Repositório Institucional - Unifesp :: Navegando por Palavras-chave "Neuropsychology"

Navegando por Palavras-chave "Neuropsychology"

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Somente Metadadados
Adaptação e correlação entre instrumentos neuropsicológicos para avaliação e acompanhamento da doença de Alzheimer em fases avançadas
(Universidade Federal de São Paulo (UNIFESP), 2012) Wajman, José Roberto [UNIFESP]; Bertolucci, Paulo Henrique Ferreira [UNIFESP]
Objetivo: foi objetivo principal deste projeto o estudo da correlacao entre instrumentos especificos para avaliacao de pacientes com demencia da doenca de Alzheimer em fases avancadas no que diz respeito a sua cognicao objetivamente ponderada e aspectos da capacidade funcional. Metodos: foram utilizadas nesta pesquisa as escalas CDR (Clinical for Dementia Rating), FAST (Functional Assessment Scale), BANS (Bedford Alzheimer Nursing Severity Scale), MMSE (Mini-Mental State Exame), MMSE-G (Mini-Mental State Exame-Grave), SIB-8 (Severe Impairment Battery) e TSI (Test for Severe impairment) para comparacao com uma escala ecologica que serviu como padraoouro, a PADL (Performance Activities of Daily Living). Como proposta estatistica foram aplicadas analises descritivas, analise de Variancia (ANOVA), o Teste de Kruskal-Wallis para efeito de comparacao, alem de ter sido adotado nivel de significancia de 5% para as analises inferenciais. Resultados: foram incluidos 95 individuos acompanhados junto ao Setor de Neurologia do Comportamento do Hospital São Paulo - UNIFESP, sendo 33 (34,7%) do genero masculino e 62 (65,3%) do feminino. A idade media dos 95 individuos foi de 74,7 anos, variando de 60 a 89 anos, com desvio padrao de 6,2 anos. Em media, o tempo de escolaridade foi de 4,2 anos, variando de 3 a 8 anos, com desvio padrao de 1,5 anos. O tempo medio de doenca dos individuos foi de 7,3 anos, variando de 5 a 12 anos, com desvio padrao de 1,7 anos. Conclusoes: as evidencias encontradas sugerem uma correlacao linear crescente e estatisticamente significante entre a PADL e os instrumentos MEEM-G, SIB-8 e TSI. Houve, ainda, relacao estatisticamente significante entre os resultados alcancados na escala PADL uma vez comparada com o MEEM-G, a SIB-8 e a TSI e a fase da doenca em que os pacientes se encontravam, na medida em que quanto mais prejudicados foram seus desempenhos nesses tres testes, maior o indice de progressao da doenca na escala funcional FAST e em suas subdivisoes. Estes resultados indicam que para populacoes com estas caracteristicas escalas especificas para demencia grave sao uteis na avaliacao mais acurada do estagio da doenca e sua progressao
Acesso aberto (Open Access)
Análise do padrão articulatório da tarefa de fluência verbal frutas no comprometimento cognitivo leve, na demência de Alzheimer leve e moderado
(Universidade Federal de São Paulo (UNIFESP), 2017-11-17) Giacominelli, Carla [UNIFESP]; Bertolucci, Paulo Henrique Ferreira [UNIFESP]; http://lattes.cnpq.br/0536597854124056; http://lattes.cnpq.br/3138949086178926; Universidade Federal de São Paulo (UNIFESP)
The semantic verbal fluency task as a neuropsychological assessment, is widely used in the clinical practice of Alzheimer's Disease (AD) and involves the subject generate during 60s to generate the highest number of words belonging to a specific semantic category. Verbal fluency animals and verbal fluency fruits (VFf) have previously been described to be similarly effective in discriminating normal participants from subjects with AD. Both tasks were less accurate in discriminating AD-stages for unknown reasons. Based on semantic clustering scores in verbal fluency animals, a literacy depending pattern has been revealed across cultures; however, no previous analysis has been performed for VFf. The aim of this study is to investigate whether the task of verbal fluency fruit is useful for discriminating controls, Mild Cognitive Impairment (MCI), Mild Alzheimer Disease (MAD) and Moderate Alzheimer Disease(ModAD) and to determine task’s specificities and sensibilities at various stages of the AD. Methods: Three-hundred-fourteen native Brazilian Portuguese speakers were divided in four groups: Control Group (CG) and Mild Cognitive Impairment (MCI), Mild Alzheimer’s Disease (MAD) and Moderate Alzheimer’s Disease (ModAD) groups. A quantitative total score and a qualitative, clusters analysis, were conducted for VFf and were compared to other cognitive tasks. As no semantic setting was found, a non-arbitrary classification of fruits based on sub categorical items, according to the articulatory point of International Phonetic Alphabetic (2015) was performed. The words were grouped as follows: 1) bilabial, 2) velars, 3) open vowels, 4) closed vowels, 5) lateral dental/ alveolar, 6) dental /alveolar, and 7) labio- dentals. Results: Clustering strategies in the AD groups differed from those of the CG. Clustering revealed differences beyond groups depending on which articulatory point was emitted. MCI had a 73% lower chance of attaining an NV than did the CG and with AD groups presented odds ratios of using the /k/, /g/ velars feature 85% lower than those of the CG. Participants who used bilabials had 2.04 times higher total scores than those who did not. Younger subjects had a higher probability to perform better on the task. Participants with ≥ 9 years of education had a higher probability of higher performance with respect to the total score. Conclusion: Articulatory deterioration occurred in AD since the early stages. VFf seems to be a suitable task since MCI evaluation.
Somente Metadadados
Aspectos neuropsicológicos em adolescentes vítimas de violência sexual com TEPT
(Universidade Federal de São Paulo (UNIFESP), 2019-11-13) Silva, Fernanda Mary Rodrigues Gomes Da [UNIFESP]; Mello, Marcelo Feijo De [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Summary: Objective: To evaluate the impact of PTSD as a result of sexual violence in adolescents aged 14 to 17 years, to verify if specific PTSD symptoms and subjective perception of traumatic experience are associated with cognitive impairment. Method: 28 adolescents with a history of sexual violence in the last six months, with a mean age of 14.96 (± 1.07) and 11 healthy volunteers with a mean age of 16.18 (± 1.08), matched by education (p = 0.299) were submitted to neuropsychological assessment and PTSD scales. Results: Comparison between the groups shows that the patient group presents poorer performance in global cognition, verbal learning, short-term verbal memory, audioverbal attention, visuospatial working memory, slowed processing speed, impaired target stimuli identification, higher incidence of errors. Patients have slowness in automatic, voluntary tasks, inhibitory control, and cognitive flexibility. There is a moderate correlation between PTSD severity and cognitive processing speed, as well as intrusive symptoms with attentional impairments and inhibitory control, negative mood and cognition symptoms, and the ability to concentrate and cognitive processing speed. The perception of traumatizing events was not associated with any specific cognitive deficit. Conclusion: PTSD patients have motor and cognitive slowing in automatic and voluntary tasks that directly impact attention, learning, verbal memory and executive functions. The most frequently observed cognitive changes showed a moderate correlation with the severity of PTSD and intrusive and negative symptoms of mood and cognition.
Acesso aberto (Open Access)
Attention in schizophrenia and in epileptic psychosis
(Associação Brasileira de Divulgação Científica, 2008-01-01) Kairalla, Ivette Catarina Jabour [UNIFESP]; Mattos, Paulo Eduardo Luiz; Hoexter, Marcelo Queiroz [UNIFESP]; Bressan, Rodrigo Affonseca [UNIFESP]; Mari, Jair de Jesus [UNIFESP]; Shirakawa, Itiro [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Rio de Janeiro Instituto de Psiquiatria
The adaptive behavior of human beings is usually supported by rapid monitoring of outstanding events in the environment. Some investigators have suggested that a primary attention deficit might trigger symptoms of schizophrenia. In addition, researchers have long discussed the relationship between schizophrenia and the schizophrenia-like psychosis of epilepsy (SLPE). On the basis of these considerations, the objective of the present study was to investigate attention performance of patients with both disorders. Patient age was 18 to 60 years, and all patients had received formal schooling for at least four years. Patients were excluded if they had any systemic disease with neurologic or psychiatric comorbidity, or a history of brain surgery. The computer-assisted TAVIS-2R test was applied to all patients and to a control group to evaluate and discriminate between selective, alternating and sustained attention. The TAVIS-2R test is divided into three parts: one for selective attention (5 min), the second for alternating attention (5 min), and the third for the evaluation of vigilance or sustained attention (10 min). The same computer software was used for statistical analysis of reaction time, omission errors, and commission errors. The sample consisted of 36 patients with schizophrenia, 28 with interictal SLPE, and 47 healthy controls. The results of the selective attention tests for both patient groups were significantly lower than that for controls. The patients with schizophrenia and SLPE performed differently in the alternating and sustained attention tests: patients with SLPE had alternating attention deficits, whereas patients with schizophrenia showed deficits in sustained attention. These quantitative results confirmed the qualitative clinical observations for both patient groups, that is, that patients with schizophrenia had difficulties in focusing attention, whereas those with epilepsy showed perseveration in attention focus.
Somente Metadadados
Attentional and executive functions are differentially affected by post-traumatic stress disorder and trauma
(Elsevier B.V., 2014-01-01) Flaks, Mariana K. [UNIFESP]; Malta, Stella M. [UNIFESP]; Almeida, Priscila P. [UNIFESP]; Bueno, Orlando F. A. [UNIFESP]; Pupo, Mariana C. [UNIFESP]; Andreoli, Sergio B. [UNIFESP]; Mello, Marcelo F.; Lacerda, Acioly L. T. [UNIFESP]; Mari, Jair J. [UNIFESP]; Bressan, Rodrigo A. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Background: Among the neurocognitive impairments observed in patients with Post-traumatic Stress Disorder (PTSD), attentional and executive dysfunctions appear to correlate with negative effects on education, work, daily life activities, and social relations, as well as the re-experiencing, avoidance, and hyperarousal symptoms of PTSD. However, there is no consensus regarding which aspects of attentional and executive functions are impaired in PTSD patients.Methods: Attentional and executive functions were assessed using the digit span (WAIS-III) and spatial span (WMS-III) tests under forward and backward recall conditions, the Stroop Test, and the Wisconsin Card Sorting Test (WCST). Our sample was composed of victims of urban violence who developed PTSD (PTSD+) (n = 81), victims of urban violence who did not develop PTSD (PTSD) (n = 70), and healthy controls not exposed to trauma (HC) (n = 50).Results: the PTSD+ group had poorer performance on the spatial span forward subtest (p = 0.023; eta(2) = 0.038) and poorer execution time (p = 0.023; eta(2) = 0.042) and accuracy (p = 0.019; eta(2) = 0.044) on the Stroop Test compared to HC.Conclusions: These data suggest that there are few differences between the PTSD+ and HC groups, which are restricted to less complex measures of attentional and executive functional processes (short term capacity, selective attention, processing speed, and inhibitory control) and are related to visual stimuli. Therefore, cognitive impairments directly correlated with the manifestation of PTSD. (C) 2013 Elsevier B.V. All rights reserved.
Acesso aberto (Open Access)
Avaliação da Memória Prospectiva antes e após o uso do extrato concentrado de soja, em mulheres na pós-menopausa com queixa de alteração de memória
(Universidade Federal de São Paulo (UNIFESP), 2013) Laprano Vieira, Lucia Helena [UNIFESP]; Silva, Ivaldo [UNIFESP]; Haidar, Mauro Abi [UNIFESP]; Dardes, Rita de Cassia de Maio [UNIFESP]; http://lattes.cnpq.br/3864318683297398; http://lattes.cnpq.br/3773357188654076; http://lattes.cnpq.br/9948402316193744; http://lattes.cnpq.br/4605481134945295
O objetivo deste estudo foi analisar os efeitos do extrato concentrado de soja na memoria prospectiva (MP), apos a menopausa, por meio de avaliacao neuropsicologica. Correlacionou-se o desempenho no teste de MP, com testes de funcoes cognitivas. (funcoes atencionais, executivas, memoria, viso-motora, abstracao e linguagem), escalas de autopercepcao e depressao. Realizou-se estudo randomizado, duplo-cego, prospectivo, com 84 pacientes na posmenopausa, atendidas no Setor de Transicao Menopausal e Pos-Menopausa da Disciplina de Endocrinologia Ginecologia, do Departamento de Ginecologia da Universidade Federal de São Paulo u Escola Paulista de Medicina (UNIFESPEPM). As pacientes foram divididas, conforme programa de randomizacao, em dois grupos Grupo I - receberam 150mg de extrato concentrado de soja sob a forma de uma capsula com 60mg de isoflavonas totais, por via oral/dia; Grupo II - receberam uma capsula contendo substancia inativa (placebo), durante seis meses. Os nossos resultados demonstraram que as mulheres em uso de extrato de isoflavonas tiveram melhora clinicamente (autopercepcao) no desempenho da memoria prospectiva (MP), entretanto nao foi possivel estabelecer correlacao destes resultados com o desempenho cognitivo. O extrato concentrado de soja teve um efeito favoravel sobre a funcao cognitiva, dentre todas as funcoes, somente na memoria verbal e tarefas da funcao executiva de planejamento e flexibilidade mental, nas demais nao teve melhora. Concluimos que o extrato concentrado tem acao somente em algumas funcoes cognitivas
Somente Metadadados
Avaliação da relação entre funções cognitivas, ansiedade e depressão em mulheres com fibromialgia
(Universidade Federal de São Paulo (UNIFESP), 2014-02-26) Goulart, Rubens [UNIFESP]; Panico, Rubens Goulart [UNIFESP]; Lombardi Júnior, Imperio [UNIFESP]; http://lattes.cnpq.br/6748923176828764; http://lattes.cnpq.br/5707670458484854; Universidade Federal de São Paulo (UNIFESP)
Fibromyalgia is the second most common rheumatologic disease in Brazil. Its prevalence varies between 2.5 % and 4.4 % population, affecting predominantly woman. Several studies have demonstrated the occurrence of cognitive impairments in people with fibromyalgia, particularly in those patients who also have comorbidities such as depression and anxiety. The psychological aspects of fibromyalgia still require further investigation. Information regarding cognitive impairment in fib romyalgia are inconsistent. The volunteers in this study were women diagnosed with fibromyalgia according to the ACR criteria. After, we set up a control group of the same size, with individuals from the general population, in order to enable the pairing a ccording to age, level of education and income. Patients were assessed using the Rey Complex Figure Test, RAVLT, Stroop, Trail Making Test, Digit Test (Battery WAIS - III), Hospital Anxiety and Depression Scale, Visual Analog Pain Scale and Modified Wisconsin Card Sorting Test. The characteristics of the groups show no significant differences in the matching criteria (Age P= 0,744, scholarity P=0,504, Income P=0,498). The difference in Pain as measured by AEV was 4.17 points higher (P < 0.001) for the fibromyalgia group. The results of the Hospital Anxiety and Depression scale, was respectively 4.64 and 4.19 higher for fibromyalgia group (P < 0.001); show that this group has a tendency to have more symptoms of both anxiety as depression. Regarding the attentional characteristics of the groups, there seems to be a slower tendency in sustained attention (55.65 seconds longer in the TM-B, P=0.025), extrapolating 120 seconds cutoff. We also observed a general trend of poorer performance on pictorial memory, as measured by the REY Figure. Finally, the performance of the groups on executive functions, demonstrates a trend to poorer performance on the copy of the Rey figure (4.1 points lower, P = 0.002). Fibromyalgia patients suffer from deficits in executive functio ns, particularly in planning and inhibitory control components and such deficits are reflected in loss of memory.
Acesso aberto (Open Access)
Avaliação de funções executivas no transtorno de compulsão alimentar : revisão sistemática da literatura e metanálise
(Universidade Federal de São Paulo (UNIFESP), 2017-09-26) Cury, Maria Elisa Gisbert [UNIFESP]; Claudino, Angelica de Medeiros [UNIFESP]; Berberian, Arthur de Almeida [UNIFESP]; http://lattes.cnpq.br/6416386670668146; http://lattes.cnpq.br/4532343545365473; http://lattes.cnpq.br/8719369837672482; Universidade Federal de São Paulo (UNIFESP)
Déficits de funções executivas (FE) são características observadas em indivíduos com transtorno da compulsão alimentar (TCA). A investigação de tais déficits contribui para uma melhor compreensão sobre a etiologia, curso e prognóstico do TCA, assim como para a adequação de terapêuticas. No entanto, ainda é limitada a literatura existente em termos de resultados consolidados, que possam contribuir para uma melhor compreensão da influência das FE no comportamento alimentar compulsivo. Objetivos: avaliar o estado de arte das investigações sobre funções executivas em pacientes com TCA através de coleta abrangente, análise crítica e síntese das evidências científicas disponíveis. Métodos: revisão sistemática da literatura buscando-se artigos que examinaram funções executivas em pessoas com diagnóstico de TCA (publicados até 25 de agosto de 2015). As buscas foram realizadas nas bases de dados eletrônicas Pubmed, Psycinfo, Scopus realizando-se o cruzamento dos seguintes descritores: binge eating disorder or binge eating and executive function or executive control or cognitive control or set-shifting or decisionmaking or working memory or inhibitory control or problem solving or attention. A revisão seguiu as recomendações propostas pelo documento Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Os critérios de inclusão foram revisões sistemáticas sobre o tema e estudos que: 1) envolveram adultos de ambos os sexos, com diagnóstico de TCA; 2) compararam pessoas com TCA a pessoas sem o transtorno (estudos experimentais do tipo caso-controle ou ensaios clínicos), e 3) que utilizaram como desfecho, qualquer medida classificada no domínio de funções executivas e, 4) publicados nas línguas inglesa, portuguesa ou espanhola. Metanálises agregando os achados de estudos elegíveis que avaliaram a mesma função cognitiva foram realizadas. Resultados: Dos 2.258 estudos identificados pelas buscas, 18 preencheram os critérios de inclusão. Destes, três eram revisões sistemáticas e 15 eram estudos caso-controle, sendo que oito deles tiveram resultados incluídos nas metanálises realizadas. Os achados das metanálises sugerem pior desempenho de pessoas com TCA em relação a controles sem TCA obesos e de peso normal na tomada de decisão (SMD = -0,63; IC 95%: - 0,95; -0,32) e na flexibilidade cognitiva – duas metanálises: 1. Trial Making Test (MD = 11,88; IC 95%: 2,92; 20,84), e 2.Winsconsin Card Sorting Test e Penn Conditional Exclusion Task Test (SMD = 0,36; IC 95%: 0,10; 0,61) – e na comparação apenas com obesos xi sem TCA no domínio solução de problemas (SMD = -0,65; IC 95% IC: -0,98;-0,32). A análise qualitativa dos resultados relativos aos domínios controle inibitório, memória de trabalho planejamento e monitoramento revelou achados mistos para déficits executivos no grupo com TCA versus pessoas sem TCA. Conclusão: Embora limitado pelo número pequeno de estudos realizados, os resultados de metanálises sugerem prejuízos em algumas esferas cognitivas de pessoas com TCA, porém os achados referentes a estudos isolados não permitem conclusões definitivas, justificando o seguimento de pesquisas neste campo, com vistas ao aprofundamento do conhecimento científico na área e potencial aplicação clínica.
Somente Metadadados
The Brazilian standardization of the MATRICS consensus cognitive battery (MCCB): Psychometric study
(Elsevier Science Bv, 2017) Fonseca, Ana Olivia [UNIFESP]; Berberian, Arthur A. [UNIFESP]; de Meneses-Gaya, Carolina [UNIFESP]; Gadelha, Ary [UNIFESP]; Vicente, Marcella de O. [UNIFESP]; Nuechterlein, Keith H.; Bressan, Rodrigo A. [UNIFESP]; Lacerda, Acioly L. T. [UNIFESP]
Objective: Translate, adapt, and validate the MATRICS Consensus Cognitive Battery (MCCB) in Brazil. Method: The present study followed three steps: 1) translation to Portuguese, cultural adaptation, and back translation to English
Somente Metadadados
Capacidade de abstração e o teste de provérbios
(Universidade Federal de São Paulo (UNIFESP), 1997) Siviero, Marilena Occhini [UNIFESP]; Bertolucci, Paulo Henrique Ferreira [UNIFESP]
Somente Metadadados
Cognitive and behavioral effects of obstructive sleep apnea syndrome in children: a systematic literature review
(Elsevier Science Bv, 2018) Cardoso, Thiago da Silva Gusmão [UNIFESP]; Pompeia, Sabine [UNIFESP]; Miranda, Monica Carolina [UNIFESP]
Obstructive sleep apnea syndrome (OSA) is a common respiratory sleep disorder in children that is believed to adversely affect both quality of life and cognition. The purpose of the present systematic review was to obtain evidence of the impact of OSA on children's cognitive/behavioral abilities from primary studies published in MEDLINE/PubMed, LILACS, SciELO, ISI Web of Science, and PsycINFO databases from 2002 to 2016. Of the 649 articles found, only 34 met the eligibility criteria: studies that evaluated cognition, behavior, and/or academic achievement of children meeting clinical criteria for OSA to compare their data to those of healthy controls or normative data, provided that the samples did not present conditions that might affect cognition/behavior irrespective of OSA. The few selected articles with low risk of bias (levels of evidence I and II) showed that OSA children's intellectual abilities may be impaired but remain within the normal range. Which specific cognitive ability drives this impairment is unclear, as there was insufficient evidence of deficits in language, memory, attention, executive functions, and academic performance, due to low levels of evidence, conflicting findings, and/or heterogeneity of tasks and cognitive abilities tapped by the measures used to assess these domains. To determine why this is so, future studies must test OSA patients using measures that allow for fractionated higher-and lower-order cognitive abilities based on accepted cognitive neuropsychology models. (C) 2018 Elsevier B.V. All rights reserved.
Somente Metadadados
Cognitive impairment in Brazilian patients with Behcet's disease occurs independently of neurologic manifestation
(Elsevier B.V., 2013-04-15) Dutra, Livia Almeida [UNIFESP]; Silva de Souza, Alexandre Wagner [UNIFESP]; Alessi, Helena [UNIFESP]; Sobreira Guedes, Bruno de Vasconcelos; Braga-Neto, Pedro [UNIFESP]; Pedroso, Jose Luiz [UNIFESP]; Goncalves, Celio Roberto; Rocha, Antonio Jose da; Bertolucci, Paulo Henrique Ferreira [UNIFESP]; Barsottini, Orlando Graziani Povoas [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Fac Ciencias Med Santa Casa São Paulo; Universidade de São Paulo (USP)
Neuro-Behcet's disease (NBD) presents cognitive and behavioral symptoms possibly explained by secondary dysfunction of frontal and temporal cortices due to subcortical damage, as NBD commonly involves the brainstem and basal ganglia. Nonetheless, there are reports of cognitive impairment in patients without neurological manifestations.Objective: To evaluate cognitive function in Behcet's disease (BD) patients with and without neurological manifestations and to analyze clinical variables associated with cognitive deficits.Methods: This is a cross-sectional study that compared healthy controls, BD patients without neurological manifestations and NBD patients. Each group comprised 24 participants. All participants underwent neuropsychological evaluation, Hamilton Anxiety Rating Scale (HAM-A), Beck Depression Inventory (BDI) application and brain MRI. Cumulative prednisone dose, years of education, and presence of white-matter lesions in brain MRI were recorded.Results: 41.6% of BD and 41.6% of NBD patients showed impaired language and executive function, whereas visual memory was impaired only in NBD patients. Multiple logistic regression revealed that anxiety (OR 1.09 95% CI 1.03-1.16, p = 0.003) and lower educational level (OR 0.62 95% CI 0.48-0.80, p<0.0001) were independently associated with cognitive impairment.Conclusion: Cognitive impairment occurs frequently in patients with BD independently of neurological manifestation. Low educational level and anxiety are risk factors for cognitive impairment in BD. (c) 2013 Elsevier B.V. All rights reserved.
Acesso aberto (Open Access)
Comparação entre dois instrumentos de avaliação neuropsicológica para demencia grave
(Universidade Federal de São Paulo (UNIFESP), 2005) Wajman, José Roberto [UNIFESP]; Bertolucci, Paulo Henrique Ferreira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Objetivo: Este trabalho tem como objetivos avaliar a correlação entre dois instrumentos de avaliação cognitiva. o Mini-exame do estado Mental-grave (MEEM-g) e a Bateria para Comprometimento Grave (SIB), e comparar a Escala Funcional de Atividades Diárias Bristol e sua correlação com o Mini-exame do Estado Mental (MEEM). Nossa hipótese é que o MEEM-g e o SIB apresentam uma melhor correlação com desempenho funcional que o MEEM, em pacientes com demência moderadamente grave a grave. Para isto foi feita uma estratificação entre os desempenhos alcançados através do instrumento MEEM-g, a bateria SIB, o MEEM e a Escala Funcional de Atividades Diárias Bristol. Métodos: Foram avaliados 50 pacientes provenientes do Setor de Neurologia do Comportamento - UNIFESP-EPM - com idade entre 57 e 95 anos (média de 76,84 anos, desvio-padrão de 7.94 anos e mediana de 77,00 anos). Dezesseis (32,0 por cento) eram do sexo masculino e 34 (68,0 por cento) do sexo feminino. O tempo de doença destes pacientes variou de 2 a 10 anos (média de 3,98 anos, desvio-padrão de 1,53 anos e mediana de 4,00 anos) e o tempo de escolaridade de 4 a 15 anos (média de 5,08 anos, desvio-padrão de 2,31 anos e mediana de 4,00 anos). Nestes pacientes foram aplicados os testes MEEM, o MEEM-g, a bateria SIB e para o cuidador, a escala Bristol. Resultados: Embora os achados sejam preliminares e coletados de uma pequena parcela da população em destaque, foi possível observar aspectos de sensibilidade entre o MEEM tradicional e os outros dois instrumentos de avaliação para fases avançadas, sendo que o MEEM-g parece ser ligeiramente mais adequado quando estratificados seus valores e correlacionados com a escala funcional. Conclusões: Os dados deste projeto, precursor em nosso meio, corroboram registros de diversos centros de referência de que é possível seguir acompanhando o paciente demenciado, mesmo em fases avançadas da doença, em relação às avaliações cognitiva e funcional.
Somente Metadadados
Correlation between memory, proton magnetic resonance spectroscopy, and interictal epileptiform discharges in temporal lobe epilepsy related to mesial temporal sclerosis
(Elsevier B.V., 2009-11-01) Silva Mantoan, Marcele Araujo [UNIFESP]; Sales Ferreira Caboclo, Luis Otavio [UNIFESP]; Figueiredo Ferreira Guilhoto, Laura Maria de [UNIFESP]; Lin, Katia [UNIFESP]; Silva Noffs, Maria Helena da [UNIFESP]; Silva Tudesco, Ivanda de Souza [UNIFESP]; Belzunces, Erich [UNIFESP]; Carrete, Henrique [UNIFESP]; Bussoletti, Renato Tavares [UNIFESP]; Centeno, Ricardo Silva [UNIFESP]; Sakamoto, Americo Ceiki [UNIFESP]; Targas Yacubian, Elza Marcia [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Objective: the aim of the study described here was to examine the relationship between memory function, proton magnetic resonance spectroscopy ((1)H-MRS) abnormalities, and interictal epileptiform discharge (IED) lateralization in patients with temporal lobe epilepsy (TLE) related to unilateral mesial temporal sclerosis.Methods: We assessed performance on tests of memory function and intelligence quotient (IQ) in 29 right-handed outpatients and 24 controls. IEDs were assessed on 30-minute-awake and 30-minute-sleep EEG samples. Patients had (1)H-MRS at 1.5 T.Results: There was a negative correlation between IQ (P = 0.031) and Rey Auditory Verbal Learning Test results (P = 0.022) and epilepsy duration: between (1)H-MRS findings and epilepsy duration (P = 0.027); and between N-acetylaspartate (NAA) levels and IEDs (P = 0.006) in contralateral mesial temporal structures in the left MTS group. (1)H-MRS findings, IEDs, and verbal function were correlated.Conclusions: These findings suggest that IEDs and NAA/(Cho + Cr) ratios reflecting neural metabolism are closely related to verbal memory function in mesial temporal sclerosis. Higher interictal activity on the EEG was associated with a decline in total NAA in contralateral mesial temporal structures. (C) 2009 Elsevier Inc. All rights reserved.
Acesso aberto (Open Access)
Desenvolvimento do Instrumento de Avaliação Neuropsicológica Breve Infantil NEUPSILIN-INF
(Universidade de São Francisco, Programa de Pós-Graduação Stricto Sensu em Psicologia, 2011-12-01) Salles, Jerusa Fumagalli de; Fonseca, Rochele Paz; Cruz-Rodrigues, Camila; Mello, Claudia B. [UNIFESP]; Barbosa, Thais [UNIFESP]; Miranda, Mônica Carolina [UNIFESP]; Universidade Federal do Rio Grande do Sul; Pontifícia Universidade Católica do Rio Grande do Sul; Universidade Presbiteriana Mackenzie; Universidade Federal de São Paulo (UNIFESP)
The aim of this study is to present the development process and content validation of Child Brief Neuropsychological Assessment Battery NEUPSILIN-INF, which briefly assesses the components of eight neuropsychological functions in school-aged children: orientation, attention, visual perception, memory, arithmetic abilities, language, visuoconstructive abilities and executive functions. The process comprised: 1) the analysis of the original NEUPSILIN instrument and definition of the functions and tasks to be adapted for the child neuropsychological assessment; 2) the development of new tasks considered as fundamental for the assessment in children; 3) pilot study 1 with the preliminary version of the instrument; 4) analysis by specialist judges; 5) pilot studies 2 and 3, new reformulation of the instrument's tasks and preparation of its final version. The instrument presented appropriate face and content validity.
Acesso aberto (Open Access)
Efeitos da exposição à altitude sobre os aspectos neuropsicológicos: uma revisão da literatura
(Associação Brasileira de Psiquiatria - ABP, 2010-03-01) Lemos, Valdir de Aquino [UNIFESP]; Antunes, Hanna Karen Moreira [UNIFESP]; Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]; Prado, Juliana Martuscelli da Silva; Tufik, Sergio [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Centro de Estudos em Psicobiologia e Exercício; Conselho Nacional de Desenvolvimento Científico e Tecnológico
OBJECTIVE: Discuss the effects of altitude exposure on neuropsychological functions. METHOD: We have conducted a literature review using as source indexed articles at Pubmed in the period from 1921 to 2008, using the following key words: cognition and hypoxia, hypoxia and neuropsychology, acute hypoxia, chronic hypoxia, and acclimatization and hypoxia, as well as specific books on the subject. DISCUSSION: Acute and chronic effects of Hypoxia can alter many of the neuropsychological functions in different altitudes due to physiological changes resulted by the oxygen (O2) partial decrease that can lead to neuropsychological alterations in individuals exposed to high altitudes. CONCLUSION: Individuals exposed to high altitudes must use an O2 supplementation and the practice of acclimatization, among other strategy ways that can be used in order to minimize the negative effects of hypoxia on neuropsychological aspects.
Acesso aberto (Open Access)
Esquizofrenia: uma revisão
(Instituto de Psicologia da Universidade de São Paulo, 2006-01-01) Silva, Regina Cláudia Barbosa da [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
The current definition of schizophrenia indicates that it is a term reserved for idiopathic cases of chronic psychosis. It may prove to be a cluster of different illnesses, with similar and overlapping symptoms. Schizophrenia is of multifactorial origin. Both genetic and environmental factors have been associated with an increased risk for schizophrenia. This paper is a review of some aspects of the history, symptoms, treatments and experimental models of schizophrenia.
Acesso aberto (Open Access)
Estudo sobre os efeitos de uma intervenção baseada em mindfulness nas funções neuropsicológicas de estudantes universitários
(Universidade Federal de São Paulo (UNIFESP), 2018) Cicuto, Karen Messas [UNIFESP]; Demarzo, Marcelo Marcos Piva [UNIFESP]; http://lattes.cnpq.br/9242996936416312; http://lattes.cnpq.br/9905267940193868; Universidade Federal de São Paulo (UNIFESP)
Objetivo: investigar os efeitos de uma intervenção baseadas em mindfulness nas funções neuropsicológicas de estudantes universitários saudáveis e correlacionar níveis de mindfulness, impulsividade e medidas cognitivas. Métodos: foram feitos dois estudos, baseline, no qual foram realizadas correlações entre as variáveis de mindfulness, impulsividade e medidas neuropsicológicas de 84 participantes sem terem sofrido nenhuma intervenção, e ensaio controlado e randomizado, no qual 51 participantes foram divididos aleatoriamente em um grupo de intervenção de mindfulness e um grupo controle passivo, e foram investigados efeitos da intervenção nas medidas neuropsicológicas. Resultados: fortes correlações entre níveis de mindfulness e impulsividade foram encontradas no estudo baseline, e foram encontradas associações importantes entre melhoras nas medidas cognitivas (atenção e memória) e a intervenção direta de mindfulness, sem serem intermediadas por outras variáveis. Conclusão: há evidências de forte correlação entre os constructos de mindfulness e impulsividade, e evidências de benefícios cognitivos associados a intervenção de mindfulness.
Acesso aberto (Open Access)
Funcionamento executivo em pacientes com esquizofrenia refratária
(Universidade Federal de São Paulo (UNIFESP), 2016-12-21) Vicente, Marcella de Oliveira [UNIFESP]; Lacerda, Acioly Luiz Tavares de [UNIFESP]; http://lattes.cnpq.br/2130804932385877; http://lattes.cnpq.br/9732472446053745; Universidade Federal de São Paulo (UNIFESP)
Background: Treatment resistance affects up to one third of patients with schizophrenia. Cognitive deficits, especially executive ones, have been considered core features of the illness. The nature of such deficits in treatment-resistant subjects, however, is still unknown. The main aim of present study was to evaluate specific components of executive functioning in treatment-resistant schizophrenia subjects (TRS), comparing with schizophrenia subjects without history of resistance to treatment (Non-TRS) and healthy subjects. Methodology: 65 TRS patients (adapted IPAP criteria), 60 NonTRS patients, and 112 healthy controls were examined. Subjects were tested with a comprehensive and computerized battery of cognitive tests, including measures to assess three specific executive components, namely updating, shifting and inhibition. Results: Schizophrenia subjects performed poorly on general executive functioning, updating and inhibition tasks in comparison to healthy controls. The global measure (TOL) could not differentiate TRS from NonTRS patients. Among the three executive dimensions, TRS subjects performed worse than NonTRS only in updating of working memory function. Conclusion: Present findings suggest a more severe executive dysfunction in TRS as compared to NonTRS subjects, particularly affecting updating of working memory function. In addition, results support the hypothesis that TRS is a more severe stage or a more severe subtype of schizophrenia. Future longitudinal studies examining first-episode schizophrenia subjects may be particularly elucidative to determine whether patients who develop TRS already present such deficits at the disease onset.
Acesso aberto (Open Access)
Kleine-Levin syndrome: interface between neurology and psychiatry
(Academia Brasileira de Neurologia - ABNEURO, 2007-03-01) Justo, Luís Pereira [UNIFESP]; Calil, Helena Maria [UNIFESP]; Bolognani, Silvia Adriana Prado [UNIFESP]; Muszkat, Mauro [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
We report the first episode of Kleine-Levin (KLS) syndrome in a 17-year-old male. The illness onset, clinical features, neuropsychological evaluation and polysomnographic recording are described. Typical symptoms hypersomnia, hyperphagia and sexual disinhibition were observed besides behavioral disturbances, polysonographic and neuropsychological alterations. Behavioral disturbances similar to a manic episode including psychotic symptoms were relevant. The pharmacologic treatment included lithium, methylphenidate and risperidone. The introduction of risperidone aimed the control of psychotic symptoms and the persistent manifestations of hypersexuality after sleepness control and to the best of our knowledge there are no other report regarding risperidone use for KLS in the literature.

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