Repositório Institucional - Unifesp :: Navegando por Palavras-chave "Migration"

Navegando por Palavras-chave "Migration"

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Comida de cá e de lá: processos migratórios e alimentação migrantes em situação vulnerável: narrativas de vida e trajetórias alimentares
(Universidade Federal de São Paulo (UNIFESP), 2019-03-19) Martins, Livia De Campos [UNIFESP]; Juzwiak, Claudia Ridel [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Migration processes and the migrant’s integration into the new society can intensify the vulnerability of the individuals, as well as of their groups, affecting their food practices. The objective of this study is to trace the food trajectories of vulnerable migrants, to identify the processes involved in their food choices, to investigate the adaptation strategies and processes adopted in their food practices, and to understand the re- signification of food in the host country. This is a qualitative study using the Narrative Methodology, based on semi-structured interviews. Participants were recruited through snowball sampling, and ten migrants with different nationalities and status were interviewed. Elements from The Food Choice Process Model were chosen as the basis for analysis of food choices. The interviews were analyzed with the Content Analysis technique. Accessing the migrants was difficult and, consequently, so was creating a bond with the population. Six categories were defined for the analysis: "Displacements: motivations, trajectories, and vulnerability", which summarizes the motivations for migration, displacements and how vulnerability presents itself in the migration context; "Cultural processes: acculturation", which explores the processes of acculturation, based on the migrants’ experiences with Brazilian cuisine; "Identity and food from here and there", which discusses perceptions of identity and how they are associated with the meanings of food; "Commensality and Traditions," which analyzes the act of eating in the company of others as a significant food ritual, and how rituals become traditions and central elements in celebrations; "Autonomy in migration: the role of support networks and the Human Right to Adequate Food", which discusses food autonomy in the face of migratory conditions, and the last category "The role of women: gender issues in food", which explores the role of women in eating practices. This study concludes that the economic hardship and intricacies regarding the language of the host country are factors associated with vulnerability. Overcoming integration challenges depends on the support provided by civil society organizations and ethnic groups, which influence attitudes of acculturation, how much contact the migrant has with local cuisine, and their autonomy in food choices. The cuisine of the country of origin, however, remains an important link between historical and cultural identities.
Acesso aberto (Open Access)
Competição e persistência populacional em Acanthoscelides macrophthalmus: uma análise de estrutura populacional
(Universidade Federal de São Paulo, 2018-03-29) Iano, Daniela Mayumi [UNIFESP]; Rossi, Marcelo Nogueira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
The understanding of how variations in demographic processes directly influence population dynamics and persistence has been the focus of ecology for many years. It is already known that competition is one of the ecological interactions that most interfere in the biological parameters and in the abundance of the species. In this study, we have investigated how larval competition may affect the structure and population persistence of Acanthoscelides macrophthalmus, as well as its interference with the finite rate of population increase and the contribution of dispersion to the persistence of this species. Mature fruits of the host plant Leucaena leucocephala were collected from a population located in São Paulo, SP. The fruits were taken to the laboratory where they were dissected. The seeds were conditioned in six transparent plastic containers and the second generation of bruchine was established as a control population. Seeds with one or two eggs were individualized, and two treatments were established: 1) seeds without larval competition and 2) seeds with larval competition. The seeds containing eggs were individualized, and after five days 20 seeds per treatment were dissected every two days to remove the larvae. After that, the cephalic capsule of each larva was measured. The population structure was determined through the elaboration of projection matrices, from which the finite rate of increase (R), the stable distribution of stages, the sensitivity and the elasticity were estimated. Considering a single population, the simulations were done to calculate the population persistence time and the proportion of occupied patches adding 0, 5, and 10% of migration. The finite rate of population growth (R) was higher for the treatment without competition. Competition also reduced the body size of third instar larva and sensitivity results showed that the transition from the third to the fourth instar was the most important for R estimation, suggesting that this stage was mostly affected by competition. The stable stage distribution showed that the probability of populations being extinct is higher when competition is present. It was observed that competition should occur at high rates in populations to produce a significant decrease in R. Populations showed high levels of persistence (for 100 generations), even with competition, and only 5% of migration increased the persistence of populations.
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Endurance training restores peritoneal macrophage function in post-MI congestive heart failure rats
(Amer Physiological Soc, 2007-05-01) Batista, M. L.; Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]; Oliveira, E. M.; Seelaender, M. C. L.; Rosa, L. F. B. P. Costa; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Univ Mogi das Cruzes
Congestive heart failure (CHF) induces a state of immune activation, and peritoneal macrophages (M Phi s) may play an important role in the development and progression of one such condition. Moderate endurance training modulates peritoneal M Phi function. We evaluated the effect of endurance training on different stages of the phagocytic process and in the production of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) after LPS stimulation. Either ligation of the left coronary artery or Sham operations were performed in adult Wistar rats. After 4 wk, control (Sham operated) and MI (ligation of the left coronary artery) animals were randomly assigned to either a sedentary (Sham-operated sedentary, n = 7 and MI sedentary, n = 10) or a trained group (Sham-operated trained, n = 8 and MI trained, n = 8). Trained rats ran on a treadmill (0% grade at 13-20 m/min) for 60 min/day, 5 days/wk, for 8-10 wk, whereas sedentary rats had only limited activity. Training increased maximal oxygen uptake normalized for body weight (ml . kg(-1). min(-1)), as well as skeletal muscle citrate synthase maximal activity, when compared with sedentary groups. the resident and total cell number, the chemotaxis index, and the production of TNF-alpha stimulated by LPS were significantly higher in the MI sedentary group when compared with the Sham sedentary group. Moderate endurance training reversed these alterations promoted by post-MI. These results demonstrate that moderate intensity exercise training modulates peritoneal M Phi function and induces beneficial metabolic effects in rats with post-MI CHF.
Acesso aberto (Open Access)
Estudo da compartimentalização da sGTPASES RAS e RAC1 em células da linhagem de tumores humanos de mama MAMA MDA-MB-231 mediante ativação por fontes endógenas e exógenas de óxido nítrico: associação com a migração celular
(Universidade Federal de São Paulo (UNIFESP), 2019-09-26) Strumillo, Scheilla Teixeira [UNIFESP]; Monteiro, Hugo Pequeno [UNIFESP]; Batista, Wagner Luiz; http://lattes.cnpq.br/6154759166234850; http://lattes.cnpq.br/4373797404389169; http://lattes.cnpq.br/5127472266893954; Universidade Federal de São Paulo (UNIFESP)
Ras is a protein with GTPase activity expressed in all cells with high cell proliferation rates and despite the low frequency of mutated forms of RAS oncogene in breast cancer (less than 5%), there is evidence to suggest that hyperactivity of Ras oncogenic protein promotes the growth and development of this cancer. Like Ras, Rac1 is a GTPase and is targeted by Ras mediated signaling. Recent published studies have shown the involvement of Rac1 in the migration of breast tumors. The overall objective that guided the development of this project was to evaluate whether endogenous nitric oxide (NO) production by the MDA-MB-231 cell line, representative of triplenegative breast cancer, or exposure of these cells to an exogenous source of s-nitrosothiol snitrosoglutathione (GSNO) would stimulate cellular signaling through Ras GTPase and if this was a process that could occur in two cell compartments, the plasma membrane and the Golgi apparatus. Subsequently, we analyzed the involvement of GTPase Rac1, which is downstream in the Ras signaling pathway. We also wanted to determine whether the compartmentalization of this NO-mediated cell signaling process would be determinant for the migration and proliferation capabilities of the MDA-MB-231 tumor line. In our results we found that GSNO stimulated Ras activity in MDA-MB-231 cells, but did not stimulate the migration of these cells. Although GSNO treatment stimulated cell viability, MDA-MB-231 cell proliferation increased slightly, results that we also observed after LPS stimulation. We speculate that the high baseline NO production in these cells is a critical factor in explaining the mild effects of NO donor on MDA-MB-231 cell proliferation. The stimulation of these cells with LPS resulted in endogenous NO production and compartmentalization of Rac1 to the perinuclear region after two hours of stimulation, a period that coincided with the stimulation of its activity. Our results also suggested that in MDA-MB-231 cells Ras was apparently resident in the perinuclear region. We concluded that endogenously produced NO, by stimulating cells with LPS, was determinant for the migration stimulus of MDA-MB-231 cells. In this signaling pathway associated with cell migration participate the Ras and Rac1 GTPases, iNOS, Src, PLC and Ca2+ ions.
Acesso aberto (Open Access)
Estudo dos Fatores de Risco Associados a Arteriopatia Periferica em Nipo-brasileiros de Bauru (SP)
(Sociedade Brasileira de Cardiologia - SBC, 2014-03-25) Garofolo, Luciana [UNIFESP]; Ferreira, Sandra Roberta Gouvea [UNIFESP]; Miranda Junior, Fausto; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
Background:Cardiovascular diseases are the major cause of morbidity and mortality in developed and emerging countries. Their main etiology, atherosclerosis, is a disseminated disease that affects the coronary, cerebral and peripheral territories. The peripheral arterial disease (PAD), as well as its consequences, indicates the involvement of the coronary territory. Therefore, its better understanding enables proper treatment, delaying local and long-term complications, reducing the cost to the health system.Objective:This study estimates the percentage of PAD in Japanese-Brazilians from Bauru (SP), recognized by the high prevalence of metabolic disorders such as hypertension (43%), diabetes mellitus (33%) and hypercholesterolemia (60%), and examines the association with risk biomarkers.Methods:This cross-sectional population study evaluated 1,330 Japanese-Brazilians of both genders aged ≥ 30 who underwent a complete physical examination, anthropometric measurements, laboratory tests and ankle-brachial index (ABI). Participants with ABI ≤ 0.90 were diagnosed as having PAD. After applying the exclusion criteria, 1,038 individuals were part of the analysis. We used Poisson regression to analyze associations with PAD.Results:The mean age was 56.8 years and the percentage of PAD was 21.1%, equal among the genders. PAD was associated with smoking (PR 2.16 [1.33 to 3.48]) and hypertension (PR 1.56 [1.12-2.22]).Conclusion:The percentage of PAD in Japanese-Brazilians was similar to other populations of adverse cardiometabolic profile (US PARTNERS and POPADAD). The independent association of PAD with smoking and hypertension, but not with other classical risk factors, may depend on the very high frequencies of metabolic disorders in this population.
Acesso aberto (Open Access)
Excesso de peso e gordura abdominal para a síndrome metabólica em nipo-brasileiros
(Faculdade de Saúde Pública da Universidade de São Paulo, 2002-02-01) Lerario, Daniel D G [UNIFESP]; Gimeno, Suely Godoy Agostinho [UNIFESP]; Franco, Laercio Joel [UNIFESP]; Iunes, Magid [UNIFESP]; Ferreira, Sandra Roberta Gouvea [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
OBJECTIVE: Obesity, especially abdominal, has been associated with cardiovascular risk factors such as dyslipidemia, hypertension and diabetes mellitus (DM). The importance of these risk factors among Japanese-Brazilians was previously shown, although obesity is not a typical characteristic of Japanese migrants. In this study the prevalence of weight excess and central adiposity (CA) among Japanese-Brazilians and their association with metabolic disorders was evaluated. METHODS: A sample of 530 1st and 2nd generation Japanese-Brazilians (aged 40--79 years) went through anthropometric and blood pressure measurements, lipid profile and oral glucose tolerance tests. The prevalence rate (point and confidence interval) of overweight was calculated using a cut-off value of >26.4 kg/m². CA diagnosis was based on waist-to-hip circumference ratio (WHR):> or =0.85 and 0.95 in women and men, respectively. RESULTS: The prevalence of weight excess was 22.4% (CI 95% 20.6--28.1), and CA was 67.0% (95% CI 63.1--70.9). In addition to higher prevalence of DM, hypertension and dyslipidemia, stratifying by BMI and WHR, people with weight excess and CA revealed a poorer metabolic profile: blood pressure levels were significantly higher among those with weight excess with or without CA; CA individuals had higher glucose, triglycerides, total and LDL cholesterol, and lower HDL than those without weight excess or CA; fasting insulinemia was significantly higher among subjects with weight excess (with or without CA) than among those without weight excess or CA. CONCLUSION: Comparing subgroups with and without CA supports the hypothesis that abdominal fat accumulation represents a risk factor for insulin resistance-related diseases, even among Japanese descendants. The increased prevalence of metabolic syndrome among Japanese migrants could be attributed to visceral fat deposition, which has been implicated in the genesis of insulin resistance.
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Exoplanets in binary star systems: on the switch from prograde to retrograde orbits
(Springer, 2016) Carvalho, Jean Paulo de Sousa; Mourão, Daniela Cardoso de; Vilhena de Moraes, Rodolpho [UNIFESP]; Prado, Antonio Fernando Bertachini de Almeida; Winter, Othon Cabo
The eccentric Kozai-Lidov mechanism, based on the secular theory, has been proposed as a mechanism that plays an important role in producing orbits that switch from prograde to retrograde. In the present work we study the secular dynamics of a triple system composed of a Sun-like central star and a Jupiter-like planet, which are under the gravitational influence of another perturbing star (brown dwarf). The perturbation potential is developed in closed form up to the fifth order in a small parameter (), where is the semimajor axis of the extrasolar planet and is the semimajor axis of the perturbing star. To eliminate the short-period terms of the perturbation potential, the double-average method is applied. In this work we do not eliminate the nodes, a standard method in the literature, before deriving the equations of motion. The main goal is to study the effects of the higher-order terms of the expansion of the perturbing force due to the third body in the orbital evolution of the planet. In particular, we investigate the inclination and the shape (eccentricity) of these orbits. We show the importance of the higher-order terms in changing the inversion times of the flip, i.e., the times where the inclination of the inner planet flips from prograde to retrograde trajectories. We also show the dependence of the first flip with respect to the semimajor axis and eccentricity of the orbit of the planet. The general conclusion is that the analytical model increases its accuracy with the inclusion of higher-order terms. We also performed full numerical integrations using the Bulirsch-Stoer method available in the Mercury package for comparison with the analytical model. The results obtained with the equations developed in this work are in accordance with direct numerical simulations.
Acesso aberto (Open Access)
The extracellular matrix provides directional cues for neuronal migration during cerebellar development
(Associação Brasileira de Divulgação Científica, 2006-03-01) Porcionatto, Marimélia Aparecida [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Normal central nervous system development relies on accurate intrinsic cellular programs as well as on extrinsic informative cues provided by extracellular molecules. Migration of neuronal progenitors from defined proliferative zones to their final location is a key event during embryonic and postnatal development. Extracellular matrix components play important roles in these processes, and interactions between neurons and extracellular matrix are fundamental for the normal development of the central nervous system. Guidance cues are provided by extracellular factors that orient neuronal migration. During cerebellar development, the extracellular matrix molecules laminin and fibronectin give support to neuronal precursor migration, while other molecules such as reelin, tenascin, and netrin orient their migration. Reelin and tenascin are extracellular matrix components that attract or repel neuronal precursors and axons during development through interaction with membrane receptors, and netrin associates with laminin and heparan sulfate proteoglycans, and binds to the extracellular matrix receptor integrins present on the neuronal surface. Altogether, the dynamic changes in the composition and distribution of extracellular matrix components provide external cues that direct neurons leaving their birthplaces to reach their correct final location. Understanding the molecular mechanisms that orient neurons to reach precisely their final location during development is fundamental to understand how neuronal misplacement leads to neurological diseases and eventually to find ways to treat them.
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Human introduction or natural dispersion? Atlantic Ocean occurrence of the Indo-Pacific whitetip reef shark Triaenodon obesus
(Wiley, 2018) Bornatowski, Hugo; Loose, Robin; Sampaio, Cláudio Luis Santos; Gadig, Otto Bismarck Fazzano; Carvalho-Filho, Alfredo; Domingues, Rodrigo Rodrigues [UNIFESP]
Occurrence of multiple whitetip reef sharks Triaenodon obesus in the Atlantic Ocean is reported for the first time from near a sunken ferry off the Parana coast in south-eastern Brazil. This occurrence is hypothesized to have been caused by either a human introduction or a remarkably long oceanic displacement.
Acesso aberto (Open Access)
Ingresso de estudantes refugiados (as), apátridas e portadores (as) de visto humanitário nos cursos de graduação da Universidade Federal de São Paulo (Unifesp)
(Universidade Federal de São Paulo, 2023-12-20) Flores, Jesús Enrique Quijada [UNIFESP]; Galvani, Debora [UNIFESP]; http://lattes.cnpq.br/9874847063643955; http://lattes.cnpq.br/5750352905564365; Universidade Federal de São Paulo (UNIFESP)
Esta pesquisa teve como propósito reunir informações para poder compreender como se dá o ingresso de estudantes refugiados(as), apátridas e portadores(as) de visto humanitário nos cursos de graduação da Universidade Federal de São Paulo (UNIFESP). Desde 2003, o Alto Comissariado das Nações Unidas para Refugiados (ACNUR) implementa a Cátedra Sérgio Vieira de Mello (CSVM) em cooperação com centros universitários nacionais e, ao longo dos anos, a Cátedra tem se revelado um ator fundamental para garantir que pessoas refugiadas e solicitantes de refúgio tenham acesso a direitos e serviços no Brasil, oferecendo valioso apoio ao processo de integração local. Dentro da UNIFESP, foi implementada a Cátedra a partir de 2014, apenas em 2019 realizaram o primeiro lançamento do edital para o processo seletivo diferenciado de estudantes refugiados(as), apátridas e portadores(as) de visto humanitário. Trata-se de estudo exploratório (GIL, 2008) realizado através de levantamento bibliográfico e de documentos. Fizemos o levantamento de editais de processo seletivo para estudantes internacionais dos anos 2019, 2020, 2021, 2022. Após a reunião dos documentos, foi feita a leitura e identificação de questões que se referem ao procedimento de ingresso desses estudantes na UNIFESP. A análise foi elaborada a partir dos seguintes temas que emergiram na leitura e experiências acadêmicas: 1. Acesso à informação; 2. Acessibilidade linguística; 3. Divulgação dos editais; 4. Via de inscrição; 5. Processo seletivo; 6. Sigilo. Discutimos as dimensões do ingresso diferenciado à luz de documentos da ACNUR e de bibliografia sobre o tema. O estudo nos mostra que nem todos os campi disponibilizaram vagas exclusivas entre os anos 2019 e 2022, mas, ainda assim, as vagas não foram todas ocupadas, e que muitas vezes não foram respeitadas as cláusulas de sigilo dos editais. A documentação exigida pode ser uma barreira de acesso importante, quando se trata de refugiados, apátridas e portadores de visto humanitário, sobretudo a comprovação de conclusão do ensino médio, que entre 2019 e 2022 obstaculiza a homologação de mais de 500 estudantes. Apesar de se tratar de um processo seletivo diferenciado e com mudanças no edital ao longo dos anos, ainda há barreiras importantes para o acesso ao ensino superior, bem como dificuldades de permanência estudantil, que não foram abordadas neste estudo. Deste modo, propomos criar consciência sobre o tema, apontamos a necessidade de orientar novas ações para a capacitação por parte dos servidores em direitos humanos e migrações, que seja visto como um plano a implementar, para que as universidades apliquem de forma conjunta.
Acesso aberto (Open Access)
LFA-1 Mediates Cytotoxicity and Tissue Migration of Specific CD8(+) T Cells after Heterologous Prime-Boost Vaccination against Trypanosoma cruzi Infection
(Frontiers Media Sa, 2017) Ferreira, Camila Pontes [UNIFESP]; Cariste, Leonardo Moro [UNIFESP]; Virgilio, Fernando dos Santos [UNIFESP]; Moraschi, Barbara Ferri [UNIFESP]; Monteiro, Caroline Brandao [UNIFESP]; Machado, Alexandre de Magalhaes Vieira; Gazzinelli, Ricardo Tostes; Bruna-Romero, Oscar; Ruiz, Pedro Luiz Menin [UNIFESP]; Ribeiro, Daniel Araki [UNIFESP]; Lannes-Vieira, Joseli; Lopes, Marcela de Freitas; Rodrigues, Mauricio Martins [UNIFESP]; Vasconcelos, Jose Ronnie Carvalho de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Integrins mediate the lymphocyte migration into an infected tissue, and these cells are essential for controlling the multiplication of many intracellular parasites such as Trypanosoma cruzi, the causative agent of Chagas disease. Here, we explore LFA-1 and VLA-4 roles in the migration of specific CD8(+) T cells generated by heterologous prime-boost immunization during experimental infection with T. cruzi. To this end, vaccinated mice were treated with monoclonal anti-LFA-1 and/or anti-VLA-4 to block these molecules. After anti-LFA-1, but not anti-VLA-4 treatment, all vaccinated mice displayed increased blood and tissue parasitemia, and quickly succumbed to infection. In addition, there was an accumulation of specific CD8(+) T cells in the spleen and lymph nodes and a decrease in the number of those cells, especially in the heart, suggesting that LFA-1 is important for the output of specific CD8(+) T cells from secondary lymphoid organs into infected organs such as the heart. The treatment did not alter CD8(+) T cell effector functions such as the production of pro-inflammatory cytokines and granzyme B, and maintained the proliferative capacity after treatment. However, the specific CD8(+) T cell direct cytotoxicity was impaired after LFA-1 blockade. Also, these cells expressed higher levels of Fas/CD95 on the surface, suggesting that they are susceptible to programmed cell death by the extrinsic pathway. We conclude that LFA-1 plays an important role in the migration of specific CD8(+) T cells and in the direct cytotoxicity of these cells.
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Migração e mobilidade intergeracional de educação no Brasil
(Universidade Federal de São Paulo (UNIFESP), 2020-11-27) Alves, Thamirys Silva [UNIFESP]; Vaz, Daniela Verzola [UNIFESP]; Universidade Federal de São Paulo
The objective of this research is to analyze the intergenerational educational mobility in Brazil according to the condition of migration. It is intended to verify changes in the educational status of individuals, given parental education status, with an emphasis on the differences observed between migrants' and natives' children. Special attention is given to the analysis of the educational mobility of the children of individuals who migrated from the Northeast to the Southeast between the 1950s and 1980s, considering the importance of this migratory flow in the recent history of the country. The data to be used come from National Household Sample Survey (PNAD/IBGE) of 1996 and 2014, which included socio-occupational mobility supplementary information. It should be noted that between these years the country has shown an expansion of schooling, thus, it is relevant to verify educational mobility through more recent data. We work with the premise, arising from the literature review, that migrant families are more often upwardly mobile when compared to native families in the regions of origin and destination. The methodology of the study is divided into three parts: the use of Markov transition matrices; the estimation of intergenerational persistence of education, using a linear regression model; and the adjustment of an ordered logit model for schooling levels.
Acesso aberto (Open Access)
Migration and mental health: Japanese Brazilians in Japan and in Brazil
(Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro, 2007-01-01) Miyasaka, Lincoln Sakiara [UNIFESP]; Canasiro, Soraya; Abe, Yu; Otsuka, Koichiro; Tsuji, Keisuke; Hayashi, Takuji; Andreoli, Sergio Baxter [UNIFESP]; Nakagawa, Décio; Shirakawa, Itiro [UNIFESP]; Atallah, Álvaro Nagib [UNIFESP]; Kato, Satoshi; Universidade Federal de São Paulo (UNIFESP); Beneficência Nipo-Brasileira; Meiji Gakuin University Faculty of Psychology; Jichi Medical University School of Nursing; Musashino University Faculty of Human Studies Department of Human Studies; Kyoto University Graduate School of Medicine Department of Neuropsychiatry; Clínica Sunrise; Jichi Medical University Department of Psychiatry
OBJECTIVE: Brazil is the country with the largest community of Japanese descendants in the world, from a migration movement that started in 1908. However, more recently (1988), a movement in the opposite direction began. Many of these descendants went to Japan for work purposes and suffered mental distress. Some of them sought treatment in Japan, while others returned to Brazil to seek treatment. The aim of the present study was to compare the sociodemographic profile and diagnoses of Japanese Brazilian psychiatric outpatients in Japan (remaining group) and in Brazil (returning group). METHOD: All consecutive Japanese Brazilian outpatients who received care from the psychiatric units in Japan and Brazil from April 1997 to April 2000 were compared. The diagnoses were based on ICD-10 and were made by psychiatrists. Sociodemographic data and diagnoses in Brazil and Japan were compared by means of the Chi-Squared Test. RESULTS: The individuals who returned to Brazil were mostly male and unmarried, had lived alone in Japan, had stayed there for short periods and were classified in the schizophrenia group. The individuals who remained in Japan were mostly female and married, were living with family or friends, had stayed there for long periods and were classified in the anxiety group. Logistic regression showed that the most significant factors associated with the returning group were that they had lived alone and stayed for short periods (OR = 0.93 and 40.21, respectively). CONCLUSION: We conclude that living with a family and having a network of friends is very important for mental health in the context evaluated.
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Porto de chegada e lugares de passagem: Intercâmbio estudantil de brasileiros na Universidade do Porto, Portugal, no ano acadêmico 2008/2009
(Universidade Federal de São Paulo (UNIFESP), 2012) Ribeiro, Thaís Leal [UNIFESP]; Albuquerque, José Lindomar Coelho [UNIFESP]; http://lattes.cnpq.br/0312592126188264; http://lattes.cnpq.br/7584777209195665; Universidade Federal de São Paulo (UNIFESP)
This study examined the memories and experiences of graduate students who have made Brazilian academic exchange at the University of Porto in Portugal in the academic year 2008/2009 seeking to realize the representations that these students build themselves, the Portuguese and other foreign students in a context of sociability. From this exchange experience also seek to enter the exchanges within the context of migration.
Acesso aberto (Open Access)
Proteolytic processed form of CXCL12 abolishes migration and induces apoptosis in neural stem cells in vitro
(Elsevier Science Bv, 2017) Adelita, Tais [UNIFESP]; Stilhano, Roberta Sessa [UNIFESP]; Han, SangWon [UNIFESP]; Justo, Giselle Zenker [UNIFESP]; Porcionatto, Marimelia [UNIFESP]
The subventricular zone (SVZ) of the adult mammalian brain hosts full potential neural stem cells (NSCs). NSCs are able to respond to extracellular signals in the brain, amplifying the pool of progenitor cells and giving rise to neuroblasts that showability to migrate towards an injury site. These signals can come fromvascular system, cerebrospinal fluid, glial cells, or projections of neurons in adjoining regions. CXCL12, a chemokine secreted after brain injury, reaches the SVZ in a gradient manner and drives neuroblasts towards the lesion area. Among many other molecules, matrix metalloproteinase 2 and 9 (MMP-2/9) are also released during brain injury. MMP-2/9 can cleave CXCL12 generating a new molecule, CXCL12(5-67), and its effects on NSCs viability is not well described. Here we produced recombinant CXCL12 and CXCL12(5-67) and evaluated their effect inmurine adultNSCsmigration and survival in vitro. We showed CXCL12(5-67) does not promote NSCsmigration, but does induce cell death. The NSC death induced by CXCL12(5-67) involves caspases 9 and 3/7 activation, implying the intrinsic apoptotic pathway in this phenomenon. Our evidences in vitromake CXCL12(5-67) and its receptor potential candidates for brain injuries and neurodegeneration studies. (C) 2017 The Author(s). Published by Elsevier B.V.

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