidases in schizophrenia
    (Pergamon Press, 2020-01) Rodriguez, Benjamín [UNIFESP]; Nani, João Victor [UNIFESP]; Almeida, Priscila G. C. [UNIFESP]; Brietzke, Elisa; Lee, Richard S.; Hayashi, Mirian A. F. [UNIFESP]; http://lattes.cnpq.br/5559309395232147
    Schizophrenia (SCZ) is a complex psychiatric disorder with severe impact on patient's livelihood. In the last years, the importance of neuropeptides in SCZ and other CNS disorders has been recognized, mainly due to their ability to modulate the signaling of classical monoaminergic neurotransmitters as dopamine. In addition, a class of enzymes coined as oligopeptidases are able to cleave several of these neuropeptides, and their potential implication in SCZ was also demonstrated. Interestingly, these enzymes are able to play roles as modulators of neuropeptidergic systems, and they were also implicated in neurogenesis, neurite outgrowth, neuron migration, and therefore, in neurodevelopment and brain formation. Altered activity of oligopeptidases in SCZ was described only more recently, suggesting their possible utility as biomarkers for mental disorders diagnosis or treatment response. We provide here an updated and comprehensive review on neuropeptides and oligopeptidases involved in mental disorders, aiming to attract the attention of physicians to the potential of targeting this system for improving the therapy and for understanding the neurobiology underlying mental disorders as SCZ.