Navegando por Palavras-chave "Metaplasia"
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- ItemAcesso aberto (Open Access)Cell proliferation and apoptosis in gastric cancer and intestinal metaplasia(Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED, 2005-03-01) Forones, Nora Manoukian [UNIFESP]; Carvalho, Ana Paula Souza; Giannotti-Filho, Oswaldo; Lourenço, Laércio Gomes [UNIFESP]; Oshima, Celina Tizuko Fujiyama [UNIFESP]; IOncology Group Gastroenterology Division; Pathology Department; Universidade Federal de São Paulo (UNIFESP)BACKGROUND: Higher proliferation is commonly observed in cancer cells. Apoptosis can be a useful measure of a tumor cell kinetic. Alteration of the balance between proliferation and apoptosis is associated with cancer. AIM: To study proliferation and apoptosis on gastric cancer and in intestinal metaplasia. METHODOLOGY: Twenty-two samples from gastric adenocarcinomas and 22 biopsies from intestinal metaplasia were studied. The apoptotic bodies in hematoxylin-eosin slides and the expression of p53, bcl-2 and Ki67 were determined by immunohistochemistry. RESULTS: The number of the apoptotic cells was higher in cancer. Ki 67LI increased from intestinal metaplasia to gastric cancer. p53 was positive in 68% of the patients with cancer, more frequently in advanced stage and negative in samples of intestinal metaplasia. Although there was no significant difference between the groups, bcl-2 was positive in 45% of gastric cancer tissue and in 68% of metaplasia. In gastric cancer patients bcl-2 was expressed in early gastric cancer more frequently than in advanced stage. CONCLUSION: The positivity of bcl-2 was higher in metaplasia and probably is involved in the progression of carcinogenesis. p53 was negative in metaplasia and positive in more than half of the gastric cancer, mostly in stage IV, suggesting a late event in gastric cancer.
- ItemSomente MetadadadosContribuição ao estudo da classificação e histogênese do carcinoma gástrico(Universidade Federal de São Paulo (UNIFESP), 1986) Silva Júnior, João Péricles da [UNIFESP]; Michalany, Jorge [UNIFESP]
- ItemSomente MetadadadosEstudo histologico da metaplasia intestinal em biopsias endoscopicas de mucosa gastrica(Universidade Federal de São Paulo (UNIFESP), 1986) Oliveira, Paulo Roberto Grimaldi [UNIFESP]
- ItemAcesso aberto (Open Access)Intestinal metaplasia in gallbladders: prevalence study(Associacao Paulista Medicina, 2008-07-03) Fernandes, Jose Eduardo Vasconcelos; Franco, Maria Isete Fares; Suzuki, Reinaldo Kenji; Tavares, Nelson Mattos; Bromberg, Sansom Henrique [UNIFESP]; Hosp Serv Publ Estadual Sao Paulo; Univ Metropolitana Santos; Universidade de São Paulo (USP); Univ Lusiada; Santa Casa Misericordia Santos; Universidade Federal de São Paulo (UNIFESP)CONTEXT AND OBJECTIVE: Gallbladder cancer is usually diagnosed at a late stage and generally results in death. Discovery of predisposing factors for this neoplasia could prevent this outcome. In this study, we assess the presence of one of these factors: intestinal metaplasia in gallbladders with stones and inflammatory processes.DESIGN AND SETTING: Cross-sectional study in Hospital do Servidor Publico Estadual de Sao Paulo.METHOD: The first 80 gallbladders from patients who underwent elective cholecystectomy between April and August 2002, presenting stones and chronic inflammation, were studied. The patients were divided into groups according to their age: CC 1, from 15 to 40 years; CC2, from A I to 60 years; and CC3, from 61 to 85 years.RESULTS: Twenty-one patients (26%) were male, while 59 (74%) were female. In the group CC 1, intestinal metaplasia was present in 85.71% of the 21 patients studied; in CC2, in 79.41% of 34 patients; and in CC3, in 56.00% of 25 patients. These differences presented statistical significance (p = 0.04542).CONCLUSION: Intestinal metaplasia is extremely frequent in gallbladders with inflammation and lithiasis, especially in younger patients.
- ItemSomente MetadadadosMetaplasia gastrica, duodenite e infeccao pelo Helicobacter pylori em crianas dispeticas(Universidade Federal de São Paulo (UNIFESP), 2005) Fukushima, Erika [UNIFESP]
- ItemAcesso aberto (Open Access)Metaplasia óssea endometrial: quadro clínico e seguimento após tratamento(Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2010-01-01) Parente, Raphael Câmara Medeiros; Freitas, Vilmon de [UNIFESP]; Moura Neto, Rodrigo Soares de; Oliveira, Marco Aurélio Pinho de; Lasmar, Ricardo Bassil; Patriarca, Marisa Teresinha [UNIFESP]; Canavez, Felipe Simões; Ministério da Saúde; Universidade Federal do Rio de Janeiro; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Rio de Janeiro Instituto de Biologia; Universidade do Estado do Rio de Janeiro Departamento de Ginecologia; Universidade Federal Fluminense Departamento de Ginecologia; Ministério da Saúde Hospital dos Servidores do Estado do Rio de JaneiroPURPOSE: to describe the clinical signs and symptoms of patients with bone metaplasia and to assess the risk factors for changes in these symptoms after removal of the bone fragment. METHODS: a cross-sectional study was conducted on 16 patients with a diagnosis of bone fragments in the uterine cavity during the period comprising July 2006 to January 2009. The inclusion criterion was the detection of a bone fragment removed from the uterine cavity. The presence of bone tissue in the endometrial cavity was histologically confirmed in all patients. The data of all patients were obtained before and after removal by means of a questionnaire for the evaluation of the effect of removal on the symptoms and for the search of possible factors related to the onset of the disease. RESULTS: half the patients (8/16) had hemorrhagic symptoms and one third (6/16) were infertile. Removal of the fragments was quite effective in improving the complaints, with the disappearance of symptoms in all cases of hemorrhage and of pelvic pain. CONCLUSION: removal of bone fragments can restore the fertility of selected patients whose infertility is caused by bone metaplasia and is quite effective in leading to improvement in patients with pelvic pain and menorrhage.