Navegando por Palavras-chave "PARADOXICAL SLEEP DEPRIVATION"
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- ItemSomente MetadadadosATROPINE INCREASES PILOCARPINE-INDUCED YAWNING BEHAVIOR in PARADOXICAL SLEEP-DEPRIVED RATS(Elsevier B.V., 1995-11-01) Lobo, L. L.; Demedeiros, R.; Hipolide, D. C.; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Paradoxical sleep (PS) deprivation has been suggested to induce supersensitivity of postsynaptic dopamine (DA) receptors and subsensitivity of acetylcholine (ACh) receptors. Yawning behavior is reduced after PS deprivation and is believed to result from an interaction between ACh and DA systems. Concomitant treatment of PS deprived animals with DA agonists reverses PS deprivation effects on stereotypy and aggressiveness. To examine this possibility on yawning behavior, rats were treated, during the deprivation period, with atropine, methamphetamine, haloperidol or distilled water. Following PS deprivation, rats were injected with apomorphine or pilocarpine and number of yawns was recorded. Atropine increased yawning of PS deprived rats induced by pilocarpine, but not by apomorphine. Treatment with methamphetamine and haloperidol did not change PS deprivation effect on pilocarpine- and apomorphine-induced yawning. the data suggest that reversal of PS deprivation-induced yawning inhibition is mediated distinctly by both acetylcholine and dopamine systems.
- ItemSomente MetadadadosAUTORADIOGRAPHIC ANALYSIS of D-1 and D-2 DOPAMINERGIC RECEPTORS in RAT-BRAIN AFTER PARADOXICAL SLEEP-DEPRIVATION(Elsevier B.V., 1994-01-01) Nunes, G. P.; Tufik, S.; Nobrega, J. N.; CLARKE INST PSYCHIAT; Universidade Federal de São Paulo (UNIFESP)Previous work had shown that paradoxical sleep deprivation (PSD) results in potentiation of several apomorphine-induced behaviors, leading to the suggestion that PSD induces an upre,oulation of brain dopamine receptors. in this study, quantitative receptor autoradiography was used to verify whether PSD does, in fact, induce alterations in D-1 or D-2 receptor binding, and to investigate the regional brain specificity of such effects. After 96 h of PSD, [H-3]SCH-23390 binding to D-1 receptors was examined in 30 different brain areas of 10 experimental and 10 cage control rats. [H-3]Spiperone was used to label D-2 sites in adjacent tissue sections. Results revealed a 39% increase in [H-3]SCH 23390 binding in the entorhinal cortex of PSD rats (p < 0.05), but no other changes in any of the remaining 29 brain areas examined. in contrast, [H-3]spiperone binding was significantly elevated in the n. accumbens (+45%) and in all subregions of the caudate-putamen (range: +13% to +23%). These results, thus, provide evidence that PSD increases D-2 but not D-1 receptor binding in brain. the present results also suggest that upregulated D-2 receptors can account for the previously reported changes in apomorphine-induced behaviors after PSD.
- ItemSomente MetadadadosDECREASED MUSCARINIC RECEPTOR-BINDING in RAT-BRAIN AFTER PARADOXICAL SLEEP-DEPRIVATION - AN AUTORADIOGRAPHIC STUDY(Elsevier B.V., 1994-05-09) Nunes, G. P.; Tufik, S.; Nobrega, J. N.; CLARKE INST PSYCHIAT; Universidade Federal de São Paulo (UNIFESP)Previous work demonstrated that paradoxical sleep deprivation (PSD) leads to a decrease in yawning behavior elicited by cholinergic agonists, suggesting that a downregulation of cholinergic muscarinic receptors may occur after PSD. More recent work using intracerebral injections of muscarinic agonists has suggested a critical role for M2 receptors in paradoxical sleep. in this study [H-3]AF-DX 384 was used to investigate the effects of PSD on M2-type cholinergic receptors throughout the brain using quantitative autoradiography. After 96 h of paradoxical sleep deprivation, [3H]AF-DX 384 binding was generally reduced throughout the brain, and significantly so in the olfactory tubercle (-20%), n. accumbens (-23%), frontal caudate-putamen (-16%), islands of Callejas (-20%), piriform cortex (-24%), lateral (-26%) and medial (-24%) septum, anteromedial (-19%), ventrolateral (-22%), and lateral geniculate (-15%) nuclei of thalamus, deep layers of the superior colliculus (-15%), entorhinal cortex (-12%) and subiculum (-23%). [H-3]AF-DX 384 binding was reduced in pontine structures, but not to a higher degree than in other brain areas. the observed downregulation of M2-type muscarinic receptors after PSD may be causally related to the previously reported decrease in cholinergically induced behaviors after PSD.
- ItemSomente MetadadadosPARADOXICAL SLEEP-DEPRIVATION in FEMALE RATS ALTERS DRUG-INDUCED BEHAVIORS(Elsevier B.V., 1995-06-01) Hipolide, D. C.; Tufik, S.; Universidade Federal de São Paulo (UNIFESP)Paradoxical sleep deprivation (PSD) induces changes in behaviors induced by dopaminergic and cholinergic agonists, including increased aggressive behavior and stereotypy, decreased number of yawns, and shedding of bloody tears in male rats. in female rats, however, very little is known about the relationship between PSD and the effect of these drugs. the present study sought to examine this issue. As in males, PSD in females resulted in increased apomorphine-induced stereotypy, decreased pilocarpine-induced chromodacryorrhea, and hyperthermia. Unlike males, however, no apomorphine-induced aggressiveness or apomorphine- and pilocarpine-induced yawning were observed in PSD females. These findings suggest that female sexual hormones may affect the expression of some behaviors and not the neurotransmission as a whole, because drug-induced behaviors in PSD females were partly similar to those observed in PSD males.
- ItemSomente MetadadadosSODIUM DICLOFENAC INHIBITS HYPERTHERMIA-INDUCED BY PARADOXICAL SLEEP-DEPRIVATION - the POSSIBLE PARTICIPATION of PROSTAGLANDINS(Elsevier B.V., 1993-11-01) Seabra, MDV; Tufik, S.; Universidade Federal de São Paulo (UNIFESP)Sodium diclofenac inhibits hyperthermia induced by paradoxical sleep deprivation (PSD), which suggests the participation of prostaglandins. the temperature of paradoxical sleep-deprived rats increased from the first to the fourth day of deprivation. This hyperthermia was blocked on the second, third, and fourth days by daily administration, twice a day, of 10 mg/kg of sodium diclofenac, a potent prostaglandin synthesis inhibitor. in the dose of 10 mg/kg, a decrease of temperature was observed only on the second and third days of PSD. These data suggest the participation of prostaglandins in modulating the increase in temperature during PSD.