Navegando por Palavras-chave "Migraine"
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- ItemAcesso aberto (Open Access)Avaliação da cefaleia em pacientes com diagnóstico de neurofibromatose tipo 1(Universidade Federal de São Paulo (UNIFESP), 2015-07-29) Pinho, Ricardo Silva [UNIFESP]; Rodrigues, Marcelo Masruha [UNIFESP]; Vilanova, Luiz Celso Pereira [UNIFESP]; http://lattes.cnpq.br/8403773717511464; http://lattes.cnpq.br/6440065539616739; http://lattes.cnpq.br/6913051651166970; Universidade Federal de São Paulo (UNIFESP)Objetivo: avaliar a presença da queixa de cefaleia em pacientes com Neurofibromatose tipo 1 (NF1) e em grupos controles, comparando as características da cefaleia entre os grupos e, quando possível, estabelecendo o diagnóstico tipo específico. Métodos: o estudo foi realizado em duas etapas. Inicialmente, 50 pacientes com diagnóstico de NF1 baseado nos critérios do National Institutes of Health (NIH) Consensus Conference (Instituto Nacional de Saúde e Conferência de Consensos) foram recrutados no Ambulatório de Neuro-oncologia do Instituto de Oncologia Pediátrica/Grupo de Apoio à Criança e ao Adolescente (IOP/GRAAC), e 50 pacientes controles recrutados consecutivamente dos ambulatórios de Pediatria-Geral e Adolescência da Universidade Federal de São Paulo. Numa segunda etapa, 27 pacientes com diagnóstico de NF1 que apresentavam enxaqueca foram comparados a 34 pacientes com diagnóstico de enxaqueca recrutados consecutivamente do ambulatório de Neurologia Pediátrica da Universidade Federal de São Paulo. Resultados: dos 50 pacientes com diagnóstico de NF1, 31 (62%) apresentavam cefaleia, enquanto no controle a queixa foi de 14%. Desses 31 pacientes, 23 (74%) tinham diagnóstico de enxaqueca sem aura, 4 (13%) enxaqueca com aura, 2 (6,5%) com cefaleia tensional e 2 (6,5%) com cefaleia secundária a neoplasia. A idade entre os grupos variou entre 4 e 19 anos, sendo a média do Grupo Controle de 13,12 anos e a média do Grupo NF1 de 13,22 anos. Numa segunda etapa do estudo, dos 27 pacientes com NF1 que apresentavam enxaqueca, 11 (41%) faziam uso de analgésico por mais de quatro vezes por semana, enquanto no Grupo Enxaqueca só 4 (12%). Conclusões: a cefaleia é frequente em pacientes portadores de NF1. A frequência das crises de enxaqueca é maior em pacientes com NF1. Pacientes com NF1 que apresentam enxaqueca fazem mais uso de analgésico.
- ItemSomente MetadadadosAvaliação da composição corporal dos pacientes com migrânea em tratamento profilático com Topiramato(Universidade Federal de São Paulo (UNIFESP), 2019-05-30) Caverni, Camila Naegeli [UNIFESP]; Tengan, Celia Harumi [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Introduction: Migraine is a primary headache that affects 15% of the Brazilian population. The use of prophylactic medication, such as topiramate, may be necessary to manage crisis, however, these medications may lead to the loss of weight and appetite. Additionally, there is a relation between migraine and body mass index, meaning that obese individuals are more susceptible to develop more frequent and disabling crisis. Through an anthropometric evaluation it is possible to study certain body constituents, such as percentage of body fat and fat free mass, allowing to determine which of these constituents are indicative of the current health condition and, therefore, of quality of life. Objective: The purpose of this study was to evaluate the body composition of female patients with migraine using topiramate before and after three months of treatment. Methods: 50 female patients, between 18 and 45 years old were included. The patients were initially evaluated by a neurologist to diagnose the type of migraine between migraine with or without aura and/or chronic migraine and initiate the prophylactic treatment: topiramate 50mg/day, throughout three months. In the beginning and at the end the patients were evaluated by a nutritionist the define the body composition and its change during the study, through a detailed anthropometric evaluation. Results: a total of 37 patients were evaluated in the end of the study, with average age of 31 years, average initial body mass index of 25.89kg/m2, initial average body fat of 36.1% and initial average fat free mass of 42.7kg. After 3 months of prophylactic treatment, the patients reduced significantly the frequency of days of headache per month from 21 days to 7 days (p <0.0001). Regarding the anthropometric parameters, there was a reduction of the body mass index, from 25.89kg/m2 to 25.19kg/m2 (p 0,0001) and percentage of body fat, from 36.1% to 33.2% (p <0.0001). On the other side, the treatment lead to an increase of fat free mass, from 42.7kg to 43.6kg (p 0.0074), mainly to the group with chronic migraine, which increased from 43.2kg to 44;3kg (p 0.0173). Fat free mass increase for patients with overweight (from 44.8kg to 45.8kg; p 0.0128) and obese patients (from 40.3kg to 44.2kg; p 0.0102), but there were no change on eutrophic patients. Considering age, it was observed that the increase of fat free mass, from 42.9kg to 44,3kg (p 0.0087) occurred on patients with lower age range, between 31 and 45 years old. Conclusion: The study demonstrated that the treatment with topiramate has modified the patient’s body composition by reducing the body mass index and body fat, while increasing fat free mass. The group that benefited the most from this treatment was overweight or obese patients, with chronic migraine and over 31 years old. These results suggest that the improvement of body composition may be a parameter of improvement of chronic migraine, however, further studies are required to evaluate the importance of the body composition in patients under treatment for migraine and chronic migraine.
- ItemAcesso aberto (Open Access)Características clínicas de uma população com migrânea e tontura e resposta ao tratamento profilático após três e seis meses(Universidade Federal de São Paulo (UNIFESP), 2019-01-31) Costa, Aline Turbino Neves Martins Da [UNIFESP]; Ferraz, Henrique Ballalai [UNIFESP]; http://lattes.cnpq.br/6405640945393510; http://lattes.cnpq.br/7356157635063797; Universidade Federal de São Paulo (UNIFESP)A retrospective study carried out in the headache sector at the Migraine Clinic and University of the Federal University of São Paulo, through the review of patient charts from the outpatient clinic, attended from January 2014 to June 2016, in order to evaluate the clinical characteristics of patients, an aura presence associated with vertigo and / or non-vertiginous dizziness, as well as the efficacy of treatment at 3 months 6 months. In patients with a diagnosis of migrânea associated with vestibular symptoms, a presence of aura for the most prevalent subtype, being an average frequency of days of headache / month compatible with chronic migraine (pain more than 15 days in the month). Patients with migraine presented mostly vertigo, but an occurrence of dizziness combined with non-vertigo dizziness was also found verified. It was possible to observe that some otovestibular symptoms such as tinnitus, aural fullness, dizziness associated with dizziness, phonophobia, nausea, vomiting, osmophobia and kinesiophobia had a higher relative risk of occurrence in migraine with aura. Therapeutic therapies for vestibular migrans (MV), the outlets are direct from the treatment of migration, through studies comparing patients with MV, with the treatment with profile. In this group of patients with health problems, intensity and frequency of episodic dizziness / vertigo, as well as their associated characteristics, with time effect (the longer the treatment time the greater the improvement of symptoms) for improvement of pain and vestibular symptoms and without statistical classification of response between classes of medications choices for their treatment.
- ItemAcesso aberto (Open Access)Central auditory processing and migraine: a controlled study(Springer, 2014-11-08) Agessi, Larissa Mendonca [UNIFESP]; Villa, Thais Rodrigues [UNIFESP]; Dias, Karin Ziliotto [UNIFESP]; Carvalho, Deusvenir de Souza [UNIFESP]; Pereira, Liliane Desgualdo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)This study aimed to verify and compare central auditory processing (CAP) performance in migraine with and without aura patients and healthy controls.Forty-one volunteers of both genders, aged between 18 and 40 years, diagnosed with migraine with and without aura by the criteria of the International Classification of Headache Disorders (ICDH-3 beta) and a control group of the same age range and with no headache history, were included. Gaps-in-noise (GIN), Duration Pattern test (DPT) and Dichotic Digits Test (DDT) tests were used to assess central auditory processing performance.The volunteers were divided into 3 groups: Migraine with aura (11), migraine without aura (15), and control group (15), matched by age and schooling. Subjects with aura and without aura performed significantly worse in GIN test for right ear (p = .006), for left ear (p = .005) and for DPT test (p < .001) when compared with controls without headache, however no significant differences were found in the DDT test for the right ear (p = .362) and for the left ear (p = .190).Subjects with migraine performed worsened in auditory gap detection, in the discrimination of short and long duration. They also presented impairment in the physiological mechanism of temporal processing, especially in temporal resolution and temporal ordering when compared with controls. Migraine could be related to an impaired central auditory processing.Research Ethics Committee (CEP 0480.10) - UNIFESP.
- ItemAcesso aberto (Open Access)Estudo da vasorreatividade cerebral em crianças com doença falciforme: avaliação pelo doppler transcraniano(Universidade Federal de São Paulo (UNIFESP), 2016-10-25) Campos, Rejane de Souza Macêdo [UNIFESP]; Silva, Gisele Sampaio [UNIFESP]; http://lattes.cnpq.br/6812788681744190; http://lattes.cnpq.br/7204169771610580; Universidade Federal de São Paulo (UNIFESP)Objectives: The purposes of this study were: to evaluate cerebral blood flow velocities and vasoreactivity using transcranial Doppler (TCD) in children with SCD and to compare them with healthy subjects; to compare cerebral blood flow velocities and vasoreactivity with TCD in children with SCD, with and without migraine, and healthy subjects; to determine headache and migraine frequencies in children with SCD. Methods: Children aged 10 to 18 years old with SCD were evaluated from the hemoglobinopathy clinics at UNIFESP. Healthy children of similar age and gender were included. A structured questionnaire was applied to all patients evaluating the presence of headache, its frequency and if migraine criteria were fulfilled. Demographic characteristics, comorbidities, medication use, laboratory and imaging exams data were collected from medical records. TCD was performed in all patients and controls subjects, with breath-holding maneuver and calculation of the breathholding index (BHI) to assess cerebral vasoreactivity. Cerebral blood flow velocities were assessed in both middle, anterior, posterior, vertebrals and basilar arteries. Cerebral blood flow velocities and vasorreactivity were compared between patients and control subjects and also between patients with SCD with and without migraine and healthy controls. Statistical analyses were performed using SPSS 18.0. Results: TCD was performed in 42 patients, mean age 12,67?2,18 years, and 20 controls subjects, mean age 13,90?3,04 years. Blood flow velocities were higher in patients with SCD than health volunteers in all arteries evaluated. Cerebral blood flow velocities were negatively correlated with hemoglobin levels (p<0,05). BHI was abnormal in 19% of the patients and in none of the controls (p=0.04). BHI values in patients were significantly lower than in control subjects (p<0.01 at right and p=0.01 at left). There were no differences in blood flow velocities between patients with or without migraine. BHI was similar in children with SCD with or without migraine, and between both and control subjects. A total of 57,1% had headache and 38% fulfilled criteria for migraine Conclusions: Cerebral vasoreactivity may be impaired in children with SCD, with BHI significantly lower in this group, maybe reflecting a low vascular reserve and autoregulation capacity in these patients. Cerebral vasoreactivity was not different between patients with or without migraine and both and controls subjects. Migraine was found in more than one third of our patients.
- ItemSomente MetadadadosExercise-Induced Change in Plasma IL-12p70 Is Linked to Migraine Prevention and Anxiolytic Effects in Treatment-Naive Women: A Randomized Controlled Trial(Karger, 2017) Oliveira, Arao Belitardo [UNIFESP]; Lacerda Bachi, Andre Luis; Ribeiro, Reinaldo Teixeira; Mello, Marco Tulio; Vaisberg, Mauro [UNIFESP]; Prieto Peres, Mario FernandoObjective: To conduct a randomized controlled trial to evaluate the effect of a 12-week aerobic exercise program for migraine prevention, plasma cytokines concentrations (TNF-alpha, interleukin [IL]-1 beta, IL-6, IL-8, IL-10, and IL-12p70), and anxiety in women with migraine. Methods: Women with episodic migraine (ICHD-II), aged between 20 and 50 years, who had never taken any prophylactic medication, and were physically inactive in the past 12 months were recruited from the university's hospital and a tertiary headache clinic between March 2012 and March 2015. Migraine attacks were recorded in headache diaries, cytokines were quantified by flow cytometry, and anxiety was assessed by the 7-item General Anxiety Disorder (GAD-7) scale. Blood sampling and psychometric interviews were undertaken on headache-free days. Results: Twenty participants ([mean +/- SD] age 33.8 +/- 10.5
- ItemAcesso aberto (Open Access)Low urinary 6-sulphatoxymelatonin concentrations in acute migraine(Springer, 2008-08-01) Masruha, Marcelo Rodrigues [UNIFESP]; Vieira, Domingos Sávio de Souza [UNIFESP]; Minett, Thaís Soares Cianciarullo [UNIFESP]; Cipolla-Neto, Jose; Zukerman, Eliova [UNIFESP]; Vilanova, Luiz Celso Pereira [UNIFESP]; Peres, Mario Fernando Prieto [UNIFESP]; Hosp Israelita Albert Einstein; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)Substantial evidence points to melatonin as playing a role in the regulation of circadian rhythms, sleep, and headache disorders. the objective of the study was to assess 6-sulphatoxymelatonin (aMT6s) levels in a large consecutive series of patients with migraine, comparing with controls. A total of 220 subjects were evaluated-146 had migraine and 74 were control subjects. Urinary samples were collected into the same plastic container since 8:00 p.m. to 8:00 a.m. of the next day (12-h period) and aMT6s was measured with quantitative ELISA technique. Among patients with migraine, 53% presented pain on the day of the urine samples collection. Their urinary aMT6s concentration was significantly lower than in the urine of patients without pain [14.0 +/- 7.3 vs. 49.4 +/- 19.0; t(143) = -15.1; 95% CI = -40.0 to -30.8; P<0.001]. There was no significant difference in the aMT6s concentration of patients with migraine without pain on the day of their urine samples collection and controls [49.4 +/- 19.0 vs. 42.5 +/- 27.9; t(140) = 1.7; 95% CI = -1.2 to 14.8; P = 0.094]. To our knowledge, this is the first study to demonstrate reduction in melatonin levels during attacks in episodic and chronic migraine.
- ItemAcesso aberto (Open Access)Melatonin treatment decreases c-fos expression in a headache model induced by capsaicin(Springer, 2009-04-01) Tanuri, Fabiano da Cunha [UNIFESP]; Lima, Eliângela de [UNIFESP]; Peres, Mario Fernando Prieto [UNIFESP]; Cabral, Francisco Romero [UNIFESP]; Naffah-Mazzacoratti, Maria da Graca [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Cipolla-Neto, Jose; Zukerman, Eliova [UNIFESP]; Amado, Débora [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Hosp Israelita Albert Einstein; Universidade de São Paulo (USP)The aim of the present work was to analyze c-fos response within the trigeminal nucleus caudalis (TNC) of pinealectomized rats and animals that received intraperitoneal melatonin, after intracisternal infusion of capsaicin, used to induce intracranial trigeminovascular stimulation. Experimental groups consisted of animals that received vehicle solution (saline-ethanol-Tween 80, 8:1:1, diluted 1:50) only (VEI, n = 5); animals that received capsaicin solution (200 nM) only (CAP, n = 6); animals submitted to pinealectomy (PX, n = 5); sham-operated animals (SH, n = 5); animals submitted to pinealectomy followed by capsaicin stimulation (200 nM) after 15 days (PX + CAP, n = 7); and animals that received capsaicin solution (200 nM) and intraperitoneal melatonin (10 mg/kg) (CAP + MEL, n = 5). Control rats, receiving vehicle in the cisterna magna, showed a small number of c-fos-positive cells in the TNC (layer I/II) as well as the sham-operated and pinealectomized rats, when compared to animals stimulated by capsaicin. On the other hand, pinealectomized rats, which received capsaicin, presented the highest number of c-fos-positive cells. Animals receiving capsaicin and melatonin treatment had similar expression of the vehicle group. Our data provide experimental evidence to support the role of melatonin and pineal gland in the pathophysiology of neurovascular headaches.
- ItemSomente MetadadadosNocturnal Enuresis Antecedent Is Common in Adolescents with Migraine(Karger, 2012-01-01) Lin, Jaime; Masruha, Marcelo Rodrigues [UNIFESP]; Prieto Peres, Mario Fernando [UNIFESP]; Cianciarullo Minett, Thais Soares [UNIFESP]; Souza Vitallee, Maria Sylvia de [UNIFESP]; Scerni, Debora Amado [UNIFESP]; Pereira Vilanova, Luiz Celso [UNIFESP]; Univ Sul Santa Catarina UNISUL; Universidade Federal de São Paulo (UNIFESP)Background: Migraine and nocturnal enuresis are highly prevalent disorders with striking similarities. Both have unknown pathophysiology and are considered multifactorial, with neurobiological, genetic, and behavioral aspects involved. Interestingly, the same neurological structures thought to be involved in the pathogenesis of migraine are also thought to be involved in nocturnal enuresis. Few studies, however, have addressed these conditions as related. the aim of this study was to evaluate the antecedent of nocturnal enuresis in a large consecutive series of adolescents with migraine as compared to controls. Methods: A total of 151 subjects were evaluated; 50 had episodic migraine, 50 had chronic migraine, and 51 were control subjects. All patients were submitted to a detailed questionnaire addressing epidemiological and clinical aspects. Results: There was a strong correlation between the clinical history of nocturnal enuresis and the diagnosis of migraine. Conclusion: Our study showed that nocturnal enuresis is a precursor of migraine and a migraine comorbid condition. These results support a pathophysiological linkage between the two conditions. Copyright (C) 2012 S. Karger AG, Basel
- ItemSomente MetadadadosPerfil comportamental de crianças com migrânea com e sem aura(Universidade Federal de São Paulo (UNIFESP), 2020-01-30) Fukue, Rosemeire Rocha [UNIFESP]; Tengan, Celia Harumi [UNIFESP]; Universidade Federal de São PauloMigraine in children and adolescents is often accompanied by psychological symptoms. Previous studies using the Child Behavior Checklist (CBCL) compared healthy and migraine patients and found a higher frequency of internalization symptoms in migraine children. However, it is still uncertain whether the presence of aura can impact the development of behavioral symptoms in patients with migraine. The study aimed to compare the behavioral profile of children and adolescents with migraine with and without aura through the CBCL Inventory. Ninety-eight children and adolescents aged 6 to 15 years with migraine, with and without aura, were recruited and their mothers completed the CBCL (618 years). Responses in the different subscales (Internalizing, externalizing, total problems, anxious/depressed, withdrawn/depression, somatic complaints, social problems, thought problems, delinquent behavior/rule break, aggressive behavior) were analyzed. The comparison between both groups, migraine with aura and migraine without aura, showed significantly higher scores in the externalizing scale (raw scores= 17 vs 13,14, p=0,0373). The analysis of the subscales showed only a significantly difference in the aggressiveness behavior, with higher values in the group with aura (T score=13,69 vs 10,37, p=0,0269) and higher proportion of patients classified in the clinical range (43,59% vs 15,25%). Frequency of episodes of migraine, age and gender did not affect the results on aggressive behavior. We conclude that children and adolescents with migraine with aura may have a higher risk of developing externalizing and aggressive behaviors when compared to children with migraine without aura. Our study shows the relevance of early clinical and psychological interventions in children and adolescents with migraine, specially migraine with aura, regardless of the frequency of migraine episodes.
- ItemAcesso aberto (Open Access)Primary headaches in patients with generalized anxiety disorder(Springer, 2011-06-01) Mercante, Juliane Prieto Peres; Peres, Mario Fernando Prieto [UNIFESP]; Bernik, Márcio Antonini; Universidade de São Paulo (USP); Hosp Israelita Albert Einstein; Universidade Federal de São Paulo (UNIFESP)Although anxiety disorders and headaches are comorbid conditions, there have been no studies evaluating the prevalence of primary headaches in patients with generalized anxiety disorder (GAD). the aim of this study was to analyze the lifetime prevalence of primary headaches in individuals with and without GAD. A total of 60 individuals were evaluated: 30 GAD patients and 30 controls without mental disorders. Psychiatric assessments and primary headache diagnoses were made using structured interviews. Among the GAD patients, the most common diagnosis was migraine, which was significantly more prevalent among the GAD patients than among the controls, as were episodic migraine, chronic daily headache and aura. Tension-type headache was equally common in both groups. Primary headaches in general were significantly more common and more severe in GAD patients than in controls. in anxiety disorder patients, particularly those with GAD, accurate diagnosis of primary headache can improve patient management and clinical outcomes.
- ItemAcesso aberto (Open Access)Prophylactic treatment of vestibular migraine(Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2017) Salmito, Marcio Cavalcante [UNIFESP]; Duarte, Juliana Antoniolli [UNIFESP]; Golcalves Morganti, Ligia Oliveira [UNIFESP]; Caus Brandao, Priscila Valeria [UNIFESP]; Nakao, Bruno Higa [UNIFESP]; Villa, Thais Rodrigues [UNIFESP]; Gananca, Fernando Freitas [UNIFESP]Introduction: Vestibular migraine (VM) is now accepted as a common cause of episodic vertigo. Treatment of VM involves two situations: the vestibular symptom attacks and the period between attacks. For the latter, some prophylaxis methods can be used. The current recommendation is to use the same prophylactic drugs used for migraines, including beta-blockers, antidepressants and anticonvulsants. The recent diagnostic definition of vestibular migraine makes the number of studies on its treatment scarce. Objective: To evaluate the efficacy of prophylactic treatment used in patients from a VM outpatient clinic. Methods: Review of medical records from patients with VM according to the criteria of the Barany Society/International Headache Society of 2012 criteria. The drugs used in the treatment and treatment response obtained through the visual analog scale (VAS) for dizziness and headache were assessed. The pre and post-treatment VAS scores were compared (the improvement was evaluated together and individually, per drug used). Associations with clinical subgroups of patients were also assessed. Results: Of the 88 assessed records, 47 were eligible. We included patients that met the diagnostic criteria for VM and excluded those whose medical records were illegible and those of patients with other disorders causing dizziness and/or headache that did not meet the 2012 criteria for VM. 80.9% of the patients showed improvement with prophylaxis (p < 0.001). Amitriptyline, Flunarizine, Propranolol and Topiramate improved vestibular symptoms (p < 0.001) and headache (p < 0.015). The four drugs were effective in a statistically significant manner. There was a positive statistical association between the time of vestibular symptoms and clinical improvement. There was no additional benefit in hypertensive patients who used antihypertensive drugs as prophylaxis or depressed patients who used antidepressants in relation to other prophylactic drugs. Drug association did not show statistically significant results in relation to the use of a single drug. Conclusions: Prophylactic medications used to treat VM improve the symptoms of this disease, but there is no statistically significant difference between the responses of prophylactic drugs. The time of vestibular symptom seems to increase the benefit with prophylactic treatment. (C) 2016 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.
- ItemSomente MetadadadosRestless Legs Syndrome and Pain Disorders: What's in common?(Springer, 2014-11-01) Goulart, Leonardo Ierardi; Delgado Rodrigues, Raimundo Nonato; Peres, Mario Fernando Prieto [UNIFESP]; Hosp Israelita Albert Einstein; Universidade de Brasília (UnB); Universidade Federal de São Paulo (UNIFESP)Between 10 % and 30 % of the population report chronic pain. More than half of these also have sleep complaints. From considering these data, it can be inferred there is a significant overlapping between these conditions. Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is characterized by complaints of an urge to move frequently associated with dysesthesias. From that perspective, these sensations can also have painful characteristics. By the same token, the presence of comorbid diseases as predicted by a higher prevalence RLS/WED, have many of them with pain as an important complaint. Pain is a multidimensional response involving several levels of expression ranging from somatosensory to emotional. the potential shared mechanisms between RLS/WED and pain may involve sleep deprivation/fragmentation effect, inducing an increase in markers of inflammation and reduction in pain thresholds. These are modulated by several different settings of neurotransmitters with a huge participation of monoaminergic dysfunctional circuits. A thorough comprehension of these mechanisms is of utmost importance for the correct approach and treatment choices.
- ItemSomente MetadadadosVisual attention in children with migraine: a controlled comparative study(Wiley-Blackwell, 2009-06-01) Villa, T. R. [UNIFESP]; Correa Moutran, A. R. [UNIFESP]; Sobirai Diaz, L. A. [UNIFESP]; Pereira Pinto, M. M. [UNIFESP]; Carvalho, F. A. [UNIFESP]; Gabbai, Alberto Alain [UNIFESP]; Carvalho, D. de Souza [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The aim of this study was to evaluate the visual attention of children with migraine and compare it with a control group. Thirty migrainous children and 30 controls without headache were subjected to a visual attention assessment with Trail Making Tests (TMT) A/B, Letter Cancellation Test, and the Brazilian computerized test Visual Attention Test, third edition. the migraine group was evaluated after 2 days without headache. the migraine group had an inferior performance compared with the control group on TMT A (P = 0.03) and B (P = 0.001), and more errors on tasks 1 (P = 0.032) and 2 (P = 0.015) of the Visual Attention Test, presenting difficulty with selective and alternate attention. Attention is a neurological function that depends on structures such as the brainstem, cerebral cortex and the limbic system and on neurotransmitters such as dopamine and noradrenaline. the neurochemical aspects involved in the physiopathology of migraine and attention mechanisms probably predispose these children to visual attention deficits.