Navegando por Palavras-chave "Mood Disorders"
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- ItemSomente MetadadadosAplicação de técnicas de revisão sistemática, metanálise e meta-regressão na relação entre distúrbios metabólicos e transtornos do humor(Universidade Federal de São Paulo (UNIFESP), 2021) Grigolon, Ruth Bartelli [UNIFESP]; Brietzke, Elisa Macedo [UNIFESP]; Universidade Federal de São PauloThis doctoral project contemplated issues relevant to the area of Psychiatry. The use of alternative therapies, in the case of medication (antihyperglycemic agents) or dietetic/nutritional (DC) for the treatment of MDD, focusing on on disease-maintaining mechanisms (e.g., cognitive and symptoms of anhedonia) as inflammatory and metabolic factors. Corroborating with these findings, a CR-specific nutritional intervention was also able to demonstrate changes in the functioning of domains important to practice clinic related to MDD. In addition, the impact of factors that interfere in the treatment of BAD and TMD, such as hypersomnia and BMI. Approximately one third of individuals with BAD have hypersomnia, a symptom which can be a confounding factor for psychotropic therapy and the identification of depressive processes. BMI, in turn, should be a factor to be considered in the initiation of MDD treatment, in addition to choosing the type of antidepressant therapy (if monotherapy or combination therapy, e.g. with antipsychotics) as elements relevant to the prognosis and remission of the disease.
- ItemAcesso aberto (Open Access)Avaliação do estado de humor, nível de ansiedade e fissura em dependentes de tabaco após uma sessão de exercícios físicos(Universidade Federal de São Paulo (UNIFESP), 2018-12-16) Borges, Eduardo Oliveira [UNIFESP]; Ferreira, Sionaldo Eduardo [UNIFESP]; http://lattes.cnpq.br/7730654028676766; http://lattes.cnpq.br/7730654028676766; Universidade Federal de São Paulo (UNIFESP)Introdução: A relação entre os sintomas de mudanças nos padrões de humor e ansiedade, podem interferir e ser um agravante para cessação do uso de tabaco, fazendo com o efeitos do período de abstinência se tornem ainda piores e o desejo de usar a droga aumente. O exercício físico vem sendo estudado como possível auxiliador para a manutenção ou redução de tais desconfortos. Deste modo, este estudo pretendeu avaliar aspectos de humor, em dependentes de tabaco após uma sessão aguda de exercícios físicos. Métodos: Foram realizadas duas sessões agudas de exercícios físicos com indivíduos tabagistas. Estes foram divididos nos grupos controle (N=3) e grupo experimental (N=3), porém entre a primeira e segunda intervenções os indivíduos do grupo experimental deveriam ficar 24 horas sem realizar uso do tabaco. Os instrumentos utilizados foram o Questionário de Humor de Brunel, Inventário de Ansiedade de Beck (BAI), Escala de Fissura, aplicados antes e após cada intervenção. Os dados coletados foram analisados utilizando-se o software Statistica, sendo realizada estatística descritiva para apresentação dos resultados, avaliação não-paramétrica para comparação dos resultados por meio do teste de Mann-Whitney e Wilcoxon. Resultado: Não foram encontradas diferenças significativas entre o grupo controle e experimental com relação às variáveis de humor, ansiedade e desejo ao uso da substância, quando comparados os dados da primeira e segunda sessão aguda de exercícios físicos. Porém os resultados mostram que há uma tendência no qual uma sessão aguda de exercício físico pode ser benéfica para a manutenção e auxilio dos sintomas de desconforto do período de abstinência, podendo ser uma estratégia terapêutica não medicamentosa. Conclusão: Conclui-se a importância de se investigar tais variáveis e as influências da atividade física no processo de tratamento ao tabagismo, buscando tornar esse processo mais eficiente.
- ItemAcesso aberto (Open Access)Bipolar disorder and metabolic syndrome: a systematic review(Associação Brasileira de Psiquiatria - ABP, 2013-03-01) Czepielewski, Letícia; Daruy Filho, Ledo; Brietzke, Elisa [UNIFESP]; Grassi-oliveira, Rodrigo; Pontifícia Universidade Católica do Rio Grande do Sul Developmental Cognitive Neuroscience Research Group; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: Summarize data on metabolic syndrome (MS) in bipolar disorder (BD). METHODS: A systematic review of the literature was conducted using the Medline, Embase and PsycInfo databases, using the keywords metabolic syndrome, insulin resistance and metabolic X syndrome and cross-referencing them with bipolar disorder or mania. The following types of publications were candidates for review: (i) clinical trials, (ii) studies involving patients diagnosed with bipolar disorder or (iii) data about metabolic syndrome. A 5-point quality scale was used to assess the methodological weight of the studies. RESULTS: Thirty-nine articles were selected. None of studies reached the maximum quality score of 5 points. The prevalence of MS was significantly higher in BD individuals when compared to a control group. The analysis of MS subcomponents showed that abdominal obesity was heterogeneous. Individuals with BD had significantly higher rates of hypertriglyceridemia than healthy controls. When compared to the general population, there were no significant differences in the prevalence of low HDL-c in individuals with BD. Data on hypertension were also inconclusive. Rates of hyperglycemia were significantly greater in patients with BD compared to the general population. CONCLUSIONS: The overall results point to the presence of an association between BD and MS, as well as between their subcomponents.
- ItemSomente MetadadadosEfeitos de 36 horas consecutivas de privação de sono no desempenho aeróbio(Universidade Federal de São Paulo (UNIFESP), 2019-06-17) Dias, Carina Faggiani [UNIFESP]; Antunes, Hanna Karen Moreira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Introduction: Lack of sleep can negatively affect the mood and, as a consequence, it can impair the physical performance. Objective: To investigate the effects of 36 consecutive hours of sleep deprivation (SD) on the aerobic performance of moderate and high intensity in well-trained subjects, and its associations with mood parameters. Methods: 58 subjects were recruited, from which ten were included in the study. Volunteers were healthy men with no sleep or mood disorders, who are regular runners for at least 2 years. Initially, sleep, mood and peak velocity (Vpico) of the volunteers were evaluated. After that, volunteers were submitted to two experimental conditions: (1) Regular sleep (S) + physical exercise and (2) SD + physical exercise. Those experiments were at least 20 days apart. In each condition, volunteers performed a continuous run test followed by a 3-km time-trial (TT3Km) to evaluate the performance of moderate and high intensity, respectively. At four different moments: before exercise (BAS), shortly after the moderate exercise (MOD), shortly after intense exercise (INT) and after a 30 minutes recovery (REC), the volunteers answered to the following instruments to assess mood and anxiety states: Trait Anxiety Inventory (IDATE-T), Subjective Exercise Experiment Scale (SEES), Visual Analogue Mood Scale (EAH) and the Brunel Mood Scale (BRUMS). Results: SD caused an increase in the time to complete TT3Km, the mean difference (MD) was 26.08 s (p=0,046), starting the test at a slower rate than in S (MD= 1.32 Km/h, p= 0.046), besides presenting a higher level of anxiety, tension, fatigue and lower levels of well-being and vigor at the beginning of intense exercise. Conclusion: SD negatively affects the mood and the pleasure in performing physical exercise, which can impair performance in high intensity aerobic exercise due to a possible SD nocebo effect, which generates a negative expectation for exercise and underestimation the initial loads. Our study suggests accessible and easy to apply instruments for coaches, athletes, and exercise practitioners to assess aspects of sleep, mood, and anxiety before intense training sessions and competitions.
- ItemSomente MetadadadosThe imbalance of sex-hormones related to depressive symptoms in obese men(Univ Fed Rio De Janeiro, Fac Letras, 2016) Monteagudo, Patrícia Teófilo [UNIFESP]; Falcão, Adriana Andrade [UNIFESP]; Verreschi, Ieda Therezinha do Nascimento [UNIFESP]; Zanella, Maria-Teresa [UNIFESP]Obese men may present hypogonadothrofic hypogonadism, mainly related to higher insulinemia and aromatase activity. Our objectives were to evaluate the relationship of sex-hormones profiles and frequency of depressive symptoms in 43 obese men, in a cross-sectional study. They had 19-60 years, and body mass index 30-50kg/m(2). LH, total and free testosterone (TT and FT), estradiol (E-2), sex hormone binding globulin, estradiol/total testosterone ratio (E-2/T) were analyzed. Depressive symptoms were evaluated by beck depression inventory (BDI), and significant depression was considered if BDI16.Thirty-four (80%) presented low TT levels, but only 4 (14%) had low free testosterone and hypogonadism symptoms
- ItemAcesso aberto (Open Access)Peripheral chemokine levels in women with recurrent major depression with suicidal ideation(Associação Brasileira de Psiquiatria - ABP, 2012-03-01) Grassi-Oliveira, Rodrigo; Brietzke, Elisa [UNIFESP]; Teixeira, Antonio Lúcio [UNIFESP]; Pezzi, Júlio Carlos; Zanini, Márcio [UNIFESP]; Lopes, Rodrigo Pestana; Bauer, Moisés Evandro; Pontifícia Universidade Católica Post-Graduate Program in Psychology Developmental Cognitive Neuroscience Research Group; Universidade Federal de São Paulo (UNIFESP); Universidade Federal Minas Gerais School of Medicine Department of Internal Medicine; Universidade Federal de Ciências da Saúde de Porto Alegre Post-Graduate Program in Health Sciences; Pontifícia Universidade Católica Institute of Biomedical Research and Faculty of BiosciencesOBJECTIVE: To compare serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 between female patients with recurrent major depressive disorder (MDD) and healthy controls, verifying if there is a difference in the levels of these mediators between those with or without current suicidal ideation. METHODS: Thirty female outpatients with recurrent MDD were divided in two groups accordingly the presence or absence of suicidal ideation. These groups were compared with 16 healthy controls. Serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 were determined. Depression severity was evaluated by Beck Depression Inventory (BDI). Suicidal ideation was assessed by SCID-I and BDI. RESULTS: Patients with recurrent MDD and healthy controls did not differ in age, socioeconomic status, and education. All patients reported high scores of BDI (mean, SD, n; 29.75, 10.55, 28). Multivariable analysis of covariance adjusted for age and BMI showed that MDD patients with suicidal ideation presented lower levels of MCP-1/ CCL2 and RANTES/CCL5 (p < 0.001) and higher levels of Eotaxin/CCL11 (p = 0.04) compared to healthy controls. These differences remained significant after adjusting for depression severity. CONCLUSION: The findings of this study indicated that the presence of recurrent MDD with suicidal ideation is associated with differences in inflammatory chemokines when compared to those without suicidal ideation.
- ItemAcesso aberto (Open Access)Sono, qualidade de vida e humor em profissionais de enfermagem em Unidades de Terapia Intensiva Infantil(Univ Sao Paolo, 2016) Guerra, Priscilla Caetano [UNIFESP]; Oliveira, Nilton Ferraro [UNIFESP]; Ramos Ascensao Terrei, Maria Teresa de Sande e Lemos [UNIFESP]; Len, Claudio Arnaldo [UNIFESP]Objective: To assess sleep, quality of life and mood of nursing professionals of pediatric intensive care units. Method: Quantitative, cross-sectional and descriptive study. Professionals grouped by morning, afternoon and evening shifts were assessed by means of the instruments: Morningness-Eveningness Questionnaire; Pittsburgh Sleep Quality Index; Epworth Sleepiness Scale; Generic questionnaire for the assessment of quality of life (SF-36); Beck Depression Inventory; Beck Anxiety Inventory; State-Trait Anxiety Inventory. Results: Sample consisted of 168 professionals, with prevalence of neutral typology (57.49%). There was no statistical significance regarding sleep, despite scores showing a poor quality of sleep and excessive daytime sleepiness for the three shifts. Quality of life did not reveal any statistical significance, but in the field "social role functioning" of the evening shift, a lower score was observed (p<0.007). There was no statistical significance regarding levels of anxiety and depression. Conclusion: The results suggest that these professionals may present sleeping problems, but they do not have lower scores of quality of life or mood disorders. Likely explanations for these findings may include an adaptation to their work type over time and the fact that working with children is rewarding.
- ItemSomente MetadadadosTreinamento aeróbio e consumo de dieta cafeteria por 4 semanas: modulação do ciclo estral e sua relação com alterações comportamentais e parâmetros hormonais, lipídicos e inflamatórios(Universidade Federal de São Paulo (UNIFESP), 2020-02-28) Kubota, Melina Chiemi [UNIFESP]; Estadella, Debora [UNIFESP]; Universidade Federal de São PauloEpidemiology data show an increase in the prevalence of behavioral disorders in the world, such as anxiety and depression, with Brazil exhibiting high indices for both disorders. Anxiety is characterized by excessive worrying and threats anticipation while depressive behavior by is characterized sadness, disinterest and low self-esteem. It is known that these diseases have multifactorial origin and the female sex, also due to the influence of hormonal fluctuations in the menstrual cycle, appear to be more vulnerable to mood swings, even though estradiol has shown neuroprotective properties. Cafeteria-like diets or hyperlipidic diets (HDs) intake seems to have a positive relation with the development of mood disorders and/or anxiety. It is substantive to consider that the relationship between HFD consumption, neurochemistry amendments and anxiety and depression-like behavioral changes can be influenced by sexual hormones. In certain periods of estrous cycle, the lower estradiol and progesterone levels may facilitate those behavioral changes. In male and female rodents, HD consumption has already been described as having divergent effects, possibly showing anxiogenic effects in females and anxiolytic effects in males, more commonly. Through the years several pharmacological and non-pharmacological treatments have been investigated, the non-pharmacological ones drawing a lot interest. A non-pharmacological treatment example is physical activity, with emphasis on moderate aerobic training because it can improve cardiorespiratory, muscular and metabolic parameters, with glycolytic and lipidic pathways modifications. The physical training has been quite studied as a resource to minimize the negative effects of HD intake on anxious and depressive-like behaviors, as much in humans as in experimental animals. Hence, the objective of the present study was to evaluate the modulation of female rat's estrous cycle on reproductive age, of anxious and depressive-like behaviors and of hormonal, lipidic and inflammatory parameters after 4 weeks of moderate physical treadmill training and cafeteria-like diet consumption.